Drosophila melanogaster

30 known processes

pHCl (Dmel_CG33989)

CG33989 gene product from transcript CG33989-RD

(Aliases: Dmel\CG33989,BP1024,CG6112,CG13444,pHCL-A,BcDNA:GH21757,CG33989)

pHCl biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
sensory perception of salty tasteGO:005091430.449
g protein coupled receptor signaling pathwayGO:00071861360.348
adult behaviorGO:00305341370.268
axon developmentGO:00615642970.168
axonogenesisGO:00074092900.167
salt aversionGO:003519930.165
feeding behaviorGO:0007631500.124
neuron recognitionGO:00080381010.123
ion transportGO:00068111450.117
store operated calcium entryGO:000211530.114
metal ion transportGO:0030001740.111
single organism behaviorGO:00447083910.108
cation transportGO:00068121100.103
taxisGO:00423303040.098
neuron projection guidanceGO:00974852410.091
regulation of cell differentiationGO:00455953020.090
multi organism reproductive behaviorGO:00447051210.083
eye morphogenesisGO:00485922600.081
behavioral response to ethanolGO:0048149490.076
eye developmentGO:00016543230.075
multi organism behaviorGO:00517051750.074
response to organic substanceGO:00100332840.072
response to alcoholGO:0097305950.072
response to oxygen containing compoundGO:19017002000.069
reproductive behaviorGO:00190981220.066
eye photoreceptor cell developmentGO:0042462810.065
ion transmembrane transportGO:00342201220.065
cellular metal ion homeostasisGO:0006875310.063
neuropeptide signaling pathwayGO:0007218450.062
mating behaviorGO:00076171060.062
tube morphogenesisGO:00352391910.062
matingGO:00076181200.060
vesicle mediated transportGO:00161923810.059
multi multicellular organism processGO:00447061230.057
regulation of anatomical structure sizeGO:00900661630.055
sensory perceptionGO:00076001960.054
regionalizationGO:00030024160.053
compound eye photoreceptor developmentGO:0042051780.052
regulation of behaviorGO:0050795750.052
axon guidanceGO:00074112330.051
response to ethanolGO:0045471590.051
metal ion homeostasisGO:0055065440.050
regulation of transcription from rna polymerase ii promoterGO:00063573780.049
compound eye photoreceptor cell differentiationGO:00017511400.048
divalent metal ion transportGO:0070838260.048
positive regulation of nucleobase containing compound metabolic processGO:00459353320.046
tissue morphogenesisGO:00487292970.045
endocytosisGO:00068973100.045
dendrite developmentGO:00163582040.045
compound eye developmentGO:00487493070.045
phosphorylationGO:00163102940.045
synaptic target recognitionGO:0008039450.045
negative regulation of response to stimulusGO:00485852580.043
eye photoreceptor cell differentiationGO:00017541450.043
intracellular signal transductionGO:00355563000.042
lateral inhibitionGO:00463312060.042
chemotaxisGO:00069352490.042
cell recognitionGO:00080371020.042
synaptic transmissionGO:00072682880.041
photoreceptor cell differentiationGO:00465301700.041
forebrain developmentGO:003090020.041
sensory perception of chemical stimulusGO:00076061160.041
regulation of cell cycleGO:00517262910.040
response to abiotic stimulusGO:00096283410.040
multicellular organismal reproductive behaviorGO:00330571100.040
positive regulation of cellular biosynthetic processGO:00313283160.040
positive regulation of macromolecule metabolic processGO:00106044050.040
positive regulation of biosynthetic processGO:00098913160.039
organonitrogen compound metabolic processGO:19015643180.038
chemosensory behaviorGO:00076351060.038
small molecule metabolic processGO:00442813050.037
sensory organ morphogenesisGO:00905962600.037
negative regulation of gene expressionGO:00106293870.037
adult locomotory behaviorGO:0008344760.037
phagocytosisGO:00069092150.036
cation transmembrane transportGO:0098655880.036
appendage morphogenesisGO:00351073970.036
calcium ion transportGO:0006816240.036
associative learningGO:0008306650.036
cell cycle phase transitionGO:00447701400.035
positive regulation of nitrogen compound metabolic processGO:00511733540.035
compound eye morphogenesisGO:00017452490.034
embryonic development via the syncytial blastodermGO:00017001480.034
epithelial cell differentiationGO:00308553220.034
