IMP: Integrative Multi-species Prediction

Drosophila melanogaster

30 known processes

CG5899 (Dmel_CG5899)

CG5899 gene product from transcript CG5899-RA

(Aliases: Dmel\CG5899,Etl1)

FLYBASE: FBgn0032157
Entrez: 34311
UniProtKB: Q9VL72

Process Predictions
Disease Predictions

CG5899 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
chromatin organization	GO:0006325	207	0.742	Yeast
negative regulation of cellular metabolic process	GO:0031324	382	0.618	Yeast
negative regulation of rna biosynthetic process	GO:1902679	240	0.576	Yeast
negative regulation of biosynthetic process	GO:0009890	277	0.569	Yeast
negative regulation of gene expression epigenetic	GO:0045814	77	0.295	Yeast
negative regulation of gene expression	GO:0010629	387	0.287	Yeast
chromatin assembly or disassembly	GO:0006333	52	0.274	Yeast
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.250
chromatin silencing	GO:0006342	76	0.234	Yeast
negative regulation of cellular biosynthetic process	GO:0031327	277	0.226	Yeast
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.199	Yeast
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.175	Yeast
chromosome organization	GO:0051276	360	0.167	Yeast
negative regulation of transcription dna templated	GO:0045892	237	0.166	Yeast
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.160	Yeast
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.153	Yeast
regulation of gene expression epigenetic	GO:0040029	128	0.142	Yeast
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.128	Yeast
heterochromatin organization	GO:0070828	25	0.108	Yeast
positive regulation of gene expression	GO:0010628	290	0.105
cellular catabolic process	GO:0044248	372	0.104	Yeast
dna metabolic process	GO:0006259	227	0.099	Yeast
chromatin modification	GO:0016568	147	0.097	Yeast
positive regulation of rna metabolic process	GO:0051254	271	0.090
negative regulation of rna metabolic process	GO:0051253	251	0.090	Yeast
regulation of cell differentiation	GO:0045595	302	0.090
regulation of cell cycle process	GO:0010564	181	0.087
regulation of protein metabolic process	GO:0051246	256	0.076
cellular macromolecular complex assembly	GO:0034622	153	0.064
single organism catabolic process	GO:0044712	228	0.056	Yeast
rna processing	GO:0006396	147	0.056
nucleoside phosphate metabolic process	GO:0006753	162	0.054	Yeast
negative regulation of developmental process	GO:0051093	201	0.053
atp dependent chromatin remodeling	GO:0043044	22	0.051	Yeast
dna conformation change	GO:0071103	105	0.051	Yeast
regulation of cellular protein metabolic process	GO:0032268	243	0.051
programmed cell death	GO:0012501	257	0.050
positive regulation of macromolecule metabolic process	GO:0010604	405	0.050
gene silencing	GO:0016458	138	0.049	Yeast
positive regulation of rna biosynthetic process	GO:1902680	266	0.045
immune system development	GO:0002520	57	0.045
positive regulation of biosynthetic process	GO:0009891	316	0.039
organonitrogen compound metabolic process	GO:1901564	318	0.038	Yeast
organonitrogen compound catabolic process	GO:1901565	128	0.037	Yeast
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.036
cellular macromolecule localization	GO:0070727	220	0.036
single organism cellular localization	GO:1902580	180	0.034
positive regulation of endopeptidase activity	GO:0010950	26	0.033
hematopoietic or lymphoid organ development	GO:0048534	57	0.032
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.031
regulation of cell proliferation	GO:0042127	163	0.031
regulation of cell cycle	GO:0051726	291	0.031
connective tissue development	GO:0061448	3	0.029
stem cell maintenance	GO:0019827	67	0.029
transcription from rna polymerase ii promoter	GO:0006366	368	0.028
regulation of translation	GO:0006417	56	0.028
