IMP: Integrative Multi-species Prediction

Drosophila melanogaster

51 known processes

Sod (Dmel_CG11793)

Superoxide dismutase

(Aliases: CG11793,ZnSod,sod,Sod1,To,l(3)108,Cu/Zn sod,CuZnSOD,cSOD,SOD,sod1,Sod-1,CuSOD,Cu/Zn SOD,G,SOD1,To-1,Cu-Zn SOD,Dmel\CG11793,Cu[2+]/Zn[2+]SOD,Cu/ZnSOD,l(3)68Af',Zn Sod,cSod,l(3)G,SOD-1,Cu/Zn superoxide dismutase,CuZn-SOD,CuZn SOD,Zn-SOD,Cu)

Entrez: 39251
FLYBASE: FBgn0003462
UniProtKB: M9PF91
UniProtKB: P61851

Process Predictions
Disease Predictions

Sod biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
response to oxidative stress	GO:0006979	86	1.000
cellular response to oxidative stress	GO:0034599	28	0.997
cellular response to reactive oxygen species	GO:0034614	14	0.991
response to reactive oxygen species	GO:0000302	24	0.951
response to hydrogen peroxide	GO:0042542	11	0.924	Mouse
programmed cell death	GO:0012501	257	0.792	Human Mouse Rat
response to oxygen containing compound	GO:1901700	200	0.722
homeostatic process	GO:0042592	199	0.707	Yeast Zebrafish Mouse
learning or memory	GO:0007611	141	0.686
age dependent response to oxidative stress	GO:0001306	3	0.653
response to organic substance	GO:0010033	284	0.603	Human Zebrafish Mouse Rat
determination of adult lifespan	GO:0008340	137	0.589
single organism biosynthetic process	GO:0044711	206	0.574	Human
pigmentation	GO:0043473	75	0.540
oxoacid metabolic process	GO:0043436	103	0.532	Mouse
regulation of multicellular organismal development	GO:2000026	414	0.528
cellular lipid metabolic process	GO:0044255	83	0.472
multicellular organismal aging	GO:0010259	140	0.472
small molecule metabolic process	GO:0044281	305	0.469	Human Mouse
paracrine signaling	GO:0038001	7	0.465
response to abiotic stimulus	GO:0009628	341	0.457	Mouse
regulation of catabolic process	GO:0009894	170	0.449
carboxylic acid metabolic process	GO:0019752	92	0.439	Mouse
response to metal ion	GO:0010038	23	0.439	Zebrafish Rat
cellular amide metabolic process	GO:0043603	80	0.435	Mouse
oxidation reduction process	GO:0055114	123	0.423
regulation of apoptotic process	GO:0042981	130	0.395	Human Mouse Rat
hydrogen peroxide catabolic process	GO:0042744	6	0.365
death	GO:0016265	284	0.333	Human Mouse Rat
aging	GO:0007568	143	0.328
positive regulation of macromolecule metabolic process	GO:0010604	405	0.315	Yeast Mouse
organophosphate biosynthetic process	GO:0090407	46	0.293
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.256
developmental programmed cell death	GO:0010623	138	0.242
epithelial cell differentiation	GO:0030855	322	0.242	Mouse
organic acid metabolic process	GO:0006082	103	0.240	Mouse
cellular response to chemical stimulus	GO:0070887	199	0.235
regulation of cell differentiation	GO:0045595	302	0.225
regulation of cell death	GO:0010941	173	0.206	Human Mouse Rat
lipid metabolic process	GO:0006629	121	0.201	Human
neurological system process	GO:0050877	358	0.197	Mouse
response to radiation	GO:0009314	155	0.190
cellular response to dna damage stimulus	GO:0006974	223	0.184
appendage development	GO:0048736	401	0.173
regulation of cellular catabolic process	GO:0031329	157	0.170
cell death	GO:0008219	279	0.163	Human Mouse Rat
cation transport	GO:0006812	110	0.162
negative regulation of apoptotic process	GO:0043066	63	0.154	Mouse Rat
intracellular signal transduction	GO:0035556	300	0.150	Human Mouse
age dependent general metabolic decline	GO:0007571	3	0.142
organophosphate metabolic process	GO:0019637	195	0.138	Human
localization of cell	GO:0051674	257	0.136
regulation of catalytic activity	GO:0050790	185	0.135	Human Mouse Rat
intracellular transport	GO:0046907	228	0.135	Mouse
cell aging	GO:0007569	2	0.131	Human Yeast
immune system process	GO:0002376	347	0.127	Mouse
ion transport	GO:0006811	145	0.123
reactive oxygen species metabolic process	GO:0072593	22	0.123
establishment of localization in cell	GO:0051649	402	0.123	Mouse
