IMP: Integrative Multi-species Prediction

Drosophila melanogaster

7 known processes

Prosbeta2 (Dmel_CG3329)

Proteasome beta2 subunit

(Aliases: DTS7,DTS-7,Dmel\CG3329,Dts7,CG3329,l(3)DTS7,anon-EST:fe1E6,beta2,Prosbeta,3329,anon-EST:fe1G6,beta2_dm)

Entrez: 39628
FLYBASE: FBgn0023174
UniProtKB: Q9VUJ1

Process Predictions
Disease Predictions

Prosbeta2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
modification dependent protein catabolic process	GO:0019941	78	0.982	Yeast
modification dependent macromolecule catabolic process	GO:0043632	79	0.969	Yeast
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.953	Yeast
ubiquitin dependent protein catabolic process	GO:0006511	78	0.939	Yeast
cellular response to dna damage stimulus	GO:0006974	223	0.888
proteasomal protein catabolic process	GO:0010498	59	0.829	Yeast
protein catabolic process	GO:0030163	101	0.806	Yeast
proteolysis	GO:0006508	192	0.805	Yeast
cellular protein catabolic process	GO:0044257	83	0.779	Yeast
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.777	Yeast
cellular macromolecule catabolic process	GO:0044265	136	0.723	Yeast
cellular catabolic process	GO:0044248	372	0.618	Yeast
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.588
macromolecule catabolic process	GO:0009057	161	0.518	Yeast
catabolic process	GO:0009056	409	0.296	Yeast
organic substance catabolic process	GO:1901575	308	0.237	Yeast
mitotic cell cycle phase transition	GO:0044772	138	0.233
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.215
organelle assembly	GO:0070925	198	0.183
regulation of mitotic cell cycle	GO:0007346	190	0.179
cell cycle phase transition	GO:0044770	140	0.167
macromolecular complex assembly	GO:0065003	256	0.156
mitotic spindle elongation	GO:0000022	81	0.148
multicellular organismal aging	GO:0010259	140	0.147	Worm
body morphogenesis	GO:0010171	2	0.136
determination of adult lifespan	GO:0008340	137	0.128	Worm
negative regulation of mitotic cell cycle	GO:0045930	109	0.116
larval development	GO:0002164	104	0.112	Worm
g2 dna damage checkpoint	GO:0031572	69	0.109
mitotic dna damage checkpoint	GO:0044773	74	0.108
regulation of cell cycle process	GO:0010564	181	0.105
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.097
embryo development ending in birth or egg hatching	GO:0009792	152	0.093	Worm
dna templated transcription initiation	GO:0006352	25	0.093
dna repair	GO:0006281	54	0.092
lateral inhibition	GO:0046331	206	0.089
mitotic g2 m transition checkpoint	GO:0044818	70	0.088
negative regulation of cell cycle process	GO:0010948	109	0.087
negative regulation of cell cycle	GO:0045786	116	0.086
protein complex assembly	GO:0006461	200	0.086
regulation of proteolysis	GO:0030162	87	0.083
regulation of organelle organization	GO:0033043	196	0.079
nuclear division	GO:0000280	332	0.076
response to oxidative stress	GO:0006979	86	0.075
ribonucleoside catabolic process	GO:0042454	112	0.070
dna damage checkpoint	GO:0000077	78	0.066
mitotic spindle organization	GO:0007052	220	0.066
regionalization	GO:0003002	416	0.055
organelle fission	GO:0048285	340	0.051
cellular nitrogen compound catabolic process	GO:0044270	165	0.050
ribose phosphate metabolic process	GO:0019693	145	0.050
multi multicellular organism process	GO:0044706	123	0.049
regulation of cell cycle	GO:0051726	291	0.049
mitotic g2 dna damage checkpoint	GO:0007095	69	0.048
camera type eye development	GO:0043010	4	0.048
dna templated transcriptional preinitiation complex assembly	GO:0070897	20	0.047
carbohydrate derivative catabolic process	GO:1901136	118	0.046
eye photoreceptor cell differentiation	GO:0001754	145	0.043
negative regulation of developmental process	GO:0051093	201	0.043
negative regulation of cell cycle phase transition	GO:1901988	103	0.042
morphogenesis of an epithelium	GO:0002009	276	0.041
cellular protein modification process	GO:0006464	438	0.039
regulation of cellular protein metabolic process	GO:0032268	243	0.039
cell cycle checkpoint	GO:0000075	95	0.039
cellular macromolecular complex assembly	GO:0034622	153	0.038
regulation of endopeptidase activity	GO:0052548	36	0.037
multi organism reproductive behavior	GO:0044705	121	0.036
protein complex biogenesis	GO:0070271	201	0.036
protein dna complex subunit organization	GO:0071824	86	0.036
synaptic transmission	GO:0007268	288	0.036
protein deneddylation	GO:0000338	8	0.034
stem cell differentiation	GO:0048863	117	0.034
regulation of notch signaling pathway	GO:0008593	100	0.034
cellular response to oxygen containing compound	GO:1901701	79	0.033
protein modification by small protein conjugation or removal	GO:0070647	106	0.032
positive regulation of proteolysis	GO:0045862	52	0.030
regulation of molecular function	GO:0065009	217	0.029
mitotic nuclear division	GO:0007067	213	0.029
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.028
dna integrity checkpoint	GO:0031570	81	0.028
purine nucleoside catabolic process	GO:0006152	112	0.028
nucleoside phosphate catabolic process	GO:1901292	110	0.028
positive regulation of response to stimulus	GO:0048584	323	0.027
heterocycle catabolic process	GO:0046700	166	0.027
negative regulation of transcription dna templated	GO:0045892	237	0.027
transcription from rna polymerase ii promoter	GO:0006366	368	0.026
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.026
multicellular organismal reproductive behavior	GO:0033057	110	0.026