regulation of peptidase activity	GO:0052547	39	0.028
catabolic process	GO:0009056	409	0.028	Yeast
negative regulation of neurotransmitter secretion	GO:0046929	2	0.028
ovarian follicle cell cell adhesion	GO:0007299	4	0.028
positive regulation of cellular biosynthetic process	GO:0031328	316	0.028
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.026
organic substance catabolic process	GO:1901575	308	0.026	Yeast
positive regulation of transcription dna templated	GO:0045893	266	0.026
response to dsrna	GO:0043331	15	0.025
stem cell differentiation	GO:0048863	117	0.025
regulation of organelle organization	GO:0033043	196	0.025
nucleotide metabolic process	GO:0009117	161	0.025	Yeast
negative regulation of cell differentiation	GO:0045596	143	0.024
positive regulation of proteolysis	GO:0045862	52	0.024
oxoacid metabolic process	GO:0043436	103	0.023
cellular nitrogen compound catabolic process	GO:0044270	165	0.023	Yeast
ribonucleotide metabolic process	GO:0009259	145	0.023	Yeast
cell death	GO:0008219	279	0.023
glycosyl compound metabolic process	GO:1901657	127	0.023	Yeast
nuclear division	GO:0000280	332	0.023
mrna metabolic process	GO:0016071	124	0.022
purine nucleotide metabolic process	GO:0006163	146	0.021	Yeast
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.021
regulation of meiosis	GO:0040020	3	0.021
response to nitrogen compound	GO:1901698	90	0.020
nucleoside monophosphate metabolic process	GO:0009123	52	0.020	Yeast
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.020	Yeast
purine nucleoside metabolic process	GO:0042278	127	0.020	Yeast
regulation of cellular catabolic process	GO:0031329	157	0.020
regulation of endopeptidase activity	GO:0052548	36	0.020
organic acid metabolic process	GO:0006082	103	0.020
regulation of cellular ketone metabolic process	GO:0010565	3	0.020
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.020	Yeast
production of small rna involved in gene silencing by rna	GO:0070918	15	0.019
positive regulation of hydrolase activity	GO:0051345	78	0.019
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.019	Yeast
positive regulation of catalytic activity	GO:0043085	118	0.019
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.019	Yeast
small molecule metabolic process	GO:0044281	305	0.019	Yeast
protein localization	GO:0008104	284	0.019
nucleobase containing compound catabolic process	GO:0034655	165	0.019	Yeast
purine ribonucleotide catabolic process	GO:0009154	109	0.019	Yeast
regulation of multicellular organismal development	GO:2000026	414	0.018
establishment of protein localization	GO:0045184	163	0.018
cell proliferation	GO:0008283	299	0.018
mitotic dna damage checkpoint	GO:0044773	74	0.018
carbohydrate derivative metabolic process	GO:1901135	217	0.018	Yeast
regulation of response to stress	GO:0080134	200	0.017
single organism biosynthetic process	GO:0044711	206	0.017
organelle assembly	GO:0070925	198	0.017
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.017	Yeast
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.017	Yeast
apoptotic process	GO:0006915	159	0.016
regulation of apoptotic process	GO:0042981	130	0.016
protein transport	GO:0015031	155	0.016
immune system process	GO:0002376	347	0.016
cellular response to dsrna	GO:0071359	15	0.016
intracellular protein transport	GO:0006886	104	0.016
cellular amino acid metabolic process	GO:0006520	61	0.016
cellular ketone metabolic process	GO:0042180	24	0.015
nucleobase containing small molecule metabolic process	GO:0055086	174	0.015	Yeast
response to organic substance	GO:0010033	284	0.015
protein modification by small protein conjugation	GO:0032446	79	0.015
nucleocytoplasmic transport	GO:0006913	72	0.015
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.015
