IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Tsp42Ec (Dmel_CG12847)

Tetraspanin 42Ec

(Aliases: Dmel\CG12847,CG12847,Dm.Tsp42Ec)

FLYBASE: FBgn0033124
Entrez: 35612
UniProtKB: Q9NB13

Process Predictions
Disease Predictions

Tsp42Ec biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
activation of innate immune response	GO:0002218	4	0.123
response to temperature stimulus	GO:0009266	106	0.095
immune response activating signal transduction	GO:0002757	2	0.093
response to high light intensity	GO:0009644	1	0.073	Fly
defense response	GO:0006952	300	0.071
defense response to other organism	GO:0098542	225	0.054
regulation of response to biotic stimulus	GO:0002831	63	0.049
immune response	GO:0006955	246	0.049
response to abiotic stimulus	GO:0009628	341	0.046	Fly
response to radiation	GO:0009314	155	0.046	Fly
regulation of immune system process	GO:0002682	176	0.045
positive regulation of signaling	GO:0023056	243	0.044
innate immune response	GO:0045087	144	0.041
pattern recognition receptor signaling pathway	GO:0002221	2	0.041
negative regulation of response to stimulus	GO:0048585	258	0.038
negative regulation of cell communication	GO:0010648	223	0.038
positive regulation of signal transduction	GO:0009967	223	0.035
immune response regulating signaling pathway	GO:0002764	2	0.033
vesicle mediated transport	GO:0016192	381	0.033	Fly
regulation of multi organism process	GO:0043900	131	0.033
positive regulation of response to stimulus	GO:0048584	323	0.032
response to biotic stimulus	GO:0009607	294	0.032
multicellular organismal aging	GO:0010259	140	0.031	Fly
positive regulation of immune response	GO:0050778	63	0.030
positive regulation of cell communication	GO:0010647	250	0.030
regulation of response to external stimulus	GO:0032101	115	0.026
intracellular signal transduction	GO:0035556	300	0.025
innate immune response activating signal transduction	GO:0002758	2	0.025
response to bacterium	GO:0009617	198	0.024
compound eye development	GO:0048749	307	0.024
response to other organism	GO:0051707	293	0.024
cell death	GO:0008219	279	0.024
negative regulation of gene expression	GO:0010629	387	0.024
positive regulation of immune system process	GO:0002684	68	0.023
camera type eye development	GO:0043010	4	0.022
response to external biotic stimulus	GO:0043207	293	0.022
imaginal disc derived appendage development	GO:0048737	399	0.022
negative regulation of signal transduction	GO:0009968	206	0.022
regulation of multicellular organismal development	GO:2000026	414	0.022
regulation of response to stress	GO:0080134	200	0.021
cellular catabolic process	GO:0044248	372	0.021
endocytosis	GO:0006897	310	0.021	Fly
death	GO:0016265	284	0.020
body morphogenesis	GO:0010171	2	0.020
positive regulation of multicellular organismal process	GO:0051240	143	0.020
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.020
regulation of immune response	GO:0050776	118	0.020
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.020
regulation of intracellular signal transduction	GO:1902531	236	0.019
synapse assembly	GO:0007416	143	0.019
regulation of protein metabolic process	GO:0051246	256	0.019
organonitrogen compound metabolic process	GO:1901564	318	0.019
negative regulation of signaling	GO:0023057	219	0.019
macromolecular complex assembly	GO:0065003	256	0.019
regulation of cellular catabolic process	GO:0031329	157	0.018
neurological system process	GO:0050877	358	0.018
regulation of innate immune response	GO:0045088	71	0.018
positive regulation of gene expression	GO:0010628	290	0.017
transcription from rna polymerase ii promoter	GO:0006366	368	0.017
negative regulation of cellular metabolic process	GO:0031324	382	0.017
immune effector process	GO:0002252	98	0.017
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.017
regionalization	GO:0003002	416	0.017
regulation of molecular function	GO:0065009	217	0.017
regulation of cell differentiation	GO:0045595	302	0.017
forebrain development	GO:0030900	2	0.017
wing disc morphogenesis	GO:0007472	344	0.017
regulation of cellular protein metabolic process	GO:0032268	243	0.016
eye morphogenesis	GO:0048592	260	0.016
regulation of catalytic activity	GO:0050790	185	0.016
cellular nitrogen compound catabolic process	GO:0044270	165	0.016
protein modification process	GO:0036211	438	0.016
positive regulation of defense response	GO:0031349	59	0.016
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.016
kidney development	GO:0001822	3	0.016
apoptotic process	GO:0006915	159	0.015
compound eye morphogenesis	GO:0001745	249	0.015
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.015
regulation of localization	GO:0032879	275	0.015
developmental maturation	GO:0021700	172	0.015
cellular protein modification process	GO:0006464	438	0.015
organic substance catabolic process	GO:1901575	308	0.015
appendage morphogenesis	GO:0035107	397	0.015
phagocytosis	GO:0006909	215	0.015
regulation of phosphate metabolic process	GO:0019220	210	0.015
post embryonic appendage morphogenesis	GO:0035120	385	0.015
response to oxygen containing compound	GO:1901700	200	0.015
positive regulation of intracellular signal transduction	GO:1902533	116	0.015
regulation of catabolic process	GO:0009894	170	0.015
eye development	GO:0001654	323	0.015
regulation of cell cycle	GO:0051726	291	0.015
cellular response to high light intensity	GO:0071486	1	0.015	Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.015
connective tissue development	GO:0061448	3	0.015
regulation of cellular ketone metabolic process	GO:0010565	3	0.015
tube morphogenesis	GO:0035239	191	0.014
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.014
