IMP: Integrative Multi-species Prediction

Drosophila melanogaster

111 known processes

Sxl (Dmel_CG18350)

Sex lethal

(Aliases: Su(da),Dmel\CG18350,fs(1)K1274,Sx1,l(1)6Fa,SXL,CG33070,dSXL,Mex156,CG18350,DmSxl,fs(1)M106,sxl,SxlPe,SxL,Fl,Sxl-1 Sxl-2,SxlPm)

Entrez: 3772180
FLYBASE: FBgn0003659
UniProtKB: E6PBY4
UniProtKB: M9PHB3
UniProtKB: F0JAP9
UniProtKB: M9PGW6
UniProtKB: M9PJB1
UniProtKB: P19339
UniProtKB: M9PGK6

Process Predictions
Disease Predictions

Sxl biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
germarium derived egg chamber formation	GO:0007293	101	0.980
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.886
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.793
oocyte differentiation	GO:0009994	145	0.755
female germ line cyst formation	GO:0048135	42	0.703
germarium derived female germ line cyst formation	GO:0030727	42	0.698
germ line cyst formation	GO:0048134	44	0.516
regulation of meiosis	GO:0040020	3	0.482
establishment of organelle localization	GO:0051656	122	0.479
sex determination	GO:0007530	18	0.474
cell proliferation	GO:0008283	299	0.382	Fly
meiosis i	GO:0007127	59	0.353
organelle localization	GO:0051640	148	0.294
cell fate determination	GO:0001709	91	0.231
ovarian follicle cell stalk formation	GO:0030713	17	0.217
chromatin modification	GO:0016568	147	0.169
germarium derived oocyte fate determination	GO:0007294	26	0.161
germarium derived female germ line cyst encapsulation	GO:0030708	8	0.161
oocyte construction	GO:0007308	112	0.149
oocyte development	GO:0048599	124	0.148
immune system process	GO:0002376	347	0.143
reproductive system development	GO:0061458	74	0.134
negative regulation of meiotic cell cycle	GO:0051447	2	0.129
fusome organization	GO:0045478	13	0.126
positive regulation of macromolecule metabolic process	GO:0010604	405	0.125
imaginal disc derived female genitalia development	GO:0007486	6	0.114
negative regulation of biosynthetic process	GO:0009890	277	0.112
localization of cell	GO:0051674	257	0.102
axon choice point recognition	GO:0016198	26	0.098
ovarian fusome organization	GO:0030723	11	0.097
immune response	GO:0006955	246	0.094
germ cell migration	GO:0008354	43	0.092
germarium derived oocyte differentiation	GO:0030706	29	0.089
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.086
female sex differentiation	GO:0046660	20	0.084
oocyte axis specification	GO:0007309	108	0.083
chromosome organization	GO:0051276	360	0.074
cell migration	GO:0016477	238	0.072
developmental maturation	GO:0021700	172	0.067
morphogenesis of follicular epithelium	GO:0016333	36	0.067
regulation of response to external stimulus	GO:0032101	115	0.063
regulation of synapse structure and activity	GO:0050803	128	0.061
synaptic vesicle transport	GO:0048489	50	0.061
regulation of phosphate metabolic process	GO:0019220	210	0.056
neurological system process	GO:0050877	358	0.056
positive regulation of cellular biosynthetic process	GO:0031328	316	0.055
intercellular bridge organization	GO:0043063	14	0.053
cystoblast division	GO:0007282	10	0.051
nuclear migration	GO:0007097	20	0.050
stem cell differentiation	GO:0048863	117	0.048
axon midline choice point recognition	GO:0016199	26	0.047
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0030722	6	0.046
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.045
nucleus localization	GO:0051647	34	0.043
growth	GO:0040007	359	0.042
cell motility	GO:0048870	251	0.039
embryo development ending in birth or egg hatching	GO:0009792	152	0.038
histone h4 k16 acetylation	GO:0043984	4	0.037
molting cycle	GO:0042303	56	0.036
carbohydrate derivative metabolic process	GO:1901135	217	0.036
synaptic vesicle localization	GO:0097479	53	0.035
chromatin silencing	GO:0006342	76	0.035
anterior posterior axis specification	GO:0009948	109	0.034
establishment of protein localization	GO:0045184	163	0.034
protein localization	GO:0008104	284	0.034
body morphogenesis	GO:0010171	2	0.033
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.033
defense response	GO:0006952	300	0.032	Fly
multi organism reproductive behavior	GO:0044705	121	0.031
regulation of cell differentiation	GO:0045595	302	0.030
establishment of localization in cell	GO:0051649	402	0.030
meiotic nuclear division	GO:0007126	151	0.030
developmental growth	GO:0048589	280	0.030
protein complex biogenesis	GO:0070271	201	0.029
regulation of cell division	GO:0051302	72	0.027
positive regulation of biosynthetic process	GO:0009891	316	0.027
female germ line cyst encapsulation	GO:0048139	8	0.027
stem cell division	GO:0017145	69	0.026
organic substance transport	GO:0071702	257	0.026
chromatin organization	GO:0006325	207	0.026
regulation of hemocyte proliferation	GO:0035206	37	0.026
intracellular signal transduction	GO:0035556	300	0.026
protein transport	GO:0015031	155	0.026
cellular catabolic process	GO:0044248	372	0.026
actin filament organization	GO:0007015	126	0.025
