Drosophila melanogaster

194 known processes

Top2 (Dmel_CG10223)

Topoisomerase 2

(Aliases: TOPOII,TopoII,dCHRAC,TOP2,top2,CHRAC,topoII,topo II,dTopoII,CG10223,Topo II,Dmel\CG10223,TopII)

Top2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of biosynthetic processGO:00098902770.952
agingGO:00075681430.950
multicellular organismal agingGO:00102591400.950
chromatin organizationGO:00063252070.943
embryo development ending in birth or egg hatchingGO:00097921520.893
Worm
regulation of gene expression epigeneticGO:00400291280.878
central nervous system developmentGO:00074172010.874
Mouse
chromosome organizationGO:00512763600.853
response to oxygen containing compoundGO:19017002000.786
determination of adult lifespanGO:00083401370.771
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.704
negative regulation of cellular biosynthetic processGO:00313272770.678
larval developmentGO:00021641040.661
dna metabolic processGO:00062592270.630
regulation of multicellular organism growthGO:0040014400.601
head developmentGO:00603221350.590
Mouse
cellular catabolic processGO:00442483720.583
negative regulation of nucleobase containing compound metabolic processGO:00459342610.580
centrosome organizationGO:00512971630.573
growthGO:00400073590.567
cellular response to organic substanceGO:00713101320.550
regulation of cell deathGO:00109411730.549
Human
microtubule organizing center organizationGO:00310231680.549
reproductive structure developmentGO:0048608740.544
cell deathGO:00082192790.538
Human
cognitionGO:00508901410.531
dendrite developmentGO:00163582040.519
response to abiotic stimulusGO:00096283410.478
positive regulation of rna biosynthetic processGO:19026802660.465
positive regulation of transcription dna templatedGO:00458932660.460
regulation of cell developmentGO:00602842150.459
programmed cell deathGO:00125012570.443
Human
apoptotic processGO:00069151590.423
Human
regulation of mitotic cell cycleGO:00073461900.418
nucleocytoplasmic transportGO:0006913720.415
brain developmentGO:00074201200.396
Mouse
stem cell differentiationGO:00488631170.387
negative regulation of nitrogen compound metabolic processGO:00511722650.384
heterochromatin organizationGO:0070828250.382
negative regulation of cell cycle phase transitionGO:19019881030.377
response to organic substanceGO:00100332840.376
deathGO:00162652840.361
Human
negative regulation of macromolecule biosynthetic processGO:00105582700.351
protein localizationGO:00081042840.347
dna conformation changeGO:00711031050.345
chromatin modificationGO:00165681470.342
regulation of developmental growthGO:00486381740.340
centrosome cycleGO:00070981370.336
chromatin assembly or disassemblyGO:0006333520.335
chromatin remodelingGO:0006338720.329
neuron projection guidanceGO:00974852410.323
Zebrafish
covalent chromatin modificationGO:00165691060.313
innate immune responseGO:00450871440.312
nucleolus organizationGO:000700040.311
macromolecular complex assemblyGO:00650032560.309
stem cell developmentGO:0048864790.309
dna replicationGO:0006260480.303
regulation of transcription from rna polymerase ii promoterGO:00063573780.290
cell proliferationGO:00082832990.284
cell cycle checkpointGO:0000075950.284
positive regulation of gene expressionGO:00106282900.280
mitotic cell cycle phase transitionGO:00447721380.280
negative regulation of gene expressionGO:00106293870.271
protein targeting to nucleusGO:0044744510.262
axon guidanceGO:00074112330.262
Zebrafish
reproductive system developmentGO:0061458740.256
positive regulation of macromolecule biosynthetic processGO:00105572830.250
negative regulation of nucleic acid templated transcriptionGO:19035072400.242
regulation of defense responseGO:00313471020.238
multicellular organism growthGO:0035264460.236
gene silencing by rnaGO:0031047570.227
Worm
negative regulation of rna biosynthetic processGO:19026792400.224
tissue morphogenesisGO:00487292970.224
Zebrafish
negative regulation of cellular metabolic processGO:00313243820.222
rna processingGO:00063961470.219
