IMP: Integrative Multi-species Prediction

Drosophila melanogaster

77 known processes

lva (Dmel_CG6450)

lava lamp

(Aliases: CG6450,lvl,Lava,ABP2,CG#6450,LVA,lava,Lvl,Lva,Dmel\CG6450)

FLYBASE: FBgn0029688
Entrez: 31350
UniProtKB: Q8MSS1
UniProtKB: X2JAF1

Process Predictions
Disease Predictions

lva biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
protein localization	GO:0008104	284	0.355
establishment of localization in cell	GO:0051649	402	0.353
endomembrane system organization	GO:0010256	119	0.183
regulation of cell differentiation	GO:0045595	302	0.154
nucleobase containing compound catabolic process	GO:0034655	165	0.151
carbohydrate derivative metabolic process	GO:1901135	217	0.133
aromatic compound catabolic process	GO:0019439	166	0.127
segmentation	GO:0035282	207	0.121
single organism intracellular transport	GO:1902582	207	0.120
anterior posterior axis specification embryo	GO:0008595	103	0.117
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.116
innate immune response	GO:0045087	144	0.097
heterocycle catabolic process	GO:0046700	166	0.090
defense response	GO:0006952	300	0.089
blastoderm segmentation	GO:0007350	159	0.089
immune response	GO:0006955	246	0.088
ribonucleoside catabolic process	GO:0042454	112	0.087
organic substance catabolic process	GO:1901575	308	0.086
organic substance transport	GO:0071702	257	0.084
intracellular transport	GO:0046907	228	0.083
purine nucleoside catabolic process	GO:0006152	112	0.080
endoplasmic reticulum organization	GO:0007029	13	0.080
single organism cellular localization	GO:1902580	180	0.077
regulation of cellular catabolic process	GO:0031329	157	0.071
purine nucleoside metabolic process	GO:0042278	127	0.071
cellular macromolecule localization	GO:0070727	220	0.071
nucleotide metabolic process	GO:0009117	161	0.071
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.071
cellular protein modification process	GO:0006464	438	0.069
golgi vesicle transport	GO:0048193	27	0.066
organonitrogen compound metabolic process	GO:1901564	318	0.066
establishment of protein localization	GO:0045184	163	0.065
nucleotide catabolic process	GO:0009166	109	0.063
guanosine containing compound metabolic process	GO:1901068	74	0.063
response to bacterium	GO:0009617	198	0.061
single organism membrane organization	GO:0044802	93	0.061
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.060
regulation of localization	GO:0032879	275	0.060
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.060
purine ribonucleotide catabolic process	GO:0009154	109	0.059
vesicle organization	GO:0016050	44	0.059
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.058
oocyte differentiation	GO:0009994	145	0.058
regionalization	GO:0003002	416	0.058
regulation of response to stress	GO:0080134	200	0.057
organic cyclic compound catabolic process	GO:1901361	168	0.057
macromolecule catabolic process	GO:0009057	161	0.056
regulation of protein metabolic process	GO:0051246	256	0.056
positive regulation of gtpase activity	GO:0043547	43	0.055
defense response to bacterium	GO:0042742	178	0.055
embryonic axis specification	GO:0000578	107	0.054
regulation of molecular function	GO:0065009	217	0.051
nucleobase containing small molecule metabolic process	GO:0055086	174	0.050
establishment or maintenance of cell polarity	GO:0007163	167	0.050
regulation of defense response	GO:0031347	102	0.050
immune system process	GO:0002376	347	0.049
protein modification by small protein conjugation or removal	GO:0070647	106	0.049
locomotory behavior	GO:0007626	176	0.049
protein complex biogenesis	GO:0070271	201	0.048
cellular nitrogen compound catabolic process	GO:0044270	165	0.048
single organism catabolic process	GO:0044712	228	0.048
positive regulation of defense response	GO:0031349	59	0.048
catabolic process	GO:0009056	409	0.047
regulation of gtp catabolic process	GO:0033124	44	0.046
golgi organization	GO:0007030	66	0.046
positive regulation of response to stimulus	GO:0048584	323	0.045
oocyte development	GO:0048599	124	0.045
guanosine containing compound catabolic process	GO:1901069	74	0.045
anterior posterior axis specification	GO:0009948	109	0.044
dendrite morphogenesis	GO:0048813	199	0.044
carbohydrate derivative catabolic process	GO:1901136	118	0.044
cellular catabolic process	GO:0044248	372	0.043
