IMP: Integrative Multi-species Prediction

Drosophila melanogaster

161 known processes

D (Dmel_CG5893)

Dichaete

(Aliases: DM10,l(3)LG9,DM23,Sry-rDM36,loD,DM33,DM63,Sry-rDM10,fish,SOXDP,Sry-rDM63,DM36,Sry-rDM23,Dmel\CG5893,SOXB2.1,SOX70D,Sox70,CG5893,Sox70D,Sry-rDM33,SOX70)

Entrez: 39570
FLYBASE: FBgn0000411
UniProtKB: Q24533
UniProtKB: M9PFL2

Process Predictions
Disease Predictions

D biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
tissue morphogenesis	GO:0048729	297	0.821
epithelial cell differentiation	GO:0030855	322	0.739
regionalization	GO:0003002	416	0.703
negative regulation of cell communication	GO:0010648	223	0.663
neuroblast development	GO:0014019	13	0.647
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.590
gastrulation	GO:0007369	70	0.564
negative regulation of cellular biosynthetic process	GO:0031327	277	0.564
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.552
positive regulation of macromolecule metabolic process	GO:0010604	405	0.531
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.510
positive regulation of gene expression	GO:0010628	290	0.503
negative regulation of transcription dna templated	GO:0045892	237	0.482
negative regulation of rna biosynthetic process	GO:1902679	240	0.469
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.465
regulation of apoptotic process	GO:0042981	130	0.389	Fly
embryonic development via the syncytial blastoderm	GO:0001700	148	0.385
cell death	GO:0008219	279	0.381	Fly
regulation of cell differentiation	GO:0045595	302	0.374
phosphorylation	GO:0016310	294	0.368
leg disc development	GO:0035218	92	0.357
segmentation	GO:0035282	207	0.345
positive regulation of rna metabolic process	GO:0051254	271	0.331
digestive system development	GO:0055123	149	0.301
death	GO:0016265	284	0.295	Fly
epidermal cell differentiation	GO:0009913	51	0.288
positive regulation of biosynthetic process	GO:0009891	316	0.286
dendrite morphogenesis	GO:0048813	199	0.284
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.271
regulation of multicellular organismal development	GO:2000026	414	0.244
leg disc morphogenesis	GO:0007478	80	0.238
negative regulation of signaling	GO:0023057	219	0.238
forebrain development	GO:0030900	2	0.230
appendage morphogenesis	GO:0035107	397	0.227
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.222
imaginal disc derived leg morphogenesis	GO:0007480	80	0.209
mapk cascade	GO:0000165	107	0.200
intracellular signal transduction	GO:0035556	300	0.195
hair cell differentiation	GO:0035315	47	0.191
positive regulation of rna biosynthetic process	GO:1902680	266	0.177
chorion containing eggshell formation	GO:0007304	105	0.173
axis specification	GO:0009798	167	0.166
epidermis development	GO:0008544	65	0.161
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	13	0.160
regulation of cell death	GO:0010941	173	0.152	Fly
eye antennal disc development	GO:0035214	60	0.137
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.136
regulation of organ morphogenesis	GO:2000027	78	0.130
imaginal disc derived wing hair organization	GO:0035317	45	0.126
neuroblast differentiation	GO:0014016	29	0.123
negative regulation of rna metabolic process	GO:0051253	251	0.120
central nervous system development	GO:0007417	201	0.114
non sensory hair organization	GO:0035316	47	0.109
sensory organ morphogenesis	GO:0090596	260	0.105
anterior posterior axis specification	GO:0009948	109	0.104
regulation of localization	GO:0032879	275	0.103
response to alcohol	GO:0097305	95	0.100
regulation of cell development	GO:0060284	215	0.098
negative regulation of gene expression	GO:0010629	387	0.098
developmental growth	GO:0048589	280	0.095
actin filament based process	GO:0030029	220	0.094
negative regulation of response to stimulus	GO:0048585	258	0.094
protein modification process	GO:0036211	438	0.093
regulation of neurogenesis	GO:0050767	158	0.090
axonogenesis	GO:0007409	290	0.088
