IMP: Integrative Multi-species Prediction

Drosophila melanogaster

44 known processes

5-HT2 (Dmel_CG1056)

Serotonin receptor 2

(Aliases: Dm5HT2,5-ht2Dro,5HT2Dro,5-HT[[2]]Dro,l(3)82CDb,5-HT[2]Dro,5HT-dro[[1]],CG1056,5HT2-Dro,Dmel\CG1056,5-HT[[2Dro]],5HT[[2Dro]],d5-HT2,5HT-R82A,5-HT[[2]],5-HT2Dro)

Entrez: 40575
FLYBASE: FBgn0087012
UniProtKB: Q9VN38
UniProtKB: A8JQT4
UniProtKB: E1JJ46
UniProtKB: Q8IPN2
UniProtKB: Q6AWQ4

Process Predictions
Disease Predictions

5-HT2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
larval feeding behavior	GO:0030536	15	0.448
response to nutrient levels	GO:0031667	114	0.138
epithelial cell migration	GO:0010631	148	0.130
organic hydroxy compound biosynthetic process	GO:1901617	21	0.122
circadian rhythm	GO:0007623	105	0.109
molting cycle chitin based cuticle	GO:0007591	56	0.107
multi multicellular organism process	GO:0044706	123	0.107
neuropeptide signaling pathway	GO:0007218	45	0.105
response to extracellular stimulus	GO:0009991	116	0.104
larval behavior	GO:0030537	42	0.094
cell proliferation	GO:0008283	299	0.090
stem cell differentiation	GO:0048863	117	0.090
organic hydroxy compound metabolic process	GO:1901615	83	0.089
tube morphogenesis	GO:0035239	191	0.087
circadian behavior	GO:0048512	76	0.085
single organism behavior	GO:0044708	391	0.084
mating	GO:0007618	120	0.075
multi organism reproductive behavior	GO:0044705	121	0.068
gastrulation involving germ band extension	GO:0010004	36	0.063
tissue migration	GO:0090130	155	0.059
germ cell migration	GO:0008354	43	0.058
sleep	GO:0030431	49	0.057
response to organic cyclic compound	GO:0014070	89	0.056
male courtship behavior	GO:0008049	63	0.056
positive regulation of gene expression	GO:0010628	290	0.054
olfactory behavior	GO:0042048	97	0.054
heart development	GO:0007507	82	0.053
rhythmic process	GO:0048511	106	0.050
positive regulation of multicellular organismal process	GO:0051240	143	0.049
negative regulation of rna biosynthetic process	GO:1902679	240	0.046
regulation of cell differentiation	GO:0045595	302	0.045
g protein coupled receptor signaling pathway	GO:0007186	136	0.043
carboxylic acid metabolic process	GO:0019752	92	0.042
rna localization	GO:0006403	115	0.042
gastrulation	GO:0007369	70	0.042
cell death	GO:0008219	279	0.041
sex differentiation	GO:0007548	81	0.040
single organism biosynthetic process	GO:0044711	206	0.038
cardiocyte differentiation	GO:0035051	29	0.037
mesenchymal cell differentiation	GO:0048762	1	0.036
small molecule biosynthetic process	GO:0044283	37	0.035
muscle tissue morphogenesis	GO:0060415	2	0.035
regulation of response to external stimulus	GO:0032101	115	0.035
connective tissue development	GO:0061448	3	0.034
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.033
feeding behavior	GO:0007631	50	0.032
epithelium migration	GO:0090132	148	0.032
positive regulation of developmental process	GO:0051094	143	0.031
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.031
body morphogenesis	GO:0010171	2	0.031
digestive tract morphogenesis	GO:0048546	127	0.031
response to organic substance	GO:0010033	284	0.030
dendrite development	GO:0016358	204	0.030
negative regulation of cell death	GO:0060548	81	0.029
cellular response to hormone stimulus	GO:0032870	44	0.029
lipid metabolic process	GO:0006629	121	0.029
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.029
lipid storage	GO:0019915	38	0.028
endocytosis	GO:0006897	310	0.028
response to abiotic stimulus	GO:0009628	341	0.028
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.027
negative regulation of cellular biosynthetic process	GO:0031327	277	0.027
tripartite regional subdivision	GO:0007351	103	0.026
indole containing compound biosynthetic process	GO:0042435	4	0.025