cellular macromolecule catabolic process	GO:0044265	136	0.043
secretion	GO:0046903	109	0.043
gtp metabolic process	GO:0046039	72	0.042
ribonucleotide metabolic process	GO:0009259	145	0.042
defense response to other organism	GO:0098542	225	0.042
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.041
cellular protein localization	GO:0034613	160	0.041
oocyte anterior posterior axis specification	GO:0007314	72	0.041
open tracheal system development	GO:0007424	204	0.041
purine containing compound catabolic process	GO:0072523	112	0.041
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.040
regulation of neurogenesis	GO:0050767	158	0.040
organophosphate catabolic process	GO:0046434	112	0.040
ribonucleotide catabolic process	GO:0009261	109	0.039
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.038
post golgi vesicle mediated transport	GO:0006892	11	0.038
regulation of nucleotide catabolic process	GO:0030811	48	0.038
nucleoside phosphate metabolic process	GO:0006753	162	0.038
nucleoside triphosphate metabolic process	GO:0009141	120	0.038
positive regulation of cellular catabolic process	GO:0031331	95	0.037
response to biotic stimulus	GO:0009607	294	0.037
endocytosis	GO:0006897	310	0.037
purine ribonucleotide metabolic process	GO:0009150	145	0.036
body morphogenesis	GO:0010171	2	0.036
regulation of immune system process	GO:0002682	176	0.036
protein complex disassembly	GO:0043241	36	0.036
oocyte axis specification	GO:0007309	108	0.035
nucleoside catabolic process	GO:0009164	112	0.035
single organism behavior	GO:0044708	391	0.035
regulation of catabolic process	GO:0009894	170	0.035
positive regulation of cellular component organization	GO:0051130	156	0.035
macromolecular complex assembly	GO:0065003	256	0.033
positive regulation of nucleotide metabolic process	GO:0045981	55	0.033
positive regulation of nucleoside metabolic process	GO:0045979	47	0.033
regulation of multi organism process	GO:0043900	131	0.033
microtubule based movement	GO:0007018	51	0.033
glycosyl compound catabolic process	GO:1901658	112	0.033
nucleoside phosphate catabolic process	GO:1901292	110	0.033
respiratory system development	GO:0060541	213	0.032
purine nucleotide metabolic process	GO:0006163	146	0.032
positive regulation of transport	GO:0051050	92	0.032
positive regulation of immune response	GO:0050778	63	0.032
response to other organism	GO:0051707	293	0.031
defense response to gram negative bacterium	GO:0050829	94	0.031
cell division	GO:0051301	248	0.031
organophosphate metabolic process	GO:0019637	195	0.030
protein transport	GO:0015031	155	0.030
tripartite regional subdivision	GO:0007351	103	0.030
compound eye development	GO:0048749	307	0.030
membrane organization	GO:0061024	112	0.029
dendrite development	GO:0016358	204	0.029
developmental maturation	GO:0021700	172	0.028
regulation of immune response	GO:0050776	118	0.028
larval development	GO:0002164	104	0.028
posttranscriptional regulation of gene expression	GO:0010608	145	0.027
nucleoside metabolic process	GO:0009116	127	0.027
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.027
embryonic pattern specification	GO:0009880	174	0.027
protein catabolic process	GO:0030163	101	0.026
positive regulation of gtp catabolic process	GO:0033126	43	0.026
positive regulation of phosphate metabolic process	GO:0045937	139	0.026
nucleoside triphosphate catabolic process	GO:0009143	108	0.026
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.026
protein secretion	GO:0009306	45	0.025
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.024
positive regulation of catabolic process	GO:0009896	105	0.024
purine ribonucleoside metabolic process	GO:0046128	127	0.024
humoral immune response	GO:0006959	117	0.024
exocytosis	GO:0006887	28	0.024
modification dependent protein catabolic process	GO:0019941	78	0.024
intracellular protein transport	GO:0006886	104	0.024
purine containing compound metabolic process	GO:0072521	155	0.023
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.023
molting cycle chitin based cuticle	GO:0007591	56	0.022
translation	GO:0006412	69	0.022
positive regulation of phosphorus metabolic process	GO:0010562	139	0.021
cytoskeleton dependent cytokinesis	GO:0061640	81	0.021
axon guidance	GO:0007411	233	0.021
rna catabolic process	GO:0006401	37	0.021
regulation of transport	GO:0051049	181	0.020