organelle fissionGO:00482853400.218
positive regulation of nucleobase containing compound metabolic processGO:00459353320.217
Human
positive regulation of response to stimulusGO:00485843230.214
regulation of cell cycle phase transitionGO:19019871300.209
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.205
regulation of meiosisGO:004002030.201
cell migrationGO:00164772380.201
Mouse
regulation of immune system processGO:00026821760.196
regulation of cell cycleGO:00517262910.196
cellular macromolecule localizationGO:00707272200.195
taxisGO:00423303040.192
Zebrafish
dendrite morphogenesisGO:00488131990.189
carbohydrate derivative catabolic processGO:19011361180.182
digestive tract morphogenesisGO:00485461270.181
intracellular transportGO:00469072280.178
chromatin assemblyGO:0031497480.174
positive regulation of signal transductionGO:00099672230.169
purine nucleoside triphosphate metabolic processGO:00091441190.168
cellular response to chemical stimulusGO:00708871990.166
regulation of programmed cell deathGO:00430671520.165
Human
peptidyl amino acid modificationGO:00181931050.165
meiotic cell cycle processGO:19030461320.161
macromolecule methylationGO:0043414450.161
digestive system developmentGO:00551231490.160
cell cycle phase transitionGO:00447701400.158
purine nucleoside triphosphate catabolic processGO:00091461080.157
positive regulation of nucleic acid templated transcriptionGO:19035082660.157
cellular protein modification processGO:00064644380.154
immune responseGO:00069552460.152
chemotaxisGO:00069352490.150
Zebrafish
ribonucleoprotein complex assemblyGO:0022618230.150
oocyte differentiationGO:00099941450.143
single organism behaviorGO:00447083910.140
negative regulation of developmental processGO:00510932010.137
response to light stimulusGO:00094161240.137
dna endoreduplicationGO:0042023220.136
gonad developmentGO:0008406500.133
purine ribonucleoside triphosphate metabolic processGO:00092051190.132
atp metabolic processGO:0046034490.132
purine ribonucleoside triphosphate catabolic processGO:00092071080.131
meiotic nuclear divisionGO:00071261510.128
positive regulation of rna metabolic processGO:00512542710.128
Human
regulation of chromatin organizationGO:1902275320.128
negative regulation of cell cycleGO:00457861160.127
regulation of cell proliferationGO:00421271630.125
regulation of multicellular organismal developmentGO:20000264140.124
regionalizationGO:00030024160.122
mitotic nuclear divisionGO:00070672130.122
digestive tract developmentGO:00485651490.121
dna packagingGO:0006323910.121
cell motilityGO:00488702510.121
Mouse
sex differentiationGO:0007548810.120
meiotic cell cycleGO:00513211710.119
positive regulation of biosynthetic processGO:00098913160.116
regulation of response to stressGO:00801342000.113
negative regulation of cellular component organizationGO:00511291080.113
nucleosome mobilizationGO:004276690.111
organophosphate catabolic processGO:00464341120.111
immune system processGO:00023763470.110
regulation of establishment of protein localizationGO:0070201610.109
negative regulation of transcription dna templatedGO:00458922370.109
small molecule metabolic processGO:00442813050.109
nucleobase containing small molecule metabolic processGO:00550861740.108
single organism biosynthetic processGO:00447112060.107
nuclear transportGO:0051169720.104
development of primary sexual characteristicsGO:0045137500.100
atp catabolic processGO:0006200380.100
locomotory behaviorGO:00076261760.097
positive regulation of cellular component biogenesisGO:0044089800.096
translationGO:0006412690.095
purine nucleotide catabolic processGO:00061951090.094
negative regulation of gene expression epigeneticGO:0045814770.092
epithelial cell differentiationGO:00308553220.092
positive regulation of signalingGO:00230562430.091
positive regulation of cellular biosynthetic processGO:00313283160.091
centrosome duplicationGO:00512981210.089
ribonucleoside triphosphate catabolic processGO:00092031080.089
body morphogenesisGO:001017120.088
