IMP: Integrative Multi-species Prediction

Drosophila melanogaster

33 known processes

pex12 (Dmel_CG3639)

peroxin 12

(Aliases: CG3639,Dmel\CG3639)

FLYBASE: FBgn0031282
Entrez: 33256
UniProtKB: M9PBP1
UniProtKB: Q9VPT5

Process Predictions
Disease Predictions

pex12 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
protein localization to peroxisome	GO:0072662	2	0.993	Human Yeast
establishment of protein localization to peroxisome	GO:0072663	2	0.968	Human Yeast
spermatocyte division	GO:0048137	13	0.903
protein targeting to peroxisome	GO:0006625	2	0.876	Human Yeast
intracellular protein transmembrane import	GO:0044743	4	0.797	Human Yeast
peroxisome organization	GO:0007031	14	0.734
intracellular protein transmembrane transport	GO:0065002	4	0.688	Human Yeast
peroxisomal transport	GO:0043574	2	0.595	Human Yeast
protein transmembrane transport	GO:0071806	4	0.438	Human Yeast
meiotic cell cycle process	GO:1903046	132	0.402
cytoskeleton dependent cytokinesis	GO:0061640	81	0.391
male meiosis cytokinesis	GO:0007112	26	0.326
very long chain fatty acid metabolic process	GO:0000038	4	0.284
male gamete generation	GO:0048232	201	0.269
transmembrane transport	GO:0055085	139	0.262	Human Yeast
cytokinesis	GO:0000910	90	0.226
monocarboxylic acid metabolic process	GO:0032787	29	0.210
meiotic cell cycle	GO:0051321	171	0.189
cellular protein modification process	GO:0006464	438	0.182	Yeast
protein modification by small protein conjugation or removal	GO:0070647	106	0.159	Yeast
monocarboxylic acid catabolic process	GO:0072329	10	0.146
growth	GO:0040007	359	0.128
protein localization to organelle	GO:0033365	82	0.123	Human Yeast
lipid catabolic process	GO:0016042	21	0.121
single organism catabolic process	GO:0044712	228	0.121
cell division	GO:0051301	248	0.117
establishment of localization in cell	GO:0051649	402	0.114	Human Yeast
spermatid development	GO:0007286	98	0.113
developmental growth	GO:0048589	280	0.110
protein transport	GO:0015031	155	0.109	Human Yeast
small molecule metabolic process	GO:0044281	305	0.106
oxoacid metabolic process	GO:0043436	103	0.103
protein import	GO:0017038	55	0.093	Human Yeast
spermatogenesis	GO:0007283	200	0.091
single organism cellular localization	GO:1902580	180	0.090	Human Yeast
spermatid differentiation	GO:0048515	114	0.089
protein localization	GO:0008104	284	0.077	Human Yeast
protein modification by small protein conjugation	GO:0032446	79	0.073	Yeast
cellular lipid catabolic process	GO:0044242	16	0.072
cholesterol homeostasis	GO:0042632	3	0.070
regulation of developmental growth	GO:0048638	174	0.070
cell growth	GO:0016049	108	0.070
meiotic cytokinesis	GO:0033206	33	0.069
establishment of protein localization	GO:0045184	163	0.069	Human Yeast
cellular protein localization	GO:0034613	160	0.067	Human Yeast
intracellular transport	GO:0046907	228	0.067	Human Yeast
developmental cell growth	GO:0048588	52	0.066
intracellular protein transport	GO:0006886	104	0.066	Human Yeast
fatty acid metabolic process	GO:0006631	20	0.062
protein ubiquitination	GO:0016567	70	0.061	Yeast
organic substance transport	GO:0071702	257	0.057	Human Yeast
cellular macromolecule localization	GO:0070727	220	0.057	Human Yeast
lipid metabolic process	GO:0006629	121	0.053
single organism intracellular transport	GO:1902582	207	0.053	Human Yeast
carbohydrate derivative metabolic process	GO:1901135	217	0.051
carboxylic acid metabolic process	GO:0019752	92	0.046
glycosyl compound metabolic process	GO:1901657	127	0.046
nucleoside metabolic process	GO:0009116	127	0.042
organonitrogen compound metabolic process	GO:1901564	318	0.040
organic acid metabolic process	GO:0006082	103	0.039
catabolic process	GO:0009056	409	0.036
protein targeting	GO:0006605	64	0.035	Human Yeast
purine ribonucleoside metabolic process	GO:0046128	127	0.034
negative regulation of cellular metabolic process	GO:0031324	382	0.034
ribonucleoside metabolic process	GO:0009119	127	0.032
establishment of protein localization to organelle	GO:0072594	62	0.031	Human Yeast
embryo development ending in birth or egg hatching	GO:0009792	152	0.031	Worm
organonitrogen compound catabolic process	GO:1901565	128	0.031
cytoplasmic transport	GO:0016482	130	0.031	Human Yeast
organic substance catabolic process	GO:1901575	308	0.031
homeostatic process	GO:0042592	199	0.030
purine nucleoside metabolic process	GO:0042278	127	0.030
nucleoside phosphate metabolic process	GO:0006753	162	0.030
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.029