negative regulation of chromatin silencing	GO:0031936	9	0.024
sex differentiation	GO:0007548	81	0.024
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.024
membrane organization	GO:0061024	112	0.023
response to organic substance	GO:0010033	284	0.023
positive regulation of mitotic cell cycle	GO:0045931	34	0.023
regulation of intracellular transport	GO:0032386	64	0.023
negative regulation of cellular metabolic process	GO:0031324	382	0.023
negative regulation of cellular biosynthetic process	GO:0031327	277	0.022
cellular protein complex assembly	GO:0043623	71	0.022
exocrine system development	GO:0035272	162	0.022
dna metabolic process	GO:0006259	227	0.022
mitotic spindle organization	GO:0007052	220	0.021
meiotic cell cycle	GO:0051321	171	0.021
oocyte localization involved in germarium derived egg chamber formation	GO:0030720	12	0.021
germ line cyst encapsulation	GO:0048138	8	0.020
vesicle organization	GO:0016050	44	0.020
establishment of vesicle localization	GO:0051650	51	0.019
dna alkylation	GO:0006305	4	0.019
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.019
establishment of planar polarity	GO:0001736	87	0.019
establishment or maintenance of cell polarity	GO:0007163	167	0.019
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.019
positive regulation of phosphorylation	GO:0042327	87	0.018
anatomical structure homeostasis	GO:0060249	97	0.018
stem cell maintenance	GO:0019827	67	0.018
regulation of phosphorus metabolic process	GO:0051174	210	0.018
posttranscriptional regulation of gene expression	GO:0010608	145	0.018
meiotic cell cycle process	GO:1903046	132	0.018
positive regulation of phosphorus metabolic process	GO:0010562	139	0.017
regulation of sequence specific dna binding transcription factor activity	GO:0051090	12	0.017
hindgut morphogenesis	GO:0007442	58	0.017
synapse assembly	GO:0007416	143	0.016
karyosome formation	GO:0030717	22	0.016
regulation of transcription factor import into nucleus	GO:0042990	22	0.016
homeostatic process	GO:0042592	199	0.016
small molecule metabolic process	GO:0044281	305	0.016
regulation of immune response	GO:0050776	118	0.016
regulation of synapse organization	GO:0050807	110	0.015
organonitrogen compound metabolic process	GO:1901564	318	0.015
regulation of cellular protein metabolic process	GO:0032268	243	0.015
actin filament based process	GO:0030029	220	0.015
regulation of meiotic cell cycle	GO:0051445	9	0.015
germline ring canal formation	GO:0030725	13	0.015
negative regulation of phosphatase activity	GO:0010923	3	0.015
negative regulation of response to stimulus	GO:0048585	258	0.015
cell division	GO:0051301	248	0.015
positive regulation of molecular function	GO:0044093	136	0.014
ameboidal type cell migration	GO:0001667	151	0.014
organic substance catabolic process	GO:1901575	308	0.014
cellular macromolecular complex assembly	GO:0034622	153	0.014
death	GO:0016265	284	0.014
synapse organization	GO:0050808	196	0.014
intracellular protein transport	GO:0006886	104	0.014
regulation of gene expression epigenetic	GO:0040029	128	0.013
developmental programmed cell death	GO:0010623	138	0.013
cellular protein modification process	GO:0006464	438	0.013
positive regulation of catalytic activity	GO:0043085	118	0.013
chaeta development	GO:0022416	97	0.013
cell death	GO:0008219	279	0.013
establishment of synaptic vesicle localization	GO:0097480	50	0.013
positive regulation of protein metabolic process	GO:0051247	128	0.013
cell aging	GO:0007569	2	0.013
genitalia development	GO:0048806	26	0.013
stem cell proliferation	GO:0072089	88	0.013
autophagic cell death	GO:0048102	83	0.012
positive regulation of cell cycle process	GO:0090068	28	0.012
female germline ring canal formation	GO:0007301	9	0.012
carbohydrate metabolic process	GO:0005975	82	0.012
histone h3 k9 modification	GO:0061647	12	0.012
catabolic process	GO:0009056	409	0.012
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.011
positive regulation of intracellular signal transduction	GO:1902533	116	0.011
mrna splicing via spliceosome	GO:0000398	73	0.011
gene silencing by rna	GO:0031047	57	0.011
generation of precursor metabolites and energy	GO:0006091	42	0.011
response to radiation	GO:0009314	155	0.011
spindle organization	GO:0007051	253	0.011
protein homooligomerization	GO:0051260	7	0.011
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	9	0.011
cellular protein localization	GO:0034613	160	0.011
immune system development	GO:0002520	57	0.011
protein localization to organelle	GO:0033365	82	0.011
tripartite regional subdivision	GO:0007351	103	0.011
female genitalia development	GO:0030540	6	0.010
response to ecdysone	GO:0035075	34	0.010
glucan biosynthetic process	GO:0009250	2	0.010
ion transport	GO:0006811	145	0.010
chitin based cuticle sclerotization	GO:0007593	19	0.010
positive regulation of binding	GO:0051099	4	0.010

Sxl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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