negative regulation of cell differentiation	GO:0045596	143	0.122
single organism intracellular transport	GO:1902582	207	0.121	Mouse
protein complex assembly	GO:0006461	200	0.119
regulation of molecular function	GO:0065009	217	0.115	Human Yeast Mouse Rat
cell redox homeostasis	GO:0045454	5	0.107
cellular response to hydrogen peroxide	GO:0070301	7	0.101
tissue death	GO:0016271	102	0.099
negative regulation of programmed cell death	GO:0043069	72	0.093	Mouse Rat
defense response	GO:0006952	300	0.088
regulation of cellular response to oxidative stress	GO:1900407	4	0.088	Human
immune system development	GO:0002520	57	0.086
proteolysis	GO:0006508	192	0.085
response to oxygen radical	GO:0000305	3	0.082
catabolic process	GO:0009056	409	0.081
regulation of phosphorus metabolic process	GO:0051174	210	0.078	Human Mouse
molting cycle	GO:0042303	56	0.076
cognition	GO:0050890	141	0.076
cell type specific apoptotic process	GO:0097285	38	0.075	Mouse
protein complex biogenesis	GO:0070271	201	0.075
lipid biosynthetic process	GO:0008610	46	0.074	Human
single organism behavior	GO:0044708	391	0.070
cellular catabolic process	GO:0044248	372	0.070
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.069	Yeast
appendage morphogenesis	GO:0035107	397	0.068
pigment metabolic process	GO:0042440	84	0.067
response to temperature stimulus	GO:0009266	106	0.067	Mouse
positive regulation of intracellular signal transduction	GO:1902533	116	0.066	Human Mouse
peptide metabolic process	GO:0006518	80	0.064	Mouse
glutathione metabolic process	GO:0006749	37	0.064	Mouse
organonitrogen compound metabolic process	GO:1901564	318	0.064	Human Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.061	Yeast
adult behavior	GO:0030534	137	0.060
regulation of intracellular signal transduction	GO:1902531	236	0.058	Human Mouse
regulation of proteolysis	GO:0030162	87	0.056
cell motility	GO:0048870	251	0.056
response to inorganic substance	GO:0010035	44	0.056
cell migration	GO:0016477	238	0.055
organic hydroxy compound metabolic process	GO:1901615	83	0.055	Human
intrinsic apoptotic signaling pathway	GO:0097193	16	0.055	Human
apoptotic process	GO:0006915	159	0.055	Human Mouse Rat
developmental pigmentation	GO:0048066	68	0.052
positive regulation of catalytic activity	GO:0043085	118	0.052	Human Mouse Rat
macromolecular complex assembly	GO:0065003	256	0.051
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.049	Human
hydrogen peroxide metabolic process	GO:0042743	6	0.047	Human Mouse Rat
positive regulation of molecular function	GO:0044093	136	0.046	Human Yeast Mouse Rat
tissue morphogenesis	GO:0048729	297	0.045
reproductive system development	GO:0061458	74	0.045	Mouse
cellular amino acid metabolic process	GO:0006520	61	0.044	Mouse
imaginal disc derived appendage development	GO:0048737	399	0.044
larval development	GO:0002164	104	0.044
organonitrogen compound biosynthetic process	GO:1901566	117	0.043
regulation of protein metabolic process	GO:0051246	256	0.042	Human Mouse
organic substance transport	GO:0071702	257	0.042
endocytosis	GO:0006897	310	0.042
negative regulation of molecular function	GO:0044092	51	0.041
regulation of anatomical structure size	GO:0090066	163	0.040	Mouse
salivary gland cell autophagic cell death	GO:0035071	83	0.040
inorganic cation transmembrane transport	GO:0098662	61	0.039
response to external biotic stimulus	GO:0043207	293	0.039
metal ion transport	GO:0030001	74	0.039
immune response	GO:0006955	246	0.039
positive regulation of multicellular organismal process	GO:0051240	143	0.038	Human
positive regulation of signaling	GO:0023056	243	0.038	Human Mouse
membrane organization	GO:0061024	112	0.037	Mouse
cellular amine metabolic process	GO:0044106	12	0.036
nucleotide metabolic process	GO:0009117	161	0.036	Human
nucleoside phosphate metabolic process	GO:0006753	162	0.035	Human
sex differentiation	GO:0007548	81	0.035	Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.033