ribonucleotide metabolic process	GO:0009259	145	0.029
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.028
ribose phosphate metabolic process	GO:0019693	145	0.027
nucleobase containing small molecule metabolic process	GO:0055086	174	0.027
protein polyubiquitination	GO:0000209	11	0.026
response to organic substance	GO:0010033	284	0.026
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.026
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.025
regulation of growth	GO:0040008	233	0.025
negative regulation of developmental process	GO:0051093	201	0.025
spindle organization	GO:0007051	253	0.025
macromolecular complex assembly	GO:0065003	256	0.025
negative regulation of peptide secretion	GO:0002792	1	0.024
nucleotide metabolic process	GO:0009117	161	0.024
purine containing compound metabolic process	GO:0072521	155	0.023
negative regulation of cell cycle	GO:0045786	116	0.023
nucleoside triphosphate metabolic process	GO:0009141	120	0.022
single organism behavior	GO:0044708	391	0.022
purine nucleotide metabolic process	GO:0006163	146	0.022
positive regulation of signaling	GO:0023056	243	0.022
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.021
purine nucleotide catabolic process	GO:0006195	109	0.021
purine nucleoside catabolic process	GO:0006152	112	0.021
organophosphate metabolic process	GO:0019637	195	0.020
mitotic spindle organization	GO:0007052	220	0.020
single organism biosynthetic process	GO:0044711	206	0.019
anion homeostasis	GO:0055081	3	0.019
vesicle mediated transport	GO:0016192	381	0.019
kidney development	GO:0001822	3	0.019
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.019
nucleoside catabolic process	GO:0009164	112	0.019
blastoderm segmentation	GO:0007350	159	0.018
ion transport	GO:0006811	145	0.018
protein modification process	GO:0036211	438	0.018	Yeast
organic acid catabolic process	GO:0016054	16	0.018
negative regulation of cell communication	GO:0010648	223	0.018
positive regulation of gene expression	GO:0010628	290	0.018
negative regulation of cell cycle process	GO:0010948	109	0.018
cellular catabolic process	GO:0044248	372	0.017
response to abiotic stimulus	GO:0009628	341	0.017
carboxylic acid catabolic process	GO:0046395	16	0.017
purine ribonucleotide metabolic process	GO:0009150	145	0.017
cellular response to organic substance	GO:0071310	132	0.017
chemical homeostasis	GO:0048878	92	0.017
positive regulation of molecular function	GO:0044093	136	0.017
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.017
purine ribonucleoside catabolic process	GO:0046130	112	0.017
endomembrane system organization	GO:0010256	119	0.017
developmental maturation	GO:0021700	172	0.017
multicellular organism growth	GO:0035264	46	0.017
transcription from rna polymerase ii promoter	GO:0006366	368	0.017
small molecule catabolic process	GO:0044282	21	0.017
ion transmembrane transport	GO:0034220	122	0.016
glycosyl compound catabolic process	GO:1901658	112	0.016
purine containing compound catabolic process	GO:0072523	112	0.016
regulation of multicellular organism growth	GO:0040014	40	0.016
cell death	GO:0008219	279	0.016
purine ribonucleotide catabolic process	GO:0009154	109	0.016
gland development	GO:0048732	191	0.016
positive regulation of cell communication	GO:0010647	250	0.015
protein maturation	GO:0051604	71	0.015
positive regulation of response to stimulus	GO:0048584	323	0.015
single organism membrane fusion	GO:0044801	42	0.015
response to biotic stimulus	GO:0009607	294	0.015
phagocytosis	GO:0006909	215	0.015
mitotic sister chromatid segregation	GO:0000070	87	0.015
ribonucleotide catabolic process	GO:0009261	109	0.015
positive regulation of macromolecule metabolic process	GO:0010604	405	0.014
response to light stimulus	GO:0009416	124	0.014
reciprocal dna recombination	GO:0035825	19	0.014
organelle fusion	GO:0048284	46	0.014
heterocycle catabolic process	GO:0046700	166	0.014
response to glucose	GO:0009749	2	0.014
cell migration	GO:0016477	238	0.014
aging	GO:0007568	143	0.014
oxidation reduction process	GO:0055114	123	0.014
negative regulation of erk1 and erk2 cascade	GO:0070373	3	0.014
defense response to bacterium	GO:0042742	178	0.014
ribonucleoside catabolic process	GO:0042454	112	0.014
localization of cell	GO:0051674	257	0.014
cellular nitrogen compound catabolic process	GO:0044270	165	0.014
estrogen metabolic process	GO:0008210	1	0.014
regulation of catalytic activity	GO:0050790	185	0.013
synaptic growth at neuromuscular junction	GO:0051124	119	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.013
