IMP: Integrative Multi-species Prediction

Drosophila melanogaster

50 known processes

ras (Dmel_CG1799)

raspberry

(Aliases: l(1)G0351,l(1)G0098,LD06825,l(1)9Eb,raspberry/impd,l(1)G0391,l(1)G0056,l(1)G0482,CG1799,EP(X)1093,CG11485,LD02673,l(1)G0238,IMPDH,l(1)G0127,l(1)G0002,ras-l,l(1)G0436,Dmel\CG1799,l(1)G0388,l(1)G0380,IMPdH)

FLYBASE: FBgn0003204
Entrez: 43873
UniProtKB: Q07152
UniProtKB: A4V488

Process Predictions
Disease Predictions

ras biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
axonogenesis	GO:0007409	290	0.820
cell projection assembly	GO:0030031	94	0.705
establishment of localization in cell	GO:0051649	402	0.675
mitotic nuclear division	GO:0007067	213	0.651
multicellular organismal reproductive behavior	GO:0033057	110	0.579
embryo development ending in birth or egg hatching	GO:0009792	152	0.392
vesicle mediated transport	GO:0016192	381	0.345
reproductive behavior	GO:0019098	122	0.323
single organism intracellular transport	GO:1902582	207	0.316
organelle fission	GO:0048285	340	0.301
axis specification	GO:0009798	167	0.278
regulation of multicellular organismal development	GO:2000026	414	0.265
rna splicing	GO:0008380	83	0.261
taxis	GO:0042330	304	0.255
axon development	GO:0061564	297	0.244
stem cell differentiation	GO:0048863	117	0.232
regulation of localization	GO:0032879	275	0.215
nucleoside triphosphate catabolic process	GO:0009143	108	0.214
cell division	GO:0051301	248	0.207
chemosensory behavior	GO:0007635	106	0.206
nucleobase containing small molecule metabolic process	GO:0055086	174	0.204	Mouse
protein complex assembly	GO:0006461	200	0.196
regulation of cell proliferation	GO:0042127	163	0.193
regulation of cellular protein metabolic process	GO:0032268	243	0.192
chromatin modification	GO:0016568	147	0.190
immune response activating signal transduction	GO:0002757	2	0.181
larval development	GO:0002164	104	0.167
organic substance transport	GO:0071702	257	0.163
rna processing	GO:0006396	147	0.157
regulation of protein metabolic process	GO:0051246	256	0.154
cell death	GO:0008219	279	0.147
lipid localization	GO:0010876	54	0.143
innate immune response	GO:0045087	144	0.138
cellular macromolecule catabolic process	GO:0044265	136	0.134
mrna splicing via spliceosome	GO:0000398	73	0.130
cell growth	GO:0016049	108	0.129
protein complex biogenesis	GO:0070271	201	0.129
cortical cytoskeleton organization	GO:0030865	29	0.127
oocyte axis specification	GO:0007309	108	0.127
anterior posterior pattern specification	GO:0009952	136	0.126
positive regulation of developmental process	GO:0051094	143	0.124
regulation of anatomical structure size	GO:0090066	163	0.124
regulation of cell cycle	GO:0051726	291	0.123
multi organism reproductive behavior	GO:0044705	121	0.122
proteasomal protein catabolic process	GO:0010498	59	0.118
positive regulation of protein metabolic process	GO:0051247	128	0.117
positive regulation of response to stimulus	GO:0048584	323	0.111
protein transport	GO:0015031	155	0.111
pigment metabolic process	GO:0042440	84	0.110
endocytosis	GO:0006897	310	0.110
development of primary sexual characteristics	GO:0045137	50	0.110
carbohydrate derivative metabolic process	GO:1901135	217	0.108
purine containing compound metabolic process	GO:0072521	155	0.106	Mouse
cytoplasmic transport	GO:0016482	130	0.106
reproductive system development	GO:0061458	74	0.101
positive regulation of biosynthetic process	GO:0009891	316	0.097
positive regulation of multicellular organism growth	GO:0040018	21	0.095
regulation of mrna metabolic process	GO:1903311	72	0.094
multi multicellular organism process	GO:0044706	123	0.092
growth	GO:0040007	359	0.092
death	GO:0016265	284	0.092
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.091
cellular protein modification process	GO:0006464	438	0.090
regulation of multicellular organism growth	GO:0040014	40	0.090
defense response	GO:0006952	300	0.089
activation of innate immune response	GO:0002218	4	0.086
oocyte development	GO:0048599	124	0.086
nucleobase containing compound catabolic process	GO:0034655	165	0.085
compound eye pigmentation	GO:0048072	17	0.085
regulation of cell differentiation	GO:0045595	302	0.084
chromatin organization	GO:0006325	207	0.083
regulation of cellular component size	GO:0032535	98	0.080
axon guidance	GO:0007411	233	0.079
programmed cell death	GO:0012501	257	0.077
