Drosophila melanogaster

60 known processes

ASPP (Dmel_CG18375)

Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein

(Aliases: dASPP,Dmel\CG18375,CG18375)

ASPP biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of multicellular organismal developmentGO:20000264140.232
compound eye morphogenesisGO:00017452490.217
photoreceptor cell differentiationGO:00465301700.185
intracellular signal transductionGO:00355563000.184
Human
ovarian follicle cell developmentGO:00307072480.180
notch signaling pathwayGO:00072191200.174
positive regulation of response to stimulusGO:00485843230.173
epithelial cell differentiationGO:00308553220.138
eye developmentGO:00016543230.133
sensory organ morphogenesisGO:00905962600.131
regulation of nervous system developmentGO:00519602480.127
regulation of apoptotic processGO:00429811300.121
enzyme linked receptor protein signaling pathwayGO:00071671790.111
immune system processGO:00023763470.108
negative regulation of developmental processGO:00510932010.104
forebrain developmentGO:003090020.101
negative regulation of cell communicationGO:00106482230.099
open tracheal system developmentGO:00074242040.097
growthGO:00400073590.096
multi organism behaviorGO:00517051750.096
appendage developmentGO:00487364010.094
negative regulation of response to stimulusGO:00485852580.092
eye morphogenesisGO:00485922600.092
regulation of gene expression epigeneticGO:00400291280.091
store operated calcium entryGO:000211530.089
imaginal disc derived appendage developmentGO:00487373990.085
compound eye developmentGO:00487493070.084
tube morphogenesisGO:00352391910.082
regulation of programmed cell deathGO:00430671520.081
regulation of transcription from rna polymerase ii promoterGO:00063573780.078
organelle fissionGO:00482853400.074
protein modification by small protein conjugationGO:0032446790.072
nuclear divisionGO:00002803320.071
programmed cell deathGO:00125012570.068
Human
protein modification by small protein conjugation or removalGO:00706471060.067
ommatidial rotationGO:0016318200.067
negative regulation of multicellular organismal processGO:00512411420.067
regulation of neurogenesisGO:00507671580.067
cellular protein modification processGO:00064644380.066
synapse organizationGO:00508081960.066
post embryonic appendage morphogenesisGO:00351203850.065
negative regulation of signalingGO:00230572190.065
columnar cuboidal epithelial cell developmentGO:00020662490.064
apoptotic processGO:00069151590.064
Human
lateral inhibitionGO:00463312060.064
positive regulation of signalingGO:00230562430.064
regulation of catalytic activityGO:00507901850.062
negative regulation of signal transductionGO:00099682060.061
negative regulation of apoptotic processGO:0043066630.060
columnar cuboidal epithelial cell differentiationGO:00020652560.059
wing disc morphogenesisGO:00074723440.059
organonitrogen compound metabolic processGO:19015643180.057
positive regulation of cellular amino acid metabolic processGO:004576400.057
regulation of notch signaling pathwayGO:00085931000.057
establishment of planar polarityGO:0001736870.056
negative regulation of programmed cell deathGO:0043069720.056
modification dependent macromolecule catabolic processGO:0043632790.056
epithelial cell developmentGO:00020642740.056
behavioral response to ethanolGO:0048149490.054
single organism behaviorGO:00447083910.052
regulation of mitotic cell cycleGO:00073461900.052
tissue morphogenesisGO:00487292970.051
developmental growthGO:00485892800.051
regulation of cell deathGO:00109411730.050
regulation of protein metabolic processGO:00512462560.050
regulation of response to stressGO:00801342000.050
neurological system processGO:00508773580.049
mitotic nuclear divisionGO:00070672130.048
protein ubiquitinationGO:0016567700.048
compound eye photoreceptor developmentGO:0042051780.048
regulation of cell differentiationGO:00455953020.046
imaginal disc derived wing morphogenesisGO:00074763370.045
transcription from rna polymerase ii promoterGO:00063663680.044
tube developmentGO:00352952440.044
proteolysisGO:00065081920.043
cell cell signaling involved in cell fate commitmentGO:00451682100.043
regulation of cellular amino acid metabolic processGO:000652100.042
imaginal disc derived appendage morphogenesisGO:00351143950.041
cellular protein catabolic processGO:0044257830.040
negative regulation of cellular component organizationGO:00511291080.039
negative regulation of cell deathGO:0060548810.039
negative regulation of cell differentiationGO:00455961430.039
central nervous system developmentGO:00074172010.039
Mouse
brain developmentGO:00074201200.038
regulation of intracellular signal transductionGO:19025312360.038
positive regulation of catalytic activityGO:00430851180.038