positive regulation of secretion	GO:0051047	22	0.020
vesicle mediated transport	GO:0016192	381	0.020
regulation of cellular protein metabolic process	GO:0032268	243	0.019
axonogenesis	GO:0007409	290	0.019
secretion by cell	GO:0032940	101	0.019
cuticle pigmentation	GO:0048067	22	0.019
macroautophagy	GO:0016236	42	0.019
positive regulation of immune system process	GO:0002684	68	0.018
rna localization	GO:0006403	115	0.018
cytoplasmic transport	GO:0016482	130	0.018
positive regulation of nervous system development	GO:0051962	69	0.018
pigmentation	GO:0043473	75	0.018
regulation of translation	GO:0006417	56	0.018
synaptic transmission	GO:0007268	288	0.018
purine ribonucleoside catabolic process	GO:0046130	112	0.018
cell maturation	GO:0048469	144	0.018
organelle fusion	GO:0048284	46	0.017
response to inorganic substance	GO:0010035	44	0.016
male meiosis cytokinesis	GO:0007112	26	0.016
anterior posterior pattern specification	GO:0009952	136	0.016
eye development	GO:0001654	323	0.016
protein modification process	GO:0036211	438	0.016
cytokinesis	GO:0000910	90	0.016
regulation of catalytic activity	GO:0050790	185	0.016
molting cycle	GO:0042303	56	0.016
positive regulation of molecular function	GO:0044093	136	0.015
protein ubiquitination	GO:0016567	70	0.015
response to external biotic stimulus	GO:0043207	293	0.015
cytoplasm organization	GO:0007028	64	0.015
regulation of phosphorus metabolic process	GO:0051174	210	0.015
aging	GO:0007568	143	0.015
regulation of reproductive process	GO:2000241	54	0.015
regulation of cellular localization	GO:0060341	136	0.015
extracellular structure organization	GO:0043062	46	0.015
regulation of purine nucleotide catabolic process	GO:0033121	48	0.014
death	GO:0016265	284	0.014
cellular macromolecular complex assembly	GO:0034622	153	0.014
axis specification	GO:0009798	167	0.014
negative regulation of cytoskeleton organization	GO:0051494	30	0.013
chitin based cuticle development	GO:0040003	49	0.013
antimicrobial humoral response	GO:0019730	99	0.013
modification dependent macromolecule catabolic process	GO:0043632	79	0.013
positive regulation of catalytic activity	GO:0043085	118	0.013
wing disc morphogenesis	GO:0007472	344	0.013
cytoskeleton dependent intracellular transport	GO:0030705	44	0.013
small molecule metabolic process	GO:0044281	305	0.013
positive regulation of hydrolase activity	GO:0051345	78	0.013
regulation of anatomical structure size	GO:0090066	163	0.013
ribonucleoside metabolic process	GO:0009119	127	0.013
positive regulation of multicellular organismal process	GO:0051240	143	0.013
oligosaccharide biosynthetic process	GO:0009312	10	0.013
rho protein signal transduction	GO:0007266	14	0.012
establishment of rna localization	GO:0051236	47	0.012
regulation of protein localization	GO:0032880	76	0.012
regulation of nucleoside metabolic process	GO:0009118	50	0.012
adult behavior	GO:0030534	137	0.012
protein complex assembly	GO:0006461	200	0.012
regulation of gtpase activity	GO:0043087	44	0.012
gtp catabolic process	GO:0006184	72	0.012
eye photoreceptor cell development	GO:0042462	81	0.012
microtubule based transport	GO:0010970	42	0.011
regulation of secretion	GO:0051046	44	0.011
biological adhesion	GO:0022610	138	0.011
tube morphogenesis	GO:0035239	191	0.011
chemotaxis	GO:0006935	249	0.011
adult locomotory behavior	GO:0008344	76	0.011
regulation of nucleotide metabolic process	GO:0006140	62	0.011
small gtpase mediated signal transduction	GO:0007264	88	0.011
organonitrogen compound catabolic process	GO:1901565	128	0.011
purine nucleotide catabolic process	GO:0006195	109	0.011
protein modification by small protein conjugation	GO:0032446	79	0.011
regulation of purine nucleotide metabolic process	GO:1900542	62	0.010
single organism carbohydrate metabolic process	GO:0044723	72	0.010
carbohydrate derivative biosynthetic process	GO:1901137	85	0.010
cuticle pattern formation	GO:0035017	27	0.010
ubiquitin dependent protein catabolic process	GO:0006511	78	0.010
regulation of membrane potential	GO:0042391	35	0.010
intracellular signal transduction	GO:0035556	300	0.010
response to calcium ion	GO:0051592	1	0.010
response to nutrient levels	GO:0031667	114	0.010

lva disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.019
	nervous system disease	DOID:863	0	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network