ribose phosphate metabolic processGO:00196931450.088
regulation of cell differentiationGO:00455953020.087
mrna transportGO:0051028150.086
memoryGO:0007613940.085
carbohydrate derivative metabolic processGO:19011352170.085
cellular response to hormone stimulusGO:0032870440.083
negative regulation of cell cycle processGO:00109481090.083
response to temperature stimulusGO:00092661060.082
regulation of intracellular signal transductionGO:19025312360.082
negative regulation of mitotic cell cycleGO:00459301090.081
purine nucleoside metabolic processGO:00422781270.081
regulation of growthGO:00400082330.080
spindle organizationGO:00070512530.079
ribonucleoprotein complex biogenesisGO:0022613310.078
cellular response to heatGO:0034605240.078
methylationGO:0032259470.078
ribonucleoside monophosphate catabolic processGO:0009158390.078
chromosome segregationGO:00070591570.077
cellular macromolecular complex assemblyGO:00346221530.077
response to radiationGO:00093141550.077
positive regulation of multicellular organism growthGO:0040018210.076
induction of programmed cell death by ecdysoneGO:0035078120.076
positive regulation of macromolecule metabolic processGO:00106044050.076
Human
nuclear importGO:0051170510.076
regulation of cell cycle processGO:00105641810.076
cellular ketone metabolic processGO:0042180240.075
macromolecule catabolic processGO:00090571610.074
axon developmentGO:00615642970.074
Zebrafish Mouse
ecdysone mediated induction of salivary gland cell autophagic cell deathGO:0035072120.074
regulation of protein metabolic processGO:00512462560.073
purine nucleoside monophosphate metabolic processGO:0009126500.071
heterocycle catabolic processGO:00467001660.069
glycosyl compound metabolic processGO:19016571270.068
purine nucleoside monophosphate catabolic processGO:0009128380.068
genitalia developmentGO:0048806260.068
double strand break repairGO:0006302260.065
positive regulation of cell communicationGO:00106472500.065
nuclear pore organizationGO:000699910.065
response to external biotic stimulusGO:00432072930.064
female germ line cyst formationGO:0048135420.064
histone acetylationGO:0016573380.063
positive regulation of growthGO:0045927750.063
tube developmentGO:00352952440.062
histone modificationGO:00165701060.062
cell cycle dna replicationGO:0044786230.061
regulation of neurogenesisGO:00507671580.061
organonitrogen compound metabolic processGO:19015643180.060
learning or memoryGO:00076111410.060
regulation of small gtpase mediated signal transductionGO:0051056930.059
aromatic compound catabolic processGO:00194391660.059
regulation of localizationGO:00328792750.058
ribonucleotide metabolic processGO:00092591450.058
catabolic processGO:00090564090.058
nuclear envelope organizationGO:000699870.057
positive regulation of mitotic cell cycleGO:0045931340.056
homeostatic processGO:00425921990.056
tube morphogenesisGO:00352391910.055
regulation of actin filament based processGO:0032970420.054
regulation of nervous system developmentGO:00519602480.053
nucleoside phosphate metabolic processGO:00067531620.053
glycosyl compound catabolic processGO:19016581120.052
negative regulation of mitotic cell cycle phase transitionGO:19019911030.052
defense responseGO:00069523000.052
nucleoside metabolic processGO:00091161270.051
regulation of cellular localizationGO:00603411360.051
regulation of cellular component biogenesisGO:00440872010.050
positive regulation of developmental growthGO:0048639620.050
protein import into nucleusGO:0006606510.050
stem cell maintenanceGO:0019827670.049
purine ribonucleoside monophosphate metabolic processGO:0009167500.049
developmental growthGO:00485892800.049
response to sterolGO:0036314340.048
single organism nuclear importGO:1902593510.048
negative regulation of cell proliferationGO:0008285690.048
mrna processingGO:00063971040.048
forebrain developmentGO:003090020.047
Mouse
nucleosome organizationGO:0034728590.047
dna damage checkpointGO:0000077780.047
negative regulation of apoptotic processGO:0043066630.047
telencephalon developmentGO:002153720.046