positive regulation of signal transductionGO:00099672230.037
negative regulation of developmental growthGO:0048640640.037
regulation of localizationGO:00328792750.037
ubiquitin dependent protein catabolic processGO:0006511780.037
defense responseGO:00069523000.036
cell motilityGO:00488702510.036
regulation of phosphate metabolic processGO:00192202100.036
mapk cascadeGO:00001651070.035
protein modification processGO:00362114380.035
purine containing compound metabolic processGO:00725211550.035
axon developmentGO:00615642970.035
negative regulation of nervous system developmentGO:0051961920.035
negative regulation of gene expressionGO:00106293870.034
cytoplasmic transportGO:00164821300.033
cell adhesionGO:00071551360.033
olfactory behaviorGO:0042048970.033
negative regulation of nitrogen compound metabolic processGO:00511722650.033
epithelium migrationGO:00901321480.033
localization of cellGO:00516742570.033
imaginal disc pattern formationGO:0007447910.032
vesicle mediated transportGO:00161923810.032
negative regulation of neurogenesisGO:0050768530.032
telencephalon developmentGO:002153720.032
appendage morphogenesisGO:00351073970.032
regulation of cellular ketone metabolic processGO:001056530.032
establishment or maintenance of cell polarityGO:00071631670.031
cell fate determinationGO:0001709910.031
regulation of molecular functionGO:00650092170.031
regionalizationGO:00030024160.031
rna processingGO:00063961470.030
single organism intracellular transportGO:19025822070.030
cellular macromolecule catabolic processGO:00442651360.030
innate immune responseGO:00450871440.030
modification dependent protein catabolic processGO:0019941780.030
establishment of localization in cellGO:00516494020.030
regulation of epithelial cell proliferationGO:005067840.030
posttranscriptional regulation of gene expressionGO:00106081450.029
biological adhesionGO:00226101380.029
eggshell formationGO:00307031050.029
regulation of cell developmentGO:00602842150.029
eye photoreceptor cell developmentGO:0042462810.029
chemotaxisGO:00069352490.029
regulation of cellular component sizeGO:0032535980.029
proteolysis involved in cellular protein catabolic processGO:0051603830.029
positive regulation of molecular functionGO:00440931360.028
positive regulation of cell deathGO:0010942690.028
endocytosisGO:00068973100.028
regulation of growthGO:00400082330.028
peptidyl amino acid modificationGO:00181931050.027
positive regulation of cell communicationGO:00106472500.027
regulation of glial cell differentiationGO:004568510.027
calcium ion transportGO:0006816240.027
establishment of tissue polarityGO:0007164870.026
nucleotide metabolic processGO:00091171610.026
sensory perceptionGO:00076001960.026
axonogenesisGO:00074092900.026
eye photoreceptor cell differentiationGO:00017541450.026
photoreceptor cell developmentGO:0042461960.026
ras protein signal transductionGO:0007265880.025
catabolic processGO:00090564090.025
morphogenesis of a polarized epitheliumGO:0001738930.025
cellular component assembly involved in morphogenesisGO:00109271510.025
actin cytoskeleton organizationGO:00300362060.025
carbohydrate derivative metabolic processGO:19011352170.025
protein localizationGO:00081042840.025
positive regulation of cellular amine metabolic processGO:003324000.025
positive regulation of nucleic acid templated transcriptionGO:19035082660.024
multicellular organism growthGO:0035264460.024
regulation of transportGO:00510491810.024
cellular amino acid metabolic processGO:0006520610.023
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.023
cellular macromolecule localizationGO:00707272200.023
chemosensory behaviorGO:00076351060.023
regulation of phosphorus metabolic processGO:00511742100.023
hindgut morphogenesisGO:0007442580.023
ion transportGO:00068111450.023
positive regulation of protein metabolic processGO:00512471280.023
nephron developmentGO:007200630.022
positive regulation of phosphate metabolic processGO:00459371390.022
cell cell adhesion via plasma membrane adhesion moleculesGO:0098742260.022
regulation of cell cycle processGO:00105641810.022
organic acid metabolic processGO:00060821030.022
chorion containing eggshell formationGO:00073041050.022
respiratory system developmentGO:00605412130.022
cognitionGO:00508901410.022
imaginal disc derived wing vein morphogenesisGO:0008586440.021
camera type eye developmentGO:004301040.021
actin filament based processGO:00300292200.021
imaginal disc derived wing vein specificationGO:0007474480.021
regulation of developmental growthGO:00486381740.021
cell migrationGO:00164772380.020
larval developmentGO:00021641040.020
regulation of cellular amine metabolic processGO:003323830.020
negative regulation of insulin secretionGO:004667610.020