negative regulation of purine nucleotide catabolic process	GO:0033122	1	0.026
regulation of cell cycle phase transition	GO:1901987	130	0.026
oviposition	GO:0018991	19	0.025
organonitrogen compound metabolic process	GO:1901564	318	0.025
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.025
cellular component assembly involved in morphogenesis	GO:0010927	151	0.025
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.024
mitotic dna integrity checkpoint	GO:0044774	75	0.024
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.024
regulation of striated muscle contraction	GO:0006942	2	0.023
positive regulation of peptidase activity	GO:0010952	29	0.023
positive regulation of macromolecule metabolic process	GO:0010604	405	0.022
positive regulation of transcription dna templated	GO:0045893	266	0.022
regulation of chromosome organization	GO:0033044	64	0.022
small molecule metabolic process	GO:0044281	305	0.022
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	20	0.020
regulation of vesicle mediated transport	GO:0060627	59	0.020
peptidyl amino acid modification	GO:0018193	105	0.019
positive regulation of cellular protein metabolic process	GO:0032270	118	0.019
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.019
actin cytoskeleton organization	GO:0030036	206	0.019
positive regulation of cellular component organization	GO:0051130	156	0.019
mitotic cell cycle checkpoint	GO:0007093	88	0.019
negative regulation of phosphatase activity	GO:0010923	3	0.019
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.019
notch receptor processing	GO:0007220	13	0.018
nucleoside catabolic process	GO:0009164	112	0.018
regulation of catalytic activity	GO:0050790	185	0.018
chemotaxis	GO:0006935	249	0.018
protein modification process	GO:0036211	438	0.018
nucleoside phosphate metabolic process	GO:0006753	162	0.018
molting cycle	GO:0042303	56	0.018
cell division	GO:0051301	248	0.018
reproductive behavior	GO:0019098	122	0.018
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.017
vesicle mediated transport	GO:0016192	381	0.017
endocytosis	GO:0006897	310	0.017
cell motility	GO:0048870	251	0.017
regulation of cellular protein catabolic process	GO:1903362	44	0.017
dna templated transcription elongation	GO:0006354	18	0.017
transcription initiation from rna polymerase ii promoter	GO:0006367	25	0.016
proteasome assembly	GO:0043248	2	0.016
columnar cuboidal epithelial cell development	GO:0002066	249	0.016
spindle organization	GO:0007051	253	0.016
intracellular transport	GO:0046907	228	0.016
dna metabolic process	GO:0006259	227	0.016
single organism catabolic process	GO:0044712	228	0.015
response to other organism	GO:0051707	293	0.015
regulation of phosphatase activity	GO:0010921	3	0.015
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.015
organonitrogen compound catabolic process	GO:1901565	128	0.015
negative regulation of response to stimulus	GO:0048585	258	0.014
chromosome segregation	GO:0007059	157	0.014
aromatic compound catabolic process	GO:0019439	166	0.014
purine ribonucleotide catabolic process	GO:0009154	109	0.014
epithelial cell differentiation	GO:0030855	322	0.014
protein modification by small protein conjugation	GO:0032446	79	0.014
purine ribonucleoside catabolic process	GO:0046130	112	0.014
phospholipid transport	GO:0015914	2	0.014
cellular response to nutrient	GO:0031670	1	0.013
cellular protein complex assembly	GO:0043623	71	0.013
positive regulation of catabolic process	GO:0009896	105	0.013
response to organic substance	GO:0010033	284	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.013
spindle assembly	GO:0051225	80	0.013
purine ribonucleotide metabolic process	GO:0009150	145	0.013
negative regulation of cellular protein metabolic process	GO:0032269	85	0.013
response to external biotic stimulus	GO:0043207	293	0.012
regulation of gtpase activity	GO:0043087	44	0.012
chromatin organization	GO:0006325	207	0.012
positive regulation of cellular component biogenesis	GO:0044089	80	0.012
meiotic cell cycle	GO:0051321	171	0.012
negative regulation of transcription factor import into nucleus	GO:0042992	4	0.012
imaginal disc derived wing morphogenesis	GO:0007476	337	0.012
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.012
digestive tract morphogenesis	GO:0048546	127	0.011
regulation of response to stress	GO:0080134	200	0.011
positive regulation of endopeptidase activity	GO:0010950	26	0.011
neuron projection guidance	GO:0097485	241	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.011
regulation of atp catabolic process	GO:1903289	4	0.011
neurological system process	GO:0050877	358	0.011
cell migration	GO:0016477	238	0.011
spindle assembly involved in mitosis	GO:0090307	50	0.011
positive regulation of cellular biosynthetic process	GO:0031328	316	0.011
regulation of cellular catabolic process	GO:0031329	157	0.010
regulation of cellular response to stress	GO:0080135	89	0.010
organophosphate catabolic process	GO:0046434	112	0.010
amine metabolic process	GO:0009308	12	0.010
regulation of hemocyte proliferation	GO:0035206	37	0.010
nucleoside metabolic process	GO:0009116	127	0.010
peptidyl serine phosphorylation	GO:0018105	7	0.010
positive regulation of catalytic activity	GO:0043085	118	0.010

Prosbeta2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of cellular proliferation	DOID:14566	0	0.021
	benign neoplasm	DOID:0060072	0	0.021

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