IMP: Integrative Multi-species Prediction

Drosophila melanogaster

60 known processes

ASPP (Dmel_CG18375)

Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein

(Aliases: dASPP,Dmel\CG18375,CG18375)

Entrez: 37422
FLYBASE: FBgn0034606
UniProtKB: Q86BG1
UniProtKB: Q9W2J2

Process Predictions
Disease Predictions

ASPP biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of multicellular organismal development	GO:2000026	414	0.232
compound eye morphogenesis	GO:0001745	249	0.217
photoreceptor cell differentiation	GO:0046530	170	0.185
intracellular signal transduction	GO:0035556	300	0.184	Human
ovarian follicle cell development	GO:0030707	248	0.180
notch signaling pathway	GO:0007219	120	0.174
positive regulation of response to stimulus	GO:0048584	323	0.173
epithelial cell differentiation	GO:0030855	322	0.138
eye development	GO:0001654	323	0.133
sensory organ morphogenesis	GO:0090596	260	0.131
regulation of nervous system development	GO:0051960	248	0.127
regulation of apoptotic process	GO:0042981	130	0.121
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.111
immune system process	GO:0002376	347	0.108
negative regulation of developmental process	GO:0051093	201	0.104
forebrain development	GO:0030900	2	0.101
negative regulation of cell communication	GO:0010648	223	0.099
open tracheal system development	GO:0007424	204	0.097
growth	GO:0040007	359	0.096
multi organism behavior	GO:0051705	175	0.096
appendage development	GO:0048736	401	0.094
negative regulation of response to stimulus	GO:0048585	258	0.092
eye morphogenesis	GO:0048592	260	0.092
regulation of gene expression epigenetic	GO:0040029	128	0.091
store operated calcium entry	GO:0002115	3	0.089
imaginal disc derived appendage development	GO:0048737	399	0.085
compound eye development	GO:0048749	307	0.084
tube morphogenesis	GO:0035239	191	0.082
regulation of programmed cell death	GO:0043067	152	0.081
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.078
organelle fission	GO:0048285	340	0.074
protein modification by small protein conjugation	GO:0032446	79	0.072
nuclear division	GO:0000280	332	0.071
programmed cell death	GO:0012501	257	0.068	Human
protein modification by small protein conjugation or removal	GO:0070647	106	0.067
ommatidial rotation	GO:0016318	20	0.067
negative regulation of multicellular organismal process	GO:0051241	142	0.067
regulation of neurogenesis	GO:0050767	158	0.067
cellular protein modification process	GO:0006464	438	0.066
synapse organization	GO:0050808	196	0.066
post embryonic appendage morphogenesis	GO:0035120	385	0.065
negative regulation of signaling	GO:0023057	219	0.065
columnar cuboidal epithelial cell development	GO:0002066	249	0.064
apoptotic process	GO:0006915	159	0.064	Human
lateral inhibition	GO:0046331	206	0.064
positive regulation of signaling	GO:0023056	243	0.064
regulation of catalytic activity	GO:0050790	185	0.062
negative regulation of signal transduction	GO:0009968	206	0.061
negative regulation of apoptotic process	GO:0043066	63	0.060
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.059
wing disc morphogenesis	GO:0007472	344	0.059
organonitrogen compound metabolic process	GO:1901564	318	0.057
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.057
regulation of notch signaling pathway	GO:0008593	100	0.057
establishment of planar polarity	GO:0001736	87	0.056
negative regulation of programmed cell death	GO:0043069	72	0.056
modification dependent macromolecule catabolic process	GO:0043632	79	0.056
epithelial cell development	GO:0002064	274	0.056
behavioral response to ethanol	GO:0048149	49	0.054
single organism behavior	GO:0044708	391	0.052
regulation of mitotic cell cycle	GO:0007346	190	0.052
tissue morphogenesis	GO:0048729	297	0.051
developmental growth	GO:0048589	280	0.051
regulation of cell death	GO:0010941	173	0.050
regulation of protein metabolic process	GO:0051246	256	0.050
regulation of response to stress	GO:0080134	200	0.050
neurological system process	GO:0050877	358	0.049
