Drosophila melanogaster

193 known processes

Tor (Dmel_CG5092)

Target of rapamycin

(Aliases: CT24745,l(2)k17004,dTOR,TOR,DmTOR,5092,dtor,CT24817,tor,Dmel\CG5092,dTor,CT16317,CG5092,mTOR,FRAP/TOR)

Tor biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
growthGO:00400073590.999
transcription from rna polymerase ii promoterGO:00063663680.937
cellular catabolic processGO:00442483720.925
cell motilityGO:00488702510.920
determination of adult lifespanGO:00083401370.900
positive regulation of gene expressionGO:00106282900.885
Human Worm
multicellular organism growthGO:0035264460.873
catabolic processGO:00090564090.867
positive regulation of nucleobase containing compound metabolic processGO:00459353320.791
Human Yeast
regulation of multicellular organism growthGO:0040014400.770
cellular response to extracellular stimulusGO:0031668640.765
salivary gland morphogenesisGO:00074351450.751
tissue deathGO:00162711020.732
regulation of growthGO:00400082330.685
regulation of response to nutrient levelsGO:0032107180.667
regionalizationGO:00030024160.655
regulation of autophagyGO:0010506620.634
gland developmentGO:00487321910.626
developmental growthGO:00485892800.622
skin developmentGO:0043588650.617
Zebrafish
positive regulation of multicellular organism growthGO:0040018210.617
regulation of cell deathGO:00109411730.585
apoptotic processGO:00069151590.562
positive regulation of developmental growthGO:0048639620.557
cell maturationGO:00484691440.547
gland morphogenesisGO:00226121450.532
regulation of developmental growthGO:00486381740.517
developmental programmed cell deathGO:00106231380.449
deathGO:00162652840.426
positive regulation of rna biosynthetic processGO:19026802660.424
Human
multicellular organismal agingGO:00102591400.421
salivary gland histolysisGO:0035070880.420
cellular response to external stimulusGO:0071496660.398
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.398
eye developmentGO:00016543230.395
cell cycle phase transitionGO:00447701400.391
single organism catabolic processGO:00447122280.366
cell cell signaling involved in cell fate commitmentGO:00451682100.343
salivary gland cell autophagic cell deathGO:0035071830.330
negative regulation of cell communicationGO:00106482230.323
response to oxygen containing compoundGO:19017002000.322
Human Mouse
regulation of phosphatase activityGO:001092130.317
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.311
larval developmentGO:00021641040.306
Worm
positive regulation of macromolecule biosynthetic processGO:00105572830.305
Human Worm
histolysisGO:00075591020.294
cellular response to starvationGO:0009267610.271
compound eye morphogenesisGO:00017452490.266
segmentationGO:00352822070.262
sensory organ morphogenesisGO:00905962600.262
exocrine system developmentGO:00352721620.258
localization of cellGO:00516742570.254
cell deathGO:00082192790.249
neuromuscular junction developmentGO:00075281490.245
response to endogenous stimulusGO:00097191190.240
Human Mouse
regulation of cellular catabolic processGO:00313291570.239
negative regulation of response to stimulusGO:00485852580.238
regulation of apoptotic processGO:00429811300.236
regulation of macroautophagyGO:0016241150.234
positive regulation of multicellular organismal processGO:00512401430.227
hemocyte differentiationGO:0042386380.212
programmed cell deathGO:00125012570.212
negative regulation of cellular metabolic processGO:00313243820.209
positive regulation of growthGO:0045927750.196
negative regulation of signal transductionGO:00099682060.184
cellular response to nutrient levelsGO:0031669620.180
regulation of transcription from rna polymerase ii promoterGO:00063573780.178
positive regulation of developmental processGO:00510941430.176
Mouse
autophagic vacuole assemblyGO:000004520.168
macroautophagyGO:0016236420.167
