IMP: Integrative Multi-species Prediction

Drosophila melanogaster

227 known processes

skpA (Dmel_CG16983)

CG16983 gene product from transcript CG16983-RD

(Aliases: CG16983,l(1)G0037,Skp,dSkp-1,Skp1,l(1)G0058,l(1)G0109,Dmel\CG16983,dskpA,dSkpA,l(1)G0389,anon-WO03040301.238,SkpA,anon-WO03040301.236,anon-WO03040301.234,EG:115C2.4,spkA)

FLYBASE: FBgn0025637
Entrez: 31016
UniProtKB: O77430

Process Predictions
Disease Predictions

skpA biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of cell cycle	GO:0045786	116	0.995
cellular response to dna damage stimulus	GO:0006974	223	0.991
protein modification by small protein conjugation or removal	GO:0070647	106	0.989	Human
synapse organization	GO:0050808	196	0.982
negative regulation of neuroblast proliferation	GO:0007406	27	0.973
dna integrity checkpoint	GO:0031570	81	0.967
regulation of cell cycle phase transition	GO:1901987	130	0.967
protein ubiquitination	GO:0016567	70	0.963	Human
organelle fission	GO:0048285	340	0.956
dna replication	GO:0006260	48	0.946
negative regulation of cell cycle phase transition	GO:1901988	103	0.943
developmental maturation	GO:0021700	172	0.931
vesicle mediated transport	GO:0016192	381	0.929	Worm
mitotic g2 dna damage checkpoint	GO:0007095	69	0.913
regulation of cellular component biogenesis	GO:0044087	201	0.907
meiotic cell cycle	GO:0051321	171	0.903	Worm
apoptotic process	GO:0006915	159	0.886
single organism intracellular transport	GO:1902582	207	0.883
cell cycle phase transition	GO:0044770	140	0.882
cell maturation	GO:0048469	144	0.871
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.861
mitotic cell cycle phase transition	GO:0044772	138	0.861
mitotic cell cycle checkpoint	GO:0007093	88	0.855
regulation of phosphate metabolic process	GO:0019220	210	0.854
regulation of protein stability	GO:0031647	43	0.839
regulation of response to stress	GO:0080134	200	0.839
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.837
negative regulation of nervous system development	GO:0051961	92	0.828
dna conformation change	GO:0071103	105	0.800
dna packaging	GO:0006323	91	0.784
negative regulation of cell cycle process	GO:0010948	109	0.778
jnk cascade	GO:0007254	50	0.774
death	GO:0016265	284	0.769
intracellular transport	GO:0046907	228	0.752
axonogenesis	GO:0007409	290	0.750
cellular protein modification process	GO:0006464	438	0.741	Human
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.740
protein catabolic process	GO:0030163	101	0.739	Human
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.729
mitotic dna integrity checkpoint	GO:0044774	75	0.721
neuron remodeling	GO:0016322	29	0.719
dna damage checkpoint	GO:0000077	78	0.702
regulation of cell cycle process	GO:0010564	181	0.697
negative regulation of response to stimulus	GO:0048585	258	0.688
modification dependent protein catabolic process	GO:0019941	78	0.685	Human
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.675	Human
stress activated mapk cascade	GO:0051403	52	0.663
chromosome organization	GO:0051276	360	0.658
regulation of cytoskeleton organization	GO:0051493	89	0.653
regulation of cellular response to stress	GO:0080135	89	0.652
negative regulation of mitotic cell cycle	GO:0045930	109	0.616
programmed cell death	GO:0012501	257	0.567
developmental growth	GO:0048589	280	0.553
cell death	GO:0008219	279	0.535
positive regulation of cellular biosynthetic process	GO:0031328	316	0.508
negative regulation of developmental process	GO:0051093	201	0.488
response to organonitrogen compound	GO:0010243	75	0.486
stress activated protein kinase signaling cascade	GO:0031098	55	0.477
synaptic growth at neuromuscular junction	GO:0051124	119	0.472
cellular protein catabolic process	GO:0044257	83	0.469	Human
neuromuscular junction development	GO:0007528	149	0.468
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.456
cellular response to endogenous stimulus	GO:0071495	80	0.441
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.434
growth	GO:0040007	359	0.433
endocytosis	GO:0006897	310	0.422	Worm
regulation of cellular protein metabolic process	GO:0032268	243	0.411
response to endogenous stimulus	GO:0009719	119	0.409
cellular macromolecule catabolic process	GO:0044265	136	0.401	Human