mitotic nuclear division	GO:0007067	213	0.048
protein ubiquitination	GO:0016567	70	0.048
compound eye photoreceptor development	GO:0042051	78	0.048
regulation of cell differentiation	GO:0045595	302	0.046
imaginal disc derived wing morphogenesis	GO:0007476	337	0.045
transcription from rna polymerase ii promoter	GO:0006366	368	0.044
tube development	GO:0035295	244	0.044
proteolysis	GO:0006508	192	0.043
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.043
regulation of cellular amino acid metabolic process	GO:0006521	0	0.042
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.041
cellular protein catabolic process	GO:0044257	83	0.040
negative regulation of cellular component organization	GO:0051129	108	0.039
negative regulation of cell death	GO:0060548	81	0.039
negative regulation of cell differentiation	GO:0045596	143	0.039
central nervous system development	GO:0007417	201	0.039	Mouse
brain development	GO:0007420	120	0.038
regulation of intracellular signal transduction	GO:1902531	236	0.038
positive regulation of catalytic activity	GO:0043085	118	0.038
positive regulation of signal transduction	GO:0009967	223	0.037
negative regulation of developmental growth	GO:0048640	64	0.037
regulation of localization	GO:0032879	275	0.037
ubiquitin dependent protein catabolic process	GO:0006511	78	0.037
defense response	GO:0006952	300	0.036
cell motility	GO:0048870	251	0.036
regulation of phosphate metabolic process	GO:0019220	210	0.036
mapk cascade	GO:0000165	107	0.035
protein modification process	GO:0036211	438	0.035
purine containing compound metabolic process	GO:0072521	155	0.035
axon development	GO:0061564	297	0.035
negative regulation of nervous system development	GO:0051961	92	0.035
negative regulation of gene expression	GO:0010629	387	0.034
cytoplasmic transport	GO:0016482	130	0.033
cell adhesion	GO:0007155	136	0.033
olfactory behavior	GO:0042048	97	0.033
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.033
epithelium migration	GO:0090132	148	0.033
localization of cell	GO:0051674	257	0.033
imaginal disc pattern formation	GO:0007447	91	0.032
vesicle mediated transport	GO:0016192	381	0.032
negative regulation of neurogenesis	GO:0050768	53	0.032
telencephalon development	GO:0021537	2	0.032
appendage morphogenesis	GO:0035107	397	0.032
regulation of cellular ketone metabolic process	GO:0010565	3	0.032
establishment or maintenance of cell polarity	GO:0007163	167	0.031
cell fate determination	GO:0001709	91	0.031
regulation of molecular function	GO:0065009	217	0.031
regionalization	GO:0003002	416	0.031
rna processing	GO:0006396	147	0.030
single organism intracellular transport	GO:1902582	207	0.030
cellular macromolecule catabolic process	GO:0044265	136	0.030
innate immune response	GO:0045087	144	0.030
modification dependent protein catabolic process	GO:0019941	78	0.030
establishment of localization in cell	GO:0051649	402	0.030
regulation of epithelial cell proliferation	GO:0050678	4	0.030
posttranscriptional regulation of gene expression	GO:0010608	145	0.029
biological adhesion	GO:0022610	138	0.029
eggshell formation	GO:0030703	105	0.029
regulation of cell development	GO:0060284	215	0.029
eye photoreceptor cell development	GO:0042462	81	0.029
chemotaxis	GO:0006935	249	0.029
regulation of cellular component size	GO:0032535	98	0.029
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.029
positive regulation of molecular function	GO:0044093	136	0.028
positive regulation of cell death	GO:0010942	69	0.028
endocytosis	GO:0006897	310	0.028
regulation of growth	GO:0040008	233	0.028
peptidyl amino acid modification	GO:0018193	105	0.027
positive regulation of cell communication	GO:0010647	250	0.027
regulation of glial cell differentiation	GO:0045685	1	0.027
calcium ion transport	GO:0006816	24	0.027
establishment of tissue polarity	GO:0007164	87	0.026
nucleotide metabolic process	GO:0009117	161	0.026
sensory perception	GO:0007600	196	0.026
