IMP: Integrative Multi-species Prediction

Drosophila melanogaster

13 known processes

Bap (Dmel_CG12532)

Beta Adaptin

(Aliases: AP-2beta,CG12532,BAD1,bap,beta1/2,AP-beta1,cg12532,Dmel\CG12532)

FLYBASE: FBgn0010380
Entrez: 32987
UniProtKB: Q24253

Process Predictions
Disease Predictions

Bap biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cytokinesis	GO:0000910	90	0.497
nuclear division	GO:0000280	332	0.419
cell division	GO:0051301	248	0.405
vesicle organization	GO:0016050	44	0.382
cytoplasmic transport	GO:0016482	130	0.333
endocytosis	GO:0006897	310	0.310
embryo development ending in birth or egg hatching	GO:0009792	152	0.297
intracellular transport	GO:0046907	228	0.284
organelle fission	GO:0048285	340	0.253
lipid localization	GO:0010876	54	0.218
neurological system process	GO:0050877	358	0.179
vesicle mediated transport	GO:0016192	381	0.173
immune response	GO:0006955	246	0.152
body morphogenesis	GO:0010171	2	0.146
cytoskeleton dependent cytokinesis	GO:0061640	81	0.145
intracellular signal transduction	GO:0035556	300	0.131
positive regulation of response to stimulus	GO:0048584	323	0.127
mitotic nuclear division	GO:0007067	213	0.117
single organism cellular localization	GO:1902580	180	0.111
establishment or maintenance of cell polarity	GO:0007163	167	0.108
single organism intracellular transport	GO:1902582	207	0.100
oocyte development	GO:0048599	124	0.097
positive regulation of cellular component organization	GO:0051130	156	0.095
maintenance of location	GO:0051235	73	0.094
purine nucleotide metabolic process	GO:0006163	146	0.089
nucleoside phosphate catabolic process	GO:1901292	110	0.086
death	GO:0016265	284	0.085
posttranscriptional regulation of gene expression	GO:0010608	145	0.084
blastoderm segmentation	GO:0007350	159	0.083
cellular catabolic process	GO:0044248	372	0.082
regionalization	GO:0003002	416	0.079
male meiosis cytokinesis	GO:0007112	26	0.075
rna localization	GO:0006403	115	0.072
hematopoietic or lymphoid organ development	GO:0048534	57	0.070
cellular protein localization	GO:0034613	160	0.070
programmed cell death	GO:0012501	257	0.068
sensory organ morphogenesis	GO:0090596	260	0.063
regulation of phosphate metabolic process	GO:0019220	210	0.061
rna processing	GO:0006396	147	0.061
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.060
positive regulation of immune system process	GO:0002684	68	0.059
ras protein signal transduction	GO:0007265	88	0.058
eye photoreceptor cell differentiation	GO:0001754	145	0.057
organophosphate metabolic process	GO:0019637	195	0.057
carbohydrate derivative metabolic process	GO:1901135	217	0.055
response to bacterium	GO:0009617	198	0.053
single organism behavior	GO:0044708	391	0.053
catabolic process	GO:0009056	409	0.050
response to endogenous stimulus	GO:0009719	119	0.050
intracellular protein transport	GO:0006886	104	0.050
reproductive behavior	GO:0019098	122	0.050
anterior posterior axis specification embryo	GO:0008595	103	0.049
macromolecular complex assembly	GO:0065003	256	0.049
positive regulation of signal transduction	GO:0009967	223	0.049
positive regulation of cellular catabolic process	GO:0031331	95	0.049
cell death	GO:0008219	279	0.049
response to organic substance	GO:0010033	284	0.048
tube development	GO:0035295	244	0.047
regulation of organelle organization	GO:0033043	196	0.047
cellular ion homeostasis	GO:0006873	39	0.046
defense response to bacterium	GO:0042742	178	0.045
phagocytosis	GO:0006909	215	0.044
actin cytoskeleton organization	GO:0030036	206	0.044
protein transport	GO:0015031	155	0.043
negative regulation of signaling	GO:0023057	219	0.043
cellular protein complex assembly	GO:0043623	71	0.042
eye morphogenesis	GO:0048592	260	0.042