regulation of synapse assembly	GO:0051963	94	0.399
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.398
regulation of jnk cascade	GO:0046328	40	0.396
meiotic nuclear division	GO:0007126	151	0.393	Worm
regulation of cell death	GO:0010941	173	0.386
positive regulation of response to stimulus	GO:0048584	323	0.373
negative regulation of multicellular organismal process	GO:0051241	142	0.372
cellular response to chemical stimulus	GO:0070887	199	0.370
dna repair	GO:0006281	54	0.364
regionalization	GO:0003002	416	0.353
negative regulation of programmed cell death	GO:0043069	72	0.343
posttranscriptional regulation of gene expression	GO:0010608	145	0.338
chromatin assembly or disassembly	GO:0006333	52	0.335
defense response to gram negative bacterium	GO:0050829	94	0.326	Worm
regulation of protein modification process	GO:0031399	112	0.318
protein modification by small protein conjugation	GO:0032446	79	0.313	Human
regulation of developmental growth	GO:0048638	174	0.307
neuron maturation	GO:0042551	31	0.298
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.290	Human
centrosome duplication	GO:0051298	121	0.284
segmentation	GO:0035282	207	0.282
mitotic dna damage checkpoint	GO:0044773	74	0.276
negative regulation of signal transduction	GO:0009968	206	0.270
modification dependent macromolecule catabolic process	GO:0043632	79	0.262	Human
negative regulation of stem cell proliferation	GO:2000647	30	0.257
response to external biotic stimulus	GO:0043207	293	0.251	Worm
response to other organism	GO:0051707	293	0.248	Worm
regulation of innate immune response	GO:0045088	71	0.240
regulation of programmed cell death	GO:0043067	152	0.239
regulation of mapk cascade	GO:0043408	92	0.239
response to bacterium	GO:0009617	198	0.231	Worm
regulation of stem cell proliferation	GO:0072091	40	0.225
regulation of synapse organization	GO:0050807	110	0.224
ubiquitin dependent protein catabolic process	GO:0006511	78	0.223	Human
negative regulation of synapse assembly	GO:0051964	39	0.220
phagocytosis	GO:0006909	215	0.220
columnar cuboidal epithelial cell development	GO:0002066	249	0.219
axon guidance	GO:0007411	233	0.206
macromolecular complex assembly	GO:0065003	256	0.203
negative regulation of stress activated protein kinase signaling cascade	GO:0070303	20	0.198
embryonic pattern specification	GO:0009880	174	0.197
regulation of mitotic cell cycle	GO:0007346	190	0.191
positive regulation of macromolecule metabolic process	GO:0010604	405	0.186
cytoplasmic transport	GO:0016482	130	0.182
protein localization to plasma membrane	GO:0072659	13	0.180
protein modification process	GO:0036211	438	0.178	Human
axis specification	GO:0009798	167	0.168
response to biotic stimulus	GO:0009607	294	0.166	Worm
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.161
macromolecule catabolic process	GO:0009057	161	0.156	Human
larval development	GO:0002164	104	0.152	Worm
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.152
cellular response to insulin stimulus	GO:0032869	28	0.151
organic substance catabolic process	GO:1901575	308	0.150	Human
transcription from rna polymerase ii promoter	GO:0006366	368	0.149
negative regulation of phosphorus metabolic process	GO:0010563	45	0.149
negative regulation of cell death	GO:0060548	81	0.137
tissue migration	GO:0090130	155	0.136
nuclear division	GO:0000280	332	0.130
establishment of localization in cell	GO:0051649	402	0.127	Worm
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.124
spermatogenesis	GO:0007283	200	0.117
synapse assembly	GO:0007416	143	0.116
negative regulation of apoptotic process	GO:0043066	63	0.113
regulation of phosphorus metabolic process	GO:0051174	210	0.111
response to nitrogen compound	GO:1901698	90	0.110
cellular response to organic substance	GO:0071310	132	0.109
regulation of cell cycle	GO:0051726	291	0.108
histone h4 k20 methylation	GO:0034770	4	0.107
response to organic substance	GO:0010033	284	0.106
axon development	GO:0061564	297	0.106
male gamete generation	GO:0048232	201	0.106
mitochondrion organization	GO:0007005	65	0.106
spindle organization	GO:0007051	253	0.104
negative regulation of cell communication	GO:0010648	223	0.103
histone modification	GO:0016570	106	0.102	Human
muscle structure development	GO:0061061	224	0.099