nucleoside triphosphate catabolic processGO:00091431080.165
Mouse
purine ribonucleoside triphosphate metabolic processGO:00092051190.162
Mouse
regulation of cell differentiationGO:00455953020.159
Mouse
autophagyGO:00069141080.154
regulation of nucleotide catabolic processGO:0030811480.151
Yeast Mouse
autophagic cell deathGO:0048102830.150
enzyme linked receptor protein signaling pathwayGO:00071671790.150
regulation of nucleoside metabolic processGO:0009118500.148
Yeast Mouse
regulation of ras protein signal transductionGO:0046578930.148
Yeast Mouse
vesicle mediated transportGO:00161923810.145
organ growthGO:0035265560.144
meiotic cell cycleGO:00513211710.142
Yeast
positive regulation of rna metabolic processGO:00512542710.137
Human
regulation of cell developmentGO:00602842150.135
response to organic substanceGO:00100332840.134
Human Mouse
intracellular signal transductionGO:00355563000.133
Human Yeast Worm
multi multicellular organism processGO:00447061230.131
stem cell differentiationGO:00488631170.129
r3 r4 cell fate commitmentGO:0007464100.127
purine nucleoside metabolic processGO:00422781270.126
Mouse
muscle structure developmentGO:00610612240.120
protein complex assemblyGO:00064612000.119
Mouse
actin filament based processGO:00300292200.119
Human Yeast Mouse
regulation of cell proliferationGO:00421271630.113
cellular protein catabolic processGO:0044257830.112
salivary gland developmentGO:00074311620.112
sex differentiationGO:0007548810.107
negative regulation of mitotic cell cycleGO:00459301090.101
regulation of cell projection organizationGO:0031344920.099
Mouse
stem cell maintenanceGO:0019827670.098
protein catabolic processGO:00301631010.096
neuron fate commitmentGO:0048663500.096
cell cycle g1 s phase transitionGO:0044843310.096
negative regulation of phosphatase activityGO:001092330.095
nucleoside triphosphate metabolic processGO:00091411200.094
Mouse
regulation of organ growthGO:0046620420.093
larval behaviorGO:0030537420.090
axon developmentGO:00615642970.088
glycosyl compound metabolic processGO:19016571270.088
Mouse
positive regulation of transcription dna templatedGO:00458932660.086
Human
regulation of multicellular organismal developmentGO:20000264140.084
Mouse
axis specificationGO:00097981670.083
negative regulation of wnt signaling pathwayGO:0030178280.082
mesenchymal cell differentiationGO:004876210.082
negative regulation of signalingGO:00230572190.080
tripartite regional subdivisionGO:00073511030.079
open tracheal system developmentGO:00074242040.078
nucleobase containing small molecule metabolic processGO:00550861740.078
Mouse
regulation of phosphoprotein phosphatase activityGO:004366630.077
regulation of translationGO:0006417560.075
Human Worm
regulation of cell cycle phase transitionGO:19019871300.074
response to insulinGO:0032868290.073
Mouse
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediatorGO:190225410.072
ribonucleotide catabolic processGO:00092611090.071
Mouse
multicellular organismal reproductive behaviorGO:00330571100.070
purine containing compound metabolic processGO:00725211550.068
Mouse
cell migrationGO:00164772380.067
juvenile hormone mediated signaling pathwayGO:003562630.066
positive regulation of nucleotide metabolic processGO:0045981550.065
Yeast
phagocytosisGO:00069092150.064
monocarboxylic acid metabolic processGO:0032787290.064
dna metabolic processGO:00062592270.063
regulation of intracellular signal transductionGO:19025312360.062
Yeast Mouse
regulation of purine nucleotide catabolic processGO:0033121480.062
Yeast Mouse
endocytosisGO:00068973100.062
Yeast
male gamete generationGO:00482322010.061
cell proliferationGO:00082832990.061
purine nucleoside catabolic processGO:00061521120.059
Mouse
germ cell migrationGO:0008354430.059
negative regulation of cell cycle processGO:00109481090.058