establishment of protein localization	GO:0045184	163	0.041
multi organism reproductive behavior	GO:0044705	121	0.041
guanosine containing compound catabolic process	GO:1901069	74	0.041
regulation of cell cycle	GO:0051726	291	0.040
embryonic pattern specification	GO:0009880	174	0.040
establishment of localization in cell	GO:0051649	402	0.040
modification dependent macromolecule catabolic process	GO:0043632	79	0.039
regulation of immune response	GO:0050776	118	0.039
ribonucleotide catabolic process	GO:0009261	109	0.039
purine nucleotide catabolic process	GO:0006195	109	0.039
dorsal ventral pattern formation	GO:0009953	133	0.039
transcription from rna polymerase ii promoter	GO:0006366	368	0.039
respiratory system development	GO:0060541	213	0.038
cellular macromolecule localization	GO:0070727	220	0.038
camera type eye development	GO:0043010	4	0.038
cellular chemical homeostasis	GO:0055082	40	0.038
small gtpase mediated signal transduction	GO:0007264	88	0.037
cellular macromolecular complex assembly	GO:0034622	153	0.037
regulation of antimicrobial peptide production	GO:0002784	44	0.037
protein localization	GO:0008104	284	0.037
growth	GO:0040007	359	0.036
purine ribonucleoside metabolic process	GO:0046128	127	0.035
rna splicing	GO:0008380	83	0.035
regulation of cellular catabolic process	GO:0031329	157	0.034
aromatic compound catabolic process	GO:0019439	166	0.033
response to external biotic stimulus	GO:0043207	293	0.033
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.033
protein complex biogenesis	GO:0070271	201	0.033
embryonic axis specification	GO:0000578	107	0.032
golgi organization	GO:0007030	66	0.032
cellular homeostasis	GO:0019725	80	0.032
glycosyl compound metabolic process	GO:1901657	127	0.031
organonitrogen compound biosynthetic process	GO:1901566	117	0.031
gtp catabolic process	GO:0006184	72	0.031
organic substance catabolic process	GO:1901575	308	0.031
molting cycle	GO:0042303	56	0.031
heterocycle catabolic process	GO:0046700	166	0.030
regulation of cell division	GO:0051302	72	0.030
anterior posterior axis specification	GO:0009948	109	0.030
protein complex assembly	GO:0006461	200	0.030
actin filament based process	GO:0030029	220	0.029
organic substance transport	GO:0071702	257	0.029
organophosphate catabolic process	GO:0046434	112	0.029
nucleoside triphosphate metabolic process	GO:0009141	120	0.029
purine ribonucleoside catabolic process	GO:0046130	112	0.028
embryonic organ development	GO:0048568	50	0.028
gtp metabolic process	GO:0046039	72	0.028
membrane budding	GO:0006900	4	0.028
positive regulation of signaling	GO:0023056	243	0.028
endoplasmic reticulum organization	GO:0007029	13	0.028
modification dependent protein catabolic process	GO:0019941	78	0.028
regulation of intracellular signal transduction	GO:1902531	236	0.028
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.027
sensory perception	GO:0007600	196	0.027
larval development	GO:0002164	104	0.027
regulation of cell death	GO:0010941	173	0.027
nucleoside triphosphate catabolic process	GO:0009143	108	0.027
ribose phosphate metabolic process	GO:0019693	145	0.027
secretion	GO:0046903	109	0.027
regulation of phosphorus metabolic process	GO:0051174	210	0.027
axis specification	GO:0009798	167	0.027
positive regulation of catabolic process	GO:0009896	105	0.027
carbohydrate derivative catabolic process	GO:1901136	118	0.027
ubiquitin dependent protein catabolic process	GO:0006511	78	0.027
positive regulation of cellular biosynthetic process	GO:0031328	316	0.027
nucleobase containing compound catabolic process	GO:0034655	165	0.026
positive regulation of immune response	GO:0050778	63	0.026
apoptotic process	GO:0006915	159	0.026
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.026