post embryonic appendage morphogenesis	GO:0035120	385	0.033
positive regulation of cell communication	GO:0010647	250	0.033	Human Mouse
adult locomotory behavior	GO:0008344	76	0.033
regulation of hydrolase activity	GO:0051336	97	0.032	Human
energy derivation by oxidation of organic compounds	GO:0015980	32	0.032	Yeast
regulation of autophagy	GO:0010506	62	0.031
regulation of localization	GO:0032879	275	0.031
regulation of endopeptidase activity	GO:0052548	36	0.031
hemopoiesis	GO:0030097	46	0.031
amine metabolic process	GO:0009308	12	0.030
single organism catabolic process	GO:0044712	228	0.030	Human
response to biotic stimulus	GO:0009607	294	0.030
sperm mitochondrion organization	GO:0030382	7	0.030
nucleobase containing small molecule metabolic process	GO:0055086	174	0.029	Human
regulation of cellular localization	GO:0060341	136	0.029
negative regulation of cell death	GO:0060548	81	0.029	Mouse Rat
response to other organism	GO:0051707	293	0.029
transmembrane transport	GO:0055085	139	0.029
vesicle mediated transport	GO:0016192	381	0.028
intracellular protein transport	GO:0006886	104	0.028
regulation of programmed cell death	GO:0043067	152	0.028	Human Mouse Rat
regulation of anatomical structure morphogenesis	GO:0022603	242	0.027
regulation of phosphate metabolic process	GO:0019220	210	0.027	Human Mouse
regulation of cell development	GO:0060284	215	0.027
histolysis	GO:0007559	102	0.026
internal protein amino acid acetylation	GO:0006475	38	0.026
inorganic ion transmembrane transport	GO:0098660	73	0.025
cellular modified amino acid metabolic process	GO:0006575	45	0.025	Mouse
autophagic cell death	GO:0048102	83	0.025
hematopoietic or lymphoid organ development	GO:0048534	57	0.025
cellular respiration	GO:0045333	26	0.024	Yeast
regulation of neurogenesis	GO:0050767	158	0.024
brain development	GO:0007420	120	0.024
salivary gland histolysis	GO:0035070	88	0.023
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.023
gonad development	GO:0008406	50	0.023	Mouse
response to extracellular stimulus	GO:0009991	116	0.022	Rat
positive regulation of cell death	GO:0010942	69	0.022	Human
cellular protein complex assembly	GO:0043623	71	0.021
positive regulation of catabolic process	GO:0009896	105	0.021
maintenance of location	GO:0051235	73	0.021
developmental cell growth	GO:0048588	52	0.020
signal transduction by phosphorylation	GO:0023014	107	0.020	Mouse
eye pigmentation	GO:0048069	43	0.019
mitotic nuclear division	GO:0007067	213	0.019
positive regulation of developmental process	GO:0051094	143	0.019
chromatin organization	GO:0006325	207	0.019
head development	GO:0060322	135	0.019
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.019	Yeast
negative regulation of developmental process	GO:0051093	201	0.019
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.019
cell proliferation	GO:0008283	299	0.019
regulation of peptidase activity	GO:0052547	39	0.018
cellular response to extracellular stimulus	GO:0031668	64	0.018
cell adhesion	GO:0007155	136	0.018
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.018	Human
response to alcohol	GO:0097305	95	0.018	Mouse
reproductive structure development	GO:0048608	74	0.018	Mouse
regulation of lipid metabolic process	GO:0019216	15	0.017	Human
alcohol metabolic process	GO:0006066	25	0.017	Human
cellular macromolecule catabolic process	GO:0044265	136	0.017
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.017
regulation of mapk cascade	GO:0043408	92	0.017	Mouse
ion transmembrane transport	GO:0034220	122	0.017
generation of precursor metabolites and energy	GO:0006091	42	0.016	Yeast
cation transmembrane transport	GO:0098655	88	0.016
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
response to heat	GO:0009408	63	0.016	Mouse
exocrine system development	GO:0035272	162	0.016
wing disc morphogenesis	GO:0007472	344	0.016