neurological system processGO:00508773580.034
locomotory behaviorGO:00076261760.034
regulation of mitotic cell cycle phase transitionGO:19019901300.034
cell cell signaling involved in cell fate commitmentGO:00451682100.033
wing disc morphogenesisGO:00074723440.033
transcription from rna polymerase ii promoterGO:00063663680.033
photoreceptor cell developmentGO:0042461960.032
heart processGO:0003015370.032
regulation of localizationGO:00328792750.032
regulation of synapse structure and activityGO:00508031280.032
single organism biosynthetic processGO:00447112060.032
positive regulation of cell communicationGO:00106472500.032
cell projection assemblyGO:0030031940.031
actin filament based processGO:00300292200.031
positive regulation of response to stimulusGO:00485843230.031
negative regulation of rna metabolic processGO:00512532510.031
cellular ion homeostasisGO:0006873390.030
carbohydrate derivative biosynthetic processGO:1901137850.030
organonitrogen compound biosynthetic processGO:19015661170.030
positive regulation of phosphorus metabolic processGO:00105621390.030
embryonic morphogenesisGO:00485982060.030
cell proliferationGO:00082832990.030
protein modification processGO:00362114380.030
regulation of phosphorus metabolic processGO:00511742100.030
dendrite morphogenesisGO:00488131990.030
organic substance catabolic processGO:19015753080.030
positive regulation of signalingGO:00230562430.030
negative regulation of nucleobase containing compound metabolic processGO:00459342610.030
protein complex assemblyGO:00064612000.029
regulation of cellular component biogenesisGO:00440872010.029
cation homeostasisGO:0055080510.029
cyclic purine nucleotide metabolic processGO:0052652250.029
cellular response to chemical stimulusGO:00708871990.029
macromolecular complex assemblyGO:00650032560.029
divalent inorganic cation transportGO:0072511300.029
negative regulation of cellular biosynthetic processGO:00313272770.029
positive regulation of phosphate metabolic processGO:00459371390.029
appendage developmentGO:00487364010.029
cellular protein modification processGO:00064644380.029
digestive tract developmentGO:00485651490.029
catabolic processGO:00090564090.029
regulation of phosphate metabolic processGO:00192202100.028
brain developmentGO:00074201200.028
regulation of catalytic activityGO:00507901850.027
post embryonic appendage morphogenesisGO:00351203850.027
response to organic cyclic compoundGO:0014070890.027
regulation of nervous system developmentGO:00519602480.027
protein complex biogenesisGO:00702712010.027
regulation of intracellular signal transductionGO:19025312360.027
inter male aggressive behaviorGO:0002121600.027
regulation of protein metabolic processGO:00512462560.027
regulation of mitotic cell cycleGO:00073461900.027
morphogenesis of an epitheliumGO:00020092760.026
homeostatic processGO:00425921990.026
detection of visible lightGO:0009584380.026
cell cell adhesion via plasma membrane adhesion moleculesGO:0098742260.026
male mating behaviorGO:0060179700.026
nucleoside phosphate metabolic processGO:00067531620.026
digestive system developmentGO:00551231490.026
negative regulation of biosynthetic processGO:00098902770.026
cellular homeostasisGO:0019725800.026
embryonic hindgut morphogenesisGO:0048619480.026
segmentationGO:00352822070.026
regulation of cellular protein metabolic processGO:00322682430.026
growthGO:00400073590.025
regulation of multicellular organismal developmentGO:20000264140.025
negative regulation of rna biosynthetic processGO:19026792400.025
positive regulation of rna metabolic processGO:00512542710.025
nucleobase containing small molecule metabolic processGO:00550861740.025
negative regulation of nitrogen compound metabolic processGO:00511722650.025
rhabdomere developmentGO:0042052380.025
aggressive behaviorGO:0002118630.025
negative regulation of macromolecule biosynthetic processGO:00105582700.025
mitotic cell cycle phase transitionGO:00447721380.025
larval behaviorGO:0030537420.024
positive regulation of adenylate cyclase activityGO:004576280.024
programmed cell deathGO:00125012570.024
imaginal disc derived wing morphogenesisGO:00074763370.024