negative regulation of cellular metabolic process	GO:0031324	382	0.099
positive regulation of signal transduction	GO:0009967	223	0.097
protein acylation	GO:0043543	42	0.096
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.095
salivary gland morphogenesis	GO:0007435	145	0.090
regulation of multicellular organismal development	GO:2000026	414	0.088
insulin receptor signaling pathway	GO:0008286	25	0.088
ncrna metabolic process	GO:0034660	43	0.087
cellular amine metabolic process	GO:0044106	12	0.086
gland morphogenesis	GO:0022612	145	0.085
positive regulation of rna metabolic process	GO:0051254	271	0.084
regulation of neuroblast proliferation	GO:1902692	34	0.082
nuclear transport	GO:0051169	72	0.082
signal transduction by phosphorylation	GO:0023014	107	0.081
intracellular signal transduction	GO:0035556	300	0.081
regulation of apoptotic process	GO:0042981	130	0.081
tissue death	GO:0016271	102	0.079
regulation of stress activated mapk cascade	GO:0032872	41	0.078
regulation of catalytic activity	GO:0050790	185	0.077
nucleocytoplasmic transport	GO:0006913	72	0.076
scf dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031146	1	0.076	Human
positive regulation of cellular protein metabolic process	GO:0032270	118	0.076
positive regulation of biosynthetic process	GO:0009891	316	0.076
negative regulation of phosphate metabolic process	GO:0045936	45	0.076
cellular protein localization	GO:0034613	160	0.074
regulation of defense response	GO:0031347	102	0.074
cell cycle dna replication	GO:0044786	23	0.073
cellular macromolecular complex assembly	GO:0034622	153	0.071
dna metabolic process	GO:0006259	227	0.071
maintenance of location	GO:0051235	73	0.070
salivary gland cell autophagic cell death	GO:0035071	83	0.069
cellular macromolecule localization	GO:0070727	220	0.067
regulation of notch signaling pathway	GO:0008593	100	0.067
response to peptide	GO:1901652	29	0.067
anterior posterior pattern specification	GO:0009952	136	0.066
cell division	GO:0051301	248	0.065
positive regulation of immune response	GO:0050778	63	0.064
circulatory system development	GO:0072359	82	0.064
organophosphate metabolic process	GO:0019637	195	0.064
positive regulation of cell cycle	GO:0045787	43	0.061
neuron projection guidance	GO:0097485	241	0.061
developmental programmed cell death	GO:0010623	138	0.060
catabolic process	GO:0009056	409	0.059	Human
exocrine system development	GO:0035272	162	0.058
response to oxygen containing compound	GO:1901700	200	0.057
dna endoreduplication	GO:0042023	22	0.056
regulation of transferase activity	GO:0051338	58	0.055
cellular amide metabolic process	GO:0043603	80	0.054
mitotic g2 m transition checkpoint	GO:0044818	70	0.054
negative regulation of signaling	GO:0023057	219	0.053
cell cycle checkpoint	GO:0000075	95	0.053
negative regulation of developmental growth	GO:0048640	64	0.053
taxis	GO:0042330	304	0.053
regulation of nervous system development	GO:0051960	248	0.051
defense response to bacterium	GO:0042742	178	0.051	Worm
cellular response to peptide	GO:1901653	28	0.051
cytokinesis	GO:0000910	90	0.050
transmembrane transport	GO:0055085	139	0.049
mitotic nuclear division	GO:0007067	213	0.047
regulation of wnt signaling pathway	GO:0030111	68	0.047
regulation of production of molecular mediator of immune response	GO:0002700	44	0.046
trna modification	GO:0006400	2	0.046
regulation of cellular localization	GO:0060341	136	0.044
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.044
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.043
salivary gland development	GO:0007431	162	0.042
wnt signaling pathway	GO:0016055	98	0.042
proteasomal protein catabolic process	GO:0010498	59	0.042	Human
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.042
cell motility	GO:0048870	251	0.039	Worm
positive regulation of defense response	GO:0031349	59	0.039
covalent chromatin modification	GO:0016569	106	0.038	Human
body morphogenesis	GO:0010171	2	0.038
regulation of proteolysis	GO:0030162	87	0.038
immune response	GO:0006955	246	0.038	Worm
rna processing	GO:0006396	147	0.036
negative regulation of phosphorylation	GO:0042326	35	0.035
cell migration	GO:0016477	238	0.035	Worm
stem cell differentiation	GO:0048863	117	0.035