regulation of proteasomal protein catabolic process	GO:0061136	39	0.076
mrna processing	GO:0006397	104	0.076
modification dependent macromolecule catabolic process	GO:0043632	79	0.075
positive regulation of developmental growth	GO:0048639	62	0.075
regulation of cell projection organization	GO:0031344	92	0.074
salivary gland development	GO:0007431	162	0.074
organic substance catabolic process	GO:1901575	308	0.074
intracellular transport	GO:0046907	228	0.073
positive regulation of cellular protein metabolic process	GO:0032270	118	0.070
appendage development	GO:0048736	401	0.070
sex differentiation	GO:0007548	81	0.066
ribonucleoside metabolic process	GO:0009119	127	0.065
regulation of phosphorus metabolic process	GO:0051174	210	0.065
regulation of mitotic cell cycle	GO:0007346	190	0.064
small molecule metabolic process	GO:0044281	305	0.064	Mouse
hematopoietic progenitor cell differentiation	GO:0002244	1	0.062
phosphorylation	GO:0016310	294	0.061
carbohydrate derivative catabolic process	GO:1901136	118	0.060
macromolecule catabolic process	GO:0009057	161	0.059
regulation of developmental growth	GO:0048638	174	0.057
positive regulation of transcription dna templated	GO:0045893	266	0.057
positive regulation of immune response	GO:0050778	63	0.056
cell proliferation	GO:0008283	299	0.056	Mouse
ribose phosphate metabolic process	GO:0019693	145	0.055
regulation of execution phase of apoptosis	GO:1900117	5	0.055
organic acid transport	GO:0015849	18	0.054
developmental growth	GO:0048589	280	0.053
protein modification process	GO:0036211	438	0.052
positive regulation of proteolysis	GO:0045862	52	0.052
determination of adult lifespan	GO:0008340	137	0.051
cognition	GO:0050890	141	0.051
heterochromatin organization	GO:0070828	25	0.051
positive regulation of molecular function	GO:0044093	136	0.050
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.050
chemotaxis	GO:0006935	249	0.049
response to external biotic stimulus	GO:0043207	293	0.049
purine ribonucleoside metabolic process	GO:0046128	127	0.047
wing disc morphogenesis	GO:0007472	344	0.047
ubiquitin dependent protein catabolic process	GO:0006511	78	0.046
regulation of immune response	GO:0050776	118	0.045
body morphogenesis	GO:0010171	2	0.045
purine nucleoside catabolic process	GO:0006152	112	0.045
positive regulation of macromolecule metabolic process	GO:0010604	405	0.043
oocyte construction	GO:0007308	112	0.043
regulation of protein localization	GO:0032880	76	0.043
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.043
ion transport	GO:0006811	145	0.042
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.042
stress activated mapk cascade	GO:0051403	52	0.041
gonad development	GO:0008406	50	0.040
nitrogen compound transport	GO:0071705	85	0.040
positive regulation of cellular component organization	GO:0051130	156	0.040
phagocytosis	GO:0006909	215	0.040
regulation of molecular function	GO:0065009	217	0.040
cellular macromolecule localization	GO:0070727	220	0.040
carboxylic acid transport	GO:0046942	18	0.040
regulation of defense response	GO:0031347	102	0.039
nucleoside phosphate metabolic process	GO:0006753	162	0.039	Mouse
regulation of phosphorylation	GO:0042325	147	0.038
macromolecular complex assembly	GO:0065003	256	0.037
positive regulation of cellular biosynthetic process	GO:0031328	316	0.037
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.036
innate immune response activating signal transduction	GO:0002758	2	0.036
positive regulation of multicellular organismal process	GO:0051240	143	0.035
catabolic process	GO:0009056	409	0.035
regulation of anatomical structure morphogenesis	GO:0022603	242	0.035
nucleoside metabolic process	GO:0009116	127	0.034
regulation of axonogenesis	GO:0050770	32	0.034
apoptotic process	GO:0006915	159	0.033
purine ribonucleotide metabolic process	GO:0009150	145	0.033
multicellular organismal aging	GO:0010259	140	0.033
tripartite regional subdivision	GO:0007351	103	0.033
immune response regulating signaling pathway	GO:0002764	2	0.032
regulation of innate immune response	GO:0045088	71	0.032
organic cyclic compound catabolic process	GO:1901361	168	0.032
glycosyl compound catabolic process	GO:1901658	112	0.032
immune effector process	GO:0002252	98	0.032
heterocycle catabolic process	GO:0046700	166	0.032
regulation of transport	GO:0051049	181	0.032