nucleoside triphosphate catabolic process	GO:0009143	108	0.015	Yeast
regulation of hydrolase activity	GO:0051336	97	0.015
alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor clustering	GO:0097113	2	0.015
negative regulation of multicellular organismal process	GO:0051241	142	0.015
regulation of mrna processing	GO:0050684	71	0.014
protein targeting to nucleus	GO:0044744	51	0.014
regulation of molecular function	GO:0065009	217	0.014
regulation of localization	GO:0032879	275	0.014
ribonucleoside metabolic process	GO:0009119	127	0.014	Yeast
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.014
formation of a compartment boundary	GO:0060288	4	0.014
carboxylic acid metabolic process	GO:0019752	92	0.013
histone methylation	GO:0016571	40	0.013
neurological system process	GO:0050877	358	0.013
cellular response to dna damage stimulus	GO:0006974	223	0.013	Yeast
positive regulation of programmed cell death	GO:0043068	62	0.013
positive regulation of cellular catabolic process	GO:0031331	95	0.013
amine metabolic process	GO:0009308	12	0.013
nucleoside metabolic process	GO:0009116	127	0.013	Yeast
positive regulation of cellular protein metabolic process	GO:0032270	118	0.013
axonogenesis	GO:0007409	290	0.012
protein localization to organelle	GO:0033365	82	0.012
single organism intracellular transport	GO:1902582	207	0.012
purine containing compound metabolic process	GO:0072521	155	0.012	Yeast
heterocycle catabolic process	GO:0046700	166	0.012	Yeast
nucleoside triphosphate metabolic process	GO:0009141	120	0.012	Yeast
nucleosome organization	GO:0034728	59	0.012
ribonucleotide catabolic process	GO:0009261	109	0.012	Yeast
ribose phosphate metabolic process	GO:0019693	145	0.012	Yeast
mrna processing	GO:0006397	104	0.012
multi organism behavior	GO:0051705	175	0.012
cellular amine metabolic process	GO:0044106	12	0.012
proteolysis	GO:0006508	192	0.012
protein targeting	GO:0006605	64	0.012
posttranscriptional regulation of gene expression	GO:0010608	145	0.012
purine nucleoside catabolic process	GO:0006152	112	0.011	Yeast
vesicle mediated transport	GO:0016192	381	0.011
protein ubiquitination	GO:0016567	70	0.011
atp metabolic process	GO:0046034	49	0.011	Yeast
regulation of proteolysis	GO:0030162	87	0.011
phosphatidylinositol mediated signaling	GO:0048015	4	0.011
intracellular transport	GO:0046907	228	0.011
exocrine system development	GO:0035272	162	0.011
endocytosis	GO:0006897	310	0.011
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.011
protein alkylation	GO:0008213	43	0.011
rna localization	GO:0006403	115	0.011
tube morphogenesis	GO:0035239	191	0.011
macromolecular complex assembly	GO:0065003	256	0.010	Yeast
ribonucleoprotein complex subunit organization	GO:0071826	28	0.010
cellular protein modification process	GO:0006464	438	0.010
response to oxygen containing compound	GO:1901700	200	0.010
positive regulation of apoptotic process	GO:0043065	47	0.010
negative regulation of cell cycle	GO:0045786	116	0.010
nucleoside catabolic process	GO:0009164	112	0.010	Yeast
positive regulation of intracellular transport	GO:0032388	42	0.010
regulation of growth	GO:0040008	233	0.010

CG5899 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.018
bone development disease	DOID:0080006	0.017
bone disease	DOID:0080001	0.017
disease of anatomical entity	DOID:7	0.017
musculoskeletal system disease	DOID:17	0.017
connective tissue disease	DOID:65	0.017
osteogenesis imperfecta	DOID:12347	0.017
osteochondrodysplasia	DOID:2256	0.017
nervous system disease	DOID:863	0.013
eye and adnexa disease	DOID:1492	0.013
sensory system disease	DOID:0050155	0.013
cancer	DOID:162	0.012
organ system cancer	DOID:0050686	0.012
benign neoplasm	DOID:0060072	0.011

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network