embryo development ending in birth or egg hatching	GO:0009792	152	0.034	Worm
regulation of growth	GO:0040008	233	0.034
negative regulation of cellular component organization	GO:0051129	108	0.033
appendage development	GO:0048736	401	0.033
regulation of cell proliferation	GO:0042127	163	0.033	Worm
receptor mediated endocytosis	GO:0006898	21	0.033	Worm
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.033
protein maturation	GO:0051604	71	0.033
mapk cascade	GO:0000165	107	0.032
development of primary sexual characteristics	GO:0045137	50	0.032	Worm
sensory organ precursor cell division	GO:0045035	10	0.031
aging	GO:0007568	143	0.031	Worm
lipid localization	GO:0010876	54	0.031
negative regulation of neurogenesis	GO:0050768	53	0.031
positive regulation of cell communication	GO:0010647	250	0.031
ovarian follicle cell development	GO:0030707	248	0.030
positive regulation of protein metabolic process	GO:0051247	128	0.029
regulation of protein ubiquitination	GO:0031396	22	0.029
epithelial cell differentiation	GO:0030855	322	0.029
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0030722	6	0.029
regulation of microtubule based process	GO:0032886	49	0.029
regulation of synapse structure and activity	GO:0050803	128	0.029
regulation of molecular function	GO:0065009	217	0.028
pigment metabolic process	GO:0042440	84	0.028
protein processing	GO:0016485	68	0.028
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.028
centrosome cycle	GO:0007098	137	0.028
negative regulation of proteolysis	GO:0045861	31	0.027
organic substance transport	GO:0071702	257	0.027
ribosomal large subunit biogenesis	GO:0042273	1	0.027
positive regulation of rna biosynthetic process	GO:1902680	266	0.026
autophagic cell death	GO:0048102	83	0.026
dorsal ventral pattern formation	GO:0009953	133	0.026
negative regulation of defense response	GO:0031348	35	0.025
regulation of response to external stimulus	GO:0032101	115	0.025
chromosome segregation	GO:0007059	157	0.025	Worm
neural precursor cell proliferation	GO:0061351	75	0.025
dendrite development	GO:0016358	204	0.025
regulation of organelle organization	GO:0033043	196	0.024
positive regulation of multi organism process	GO:0043902	40	0.024
regulation of nucleocytoplasmic transport	GO:0046822	35	0.024
protein localization to membrane	GO:0072657	19	0.024
regulation of gene silencing	GO:0060968	63	0.023
positive regulation of phosphorus metabolic process	GO:0010562	139	0.023
phosphorylation	GO:0016310	294	0.023
chromatin modification	GO:0016568	147	0.023	Human
cellular response to hormone stimulus	GO:0032870	44	0.023
negative regulation of protein processing	GO:0010955	31	0.022
positive regulation of phosphate metabolic process	GO:0045937	139	0.022
regulation of multi organism process	GO:0043900	131	0.022
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.022
mitotic spindle organization	GO:0007052	220	0.022
blastoderm segmentation	GO:0007350	159	0.022
membrane organization	GO:0061024	112	0.022
regulation of neural precursor cell proliferation	GO:2000177	35	0.021
autophagic vacuole assembly	GO:0000045	2	0.021
telomere capping	GO:0016233	11	0.021
metal ion transport	GO:0030001	74	0.020
positive regulation of signaling	GO:0023056	243	0.020
regulation of cellular amine metabolic process	GO:0033238	3	0.020
regulation of hemocyte proliferation	GO:0035206	37	0.020
positive regulation of response to external stimulus	GO:0032103	44	0.020
imaginal disc fusion	GO:0046528	19	0.019
positive regulation of heterochromatin assembly	GO:0031453	5	0.019
regulation of protein catabolic process	GO:0042176	55	0.019
positive regulation of cell size	GO:0045793	21	0.019
positive regulation of wnt signaling pathway	GO:0030177	25	0.019
skeletal muscle tissue development	GO:0007519	13	0.019
ribosome biogenesis	GO:0042254	8	0.019
pigmentation	GO:0043473	75	0.018
positive regulation of gene expression	GO:0010628	290	0.018
epithelial cell proliferation	GO:0050673	15	0.018
oocyte differentiation	GO:0009994	145	0.018
positive regulation of protein modification process	GO:0031401	58	0.018
negative regulation of protein maturation	GO:1903318	31	0.018
positive regulation of transcription dna templated	GO:0045893	266	0.018
cell proliferation	GO:0008283	299	0.017	Worm