axonogenesis	GO:0007409	290	0.026
eye photoreceptor cell differentiation	GO:0001754	145	0.026
photoreceptor cell development	GO:0042461	96	0.026
ras protein signal transduction	GO:0007265	88	0.025
catabolic process	GO:0009056	409	0.025
morphogenesis of a polarized epithelium	GO:0001738	93	0.025
cellular component assembly involved in morphogenesis	GO:0010927	151	0.025
actin cytoskeleton organization	GO:0030036	206	0.025
carbohydrate derivative metabolic process	GO:1901135	217	0.025
protein localization	GO:0008104	284	0.025
positive regulation of cellular amine metabolic process	GO:0033240	0	0.025
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.024
multicellular organism growth	GO:0035264	46	0.024
regulation of transport	GO:0051049	181	0.024
cellular amino acid metabolic process	GO:0006520	61	0.023
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.023
cellular macromolecule localization	GO:0070727	220	0.023
chemosensory behavior	GO:0007635	106	0.023
regulation of phosphorus metabolic process	GO:0051174	210	0.023
hindgut morphogenesis	GO:0007442	58	0.023
ion transport	GO:0006811	145	0.023
positive regulation of protein metabolic process	GO:0051247	128	0.023
nephron development	GO:0072006	3	0.022
positive regulation of phosphate metabolic process	GO:0045937	139	0.022
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	26	0.022
regulation of cell cycle process	GO:0010564	181	0.022
organic acid metabolic process	GO:0006082	103	0.022
chorion containing eggshell formation	GO:0007304	105	0.022
respiratory system development	GO:0060541	213	0.022
cognition	GO:0050890	141	0.022
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.021
camera type eye development	GO:0043010	4	0.021
actin filament based process	GO:0030029	220	0.021
imaginal disc derived wing vein specification	GO:0007474	48	0.021
regulation of developmental growth	GO:0048638	174	0.021
cell migration	GO:0016477	238	0.020
larval development	GO:0002164	104	0.020
regulation of cellular amine metabolic process	GO:0033238	3	0.020
negative regulation of insulin secretion	GO:0046676	1	0.020
cellular response to dna damage stimulus	GO:0006974	223	0.020
digestive tract morphogenesis	GO:0048546	127	0.020
gene silencing by rna	GO:0031047	57	0.020
segmentation	GO:0035282	207	0.020
macromolecular complex assembly	GO:0065003	256	0.020
mitotic sister chromatid segregation	GO:0000070	87	0.020
regulation of cellular catabolic process	GO:0031329	157	0.019
somatic muscle development	GO:0007525	66	0.019
digestive tract development	GO:0048565	149	0.019
single organism cellular localization	GO:1902580	180	0.019
regulation of immune system process	GO:0002682	176	0.019
signal transduction by phosphorylation	GO:0023014	107	0.019
cell cell adhesion	GO:0098609	26	0.019
regulation of cell division	GO:0051302	72	0.019
gene silencing	GO:0016458	138	0.018
proteasomal protein catabolic process	GO:0010498	59	0.018
small molecule metabolic process	GO:0044281	305	0.018
divalent inorganic cation transport	GO:0072511	30	0.018
wing disc pattern formation	GO:0035222	66	0.018
phagocytosis	GO:0006909	215	0.018
organic substance transport	GO:0071702	257	0.018
regulation of neuron differentiation	GO:0045664	103	0.018
regulation of protein transport	GO:0051223	57	0.018
positive regulation of cellular protein metabolic process	GO:0032270	118	0.018
organonitrogen compound biosynthetic process	GO:1901566	117	0.018
regulation of purine nucleotide metabolic process	GO:1900542	62	0.017
death	GO:0016265	284	0.017	Human
secretion	GO:0046903	109	0.017
head development	GO:0060322	135	0.017
immune system development	GO:0002520	57	0.017
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.017
regulation of stem cell proliferation	GO:0072091	40	0.017
anatomical structure homeostasis	GO:0060249	97	0.017
response to other organism	GO:0051707	293	0.017
regulation of protein modification process	GO:0031399	112	0.017
negative regulation of rna metabolic process	GO:0051253	251	0.017