regulation of mitotic cell cycleGO:00073461900.057
regulation of epithelial cell proliferationGO:005067840.057
positive regulation of biosynthetic processGO:00098913160.056
Human Worm
eye morphogenesisGO:00485922600.056
regulation of locomotionGO:0040012420.056
gonad developmentGO:0008406500.055
establishment of organelle localizationGO:00516561220.055
regulation of gtp catabolic processGO:0033124440.054
Yeast Mouse
ribonucleoside triphosphate metabolic processGO:00091991190.053
Mouse
translationGO:0006412690.051
Human Yeast Worm
organelle localizationGO:00516401480.051
negative regulation of cell deathGO:0060548810.050
response to hormoneGO:0009725450.048
Mouse
compound eye developmentGO:00487493070.047
positive regulation of cell growthGO:0030307190.047
anterior posterior pattern specificationGO:00099521360.046
imaginal disc derived wing morphogenesisGO:00074763370.045
nucleoside phosphate catabolic processGO:19012921100.045
Mouse
torso signaling pathwayGO:0008293210.045
mitotic cell cycle phase transitionGO:00447721380.044
response to bacteriumGO:00096171980.044
regulation of anatomical structure sizeGO:00900661630.044
nucleotide catabolic processGO:00091661090.044
Mouse
positive regulation of response to stimulusGO:00485843230.044
Yeast
cell growthGO:00160491080.043
organonitrogen compound catabolic processGO:19015651280.043
Mouse
insulin receptor signaling pathwayGO:0008286250.043
anterior posterior axis specificationGO:00099481090.041
organic substance catabolic processGO:19015753080.040
Mouse
positive regulation of cellular biosynthetic processGO:00313283160.040
Human Worm
cellular response to peptideGO:1901653280.039
glycosyl compound catabolic processGO:19016581120.038
Mouse
macromolecule catabolic processGO:00090571610.038
larval midgut cell programmed cell deathGO:0035096190.038
blastoderm segmentationGO:00073501590.036
leg disc morphogenesisGO:0007478800.036
agingGO:00075681430.035
regulation of rac gtpase activityGO:003231410.035
Mouse
negative regulation of response to extracellular stimulusGO:003210560.035
small molecule metabolic processGO:00442813050.034
Mouse
g1 s transition of mitotic cell cycleGO:0000082310.034
purine ribonucleoside catabolic processGO:00461301120.034
Mouse
regulation of cellular ketone metabolic processGO:001056530.033
regulation of reactive oxygen species metabolic processGO:200037780.033
cellular response to insulin stimulusGO:0032869280.033
guanosine containing compound catabolic processGO:1901069740.033
Mouse
positive regulation of cellular catabolic processGO:0031331950.033
Yeast
regulation of cell growthGO:0001558430.033
ribonucleoside catabolic processGO:00424541120.032
Mouse
oocyte morphogenesisGO:004860130.032
positive regulation of chromatin silencing at telomereGO:003194020.032
regulation of catabolic processGO:00098941700.032
induction of programmed cell death by hormonesGO:0035081120.031
regulation of planar cell polarity pathway involved in axis elongationGO:200004020.031
dendrite regenerationGO:003110420.031
aromatic compound catabolic processGO:00194391660.031
Mouse
purine ribonucleoside metabolic processGO:00461281270.031
Mouse
meiotic nuclear envelope disassemblyGO:005107820.031
establishment or maintenance of cell polarityGO:00071631670.031
Yeast
locomotory behaviorGO:00076261760.030
modification dependent protein catabolic processGO:0019941780.030
morphogenesis of follicular epitheliumGO:0016333360.029
regulation of immune system processGO:00026821760.029
ecdysone mediated induction of salivary gland cell autophagic cell deathGO:0035072120.029
regulation of spindle checkpointGO:009023120.029
embryonic pattern specificationGO:00098801740.029
neuroblast differentiationGO:0014016290.028
proteolysis involved in cellular protein catabolic processGO:0051603830.028
icosanoid biosynthetic processGO:004645610.028