negative regulation of cellular metabolic processGO:00313243820.024
ras protein signal transductionGO:0007265880.024
digestive tract morphogenesisGO:00485461270.024
localization of cellGO:00516742570.024
sleepGO:0030431490.024
olfactory behaviorGO:0042048970.024
tube developmentGO:00352952440.024
head developmentGO:00603221350.023
cell motilityGO:00488702510.023
columnar cuboidal epithelial cell developmentGO:00020662490.023
regulation of membrane potentialGO:0042391350.023
imaginal disc pattern formationGO:0007447910.023
regulation of phosphorylationGO:00423251470.023
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.023
response to lipopolysaccharideGO:003249640.023
purine containing compound biosynthetic processGO:0072522300.022
muscle structure developmentGO:00610612240.022
intraspecies interaction between organismsGO:005170340.022
regulation of cell cycle processGO:00105641810.022
regulation of neuron differentiationGO:00456641030.022
chemical homeostasisGO:0048878920.022
regulation of molecular functionGO:00650092170.022
positive regulation of signal transductionGO:00099672230.022
ion homeostasisGO:0050801550.022
negative regulation of cell communicationGO:00106482230.022
imaginal disc derived appendage morphogenesisGO:00351143950.022
establishment of localization in cellGO:00516494020.022
cellular response to carbohydrate stimulusGO:007132240.021
regulation of cell proliferationGO:00421271630.021
cellular macromolecule localizationGO:00707272200.021
regulation of tube sizeGO:0035150460.021
carbohydrate derivative metabolic processGO:19011352170.021
regulation of cellular amine metabolic processGO:003323830.021
inorganic ion transmembrane transportGO:0098660730.021
protein localizationGO:00081042840.021
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.021
imaginal disc derived leg morphogenesisGO:0007480800.021
renal tubule developmentGO:0061326640.021
organophosphate metabolic processGO:00196371950.021
mitotic spindle organizationGO:00070522200.021
cellular response to organic substanceGO:00713101320.021
positive regulation of nucleic acid templated transcriptionGO:19035082660.021
regulation of transportGO:00510491810.021
circulatory system processGO:0003013370.021
cellular catabolic processGO:00442483720.021
regulation of synaptic transmissionGO:0050804690.021
muscle system processGO:0003012210.021
regulation of cell cycle phase transitionGO:19019871300.021
aromatic compound catabolic processGO:00194391660.020
columnar cuboidal epithelial cell differentiationGO:00020652560.020
olfactory learningGO:0008355560.020
camp biosynthetic processGO:0006171170.020
imaginal disc derived appendage developmentGO:00487373990.020
detection of light stimulusGO:0009583580.020
hindgut morphogenesisGO:0007442580.020
purine ribonucleotide metabolic processGO:00091501450.020
negative regulation of transcription dna templatedGO:00458922370.020
negative regulation of signalingGO:00230572190.020
positive regulation of gene expressionGO:00106282900.020
purine nucleotide metabolic processGO:00061631460.020
establishment or maintenance of cell polarityGO:00071631670.019
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188170.019
organic cyclic compound catabolic processGO:19013611680.019
ameboidal type cell migrationGO:00016671510.019
leg disc developmentGO:0035218920.019
carboxylic acid metabolic processGO:0019752920.019
body morphogenesisGO:001017120.019
apoptotic processGO:00069151590.019
protein transportGO:00150311550.019
courtship behaviorGO:0007619680.019
detection of stimulusGO:00516061560.019
regulation of cell projection organizationGO:0031344920.019
cellular divalent inorganic cation homeostasisGO:0072503230.019
regulation of synapse assemblyGO:0051963940.019
cell migrationGO:00164772380.019
nucleotide metabolic processGO:00091171610.019
regulation of excitatory postsynaptic membrane potentialGO:006007930.019
cognitionGO:00508901410.019
sensory perception of tasteGO:0050909250.018
malpighian tubule morphogenesisGO:0007443440.018
epithelial cell developmentGO:00020642740.018
embryo development ending in birth or egg hatchingGO:00097921520.018