regulation of cellular protein metabolic process	GO:0032268	243	0.016	Human Mouse
response to organic cyclic compound	GO:0014070	89	0.016	Rat
pigment cell differentiation	GO:0050931	3	0.015
ribonucleoside biosynthetic process	GO:0042455	3	0.015
regulation of rac gtpase activity	GO:0032314	1	0.015	Human
response to cold	GO:0009409	13	0.015
cellular response to oxygen containing compound	GO:1901701	79	0.015
establishment or maintenance of cell polarity	GO:0007163	167	0.015
regulation of cell cycle	GO:0051726	291	0.015
positive regulation of programmed cell death	GO:0043068	62	0.015	Human
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria	GO:0006965	3	0.015
developmental maturation	GO:0021700	172	0.015
actin cytoskeleton organization	GO:0030036	206	0.015
lipid localization	GO:0010876	54	0.014
heterocycle catabolic process	GO:0046700	166	0.014	Human
cellular biogenic amine metabolic process	GO:0006576	9	0.014
cellular response to external stimulus	GO:0071496	66	0.014
cytoplasmic transport	GO:0016482	130	0.014
phagocytosis	GO:0006909	215	0.013
lateral inhibition	GO:0046331	206	0.013
positive regulation of biosynthetic process	GO:0009891	316	0.013	Yeast
regulation of intracellular transport	GO:0032386	64	0.013
positive regulation of response to stimulus	GO:0048584	323	0.013	Human Mouse
organic substance catabolic process	GO:1901575	308	0.013	Human
development of primary sexual characteristics	GO:0045137	50	0.013	Mouse
negative regulation of cell development	GO:0010721	62	0.013
response to endogenous stimulus	GO:0009719	119	0.013	Rat
positive regulation of apoptotic process	GO:0043065	47	0.013	Human
single organism carbohydrate metabolic process	GO:0044723	72	0.012
pyridine containing compound metabolic process	GO:0072524	3	0.012
cellular macromolecular complex assembly	GO:0034622	153	0.012
transcription from rna polymerase ii promoter	GO:0006366	368	0.012	Yeast
anatomical structure homeostasis	GO:0060249	97	0.012	Zebrafish Mouse
tissue migration	GO:0090130	155	0.012
regulation of protein transport	GO:0051223	57	0.012
positive regulation of signal transduction	GO:0009967	223	0.012	Human Mouse
single organism cellular localization	GO:1902580	180	0.012
organic hydroxy compound biosynthetic process	GO:1901617	21	0.012	Human
response to bacterium	GO:0009617	198	0.012
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.012	Yeast
cellular response to arsenic containing substance	GO:0071243	6	0.012
glycerolipid metabolic process	GO:0046486	34	0.012
muscle contraction	GO:0006936	13	0.012	Mouse
phosphorylation	GO:0016310	294	0.011	Human Mouse
positive regulation of phosphate metabolic process	GO:0045937	139	0.011	Mouse
nucleobase containing compound catabolic process	GO:0034655	165	0.011	Human
regulation of cellular amine metabolic process	GO:0033238	3	0.011
positive regulation of cellular catabolic process	GO:0031331	95	0.011
protein transport	GO:0015031	155	0.011
spermatogenesis	GO:0007283	200	0.011	Mouse
regulation of cytoplasmic transport	GO:1903649	47	0.011
mapk cascade	GO:0000165	107	0.011	Mouse
regulation of protein modification process	GO:0031399	112	0.011	Human Mouse
purine ribonucleotide catabolic process	GO:0009154	109	0.010	Human
response to monosaccharide	GO:0034284	4	0.010
establishment of protein localization	GO:0045184	163	0.010
regulation of transport	GO:0051049	181	0.010
regulation of phosphorylation	GO:0042325	147	0.010	Human Mouse
negative regulation of signaling	GO:0023057	219	0.010
carbohydrate derivative metabolic process	GO:1901135	217	0.010	Human

Sod disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.088
glucose metabolism disease	DOID:4194	0.088
carbohydrate metabolism disease	DOID:0050013	0.088
acquired metabolic disease	DOID:0060158	0.088
disease of cellular proliferation	DOID:14566	0.029
cancer	DOID:162	0.029
organ system cancer	DOID:0050686	0.029

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network