tripartite regional subdivision	GO:0007351	103	0.017
female meiotic division	GO:0007143	70	0.017
dorsal ventral axis specification	GO:0009950	66	0.017
protein phosphorylation	GO:0006468	169	0.017
regulation of anatomical structure size	GO:0090066	163	0.017
response to radiation	GO:0009314	155	0.016
appendage morphogenesis	GO:0035107	397	0.016
cellular response to nitrogen compound	GO:1901699	51	0.016
regulation of heterochromatin assembly	GO:0031445	8	0.016
chromatin organization	GO:0006325	207	0.016	Human
oocyte development	GO:0048599	124	0.016
immune effector process	GO:0002252	98	0.016
cellular response to abiotic stimulus	GO:0071214	58	0.016
regulation of intracellular signal transduction	GO:1902531	236	0.015
regulation of peptidase activity	GO:0052547	39	0.015
single organism behavior	GO:0044708	391	0.015
nitric oxide metabolic process	GO:0046209	1	0.015
single organism cellular localization	GO:1902580	180	0.015	Worm
establishment of protein localization	GO:0045184	163	0.015
positive regulation of immune system process	GO:0002684	68	0.015
cellular ion homeostasis	GO:0006873	39	0.015
positive regulation of intracellular signal transduction	GO:1902533	116	0.015
histolysis	GO:0007559	102	0.015
regulation of chromatin assembly	GO:0010847	9	0.014
gland development	GO:0048732	191	0.014
multicellular organismal aging	GO:0010259	140	0.014	Worm
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.014
regulation of immune response	GO:0050776	118	0.014
negative regulation of growth	GO:0045926	84	0.014
limb development	GO:0060173	1	0.014
regulation of cellular ketone metabolic process	GO:0010565	3	0.014
instar larval development	GO:0002168	55	0.014
negative regulation of peptidase activity	GO:0010466	11	0.013
positive regulation of cellular protein catabolic process	GO:1903364	24	0.013
ncrna processing	GO:0034470	30	0.013
regulation of cytoplasmic transport	GO:1903649	47	0.013
melanin metabolic process	GO:0006582	47	0.013
notch signaling pathway	GO:0007219	120	0.013
regulation of intracellular transport	GO:0032386	64	0.013
regulation of catabolic process	GO:0009894	170	0.013
regulation of cellular component size	GO:0032535	98	0.013
eye development	GO:0001654	323	0.013
positive regulation of ribosome biogenesis	GO:0090070	3	0.013
negative regulation of protein metabolic process	GO:0051248	85	0.013
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.013
meiotic cytokinesis	GO:0033206	33	0.013
nitrogen compound transport	GO:0071705	85	0.013
negative regulation of insulin receptor signaling pathway	GO:0046627	11	0.013
response to insulin	GO:0032868	29	0.013
positive regulation of protein catabolic process	GO:0045732	34	0.013
homeostatic process	GO:0042592	199	0.013
negative regulation of innate immune response	GO:0045824	30	0.013
embryonic axis specification	GO:0000578	107	0.013
gonad development	GO:0008406	50	0.013	Worm
cell volume homeostasis	GO:0006884	1	0.013
negative regulation of molecular function	GO:0044092	51	0.012
salivary gland histolysis	GO:0035070	88	0.012
response to fungus	GO:0009620	50	0.012
regulation of transport	GO:0051049	181	0.012
ameboidal type cell migration	GO:0001667	151	0.012
divalent inorganic cation transport	GO:0072511	30	0.012
synaptic transmission	GO:0007268	288	0.011
cellular catabolic process	GO:0044248	372	0.011	Human
maintenance of location in cell	GO:0051651	28	0.011
lipid metabolic process	GO:0006629	121	0.011
regulation of canonical wnt signaling pathway	GO:0060828	15	0.011
rna localization	GO:0006403	115	0.011
nucleoside phosphate metabolic process	GO:0006753	162	0.011
detection of stimulus	GO:0051606	156	0.011
regulation of dna metabolic process	GO:0051052	34	0.011
epithelial cell migration	GO:0010631	148	0.011
regulation of rac protein signal transduction	GO:0035020	3	0.011
cell aging	GO:0007569	2	0.011
heart development	GO:0007507	82	0.011
neuromuscular synaptic transmission	GO:0007274	67	0.010
translation	GO:0006412	69	0.010
regulation of protein processing	GO:0070613	32	0.010

skpA disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	nervous system disease	DOID:863	0	0.012
	disease of anatomical entity	DOID:7	0	0.012

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