cell proliferation	GO:0008283	299	0.088	Fly
positive regulation of transcription dna templated	GO:0045893	266	0.086
skin development	GO:0043588	65	0.084
positive regulation of cellular protein metabolic process	GO:0032270	118	0.079
axon guidance	GO:0007411	233	0.075
dendrite guidance	GO:0070983	21	0.074
regulation of mitotic spindle checkpoint	GO:1903504	1	0.073
regulation of dendrite morphogenesis	GO:0048814	28	0.070
stem cell fate determination	GO:0048867	15	0.069
positive regulation of cellular biosynthetic process	GO:0031328	316	0.067
cell migration	GO:0016477	238	0.067
dendrite development	GO:0016358	204	0.066
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.063
cellular catabolic process	GO:0044248	372	0.062
kidney development	GO:0001822	3	0.059
establishment or maintenance of cell polarity	GO:0007163	167	0.058
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.057
regulation of cellular catabolic process	GO:0031329	157	0.056
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.056
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.056
response to light stimulus	GO:0009416	124	0.055
positive regulation of retinal cell programmed cell death	GO:0046670	9	0.055
limb morphogenesis	GO:0035108	1	0.055
retina morphogenesis in camera type eye	GO:0060042	2	0.055
negative regulation of signal transduction	GO:0009968	206	0.054
wing disc morphogenesis	GO:0007472	344	0.054
eye development	GO:0001654	323	0.054
programmed cell death	GO:0012501	257	0.053	Fly
negative regulation of heart induction by canonical wnt signaling pathway	GO:0003136	3	0.053
reproductive structure development	GO:0048608	74	0.051
multicellular organismal reproductive behavior	GO:0033057	110	0.050
compound eye morphogenesis	GO:0001745	249	0.050
hindbrain development	GO:0030902	2	0.050
blastoderm segmentation	GO:0007350	159	0.050
regulation of imaginal disc derived wing size	GO:0044719	20	0.049
defense response	GO:0006952	300	0.049
enteroendocrine cell differentiation	GO:0035883	1	0.048
negative regulation of cell differentiation	GO:0045596	143	0.048
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.048
organic substance catabolic process	GO:1901575	308	0.046
renal system development	GO:0072001	72	0.046
negative regulation of heart induction	GO:1901320	3	0.045
cellular response to endogenous stimulus	GO:0071495	80	0.045
establishment of tissue polarity	GO:0007164	87	0.045
regulation of establishment of protein localization	GO:0070201	61	0.045
establishment of cell polarity	GO:0030010	40	0.045
developmental maturation	GO:0021700	172	0.045	Fly
cellular response to chemical stimulus	GO:0070887	199	0.045
response to abiotic stimulus	GO:0009628	341	0.044
neuron maturation	GO:0042551	31	0.044	Fly
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.044
taxis	GO:0042330	304	0.043
protein phosphorylation	GO:0006468	169	0.042
establishment of ommatidial planar polarity	GO:0042067	49	0.041
regulation of dendrite development	GO:0050773	37	0.040
imaginal disc derived wing morphogenesis	GO:0007476	337	0.039
posttranscriptional regulation of gene expression	GO:0010608	145	0.038
regulation of phosphoprotein phosphatase activity	GO:0043666	3	0.037
jnk cascade	GO:0007254	50	0.037
protein localization	GO:0008104	284	0.037
regulation of nervous system development	GO:0051960	248	0.037
regulation of programmed cell death	GO:0043067	152	0.037	Fly
convergent extension	GO:0060026	2	0.037
negative regulation of neurogenesis	GO:0050768	53	0.037
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	24	0.036
establishment of planar polarity	GO:0001736	87	0.036
cell maturation	GO:0048469	144	0.036	Fly
oocyte development	GO:0048599	124	0.036
locomotory behavior	GO:0007626	176	0.035
digestive tract morphogenesis	GO:0048546	127	0.035
transcription from rna polymerase ii promoter	GO:0006366	368	0.035
embryo development ending in birth or egg hatching	GO:0009792	152	0.035