purine ribonucleotide metabolic processGO:00091501450.027
Mouse
regulation of small gtpase mediated signal transductionGO:0051056930.027
Yeast Mouse
induction of programmed cell deathGO:0012502120.027
defense response to other organismGO:00985422250.027
positive regulation of macromolecule metabolic processGO:00106044050.027
larval lymph gland hemopoiesisGO:0035167170.027
negative regulation of autophagyGO:0010507160.025
spermatogenesisGO:00072832000.025
regulation of mitotic cell cycle phase transitionGO:19019901300.025
cellular response to chemical stimulusGO:00708871990.025
Mouse
purine nucleoside triphosphate metabolic processGO:00091441190.025
Mouse
embryo development ending in birth or egg hatchingGO:00097921520.024
Worm
morphogenesis of a branching structureGO:0001763450.024
cellular response to oxygen containing compoundGO:1901701790.024
regulation of cell morphogenesisGO:00226041630.024
organelle inheritanceGO:004830820.024
mitotic nuclear divisionGO:00070672130.023
development of primary sexual characteristicsGO:0045137500.023
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.023
protein modification by small protein conjugationGO:0032446790.023
negative regulation of catabolic processGO:0009895360.022
tor signalingGO:0031929320.022
Human Yeast Worm
negative regulation of cell sizeGO:0045792190.022
Mouse
meiotic nuclear divisionGO:00071261510.022
Yeast
compound eye photoreceptor fate commitmentGO:0001752360.022
regulation of cell proliferation involved in compound eye morphogenesisGO:200049520.022
eye antennal disc morphogenesisGO:0007455340.021
regulation of centriole replicationGO:004659920.021
cellular protein modification processGO:00064644380.021
epidermis developmentGO:0008544650.021
extrinsic apoptotic signaling pathwayGO:009719110.021
induction of programmed cell death by ecdysoneGO:0035078120.021
apoptotic signaling pathwayGO:0097190270.021
response to nutrient levelsGO:00316671140.021
response to organic cyclic compoundGO:0014070890.021
single organism biosynthetic processGO:00447112060.021
Human Yeast
actin cytoskeleton organizationGO:00300362060.021
Human Yeast Mouse
purine ribonucleotide catabolic processGO:00091541090.020
Mouse
negative regulation of mitotic cell cycle phase transitionGO:19019911030.020
positive regulation of catabolic processGO:00098961050.020
Yeast
regulation of apoptotic signaling pathwayGO:2001233100.020
r7 cell differentiationGO:0045466430.020
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encodedGO:000807110.020
regulation of cell shapeGO:00083601130.020
multi organism reproductive behaviorGO:00447051210.020
purine nucleotide catabolic processGO:00061951090.019
Mouse
positive regulation of purine nucleotide metabolic processGO:1900544550.019
Yeast
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encodedGO:000807020.019
eye photoreceptor cell fate commitmentGO:0042706370.019
cellular nitrogen compound catabolic processGO:00442701650.019
Mouse
regulation of postsynaptic membrane potentialGO:006007850.019
response to alcoholGO:0097305950.019
ribose phosphate metabolic processGO:00196931450.019
Mouse
response to uvGO:0009411240.018
regulation of cell cycle checkpointGO:190197620.018
oocyte fate commitmentGO:004860020.018
positive regulation of nucleoside metabolic processGO:0045979470.018
Yeast
cellular protein localizationGO:00346131600.018
Mouse
dorsal closure leading edge cell differentiationGO:004666320.018
eye photoreceptor cell differentiationGO:00017541450.018
purine nucleoside triphosphate catabolic processGO:00091461080.018
Mouse
negative regulation of programmed cell deathGO:0043069720.018
dna templated transcriptional start site selectionGO:000117310.017
ribonucleotide metabolic processGO:00092591450.017
Mouse
negative regulation of mitotic anaphase promoting complex activityGO:006056420.017