protein modification processGO:00362114380.046
regulation of dna metabolic processGO:0051052340.046
Human
ribonucleoprotein complex subunit organizationGO:0071826280.046
cellular response to oxygen containing compoundGO:1901701790.046
gene silencingGO:00164581380.046
negative regulation of response to stimulusGO:00485852580.045
cellular response to peptide hormone stimulusGO:0071375280.045
purine ribonucleoside metabolic processGO:00461281270.045
protein localization to organelleGO:0033365820.045
regulation of cellular protein metabolic processGO:00322682430.045
establishment of localization in cellGO:00516494020.044
single organism catabolic processGO:00447122280.044
intracellular signal transductionGO:00355563000.044
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.044
morphogenesis of an epitheliumGO:00020092760.043
sister chromatid segregationGO:0000819920.043
mitotic cell cycle checkpointGO:0007093880.043
rna catabolic processGO:0006401370.042
regulation of apoptotic processGO:00429811300.042
Human
protein complex biogenesisGO:00702712010.042
posttranscriptional gene silencingGO:0016441460.042
Worm
ribonucleoside catabolic processGO:00424541120.042
organic acid metabolic processGO:00060821030.041
meiotic chromosome segregationGO:0045132590.041
purine nucleoside catabolic processGO:00061521120.041
mrna metabolic processGO:00160711240.041
nucleoside catabolic processGO:00091641120.041
heterochromatin organization involved in chromatin silencingGO:007086890.041
cellular amine metabolic processGO:0044106120.040
positive regulation of programmed cell deathGO:0043068620.040
Human
negative regulation of programmed cell deathGO:0043069720.039
mitotic spindle organizationGO:00070522200.039
establishment of protein localizationGO:00451841630.039
response to organic cyclic compoundGO:0014070890.039
nucleoside triphosphate metabolic processGO:00091411200.038
nucleosome positioningGO:001658430.037
ncrna metabolic processGO:0034660430.037
dna repairGO:0006281540.037
protein transportGO:00150311550.036
negative regulation of cell differentiationGO:00455961430.036
negative regulation of cell deathGO:0060548810.036
cytoplasmic transportGO:00164821300.036
positive regulation of organelle organizationGO:0010638650.036
nucleotide catabolic processGO:00091661090.035
regulation of cytoskeleton organizationGO:0051493890.035
purine nucleotide metabolic processGO:00061631460.035
single organism cellular localizationGO:19025801800.035
regulation of transcription by chromatin organizationGO:003440130.034
protein catabolic processGO:00301631010.034
negative regulation of cell communicationGO:00106482230.034
positive regulation of cellular component organizationGO:00511301560.034
regulation of organelle organizationGO:00330431960.032
localization of cellGO:00516742570.031
Mouse
production of small rna involved in gene silencing by rnaGO:0070918150.031
positive regulation of nitrogen compound metabolic processGO:00511733540.031
Human
organonitrogen compound catabolic processGO:19015651280.030
determination of dorsal ventral asymmetryGO:004826230.030
mushroom body developmentGO:0016319700.030
mitotic cell cycle embryonicGO:0045448380.030
establishment of organelle localizationGO:00516561220.030
male gamete generationGO:00482322010.030
regulation of dendrite morphogenesisGO:0048814280.030
regulation of protein localizationGO:0032880760.030
protein complex assemblyGO:00064612000.030
eye developmentGO:00016543230.029
Zebrafish
defense response to bacteriumGO:00427421780.029
cellular response to nitrogen compoundGO:1901699510.029
regulation of mitotic cell cycle phase transitionGO:19019901300.028
cellular protein localizationGO:00346131600.028
response to heatGO:0009408630.028
nucleobase containing compound catabolic processGO:00346551650.027
mrna catabolic processGO:0006402330.027
response to other organismGO:00517072930.026
chromatin silencingGO:0006342760.026
regulation of mrna metabolic processGO:1903311720.026
carboxylic acid metabolic processGO:0019752920.026