regulation of phosphorus metabolic process	GO:0051174	210	0.034
ubiquitin dependent protein catabolic process	GO:0006511	78	0.033
epithelial cell development	GO:0002064	274	0.032
tripartite regional subdivision	GO:0007351	103	0.032
protein catabolic process	GO:0030163	101	0.031
negative regulation of wnt signaling pathway	GO:0030178	28	0.031
cellular response to oxygen containing compound	GO:1901701	79	0.031
negative regulation of cardioblast differentiation	GO:0051892	7	0.030
regulation of mapk cascade	GO:0043408	92	0.029
cellular response to organic substance	GO:0071310	132	0.029
regulation of heart induction	GO:0090381	3	0.028
molting cycle	GO:0042303	56	0.028
eye photoreceptor cell differentiation	GO:0001754	145	0.028
protein targeting to nucleus	GO:0044744	51	0.028
regulation of cardioblast cell fate specification	GO:0042686	8	0.028
stem cell maintenance	GO:0019827	67	0.028
reproductive system development	GO:0061458	74	0.027
tube morphogenesis	GO:0035239	191	0.027
response to biotic stimulus	GO:0009607	294	0.026
equator specification	GO:0045317	4	0.025
limb development	GO:0060173	1	0.025
neural retina development	GO:0003407	4	0.025
cellular response to hormone stimulus	GO:0032870	44	0.024
regulation of cell fate commitment	GO:0010453	29	0.024
telencephalon development	GO:0021537	2	0.023
gland development	GO:0048732	191	0.023
regulation of cellular localization	GO:0060341	136	0.023
regulation of spindle checkpoint	GO:0090231	2	0.023
cellular response to organic cyclic compound	GO:0071407	32	0.022
retina development in camera type eye	GO:0060041	4	0.021
establishment of epithelial cell polarity	GO:0090162	13	0.021
protein modification by small protein conjugation or removal	GO:0070647	106	0.021
organic substance transport	GO:0071702	257	0.021
urogenital system development	GO:0001655	72	0.021
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.021
haltere disc development	GO:0035216	10	0.020
endoderm formation	GO:0001706	3	0.020
actin cytoskeleton organization	GO:0030036	206	0.020
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.020
negative regulation of nervous system development	GO:0051961	92	0.020
positive regulation of protein import into nucleus translocation	GO:0033160	2	0.019
hemocyte differentiation	GO:0042386	38	0.019
meiotic chromosome movement towards spindle pole	GO:0016344	1	0.019
spinal cord development	GO:0021510	1	0.019
regulation of phosphatase activity	GO:0010921	3	0.018
heart induction	GO:0003129	3	0.018
stress granule disassembly	GO:0035617	1	0.018
regulation of cell proliferation	GO:0042127	163	0.018	Fly
compound eye development	GO:0048749	307	0.018
second mitotic wave involved in compound eye morphogenesis	GO:0016330	7	0.018
protein import into nucleus	GO:0006606	51	0.018
compound eye photoreceptor cell differentiation	GO:0001751	140	0.018
cellular protein modification process	GO:0006464	438	0.017
negative regulation of signal transduction by p53 class mediator	GO:1901797	1	0.017
asymmetric protein localization	GO:0008105	33	0.017
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.017
anterior posterior axis specification follicular epithelium	GO:0030714	2	0.017
specification of organ identity	GO:0010092	3	0.017
lymph gland development	GO:0048542	28	0.016
response to nitrogen compound	GO:1901698	90	0.016
protein localization to nucleus	GO:0034504	55	0.016
cellular component assembly involved in morphogenesis	GO:0010927	151	0.016
cell division	GO:0051301	248	0.016
cellular macromolecule localization	GO:0070727	220	0.016
response to bacterium	GO:0009617	198	0.016
developmental growth involved in morphogenesis	GO:0060560	65	0.015
establishment of epithelial cell apical basal polarity	GO:0045198	10	0.015
anterior posterior axis specification embryo	GO:0008595	103	0.015
regulation of jnk cascade	GO:0046328	40	0.015
wound healing	GO:0042060	75	0.015
dorsal closure leading edge cell differentiation	GO:0046663	2	0.015