regulation of cellular amino acid metabolic processGO:000652100.018
sensory perception of smellGO:0007608800.018
rna processingGO:00063961470.018
cellular response to lipopolysaccharideGO:007122230.018
cellular cation homeostasisGO:0030003380.018
deathGO:00162652840.018
spindle organizationGO:00070512530.018
regulation of neurogenesisGO:00507671580.018
regulation of metal ion transportGO:0010959150.018
organelle assemblyGO:00709251980.018
hindgut developmentGO:0061525580.018
camera type eye developmentGO:004301040.018
regulation of gene expression epigeneticGO:00400291280.018
negative regulation of nucleic acid templated transcriptionGO:19035072400.018
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187170.018
open tracheal system developmentGO:00074242040.018
anatomical structure homeostasisGO:0060249970.018
cellular response to molecule of bacterial originGO:007121930.018
gland developmentGO:00487321910.018
learningGO:0007612750.017
positive regulation of cell motilityGO:200014730.017
positive regulation of molecular functionGO:00440931360.017
developmental growthGO:00485892800.017
positive regulation of catalytic activityGO:00430851180.017
regulation of response to stressGO:00801342000.017
secretionGO:00469031090.017
ovarian follicle cell developmentGO:00307072480.017
cellular chemical homeostasisGO:0055082400.017
cellular calcium ion homeostasisGO:0006874210.017
purine containing compound metabolic processGO:00725211550.017
positive regulation of rna biosynthetic processGO:19026802660.017
motor neuron axon guidanceGO:0008045580.017
regulation of neuron projection developmentGO:0010975690.017
positive regulation of cyclic nucleotide metabolic processGO:003080190.017
androgen metabolic processGO:000820910.017
biological adhesionGO:00226101380.017
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.017
regulation of cellular ketone metabolic processGO:001056530.017
sensory perception of painGO:001923340.017
establishment of protein localizationGO:00451841630.017
ribonucleotide biosynthetic processGO:0009260280.017
hormone catabolic processGO:004244730.017
mrna processingGO:00063971040.017
monovalent inorganic cation transportGO:0015672400.016
response to radiationGO:00093141550.016
neuromuscular synaptic transmissionGO:0007274670.016
endomembrane system organizationGO:00102561190.016
alternative mrna splicing via spliceosomeGO:0000380600.016
bolwig s organ developmentGO:005503480.016
neuron neuron synaptic transmissionGO:0007270140.016
salivary gland developmentGO:00074311620.016
respiratory system developmentGO:00605412130.016
calcium ion homeostasisGO:0055074230.016
positive regulation of cellular component biogenesisGO:0044089800.016
regulation of camp metabolic processGO:0030814120.016
gene silencingGO:00164581380.016
membrane organizationGO:00610241120.016
regulation of multi organism processGO:00439001310.016
cyclic nucleotide biosynthetic processGO:0009190250.016
regulation of epithelial cell proliferationGO:005067840.016
positive regulation of cell migrationGO:003033520.016
cellular amine metabolic processGO:0044106120.016
cellular nitrogen compound catabolic processGO:00442701650.016
tissue migrationGO:00901301550.016
regulation of mapk cascadeGO:0043408920.016
organic substance transportGO:00717022570.016
malpighian tubule developmentGO:0072002640.016
heterocycle catabolic processGO:00467001660.016
cellular ketone metabolic processGO:0042180240.016
cellular protein localizationGO:00346131600.016
amine metabolic processGO:0009308120.016
regulation of response to external stimulusGO:00321011150.015
protein phosphorylationGO:00064681690.015
rna splicingGO:0008380830.015
regulation of small gtpase mediated signal transductionGO:0051056930.015
larval locomotory behaviorGO:0008345270.015
response to glucoseGO:000974920.015
small gtpase mediated signal transductionGO:0007264880.015
cellular response to biotic stimulusGO:007121640.015
membrane depolarizationGO:005189940.015
single organism catabolic processGO:00447122280.015
cell deathGO:00082192790.015
regulation of ion transportGO:0043269390.015
secretion by cellGO:00329401010.015
cellular response to oxygen containing compoundGO:1901701790.015