regulation of organelle organization	GO:0033043	196	0.031
embryonic pattern specification	GO:0009880	174	0.031
single organism biosynthetic process	GO:0044711	206	0.031	Mouse
organophosphate biosynthetic process	GO:0090407	46	0.031	Mouse
organophosphate metabolic process	GO:0019637	195	0.030	Mouse
regulation of cellular component movement	GO:0051270	42	0.030
nucleoside phosphate biosynthetic process	GO:1901293	34	0.030	Mouse
positive regulation of cell migration	GO:0030335	2	0.029
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.029
aromatic compound catabolic process	GO:0019439	166	0.028
aging	GO:0007568	143	0.028
nuclear division	GO:0000280	332	0.028
protein catabolic process	GO:0030163	101	0.028
regulation of immune system process	GO:0002682	176	0.027
embryonic axis specification	GO:0000578	107	0.026
cellular protein catabolic process	GO:0044257	83	0.026
transmembrane transport	GO:0055085	139	0.026
immune response	GO:0006955	246	0.026
cell motility	GO:0048870	251	0.026
single organism cellular localization	GO:1902580	180	0.026
dendrite morphogenesis	GO:0048813	199	0.025
cellular response to sterol depletion	GO:0071501	3	0.025
regulation of vesicle mediated transport	GO:0060627	59	0.025
molting cycle chitin based cuticle	GO:0007591	56	0.025
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.025
stem cell maintenance	GO:0019827	67	0.024
germ line stem cell maintenance	GO:0030718	50	0.024
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.024
purine containing compound catabolic process	GO:0072523	112	0.024
blastoderm segmentation	GO:0007350	159	0.023
lipid storage	GO:0019915	38	0.023
regulation of oocyte development	GO:0060281	27	0.023
establishment of protein localization	GO:0045184	163	0.023
alternative mrna splicing via spliceosome	GO:0000380	60	0.022
germ line cyst formation	GO:0048134	44	0.022
spermatid development	GO:0007286	98	0.022
regulation of intracellular signal transduction	GO:1902531	236	0.022
multi organism behavior	GO:0051705	175	0.021
regulation of insulin receptor signaling pathway	GO:0046626	17	0.021
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.021
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.021
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.021
positive regulation of growth	GO:0045927	75	0.021
negative regulation of cellular protein metabolic process	GO:0032269	85	0.020
pattern recognition receptor signaling pathway	GO:0002221	2	0.020
male courtship behavior	GO:0008049	63	0.020
membrane organization	GO:0061024	112	0.020
organic anion transport	GO:0015711	28	0.020
dendrite development	GO:0016358	204	0.020
anterior posterior axis specification embryo	GO:0008595	103	0.020
covalent chromatin modification	GO:0016569	106	0.020
molting cycle	GO:0042303	56	0.020
cellular response to organic substance	GO:0071310	132	0.020	Mouse
regulation of mrna processing	GO:0050684	71	0.020
regulation of response to stress	GO:0080134	200	0.020
purine nucleoside metabolic process	GO:0042278	127	0.019
ribonucleoprotein complex biogenesis	GO:0022613	31	0.019
oocyte differentiation	GO:0009994	145	0.019
regulation of notch signaling pathway	GO:0008593	100	0.019
sister chromatid segregation	GO:0000819	92	0.019
acid secretion	GO:0046717	1	0.019
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.019
photoreceptor cell fate commitment	GO:0046552	41	0.019
germarium derived egg chamber formation	GO:0007293	101	0.019
nucleoside triphosphate metabolic process	GO:0009141	120	0.019
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.019
imaginal disc derived appendage development	GO:0048737	399	0.019
courtship behavior	GO:0007619	68	0.018
receptor mediated endocytosis	GO:0006898	21	0.018
ameboidal type cell migration	GO:0001667	151	0.018
cellular homeostasis	GO:0019725	80	0.018
imaginal disc derived wing morphogenesis	GO:0007476	337	0.018
germarium derived female germ line cyst formation	GO:0030727	42	0.018
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.018
cellular response to chemical stimulus	GO:0070887	199	0.018	Mouse
regulation of chitin based cuticle tanning	GO:0007564	14	0.018
positive regulation of translation	GO:0045727	12	0.018
female germ line cyst formation	GO:0048135	42	0.017
cytokinesis	GO:0000910	90	0.017
spermatogenesis	GO:0007283	200	0.017
nucleobase containing compound transport	GO:0015931	56	0.017