nucleoside triphosphate catabolic process	GO:0009143	108	0.013
intracellular signal transduction	GO:0035556	300	0.013
oocyte differentiation	GO:0009994	145	0.013
embryonic development via the syncytial blastoderm	GO:0001700	148	0.013
meiotic nuclear division	GO:0007126	151	0.013
nucleoside phosphate catabolic process	GO:1901292	110	0.013
response to organophosphorus	GO:0046683	2	0.013
carbohydrate derivative catabolic process	GO:1901136	118	0.013
nuclear division	GO:0000280	332	0.013
regulation of cellular localization	GO:0060341	136	0.013
negative regulation of signal transduction	GO:0009968	206	0.013
single organism membrane organization	GO:0044802	93	0.013
wing disc morphogenesis	GO:0007472	344	0.012
salivary gland morphogenesis	GO:0007435	145	0.012
positive regulation of transcription dna templated	GO:0045893	266	0.012
cellular macromolecular complex assembly	GO:0034622	153	0.012
protein complex assembly	GO:0006461	200	0.012
response to organic cyclic compound	GO:0014070	89	0.012
response to temperature stimulus	GO:0009266	106	0.012
regulation of molecular function	GO:0065009	217	0.012
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.012
lipid biosynthetic process	GO:0008610	46	0.012
small gtpase mediated signal transduction	GO:0007264	88	0.012
negative regulation of mitotic cell cycle	GO:0045930	109	0.012
eye morphogenesis	GO:0048592	260	0.012
secretion	GO:0046903	109	0.012
regulation of anatomical structure size	GO:0090066	163	0.012
body morphogenesis	GO:0010171	2	0.012
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.012
response to external biotic stimulus	GO:0043207	293	0.012
neurological system process	GO:0050877	358	0.012
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.012
nucleotide catabolic process	GO:0009166	109	0.012
hormone metabolic process	GO:0042445	33	0.012
response to nutrient levels	GO:0031667	114	0.012
regulation of intracellular signal transduction	GO:1902531	236	0.012
phosphorylation	GO:0016310	294	0.012
death	GO:0016265	284	0.011
positive regulation of cellular biosynthetic process	GO:0031328	316	0.011
response to radiation	GO:0009314	155	0.011
positive regulation of biosynthetic process	GO:0009891	316	0.011
developmental programmed cell death	GO:0010623	138	0.011
cellular amino acid metabolic process	GO:0006520	61	0.011
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.011
organophosphate catabolic process	GO:0046434	112	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.011
response to bacterium	GO:0009617	198	0.011
programmed cell death	GO:0012501	257	0.011
protein complex biogenesis	GO:0070271	201	0.011
regulation of transport	GO:0051049	181	0.011
chromosome segregation	GO:0007059	157	0.011
sensory organ morphogenesis	GO:0090596	260	0.011
positive regulation of catalytic activity	GO:0043085	118	0.011
regulation of catabolic process	GO:0009894	170	0.011
sterol homeostasis	GO:0055092	4	0.011
negative regulation of response to stimulus	GO:0048585	258	0.011
regionalization	GO:0003002	416	0.011
organelle fission	GO:0048285	340	0.011
nucleoside monophosphate metabolic process	GO:0009123	52	0.011
negative regulation of intracellular signal transduction	GO:1902532	57	0.011
respiratory system development	GO:0060541	213	0.011
neuron recognition	GO:0008038	101	0.010
meiosis i	GO:0007127	59	0.010
toxin metabolic process	GO:0009404	2	0.010
compound eye photoreceptor cell differentiation	GO:0001751	140	0.010
response to ionizing radiation	GO:0010212	32	0.010
regulation of synapse structure and activity	GO:0050803	128	0.010
synapse organization	GO:0050808	196	0.010
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.010
gtp catabolic process	GO:0006184	72	0.010
steroid biosynthetic process	GO:0006694	16	0.010
positive regulation of rna biosynthetic process	GO:1902680	266	0.010
glycoprotein biosynthetic process	GO:0009101	41	0.010
amine metabolic process	GO:0009308	12	0.010
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.010
golgi organization	GO:0007030	66	0.010

pex12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.023
nervous system disease	DOID:863	0.013
disease of cellular proliferation	DOID:14566	0.012
cancer	DOID:162	0.012
organ system cancer	DOID:0050686	0.012
cardiovascular system disease	DOID:1287	0.011
essential hypertension	DOID:10825	0.011
artery disease	DOID:0050828	0.011
vascular disease	DOID:178	0.011
hypertension	DOID:10763	0.011

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