ribonucleotide metabolic processGO:00092591450.015
positive regulation of transcription dna templatedGO:00458932660.015
developmental programmed cell deathGO:00106231380.015
salivary gland morphogenesisGO:00074351450.015
nuclear divisionGO:00002803320.015
exocrine system developmentGO:00352721620.015
response to sterolGO:0036314340.015
developmental maturationGO:00217001720.015
positive regulation of nucleotide metabolic processGO:0045981550.014
gland morphogenesisGO:00226121450.014
regulation of ras protein signal transductionGO:0046578930.014
cell cell adhesionGO:0098609260.014
rna splicing via transesterification reactionsGO:0000375730.014
immune system processGO:00023763470.014
regulation of purine nucleotide metabolic processGO:1900542620.014
regulation of cell deathGO:00109411730.014
ribose phosphate metabolic processGO:00196931450.014
cytosolic calcium ion homeostasisGO:0051480110.014
response to ketoneGO:1901654340.014
circadian sleep wake cycleGO:0042745280.014
regulation of alternative mrna splicing via spliceosomeGO:0000381600.014
retina development in camera type eyeGO:006004140.014
actin cytoskeleton organizationGO:00300362060.014
regulation of cell shapeGO:00083601130.014
cellular amino acid metabolic processGO:0006520610.014
regulation of system processGO:0044057360.014
response to other organismGO:00517072930.014
response to reactive oxygen speciesGO:0000302240.014
axonal defasciculationGO:0007414120.013
signal transduction by phosphorylationGO:00230141070.013
cellular component assembly involved in morphogenesisGO:00109271510.013
mrna metabolic processGO:00160711240.013
negative regulation of protein metabolic processGO:0051248850.013
purine ribonucleotide biosynthetic processGO:0009152280.013
spindle assemblyGO:0051225800.013
response to mechanical stimulusGO:0009612280.013
response to light stimulusGO:00094161240.013
posttranscriptional regulation of gene expressionGO:00106081450.013
positive regulation of macromolecule biosynthetic processGO:00105572830.013
positive regulation of purine nucleotide metabolic processGO:1900544550.013
stem cell differentiationGO:00488631170.013
cellular response to endogenous stimulusGO:0071495800.013
mitotic cytokinesisGO:0000281500.013
response to organonitrogen compoundGO:0010243750.013
nucleobase containing compound catabolic processGO:00346551650.013
organic acid metabolic processGO:00060821030.013
intracellular transportGO:00469072280.013
connective tissue developmentGO:006144830.013
learning or memoryGO:00076111410.013
negative regulation of developmental processGO:00510932010.013
positive regulation of lyase activityGO:0051349100.013
central nervous system developmentGO:00074172010.013
cell adhesionGO:00071551360.013
cytoskeleton dependent cytokinesisGO:0061640810.012
negative regulation of cellular protein metabolic processGO:0032269850.012
cellular response to dna damage stimulusGO:00069742230.012
negative regulation of gene expression epigeneticGO:0045814770.012
regulation of cell projection assemblyGO:0060491300.012
oxoacid metabolic processGO:00434361030.012
rna localizationGO:00064031150.012
nephron epithelium developmentGO:007200930.012
cell divisionGO:00513012480.012
response to external biotic stimulusGO:00432072930.012
detection of external stimulusGO:0009581660.012
regulation of cell developmentGO:00602842150.012
negative regulation of homeostatic processGO:003284520.012
reproductive system developmentGO:0061458740.012
protein heterooligomerizationGO:005129140.012
organophosphate biosynthetic processGO:0090407460.012
somatic muscle developmentGO:0007525660.012
positive regulation of phosphorylationGO:0042327870.012
regulation of rna splicingGO:0043484690.012
drinking behaviorGO:004275620.012
blood circulationGO:0008015260.012
response to oxidative stressGO:0006979860.012
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377730.012
anterior posterior pattern specificationGO:00099521360.012
epithelial cell migrationGO:00106311480.012
embryonic axis specificationGO:00005781070.012
axis specificationGO:00097981670.012
response to lipidGO:0033993380.012