oxoacid metabolic process	GO:0043436	103	0.025
cellular amino acid metabolic process	GO:0006520	61	0.024
embryonic morphogenesis	GO:0048598	206	0.024
dopamine biosynthetic process	GO:0042416	3	0.023
response to endogenous stimulus	GO:0009719	119	0.023
organelle localization	GO:0051640	148	0.023
carbohydrate metabolic process	GO:0005975	82	0.023
organic acid metabolic process	GO:0006082	103	0.023
negative regulation of rna metabolic process	GO:0051253	251	0.023
cellular response to lipid	GO:0071396	20	0.022
localization of cell	GO:0051674	257	0.022
small molecule metabolic process	GO:0044281	305	0.021
response to hormone	GO:0009725	45	0.021
mesodermal cell migration	GO:0008078	7	0.021
reproductive behavior	GO:0019098	122	0.021
positive regulation of cell motility	GO:2000147	3	0.021
digestive tract development	GO:0048565	149	0.020
steroid biosynthetic process	GO:0006694	16	0.020
rhythmic behavior	GO:0007622	76	0.020
larval locomotory behavior	GO:0008345	27	0.020
lipid biosynthetic process	GO:0008610	46	0.020
regulation of response to nutrient levels	GO:0032107	18	0.019
positive regulation of rna biosynthetic process	GO:1902680	266	0.019
cellular response to lipopolysaccharide	GO:0071222	3	0.019
regulation of programmed cell death	GO:0043067	152	0.019
circadian sleep wake cycle process	GO:0022410	24	0.019
circadian sleep wake cycle sleep	GO:0050802	23	0.019
protein localization	GO:0008104	284	0.019
positive regulation of cell migration	GO:0030335	2	0.019
phagocytosis	GO:0006909	215	0.019
mesenchymal cell development	GO:0014031	1	0.018
gastrulation with mouth forming first	GO:0001703	36	0.018
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.018
negative regulation of developmental process	GO:0051093	201	0.018
locomotory behavior	GO:0007626	176	0.018
head involution	GO:0008258	35	0.018
stem cell development	GO:0048864	79	0.018
negative regulation of multicellular organismal process	GO:0051241	142	0.018
developmental growth	GO:0048589	280	0.018
developmental maturation	GO:0021700	172	0.018
oocyte differentiation	GO:0009994	145	0.017
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.017
regulation of intracellular signal transduction	GO:1902531	236	0.017
cardiac cell fate determination	GO:0060913	3	0.017
regulation of cell death	GO:0010941	173	0.017
programmed cell death	GO:0012501	257	0.017
embryo development ending in birth or egg hatching	GO:0009792	152	0.017
negative regulation of cell cycle	GO:0045786	116	0.017
intracellular signal transduction	GO:0035556	300	0.017
cellular response to organic substance	GO:0071310	132	0.017
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
negative regulation of epithelial cell proliferation	GO:0050680	4	0.016
dendrite morphogenesis	GO:0048813	199	0.016
response to organonitrogen compound	GO:0010243	75	0.016
spinal cord development	GO:0021510	1	0.016
regulation of localization	GO:0032879	275	0.016
positive regulation of rna metabolic process	GO:0051254	271	0.016
stem cell maintenance	GO:0019827	67	0.016
negative regulation of cell differentiation	GO:0045596	143	0.015
hindgut morphogenesis	GO:0007442	58	0.015
chromosome organization	GO:0051276	360	0.015
anatomical structure homeostasis	GO:0060249	97	0.015
endoderm formation	GO:0001706	3	0.015
death	GO:0016265	284	0.015
cellular response to chemical stimulus	GO:0070887	199	0.015
negative regulation of biosynthetic process	GO:0009890	277	0.015
maintenance of location	GO:0051235	73	0.015
cellular response to organic cyclic compound	GO:0071407	32	0.015
ameboidal type cell migration	GO:0001667	151	0.015
regulation of circadian sleep wake cycle sleep	GO:0045187	21	0.015
cellular response to nitrogen compound	GO:1901699	51	0.015