organonitrogen compound catabolic process	GO:1901565	128	0.026
tissue morphogenesis	GO:0048729	297	0.025
defense response to other organism	GO:0098542	225	0.025
regulation of nucleotide metabolic process	GO:0006140	62	0.025
regulation of rna splicing	GO:0043484	69	0.025
digestive system development	GO:0055123	149	0.025
regulation of localization	GO:0032879	275	0.025
kidney epithelium development	GO:0072073	3	0.025
alternative mrna splicing via spliceosome	GO:0000380	60	0.025
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.024
regulation of protein metabolic process	GO:0051246	256	0.024
meiotic cytokinesis	GO:0033206	33	0.024
purine ribonucleotide metabolic process	GO:0009150	145	0.024
regulation of intracellular transport	GO:0032386	64	0.023
eye photoreceptor cell development	GO:0042462	81	0.023
protein modification process	GO:0036211	438	0.023
ribonucleoside metabolic process	GO:0009119	127	0.023
nucleotide catabolic process	GO:0009166	109	0.023
receptor mediated endocytosis	GO:0006898	21	0.023
cellular nitrogen compound catabolic process	GO:0044270	165	0.023
spindle organization	GO:0007051	253	0.022
positive regulation of phosphorylation	GO:0042327	87	0.022
membrane organization	GO:0061024	112	0.022
purine containing compound metabolic process	GO:0072521	155	0.022
immune system process	GO:0002376	347	0.022
glycosyl compound catabolic process	GO:1901658	112	0.022
negative regulation of cell cycle	GO:0045786	116	0.021
developmental growth	GO:0048589	280	0.021
positive regulation of multicellular organismal process	GO:0051240	143	0.021
tube morphogenesis	GO:0035239	191	0.021
guanosine containing compound metabolic process	GO:1901068	74	0.021
mrna processing	GO:0006397	104	0.021
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.021
salivary gland morphogenesis	GO:0007435	145	0.020
regulation of cellular component movement	GO:0051270	42	0.020
organic cyclic compound catabolic process	GO:1901361	168	0.020
ribonucleotide metabolic process	GO:0009259	145	0.020
germarium derived egg chamber formation	GO:0007293	101	0.020
mitotic cytokinesis	GO:0000281	50	0.020
purine containing compound catabolic process	GO:0072523	112	0.020
innate immune response	GO:0045087	144	0.020
mitotic spindle organization	GO:0007052	220	0.020
ion homeostasis	GO:0050801	55	0.019
organophosphate biosynthetic process	GO:0090407	46	0.019
nephron development	GO:0072006	3	0.019
regulation of anatomical structure morphogenesis	GO:0022603	242	0.019
positive regulation of rna metabolic process	GO:0051254	271	0.019
response to nitrogen compound	GO:1901698	90	0.019
meiotic cell cycle	GO:0051321	171	0.019
nucleoside catabolic process	GO:0009164	112	0.019
meiotic nuclear division	GO:0007126	151	0.019
cellular macromolecule catabolic process	GO:0044265	136	0.018
regulation of ras protein signal transduction	GO:0046578	93	0.018
endomembrane system organization	GO:0010256	119	0.018
regulation of growth	GO:0040008	233	0.018
response to biotic stimulus	GO:0009607	294	0.018
translational elongation	GO:0006414	4	0.018
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.018
regulation of cell cycle process	GO:0010564	181	0.018
cilium morphogenesis	GO:0060271	39	0.018
nucleoside metabolic process	GO:0009116	127	0.018
gland development	GO:0048732	191	0.018
negative regulation of cellular metabolic process	GO:0031324	382	0.018
regulation of immune effector process	GO:0002697	52	0.018
organelle localization	GO:0051640	148	0.018
metal ion homeostasis	GO:0055065	44	0.018
positive regulation of phosphorus metabolic process	GO:0010562	139	0.018
response to other organism	GO:0051707	293	0.018
immune effector process	GO:0002252	98	0.018
negative regulation of protein metabolic process	GO:0051248	85	0.017