response to ecdysoneGO:0035075340.017
neuroblast developmentGO:0014019130.017
respiratory system developmentGO:00605412130.017
negative regulation of epithelial cell proliferationGO:005068040.017
phosphatidylinositol mediated signalingGO:004801540.017
body morphogenesisGO:001017120.017
negative regulation of terminal cell fate specification open tracheal systemGO:003515520.017
negative regulation of cell differentiationGO:00455961430.016
peptidyl serine modificationGO:001820970.016
Human Mouse
organonitrogen compound metabolic processGO:19015643180.016
Yeast Mouse
meiotic spindle checkpointGO:004477910.016
response to external biotic stimulusGO:00432072930.016
nucleoside metabolic processGO:00091161270.016
Mouse
positive regulation of gtp catabolic processGO:0033126430.016
Yeast
establishment or maintenance of cytoskeleton polarityGO:0030952440.016
Yeast
dorsal ventral pattern formationGO:00099531330.016
regulation of response to extracellular stimulusGO:0032104180.016
ras protein signal transductionGO:0007265880.016
Yeast
purine containing compound catabolic processGO:00725231120.016
Mouse
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycleGO:005143620.016
detection of virusGO:000959710.015
regulation of cellular component sizeGO:0032535980.015
motor neuron axon guidanceGO:0008045580.015
negative regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediatorGO:190216610.015
regulation of lipid metabolic processGO:0019216150.015
Human Yeast
regulation of neuron differentiationGO:00456641030.015
taxisGO:00423303040.015
entry into diapauseGO:005511510.015
Worm
chromosome segregationGO:00070591570.015
histone h3 k9 modificationGO:0061647120.015
eggshell chorion assemblyGO:0007306660.015
meiotic chromosome movement towards spindle poleGO:001634410.015
ubiquitin dependent protein catabolic processGO:0006511780.015
microtubule slidingGO:005101230.015
negative regulation of mrna 3 end processingGO:003144130.015
epithelial cell migrationGO:00106311480.014
response to extracellular stimulusGO:00099911160.014
response to radiationGO:00093141550.014
negative regulation of transforming growth factor beta receptor signaling pathwayGO:003051240.014
positive regulation of cell deathGO:0010942690.014
reproductive behaviorGO:00190981220.014
response to ketoneGO:1901654340.014
regulation of ran gtpase activityGO:003231610.014
positive regulation of gtpase activityGO:0043547430.014
Yeast
carbohydrate derivative catabolic processGO:19011361180.014
Mouse
response to abiotic stimulusGO:00096283410.014
ribonucleoside triphosphate catabolic processGO:00092031080.014
Mouse
purine ribonucleoside triphosphate catabolic processGO:00092071080.013
Mouse
regulation of neurotransmitter levelsGO:0001505380.013
regulation of wnt signaling pathwayGO:0030111680.013
positive regulation of nitrogen compound metabolic processGO:00511733540.013
Human Yeast
response to nitrogen compoundGO:1901698900.013
Human Mouse
negative regulation of toll signaling pathwayGO:004575170.013
negative regulation of transcription initiation from rna polymerase ii promoterGO:006063310.013
zygotic determination of anterior posterior axis embryoGO:0007354270.013
axonogenesisGO:00074092900.013
negative regulation of cell cycleGO:00457861160.013
regulation of programmed cell deathGO:00430671520.013
tube morphogenesisGO:00352391910.013
eye photoreceptor cell developmentGO:0042462810.013
gtp metabolic processGO:0046039720.013
Mouse
defense response to bacteriumGO:00427421780.013
negative regulation of transcription factor import into nucleusGO:004299240.013
Mouse
oocyte growthGO:000155550.013
positive regulation of transcription involved in g2 m transition of mitotic cell cycleGO:009028210.013
regulation of ral gtpase activityGO:003231510.013