imaginal disc derived wing morphogenesis	GO:0007476	337	0.014
response to cold	GO:0009409	13	0.014
positive regulation of cellular biosynthetic process	GO:0031328	316	0.014
cation transport	GO:0006812	110	0.014
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.014
central nervous system development	GO:0007417	201	0.014
protein complex biogenesis	GO:0070271	201	0.014
positive regulation of macromolecule metabolic process	GO:0010604	405	0.014
regulation of cell development	GO:0060284	215	0.014
cell maturation	GO:0048469	144	0.014
regulation of immune effector process	GO:0002697	52	0.014
single organism behavior	GO:0044708	391	0.013
dendrite development	GO:0016358	204	0.013
regulation of defense response to virus	GO:0050688	14	0.013
regulation of defense response	GO:0031347	102	0.013
regulation of phosphorus metabolic process	GO:0051174	210	0.013
telencephalon development	GO:0021537	2	0.013
positive regulation of biosynthetic process	GO:0009891	316	0.013
programmed cell death	GO:0012501	257	0.013
cellular amino acid metabolic process	GO:0006520	61	0.013
catabolic process	GO:0009056	409	0.013
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.013
homeostatic process	GO:0042592	199	0.013
regulation of cellular amine metabolic process	GO:0033238	3	0.013
camera type eye morphogenesis	GO:0048593	2	0.013
defense response to virus	GO:0051607	23	0.013
response to glucose	GO:0009749	2	0.013
segmentation	GO:0035282	207	0.012
rna processing	GO:0006396	147	0.012
sensory organ morphogenesis	GO:0090596	260	0.012
response to organophosphorus	GO:0046683	2	0.012
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.012
macromolecule catabolic process	GO:0009057	161	0.012
dendrite morphogenesis	GO:0048813	199	0.012
response to virus	GO:0009615	28	0.012
response to lipopolysaccharide	GO:0032496	4	0.012
phosphorylation	GO:0016310	294	0.012
gland morphogenesis	GO:0022612	145	0.012
cell proliferation	GO:0008283	299	0.012
carboxylic acid metabolic process	GO:0019752	92	0.012
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.012
hindbrain development	GO:0030902	2	0.012
appendage development	GO:0048736	401	0.012
developmental growth	GO:0048589	280	0.012
ion transport	GO:0006811	145	0.012
immune system process	GO:0002376	347	0.012
positive regulation of cell motility	GO:2000147	3	0.012
epithelial cell development	GO:0002064	274	0.012
positive regulation of phosphorus metabolic process	GO:0010562	139	0.012
mitotic nuclear division	GO:0007067	213	0.012
positive regulation of rna metabolic process	GO:0051254	271	0.012
negative regulation of rna metabolic process	GO:0051253	251	0.012
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.012
notch signaling pathway	GO:0007219	120	0.012
organic cyclic compound catabolic process	GO:1901361	168	0.011
steroid catabolic process	GO:0006706	1	0.011
determination of adult lifespan	GO:0008340	137	0.011	Fly
negative regulation of response to external stimulus	GO:0032102	22	0.011
regulation of cell death	GO:0010941	173	0.011
regulation of toll signaling pathway	GO:0008592	17	0.011
small gtpase mediated signal transduction	GO:0007264	88	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011
gene silencing	GO:0016458	138	0.011
intracellular receptor signaling pathway	GO:0030522	19	0.011
aging	GO:0007568	143	0.011	Fly
negative regulation of biosynthetic process	GO:0009890	277	0.011
embryonic morphogenesis	GO:0048598	206	0.011
negative regulation of rna biosynthetic process	GO:1902679	240	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.011
response to hexose	GO:0009746	3	0.011
positive regulation of catabolic process	GO:0009896	105	0.011
salivary gland cell autophagic cell death	GO:0035071	83	0.011
chemical homeostasis	GO:0048878	92	0.011
negative regulation of cellular biosynthetic process	GO:0031327	277	0.011
carbohydrate derivative catabolic process	GO:1901136	118	0.010
intracellular transport	GO:0046907	228	0.010
regulation of cell proliferation	GO:0042127	163	0.010
cellular amine metabolic process	GO:0044106	12	0.010
phosphatidic acid metabolic process	GO:0046473	1	0.010
protein heterooligomerization	GO:0051291	4	0.010
regulation of developmental growth	GO:0048638	174	0.010
peptide metabolic process	GO:0006518	80	0.010
rho protein signal transduction	GO:0007266	14	0.010
organic acid metabolic process	GO:0006082	103	0.010
negative regulation of transcription dna templated	GO:0045892	237	0.010
mitotic cell cycle phase transition	GO:0044772	138	0.010
epithelial cell differentiation	GO:0030855	322	0.010
oxoacid metabolic process	GO:0043436	103	0.010
histolysis	GO:0007559	102	0.010
regulation of organelle organization	GO:0033043	196	0.010
signal transduction by phosphorylation	GO:0023014	107	0.010
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.010
single organism catabolic process	GO:0044712	228	0.010
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.010
response to endogenous stimulus	GO:0009719	119	0.010
amine metabolic process	GO:0009308	12	0.010

Tsp42Ec disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.052
cardiovascular system disease	DOID:1287	0.021
musculoskeletal system disease	DOID:17	0.018
nervous system disease	DOID:863	0.015
urinary system disease	DOID:18	0.013
connective tissue disease	DOID:65	0.012
sensory system disease	DOID:0050155	0.012
disease of metabolism	DOID:0014667	0.010
acquired metabolic disease	DOID:0060158	0.010
hypertension	DOID:10763	0.010
artery disease	DOID:0050828	0.010
vascular disease	DOID:178	0.010
essential hypertension	DOID:10825	0.010

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