regulation of cellular localization	GO:0060341	136	0.017
regulation of cellular component biogenesis	GO:0044087	201	0.017
single organism membrane budding	GO:1902591	2	0.017
retina development in camera type eye	GO:0060041	4	0.017
positive regulation of developmental process	GO:0051094	143	0.017
response to organonitrogen compound	GO:0010243	75	0.017
purine nucleoside catabolic process	GO:0006152	112	0.017
protein targeting	GO:0006605	64	0.017
cation homeostasis	GO:0055080	51	0.017
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.017
regulation of catabolic process	GO:0009894	170	0.017
production of molecular mediator of immune response	GO:0002440	46	0.017
multicellular organismal reproductive behavior	GO:0033057	110	0.017
macromolecule catabolic process	GO:0009057	161	0.017
translation	GO:0006412	69	0.016
appendage morphogenesis	GO:0035107	397	0.016
morphogenesis of follicular epithelium	GO:0016333	36	0.016
eye development	GO:0001654	323	0.016
photoreceptor cell development	GO:0042461	96	0.016
positive regulation of phosphate metabolic process	GO:0045937	139	0.016
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.016
regulation of immune system process	GO:0002682	176	0.016
anterior posterior pattern specification	GO:0009952	136	0.016
nephron epithelium development	GO:0072009	3	0.016
negative regulation of biosynthetic process	GO:0009890	277	0.016
notch signaling pathway	GO:0007219	120	0.016
ncrna metabolic process	GO:0034660	43	0.016
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.015
regulation of cell morphogenesis	GO:0022604	163	0.015
lipid storage	GO:0019915	38	0.015
response to oxygen containing compound	GO:1901700	200	0.015
positive regulation of gtp catabolic process	GO:0033126	43	0.015
protein secretion	GO:0009306	45	0.015
establishment of rna localization	GO:0051236	47	0.015
regulation of cellular protein metabolic process	GO:0032268	243	0.015
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.015
cognition	GO:0050890	141	0.015
protein ubiquitination	GO:0016567	70	0.015
multi multicellular organism process	GO:0044706	123	0.015
nephron morphogenesis	GO:0072028	3	0.015
dephosphorylation	GO:0016311	51	0.014
cellular protein modification process	GO:0006464	438	0.014
regulation of mrna metabolic process	GO:1903311	72	0.014
defense response	GO:0006952	300	0.014
nitrogen compound transport	GO:0071705	85	0.014
regulation of mitotic cell cycle	GO:0007346	190	0.014
photoreceptor cell differentiation	GO:0046530	170	0.014
protein localization to organelle	GO:0033365	82	0.014
ribonucleoside catabolic process	GO:0042454	112	0.014
rho protein signal transduction	GO:0007266	14	0.014
wing disc morphogenesis	GO:0007472	344	0.014
open tracheal system development	GO:0007424	204	0.014
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.014
centrosome organization	GO:0051297	163	0.014
regulation of cell cycle phase transition	GO:1901987	130	0.014
positive regulation of intracellular signal transduction	GO:1902533	116	0.014
regulation of mrna processing	GO:0050684	71	0.014
regulation of mrna splicing via spliceosome	GO:0048024	64	0.013
salivary gland development	GO:0007431	162	0.013
kidney development	GO:0001822	3	0.013
golgi vesicle transport	GO:0048193	27	0.013
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.013
columnar cuboidal epithelial cell development	GO:0002066	249	0.013
nucleobase containing small molecule metabolic process	GO:0055086	174	0.013
regulation of translation	GO:0006417	56	0.013
regulation of vesicle mediated transport	GO:0060627	59	0.013
circadian behavior	GO:0048512	76	0.013
proteasomal protein catabolic process	GO:0010498	59	0.013
ameboidal type cell migration	GO:0001667	151	0.013