regulation of purine nucleotide metabolic processGO:1900542620.013
Yeast Mouse
regulation of calcium ion transmembrane transportGO:190316920.013
regulation of viral entry into host cellGO:004659620.013
positive regulation of ribosome biogenesisGO:009007030.013
regulation of cell cycle g1 s phase transitionGO:1902806230.013
germarium derived cystoblast divisionGO:004814230.012
dna replicationGO:0006260480.012
regulation of imaginal disc growthGO:0045570260.012
protein destabilizationGO:003164820.012
specification of segmental identity antennal segmentGO:000738320.012
chromatin organizationGO:00063252070.012
negative regulation of cell proliferationGO:0008285690.012
ovipositionGO:0018991190.012
synaptic growth at neuromuscular junctionGO:00511241190.012
cytoplasmic sequestering of nf kappabGO:000725310.012
imaginal disc derived appendage developmentGO:00487373990.012
regulation of neuron projection developmentGO:0010975690.012
determination of dorsal ventral asymmetryGO:004826230.012
positive regulation of nucleotide catabolic processGO:0030813460.012
Yeast
negative regulation of macroautophagyGO:001624260.012
cardiac cell fate specificationGO:0060912100.012
regulation of centrosome duplicationGO:001082440.012
regulation of hematopoietic stem cell differentiationGO:190203610.011
positive regulation of phosphorus metabolic processGO:00105621390.011
cellular response to nitrogen compoundGO:1901699510.011
attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregationGO:005131610.011
purine nucleotide metabolic processGO:00061631460.011
Mouse
negative regulation of dna templated transcription initiationGO:200014310.011
positive regulation of posttranscriptional gene silencingGO:006014850.011
multi organism behaviorGO:00517051750.011
fatty acid derivative biosynthetic processGO:190157010.011
modification dependent macromolecule catabolic processGO:0043632790.011
dorsal ventral axis specificationGO:0009950660.011
mesoderm developmentGO:0007498780.011
nurse cell nucleus anchoringGO:000730210.011
post embryonic hemopoiesisGO:0035166170.011
positive regulation of purine nucleotide catabolic processGO:0033123460.011
Yeast
cell volume homeostasisGO:000688410.010
negative regulation of cell fate specificationGO:0009996150.010
positive regulation of translationGO:0045727120.010
Human Worm
dna catabolic process endonucleolyticGO:000073760.010
response to other organismGO:00517072930.010
response to decreased oxygen levelsGO:0036293580.010
Mouse
regulation of trichome morphogenesisGO:200003930.010
positive regulation of stem cell differentiationGO:200073830.010
larval midgut histolysisGO:0035069220.010
carbohydrate transportGO:000864340.010

Tor disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.138
musculoskeletal system diseaseDOID:1700.052
dysostosisDOID:193400.052
brachydactylyDOID:005058100.052
connective tissue diseaseDOID:6500.052
bone development diseaseDOID:008000600.052
disease of anatomical entityDOID:700.052
bone diseaseDOID:008000100.052
organ system cancerDOID:005068600.025
cancerDOID:16200.025
organ system benign neoplasmDOID:006008500.024
benign neoplasmDOID:006007200.024
nervous system benign neoplasmDOID:006011500.024
neuromaDOID:200100.024
artery diseaseDOID:005082800.021
cardiovascular system diseaseDOID:128700.021
aortic diseaseDOID:52000.021
aortic aneurysmDOID:362700.021
vascular diseaseDOID:17800.021
thyroid carcinomaDOID:396300.014
thyroid cancerDOID:178100.014
endocrine gland cancerDOID:17000.014
follicular thyroid carcinomaDOID:396200.014
tuberous sclerosisDOID:1351500.011
heart diseaseDOID:11400.011
myopathyDOID:42300.011
intrinsic cardiomyopathyDOID:006003600.011
arrhythmogenic right ventricular cardiomyopathyDOID:005043100.011
cardiomyopathyDOID:005070000.011
muscle tissue diseaseDOID:6600.011
muscular diseaseDOID:008000000.011