protein targetingGO:0006605640.026
regulation of mrna processingGO:0050684710.025
enzyme linked receptor protein signaling pathwayGO:00071671790.025
purine containing compound metabolic processGO:00725211550.025
purine ribonucleoside catabolic processGO:00461301120.025
response to organonitrogen compoundGO:0010243750.024
positive regulation of developmental processGO:00510941430.024
protein alkylationGO:0008213430.024
cellular response to dna damage stimulusGO:00069742230.024
protein localization to nucleusGO:0034504550.024
imaginal disc growthGO:0007446370.024
cellular response to sterol depletionGO:007150130.024
intracellular protein transportGO:00068861040.024
positive regulation of multicellular organismal processGO:00512401430.024
organic substance catabolic processGO:19015753080.023
positive regulation of phosphorylationGO:0042327870.023
purine ribonucleoside monophosphate catabolic processGO:0009169380.023
positive regulation of protein metabolic processGO:00512471280.023
regulation of phosphorylationGO:00423251470.023
chromatin maintenanceGO:007082720.022
regulation of cellular response to stressGO:0080135890.022
regulation of protein complex assemblyGO:0043254420.022
small gtpase mediated signal transductionGO:0007264880.022
multi multicellular organism processGO:00447061230.022
regulation of innate immune responseGO:0045088710.021
maintenance of locationGO:0051235730.021
nuclear exportGO:0051168240.021
endocytosisGO:00068973100.021
regulation of neuron differentiationGO:00456641030.021
protein importGO:0017038550.021
germ line stem cell maintenanceGO:0030718500.021
cell divisionGO:00513012480.021
chromosome separationGO:0051304420.021
protein phosphorylationGO:00064681690.020
nucleoside triphosphate catabolic processGO:00091431080.020
induction of programmed cell deathGO:0012502120.020
cellular response to lipidGO:0071396200.020
amine metabolic processGO:0009308120.020
positive regulation of intracellular signal transductionGO:19025331160.020
embryonic morphogenesisGO:00485982060.019
regulation of cellular amino acid metabolic processGO:000652100.019
positive regulation of cell cycle processGO:0090068280.019
response to alcoholGO:0097305950.019
organophosphate metabolic processGO:00196371950.019
organic substance transportGO:00717022570.019
regulation of protein modification processGO:00313991120.019
negative regulation of protein export from nucleusGO:004682620.019
response to dsrnaGO:0043331150.018
induction of programmed cell death by hormonesGO:0035081120.018
nucleotide metabolic processGO:00091171610.018
regulation of ras protein signal transductionGO:0046578930.018
regulation of intracellular protein transportGO:0033157460.018
establishment of nucleus localizationGO:0040023260.018
response to endogenous stimulusGO:00097191190.017
defense response to other organismGO:00985422250.017
positive regulation of mrna processingGO:005068540.017
defense response to gram negative bacteriumGO:0050829940.017
lipid localizationGO:0010876540.017
heterochromatin assemblyGO:0031507130.017
regulation of anatomical structure morphogenesisGO:00226032420.017
negative regulation of imaginal disc growthGO:004557180.017
dorsal ventral axis specificationGO:0009950660.017
negative regulation of multicellular organismal processGO:00512411420.017
response to lipidGO:0033993380.017
ribonucleoside monophosphate metabolic processGO:0009161510.017
production of mirnas involved in gene silencing by mirnaGO:0035196100.016
posttranscriptional regulation of gene expressionGO:00106081450.016
Worm
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052240.016
synapse assemblyGO:00074161430.016
phosphorylationGO:00163102940.016
regulation of chromatin modificationGO:1903308280.016
regulation of phosphorus metabolic processGO:00511742100.016
instar larval developmentGO:0002168550.016
dorsal ventral pattern formationGO:00099531330.016
post embryonic appendage morphogenesisGO:00351203850.016
positive regulation of dna endoreduplicationGO:003287740.016