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.013
axon development	GO:0061564	297	0.013
positive regulation of biosynthetic process	GO:0009891	316	0.013
mapk cascade	GO:0000165	107	0.013
regulation of hydrolase activity	GO:0051336	97	0.012
immune system development	GO:0002520	57	0.012
ncrna processing	GO:0034470	30	0.012
regulation of transport	GO:0051049	181	0.012
negative regulation of mitotic cell cycle	GO:0045930	109	0.012
cellular response to chemical stimulus	GO:0070887	199	0.012
cellular component assembly involved in morphogenesis	GO:0010927	151	0.012
cellular response to organonitrogen compound	GO:0071417	36	0.012
regulation of catalytic activity	GO:0050790	185	0.012
positive regulation of macromolecule metabolic process	GO:0010604	405	0.012
single organism catabolic process	GO:0044712	228	0.012
morphogenesis of a branching epithelium	GO:0061138	45	0.012
morphogenesis of an epithelium	GO:0002009	276	0.012
regulation of multicellular organismal development	GO:2000026	414	0.012
cellular response to endogenous stimulus	GO:0071495	80	0.012
exocrine system development	GO:0035272	162	0.012
regulation of molecular function	GO:0065009	217	0.012
hemopoiesis	GO:0030097	46	0.012
positive regulation of intracellular transport	GO:0032388	42	0.012
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.012
response to peptide hormone	GO:0043434	29	0.012
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.012
positive regulation of protein metabolic process	GO:0051247	128	0.012
imaginal disc pattern formation	GO:0007447	91	0.011
glycerophospholipid metabolic process	GO:0006650	23	0.011
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.011
intracellular mrna localization	GO:0008298	66	0.011
gland morphogenesis	GO:0022612	145	0.011
response to abiotic stimulus	GO:0009628	341	0.011
pole plasm mrna localization	GO:0019094	49	0.011
establishment of tissue polarity	GO:0007164	87	0.011
mesenchymal cell development	GO:0014031	1	0.011
protein targeting to nucleus	GO:0044744	51	0.011
regulation of hemocyte proliferation	GO:0035206	37	0.011
meiotic cell cycle process	GO:1903046	132	0.011
response to wounding	GO:0009611	94	0.011
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.011
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.011
molting cycle chitin based cuticle	GO:0007591	56	0.011
dna templated transcription elongation	GO:0006354	18	0.011
mrna metabolic process	GO:0016071	124	0.011
humoral immune response	GO:0006959	117	0.011
positive regulation of cell communication	GO:0010647	250	0.011
purine ribonucleotide catabolic process	GO:0009154	109	0.011
organonitrogen compound metabolic process	GO:1901564	318	0.011
chemical homeostasis	GO:0048878	92	0.010
positive regulation of nucleotide metabolic process	GO:0045981	55	0.010
pole plasm oskar mrna localization	GO:0045451	46	0.010
rna transport	GO:0050658	46	0.010
secretion by cell	GO:0032940	101	0.010
sensory perception of mechanical stimulus	GO:0050954	72	0.010
ovarian follicle cell development	GO:0030707	248	0.010
positive regulation of gene expression	GO:0010628	290	0.010
small molecule metabolic process	GO:0044281	305	0.010
mitotic cell cycle phase transition	GO:0044772	138	0.010
positive regulation of nucleoside metabolic process	GO:0045979	47	0.010
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.010
oocyte anterior posterior axis specification	GO:0007314	72	0.010

Bap disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
muscular disease	DOID:0080000	0.044
musculoskeletal system disease	DOID:17	0.044
disease of anatomical entity	DOID:7	0.044
muscle tissue disease	DOID:66	0.025
myopathy	DOID:423	0.025

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