response to oxygen containing compound	GO:1901700	200	0.017
response to abiotic stimulus	GO:0009628	341	0.016
regulation of cell motility	GO:2000145	23	0.016
negative regulation of cellular metabolic process	GO:0031324	382	0.016
mitotic spindle organization	GO:0007052	220	0.016
intracellular mrna localization	GO:0008298	66	0.016
purine ribonucleotide catabolic process	GO:0009154	109	0.016
nuclear transport	GO:0051169	72	0.016
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.016
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.016
negative regulation of nucleotide catabolic process	GO:0030812	1	0.015
actin cytoskeleton organization	GO:0030036	206	0.015
positive regulation of cell motility	GO:2000147	3	0.015
modification dependent protein catabolic process	GO:0019941	78	0.015
regulation of apoptotic process	GO:0042981	130	0.015
nucleotide metabolic process	GO:0009117	161	0.015	Mouse
regulation of cellular ketone metabolic process	GO:0010565	3	0.015
exocrine system development	GO:0035272	162	0.015
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.015
photoreceptor cell differentiation	GO:0046530	170	0.015
response to biotic stimulus	GO:0009607	294	0.015
negative regulation of signal transduction	GO:0009968	206	0.015
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.015
organonitrogen compound metabolic process	GO:1901564	318	0.015	Mouse
positive regulation of gene expression	GO:0010628	290	0.015
regulation of response to external stimulus	GO:0032101	115	0.014
positive regulation of catalytic activity	GO:0043085	118	0.014
regulation of phosphate metabolic process	GO:0019220	210	0.014
intracellular signal transduction	GO:0035556	300	0.014
gene silencing	GO:0016458	138	0.014
rna localization	GO:0006403	115	0.014
regulation of locomotion	GO:0040012	42	0.014
male meiosis cytokinesis	GO:0007112	26	0.014
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.014
protein localization	GO:0008104	284	0.014
immune system development	GO:0002520	57	0.014
compound eye development	GO:0048749	307	0.014
pole plasm rna localization	GO:0007316	52	0.014
mating behavior	GO:0007617	106	0.013
regulation of cell cycle process	GO:0010564	181	0.013
regulation of growth	GO:0040008	233	0.013
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.013
spindle organization	GO:0007051	253	0.013
genitalia development	GO:0048806	26	0.013
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.013
gliogenesis	GO:0042063	80	0.013
ion transmembrane transport	GO:0034220	122	0.013
lipid biosynthetic process	GO:0008610	46	0.013
cytoplasm organization	GO:0007028	64	0.012
neuron projection extension	GO:1990138	32	0.012
proteolysis	GO:0006508	192	0.012
border follicle cell migration	GO:0007298	113	0.012
lateral inhibition	GO:0046331	206	0.012
reproductive structure development	GO:0048608	74	0.012
multicellular organism growth	GO:0035264	46	0.012
rhabdomere development	GO:0042052	38	0.012
positive regulation of catabolic process	GO:0009896	105	0.012
negative regulation of multicellular organismal process	GO:0051241	142	0.012
maintenance of location	GO:0051235	73	0.011
activation of immune response	GO:0002253	5	0.011
positive regulation of protein modification process	GO:0031401	58	0.011
establishment or maintenance of cell polarity	GO:0007163	167	0.011
regulation of actin filament based process	GO:0032970	42	0.011
meiotic cytokinesis	GO:0033206	33	0.011
cell recognition	GO:0008037	102	0.011
male mating behavior	GO:0060179	70	0.011
regulation of cell growth	GO:0001558	43	0.011
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.011
embryonic hemopoiesis	GO:0035162	26	0.011
positive regulation of axon extension	GO:0045773	2	0.011
oocyte anterior posterior axis specification	GO:0007314	72	0.011
regulation of cell morphogenesis	GO:0022604	163	0.011
protein modification by small protein conjugation or removal	GO:0070647	106	0.011
ribonucleoprotein complex subunit organization	GO:0071826	28	0.010
response to radiation	GO:0009314	155	0.010
nucleic acid transport	GO:0050657	46	0.010
actin filament organization	GO:0007015	126	0.010

ras disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.019
disease of anatomical entity	DOID:7	0.019
disease of cellular proliferation	DOID:14566	0.011

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