multicellular organismal reproductive behavior	GO:0033057	110	0.015
catechol containing compound biosynthetic process	GO:0009713	3	0.015
regulation of multi organism process	GO:0043900	131	0.014
camera type eye morphogenesis	GO:0048593	2	0.014
cardioblast cell fate determination	GO:0007510	3	0.014
male mating behavior	GO:0060179	70	0.014
regulation of molecular function	GO:0065009	217	0.014
negative regulation of signaling	GO:0023057	219	0.014
chromatin remodeling	GO:0006338	72	0.014
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.013
mating behavior	GO:0007617	106	0.013
fat soluble vitamin biosynthetic process	GO:0042362	1	0.013
formation of primary germ layer	GO:0001704	24	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.013
telencephalon development	GO:0021537	2	0.013
molting cycle	GO:0042303	56	0.013
hindgut development	GO:0061525	58	0.013
spermatogenesis	GO:0007283	200	0.013
vesicle mediated transport	GO:0016192	381	0.013
negative regulation of stem cell proliferation	GO:2000647	30	0.013
multi organism behavior	GO:0051705	175	0.013
positive regulation of signaling	GO:0023056	243	0.013
multicellular organismal aging	GO:0010259	140	0.013
alcohol metabolic process	GO:0006066	25	0.013
response to lipopolysaccharide	GO:0032496	4	0.013
negative regulation of programmed cell death	GO:0043069	72	0.013
blastoderm segmentation	GO:0007350	159	0.013
regulation of cell adhesion	GO:0030155	27	0.013
positive regulation of cell development	GO:0010720	61	0.013
memory	GO:0007613	94	0.012
periodic partitioning	GO:0007365	29	0.012
salivary gland development	GO:0007431	162	0.012
positive regulation of biosynthetic process	GO:0009891	316	0.012
regulation of cell migration	GO:0030334	22	0.012
tube development	GO:0035295	244	0.012
signal transduction by phosphorylation	GO:0023014	107	0.012
courtship behavior	GO:0007619	68	0.012
positive regulation of signal transduction	GO:0009967	223	0.012
catecholamine biosynthetic process	GO:0042423	3	0.012
negative regulation of transcription dna templated	GO:0045892	237	0.011
germ band shortening	GO:0007390	19	0.011
retina development in camera type eye	GO:0060041	4	0.011
locomotor rhythm	GO:0045475	56	0.011
organic substance transport	GO:0071702	257	0.011
regulation of cell proliferation	GO:0042127	163	0.011
oxidation reduction process	GO:0055114	123	0.011
morphogenesis of a branching epithelium	GO:0061138	45	0.011
organelle assembly	GO:0070925	198	0.011
regulation of phosphorus metabolic process	GO:0051174	210	0.011
serotonin metabolic process	GO:0042428	2	0.011
synaptic vesicle localization	GO:0097479	53	0.011
heart morphogenesis	GO:0003007	32	0.011
establishment of localization in cell	GO:0051649	402	0.011
regulation of hydrolase activity	GO:0051336	97	0.011
regulation of cell cycle	GO:0051726	291	0.011
cardiovascular system development	GO:0072358	82	0.010
cellular response to endogenous stimulus	GO:0071495	80	0.010
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.010
cell fate determination	GO:0001709	91	0.010
positive regulation of response to stimulus	GO:0048584	323	0.010
establishment of organelle localization	GO:0051656	122	0.010
response to lipid	GO:0033993	38	0.010
response to temperature stimulus	GO:0009266	106	0.010
regulation of phosphatase activity	GO:0010921	3	0.010
malpighian tubule development	GO:0072002	64	0.010
amine metabolic process	GO:0009308	12	0.010
gliogenesis	GO:0042063	80	0.010
protein modification process	GO:0036211	438	0.010
axis specification	GO:0009798	167	0.010

5-HT2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.062
disease of cellular proliferation	DOID:14566	0.027
cancer	DOID:162	0.027
organ system cancer	DOID:0050686	0.018

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