regulation of cellular localizationGO:00603411360.012
non sensory hair organizationGO:0035316470.012
response to monosaccharideGO:003428440.012
muscle organ developmentGO:00075171270.012
chromosome organizationGO:00512763600.012
positive regulation of intracellular signal transductionGO:19025331160.012
regulation of circadian sleep wake cycleGO:0042749250.012
purine nucleoside catabolic processGO:00061521120.012
neuromuscular junction developmentGO:00075281490.012
r7 cell differentiationGO:0045466430.012
erk1 and erk2 cascadeGO:0070371390.012
regulation of mrna splicing via spliceosomeGO:0048024640.012
tripartite regional subdivisionGO:00073511030.012
regulation of cyclic nucleotide biosynthetic processGO:0030802130.011
single organism membrane organizationGO:0044802930.011
telencephalon developmentGO:002153720.011
response to endogenous stimulusGO:00097191190.011
purine ribonucleoside catabolic processGO:00461301120.011
wing disc pattern formationGO:0035222660.011
ribonucleoside triphosphate metabolic processGO:00091991190.011
flight behaviorGO:0007629260.011
purine nucleoside triphosphate metabolic processGO:00091441190.011
response to decreased oxygen levelsGO:0036293580.011
regulation of purine nucleotide biosynthetic processGO:1900371140.011
cell maturationGO:00484691440.011
cyclic nucleotide metabolic processGO:0009187280.011
positive regulation of exocytosisGO:004592140.011
response to hexoseGO:000974630.011
enzyme linked receptor protein signaling pathwayGO:00071671790.011
regulation of mrna processingGO:0050684710.011
regulation of mrna metabolic processGO:1903311720.011
regulation of programmed cell deathGO:00430671520.011
heart developmentGO:0007507820.011
regulation of gene silencingGO:0060968630.011
kidney developmentGO:000182230.011
positive regulation of catabolic processGO:00098961050.011
embryonic pattern specificationGO:00098801740.011
developmental pigmentationGO:0048066680.011
mrna splicing via spliceosomeGO:0000398730.011
negative regulation of signal transductionGO:00099682060.011
response to temperature stimulusGO:00092661060.011
circulatory system developmentGO:0072359820.011
regulation of developmental growthGO:00486381740.011
negative regulation of cell deathGO:0060548810.011
positive regulation of developmental processGO:00510941430.011
long term memoryGO:0007616620.011
glycosyl compound metabolic processGO:19016571270.011
lipid metabolic processGO:00066291210.011
nucleoside catabolic processGO:00091641120.011
detection of abiotic stimulusGO:0009582660.011
epithelium migrationGO:00901321480.011
positive regulation of multicellular organismal processGO:00512401430.011
ribonucleoside catabolic processGO:00424541120.011
carbohydrate metabolic processGO:0005975820.010
leg disc morphogenesisGO:0007478800.010
cell growthGO:00160491080.010
morphogenesis of embryonic epitheliumGO:0016331940.010
nucleoside phosphate catabolic processGO:19012921100.010
guanosine containing compound catabolic processGO:1901069740.010
cellular macromolecular complex assemblyGO:00346221530.010
response to ecdysoneGO:0035075340.010
regulation of neuromuscular synaptic transmissionGO:1900073150.010
positive regulation of mapk cascadeGO:0043410630.010
proteolysisGO:00065081920.010
negative regulation of multicellular organismal processGO:00512411420.010
purine nucleotide catabolic processGO:00061951090.010
nucleoside phosphate biosynthetic processGO:1901293340.010
cellular response to monosaccharide stimulusGO:007132620.010
hindbrain developmentGO:003090220.010
cytoplasmic transportGO:00164821300.010
regulation of chromatin silencingGO:0031935360.010
kidney epithelium developmentGO:007207330.010
memoryGO:0007613940.010
synaptic growth at neuromuscular junctionGO:00511241190.010
defense responseGO:00069523000.010
anterior posterior axis specificationGO:00099481090.010
regulation of catabolic processGO:00098941700.010
cell fate specificationGO:0001708710.010
sex differentiationGO:0007548810.010

pHCl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.079
cardiovascular system diseaseDOID:128700.073
nervous system diseaseDOID:86300.027
musculoskeletal system diseaseDOID:1700.017