dendritic spine developmentGO:006099640.016
negative regulation of cell developmentGO:0010721620.016
germarium derived female germ line cyst formationGO:0030727420.015
histone lysine demethylationGO:007007660.015
nitrogen compound transportGO:0071705850.015
cellular macromolecule catabolic processGO:00442651360.015
female germ line stem cell maintenanceGO:003609980.015
rna 3 end processingGO:0031123450.015
eggshell chorion gene amplificationGO:000730790.015
regulation of immune responseGO:00507761180.015
protein modification by small protein conjugation or removalGO:00706471060.015
nls bearing protein import into nucleusGO:000660750.015
mrna splice site selectionGO:000637610.014
ribonucleoside metabolic processGO:00091191270.014
regulation of cellular ketone metabolic processGO:001056530.014
gland developmentGO:00487321910.014
intermediate filament based processGO:004510310.014
cell maturationGO:00484691440.014
protein methylationGO:0006479430.014
g2 dna damage checkpointGO:0031572690.014
negative regulation of translationGO:0017148280.014
regulation of protein transportGO:0051223570.014
internal peptidyl lysine acetylationGO:0018393380.014
cytoplasmic mrna processing body assemblyGO:0033962100.014
axonogenesisGO:00074092900.014
Zebrafish Mouse
purine ribonucleotide catabolic processGO:00091541090.014
spermatogenesisGO:00072832000.014
negative regulation of cellular protein metabolic processGO:0032269850.014
oocyte developmentGO:00485991240.013
camera type eye developmentGO:004301040.013
Zebrafish
regulation of molecular functionGO:00650092170.013
response to biotic stimulusGO:00096072940.013
cellular response to organic cyclic compoundGO:0071407320.013
negative regulation of protein metabolic processGO:0051248850.013
regulation of dna templated transcription elongationGO:0032784170.013
synapse organizationGO:00508081960.013
neuron maturationGO:0042551310.013
actin cytoskeleton organizationGO:00300362060.013
cellular response to light stimulusGO:0071482370.013
cell fate determinationGO:0001709910.012
unsaturated fatty acid biosynthetic processGO:000663610.012
production of sirna involved in rna interferenceGO:0030422110.012
segmentationGO:00352822070.012
receptor mediated endocytosisGO:0006898210.012
regulation of nucleocytoplasmic transportGO:0046822350.012
positive regulation of apoptotic processGO:0043065470.012
Human
regulation of chromosome organizationGO:0033044640.012
ribonucleotide catabolic processGO:00092611090.012
regulation of heterochromatin assemblyGO:003144580.012
exocrine system developmentGO:00352721620.012
cellular response to abiotic stimulusGO:0071214580.012
nucleoside monophosphate catabolic processGO:0009125390.012
oocyte maturationGO:000155630.012
convergent extensionGO:006002620.011
multicellular organismal reproductive behaviorGO:00330571100.011
regulation of mrna splicing via spliceosomeGO:0048024640.011
negative regulation of rna metabolic processGO:00512532510.011
protein dna complex subunit organizationGO:0071824860.011
cellular nitrogen compound catabolic processGO:00442701650.011
epithelial cell developmentGO:00020642740.011
germ line stem cell divisionGO:0042078250.011
jak stat cascadeGO:0007259490.011
organic cyclic compound catabolic processGO:19013611680.011
histone methylationGO:0016571400.011
peptidyl threonine phosphorylationGO:001810720.010
eye antennal disc developmentGO:0035214600.010
posttranscriptional gene silencing by rnaGO:0035194450.010
Worm
compound eye developmentGO:00487493070.010
nucleoside phosphate catabolic processGO:19012921100.010
oxoacid metabolic processGO:00434361030.010
regulation of catalytic activityGO:00507901850.010
rna interferenceGO:0016246270.010
Worm
proteolysisGO:00065081920.010

Top2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.030
disease of cellular proliferationDOID:1456600.030
organ system cancerDOID:005068600.029
connective tissue cancerDOID:20100.012
musculoskeletal system cancerDOID:006010000.012
disease of anatomical entityDOID:700.010