regulation of cellular protein metabolic process	GO:0032268	243	0.015
anatomical structure homeostasis	GO:0060249	97	0.015
intracellular transport	GO:0046907	228	0.015
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.015
embryonic morphogenesis	GO:0048598	206	0.015
regulation of intracellular transport	GO:0032386	64	0.015
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.014
response to radiation	GO:0009314	155	0.014
oocyte morphogenesis	GO:0048601	3	0.014
columnar cuboidal epithelial cell development	GO:0002066	249	0.014
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.014
response to mechanical stimulus	GO:0009612	28	0.014
chromatin remodeling at centromere	GO:0031055	3	0.014
positive regulation of translation	GO:0045727	12	0.014
meiotic nuclear envelope disassembly	GO:0051078	2	0.014
actin filament based movement	GO:0030048	26	0.014
positive regulation of protein metabolic process	GO:0051247	128	0.014
establishment of protein localization	GO:0045184	163	0.013
protein complex biogenesis	GO:0070271	201	0.013
single organism intracellular transport	GO:1902582	207	0.013
morphogenesis of a branching epithelium	GO:0061138	45	0.013
germarium derived cystoblast division	GO:0048142	3	0.013
eye morphogenesis	GO:0048592	260	0.013
regulation of homotypic cell cell adhesion	GO:0034110	2	0.013
dendrite regeneration	GO:0031104	2	0.013
proteolysis	GO:0006508	192	0.013
response to external biotic stimulus	GO:0043207	293	0.012
regulation of intracellular signal transduction	GO:1902531	236	0.012
phagocytosis	GO:0006909	215	0.012
cellular protein localization	GO:0034613	160	0.012
response to hormone	GO:0009725	45	0.012
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	2	0.012
body morphogenesis	GO:0010171	2	0.012
olfactory behavior	GO:0042048	97	0.012
regulation of cardioblast differentiation	GO:0051890	9	0.012
regulation of intracellular protein transport	GO:0033157	46	0.012
catabolic process	GO:0009056	409	0.011
regulation of protein metabolic process	GO:0051246	256	0.011
organ induction	GO:0001759	3	0.011
negative regulation of cellular metabolic process	GO:0031324	382	0.011
syncytial blastoderm mitotic cell cycle	GO:0035186	21	0.011
synaptic growth at neuromuscular junction	GO:0051124	119	0.011
proteasomal protein catabolic process	GO:0010498	59	0.011
macromolecule catabolic process	GO:0009057	161	0.011
negative regulation of immune system process	GO:0002683	50	0.011
regulation of anatomical structure morphogenesis	GO:0022603	242	0.011
growth	GO:0040007	359	0.011
negative regulation of nucleoside metabolic process	GO:0045978	1	0.011
regulation of phosphorylation	GO:0042325	147	0.011
asymmetric cell division	GO:0008356	37	0.011
positive regulation of viral process	GO:0048524	2	0.011
protein transport	GO:0015031	155	0.011
imaginal disc derived leg segmentation	GO:0036011	26	0.011
positive regulation of stem cell maintenance	GO:1902459	1	0.011
cellular amide metabolic process	GO:0043603	80	0.010
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.010
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded	GO:0008070	2	0.010
regulation of immune system process	GO:0002682	176	0.010
regulation of molecular function	GO:0065009	217	0.010
skeletal muscle organ development	GO:0060538	48	0.010
muscle tissue development	GO:0060537	30	0.010
tissue migration	GO:0090130	155	0.010
wing disc dorsal ventral pattern formation	GO:0048190	47	0.010
instar larval development	GO:0002168	55	0.010
central nervous system projection neuron axonogenesis	GO:0021952	6	0.010
nephron development	GO:0072006	3	0.010
regulation of response to stress	GO:0080134	200	0.010

D disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.041
disease of anatomical entity	DOID:7	0.041
eye and adnexa disease	DOID:1492	0.013
sensory system disease	DOID:0050155	0.013

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