cellular response to dna damage stimulusGO:00069742230.020
digestive tract morphogenesisGO:00485461270.020
gene silencing by rnaGO:0031047570.020
segmentationGO:00352822070.020
macromolecular complex assemblyGO:00650032560.020
mitotic sister chromatid segregationGO:0000070870.020
regulation of cellular catabolic processGO:00313291570.019
somatic muscle developmentGO:0007525660.019
digestive tract developmentGO:00485651490.019
single organism cellular localizationGO:19025801800.019
regulation of immune system processGO:00026821760.019
signal transduction by phosphorylationGO:00230141070.019
cell cell adhesionGO:0098609260.019
regulation of cell divisionGO:0051302720.019
gene silencingGO:00164581380.018
proteasomal protein catabolic processGO:0010498590.018
small molecule metabolic processGO:00442813050.018
divalent inorganic cation transportGO:0072511300.018
wing disc pattern formationGO:0035222660.018
phagocytosisGO:00069092150.018
organic substance transportGO:00717022570.018
regulation of neuron differentiationGO:00456641030.018
regulation of protein transportGO:0051223570.018
positive regulation of cellular protein metabolic processGO:00322701180.018
organonitrogen compound biosynthetic processGO:19015661170.018
regulation of purine nucleotide metabolic processGO:1900542620.017
deathGO:00162652840.017
Human
secretionGO:00469031090.017
head developmentGO:00603221350.017
immune system developmentGO:0002520570.017
negative regulation of nucleobase containing compound metabolic processGO:00459342610.017
regulation of stem cell proliferationGO:0072091400.017
anatomical structure homeostasisGO:0060249970.017
response to other organismGO:00517072930.017
regulation of protein modification processGO:00313991120.017
negative regulation of rna metabolic processGO:00512532510.017
regulation of hydrolase activityGO:0051336970.016
intracellular transportGO:00469072280.016
nucleobase containing small molecule metabolic processGO:00550861740.016
positive regulation of cellular biosynthetic processGO:00313283160.016
response to external biotic stimulusGO:00432072930.016
sex differentiationGO:0007548810.016
regulation of cell cycleGO:00517262910.016
protein transportGO:00150311550.016
smoothened signaling pathwayGO:0007224490.016
negative regulation of rna biosynthetic processGO:19026792400.016
purine nucleotide metabolic processGO:00061631460.016
phosphorylationGO:00163102940.016
chromosome segregationGO:00070591570.016
negative regulation of cellular metabolic processGO:00313243820.016
purine ribonucleotide metabolic processGO:00091501450.016
positive regulation of rna metabolic processGO:00512542710.016
digestive system developmentGO:00551231490.016
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.016
morphogenesis of an epitheliumGO:00020092760.015
homeostatic processGO:00425921990.015
regulation of cellular protein metabolic processGO:00322682430.015
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.015
protein complex assemblyGO:00064612000.015
eggshell chorion assemblyGO:0007306660.015
macromolecule catabolic processGO:00090571610.015
cell fate specificationGO:0001708710.015
positive regulation of hydrolase activityGO:0051345780.015
regulation of meiosisGO:004002030.015
positive regulation of transportGO:0051050920.015
regulation of protein catabolic processGO:0042176550.015
positive regulation of nitrogen compound metabolic processGO:00511733540.015
response to oxygen containing compoundGO:19017002000.015
ribonucleotide metabolic processGO:00092591450.015
embryonic pattern specificationGO:00098801740.015
regulation of anatomical structure sizeGO:00900661630.015
blastoderm segmentationGO:00073501590.015
developmental maturationGO:00217001720.015
mitotic spindle organizationGO:00070522200.014
nucleocytoplasmic transportGO:0006913720.014
single organism nuclear importGO:1902593510.014
regulation of multicellular organism growthGO:0040014400.014
neuron projection guidanceGO:00974852410.014
erbb signaling pathwayGO:0038127580.014
nitrogen compound transportGO:0071705850.014
olfactory learningGO:0008355560.014
response to organic substanceGO:00100332840.014
positive regulation of nucleobase containing compound metabolic processGO:00459353320.014
defense response to gram negative bacteriumGO:0050829940.014
genital disc developmentGO:0035215440.014
mesenchymal cell differentiationGO:004876210.014
positive regulation of catabolic processGO:00098961050.014
oxoacid metabolic processGO:00434361030.014
glycosyl compound catabolic processGO:19016581120.013
protein catabolic processGO:00301631010.013
organic substance catabolic processGO:19015753080.013
negative regulation of nucleic acid templated transcriptionGO:19035072400.013