regulation of hydrolase activity	GO:0051336	97	0.016
intracellular transport	GO:0046907	228	0.016
nucleobase containing small molecule metabolic process	GO:0055086	174	0.016
positive regulation of cellular biosynthetic process	GO:0031328	316	0.016
response to external biotic stimulus	GO:0043207	293	0.016
sex differentiation	GO:0007548	81	0.016
regulation of cell cycle	GO:0051726	291	0.016
protein transport	GO:0015031	155	0.016
smoothened signaling pathway	GO:0007224	49	0.016
negative regulation of rna biosynthetic process	GO:1902679	240	0.016
purine nucleotide metabolic process	GO:0006163	146	0.016
phosphorylation	GO:0016310	294	0.016
chromosome segregation	GO:0007059	157	0.016
negative regulation of cellular metabolic process	GO:0031324	382	0.016
purine ribonucleotide metabolic process	GO:0009150	145	0.016
positive regulation of rna metabolic process	GO:0051254	271	0.016
digestive system development	GO:0055123	149	0.016
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.016
morphogenesis of an epithelium	GO:0002009	276	0.015
homeostatic process	GO:0042592	199	0.015
regulation of cellular protein metabolic process	GO:0032268	243	0.015
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.015
protein complex assembly	GO:0006461	200	0.015
eggshell chorion assembly	GO:0007306	66	0.015
macromolecule catabolic process	GO:0009057	161	0.015
cell fate specification	GO:0001708	71	0.015
positive regulation of hydrolase activity	GO:0051345	78	0.015
regulation of meiosis	GO:0040020	3	0.015
positive regulation of transport	GO:0051050	92	0.015
regulation of protein catabolic process	GO:0042176	55	0.015
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.015
response to oxygen containing compound	GO:1901700	200	0.015
ribonucleotide metabolic process	GO:0009259	145	0.015
embryonic pattern specification	GO:0009880	174	0.015
regulation of anatomical structure size	GO:0090066	163	0.015
blastoderm segmentation	GO:0007350	159	0.015
developmental maturation	GO:0021700	172	0.015
mitotic spindle organization	GO:0007052	220	0.014
nucleocytoplasmic transport	GO:0006913	72	0.014
single organism nuclear import	GO:1902593	51	0.014
regulation of multicellular organism growth	GO:0040014	40	0.014
neuron projection guidance	GO:0097485	241	0.014
erbb signaling pathway	GO:0038127	58	0.014
nitrogen compound transport	GO:0071705	85	0.014
olfactory learning	GO:0008355	56	0.014
response to organic substance	GO:0010033	284	0.014
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.014
defense response to gram negative bacterium	GO:0050829	94	0.014
genital disc development	GO:0035215	44	0.014
mesenchymal cell differentiation	GO:0048762	1	0.014
positive regulation of catabolic process	GO:0009896	105	0.014
oxoacid metabolic process	GO:0043436	103	0.014
glycosyl compound catabolic process	GO:1901658	112	0.013
protein catabolic process	GO:0030163	101	0.013
organic substance catabolic process	GO:1901575	308	0.013
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.013
negative regulation of cellular protein metabolic process	GO:0032269	85	0.013
cellular protein localization	GO:0034613	160	0.013
stem cell division	GO:0017145	69	0.013
establishment of ommatidial planar polarity	GO:0042067	49	0.013
regulation of cellular component biogenesis	GO:0044087	201	0.013
negative regulation of organelle organization	GO:0010639	56	0.013
response to endogenous stimulus	GO:0009719	119	0.013
regulation of protein localization	GO:0032880	76	0.013
gliogenesis	GO:0042063	80	0.013
regulation of phosphorylation	GO:0042325	147	0.013
neuron fate commitment	GO:0048663	50	0.013
kidney development	GO:0001822	3	0.012
positive regulation of macromolecule metabolic process	GO:0010604	405	0.012
striated muscle cell differentiation	GO:0051146	90	0.012
chaeta development	GO:0022416	97	0.012
embryo development ending in birth or egg hatching	GO:0009792	152	0.012	Mouse
organ growth	GO:0035265	56	0.012