negative regulation of cellular protein metabolic processGO:0032269850.013
cellular protein localizationGO:00346131600.013
stem cell divisionGO:0017145690.013
establishment of ommatidial planar polarityGO:0042067490.013
regulation of cellular component biogenesisGO:00440872010.013
negative regulation of organelle organizationGO:0010639560.013
response to endogenous stimulusGO:00097191190.013
regulation of protein localizationGO:0032880760.013
gliogenesisGO:0042063800.013
regulation of phosphorylationGO:00423251470.013
neuron fate commitmentGO:0048663500.013
kidney developmentGO:000182230.012
positive regulation of macromolecule metabolic processGO:00106044050.012
striated muscle cell differentiationGO:0051146900.012
chaeta developmentGO:0022416970.012
embryo development ending in birth or egg hatchingGO:00097921520.012
Mouse
organ growthGO:0035265560.012
positive regulation of phosphorylationGO:0042327870.012
regulation of establishment of protein localizationGO:0070201610.012
positive regulation of cell cycleGO:0045787430.012
skeletal muscle fiber developmentGO:004874130.012
regulation of embryonic developmentGO:0045995680.012
negative regulation of cell cycle processGO:00109481090.012
developmental programmed cell deathGO:00106231380.012
neuromuscular junction developmentGO:00075281490.012
compound eye photoreceptor cell differentiationGO:00017511400.012
regulation of defense responseGO:00313471020.012
positive regulation of purine nucleotide metabolic processGO:1900544550.012
hematopoietic or lymphoid organ developmentGO:0048534570.012
regulation of response to external stimulusGO:00321011150.012
protein import into nucleusGO:0006606510.012
single organism catabolic processGO:00447122280.012
wnt signaling pathwayGO:0016055980.012
adult behaviorGO:00305341370.011
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.011
reproductive behaviorGO:00190981220.011
regulation of cell shapeGO:00083601130.011
negative regulation of protein metabolic processGO:0051248850.011
muscle tissue developmentGO:0060537300.011
cellular response to external stimulusGO:0071496660.011
regulation of innate immune responseGO:0045088710.011
regulation of catabolic processGO:00098941700.011
multicellular organismal homeostasisGO:0048871410.011
muscle organ developmentGO:00075171270.011
actin filament organizationGO:00070151260.011
hippo signalingGO:0035329200.011
protein complex biogenesisGO:00702712010.011
cell maturationGO:00484691440.011
synaptic target recognitionGO:0008039450.011
multi multicellular organism processGO:00447061230.011
spermatogenesisGO:00072832000.011
mesenchymal cell developmentGO:001403110.011
locomotory behaviorGO:00076261760.011
purine nucleoside metabolic processGO:00422781270.011
cellular catabolic processGO:00442483720.011
actomyosin structure organizationGO:0031032560.011
regulation of cell morphogenesisGO:00226041630.011
response to starvationGO:0042594970.011
regulation of cell growthGO:0001558430.011
amine metabolic processGO:0009308120.011
extrinsic apoptotic signaling pathwayGO:009719110.011
regulation of purine nucleotide catabolic processGO:0033121480.011
single organism biosynthetic processGO:00447112060.011
response to woundingGO:0009611940.011
ncrna metabolic processGO:0034660430.011
regulation of nuclear divisionGO:0051783580.010
regulation of protein modification by small protein conjugation or removalGO:1903320250.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092380.010
stem cell fate commitmentGO:0048865250.010
ameboidal type cell migrationGO:00016671510.010
response to nutrient levelsGO:00316671140.010
establishment of protein localization to organelleGO:0072594620.010
epidermal growth factor receptor signaling pathwayGO:0007173580.010
cation transportGO:00068121100.010
negative regulation of phosphorus metabolic processGO:0010563450.010
inter male aggressive behaviorGO:0002121600.010
response to abiotic stimulusGO:00096283410.010
Mouse
cell divisionGO:00513012480.010
positive regulation of immune responseGO:0050778630.010
positive regulation of mapk cascadeGO:0043410630.010
positive regulation of phosphorus metabolic processGO:00105621390.010
regulation of small gtpase mediated signal transductionGO:0051056930.010
protein processingGO:0016485680.010
positive regulation of multicellular organismal processGO:00512401430.010
protein maturationGO:0051604710.010
retina homeostasisGO:0001895130.010
regulation of secretionGO:0051046440.010

ASPP disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.056
disease of cellular proliferationDOID:1456600.043
organ system cancerDOID:005068600.030
cancerDOID:16200.030
nervous system diseaseDOID:86300.013
cardiovascular system diseaseDOID:128700.011