positive regulation of phosphorylation	GO:0042327	87	0.012
regulation of establishment of protein localization	GO:0070201	61	0.012
positive regulation of cell cycle	GO:0045787	43	0.012
skeletal muscle fiber development	GO:0048741	3	0.012
regulation of embryonic development	GO:0045995	68	0.012
negative regulation of cell cycle process	GO:0010948	109	0.012
developmental programmed cell death	GO:0010623	138	0.012
neuromuscular junction development	GO:0007528	149	0.012
compound eye photoreceptor cell differentiation	GO:0001751	140	0.012
regulation of defense response	GO:0031347	102	0.012
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.012
hematopoietic or lymphoid organ development	GO:0048534	57	0.012
regulation of response to external stimulus	GO:0032101	115	0.012
protein import into nucleus	GO:0006606	51	0.012
single organism catabolic process	GO:0044712	228	0.012
wnt signaling pathway	GO:0016055	98	0.012
adult behavior	GO:0030534	137	0.011
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.011
reproductive behavior	GO:0019098	122	0.011
regulation of cell shape	GO:0008360	113	0.011
negative regulation of protein metabolic process	GO:0051248	85	0.011
muscle tissue development	GO:0060537	30	0.011
cellular response to external stimulus	GO:0071496	66	0.011
regulation of innate immune response	GO:0045088	71	0.011
regulation of catabolic process	GO:0009894	170	0.011
multicellular organismal homeostasis	GO:0048871	41	0.011
muscle organ development	GO:0007517	127	0.011
actin filament organization	GO:0007015	126	0.011
hippo signaling	GO:0035329	20	0.011
protein complex biogenesis	GO:0070271	201	0.011
cell maturation	GO:0048469	144	0.011
synaptic target recognition	GO:0008039	45	0.011
multi multicellular organism process	GO:0044706	123	0.011
spermatogenesis	GO:0007283	200	0.011
mesenchymal cell development	GO:0014031	1	0.011
locomotory behavior	GO:0007626	176	0.011
purine nucleoside metabolic process	GO:0042278	127	0.011
cellular catabolic process	GO:0044248	372	0.011
actomyosin structure organization	GO:0031032	56	0.011
regulation of cell morphogenesis	GO:0022604	163	0.011
response to starvation	GO:0042594	97	0.011
regulation of cell growth	GO:0001558	43	0.011
amine metabolic process	GO:0009308	12	0.011
extrinsic apoptotic signaling pathway	GO:0097191	1	0.011
regulation of purine nucleotide catabolic process	GO:0033121	48	0.011
single organism biosynthetic process	GO:0044711	206	0.011
response to wounding	GO:0009611	94	0.011
ncrna metabolic process	GO:0034660	43	0.011
regulation of nuclear division	GO:0051783	58	0.010
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.010
stem cell fate commitment	GO:0048865	25	0.010
ameboidal type cell migration	GO:0001667	151	0.010
response to nutrient levels	GO:0031667	114	0.010
establishment of protein localization to organelle	GO:0072594	62	0.010
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.010
cation transport	GO:0006812	110	0.010
negative regulation of phosphorus metabolic process	GO:0010563	45	0.010
inter male aggressive behavior	GO:0002121	60	0.010
response to abiotic stimulus	GO:0009628	341	0.010	Mouse
cell division	GO:0051301	248	0.010
positive regulation of immune response	GO:0050778	63	0.010
positive regulation of mapk cascade	GO:0043410	63	0.010
positive regulation of phosphorus metabolic process	GO:0010562	139	0.010
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.010
protein processing	GO:0016485	68	0.010
positive regulation of multicellular organismal process	GO:0051240	143	0.010
protein maturation	GO:0051604	71	0.010
retina homeostasis	GO:0001895	13	0.010
regulation of secretion	GO:0051046	44	0.010

ASPP disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.056
disease of cellular proliferation	DOID:14566	0.043
organ system cancer	DOID:0050686	0.030
cancer	DOID:162	0.030
nervous system disease	DOID:863	0.013
cardiovascular system disease	DOID:1287	0.011

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