IMP: Integrative Multi-species Prediction

Drosophila melanogaster

194 known processes

rdx (Dmel_CG12537)

roadkill

(Aliases: anon-WO0118547.577,CG9924,CG12537,Spop,Dromel_CG9924_FBtr0082871_rdx_mORF,hib,Rdx,CG10235,BEST:GM07940,Dmel_CG9924,D-SPOP,Dmel\CG12537)

FLYBASE: FBgn0086364
Entrez: 41704
UniProtKB: C7LAF6
UniProtKB: Q9VFP2

Process Predictions
Disease Predictions

rdx biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of protein metabolic process	GO:0051246	256	0.873
appendage morphogenesis	GO:0035107	397	0.748
negative regulation of gene expression	GO:0010629	387	0.659
regulation of cell differentiation	GO:0045595	302	0.644
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.619
positive regulation of response to stimulus	GO:0048584	323	0.595
circulatory system development	GO:0072359	82	0.577
growth	GO:0040007	359	0.562
negative regulation of biosynthetic process	GO:0009890	277	0.558
wing disc morphogenesis	GO:0007472	344	0.545
columnar cuboidal epithelial cell development	GO:0002066	249	0.491
compound eye development	GO:0048749	307	0.484
positive regulation of macromolecule metabolic process	GO:0010604	405	0.471
catabolic process	GO:0009056	409	0.457	Human
apoptotic process	GO:0006915	159	0.426
regulation of programmed cell death	GO:0043067	152	0.425
regulation of cell development	GO:0060284	215	0.422
cellular protein modification process	GO:0006464	438	0.411
regulation of cellular protein metabolic process	GO:0032268	243	0.406	Human
establishment of localization in cell	GO:0051649	402	0.392
chromosome organization	GO:0051276	360	0.342
nuclear division	GO:0000280	332	0.341
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.331
imaginal disc derived wing morphogenesis	GO:0007476	337	0.314
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.299
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.295
dendrite development	GO:0016358	204	0.284
organelle fission	GO:0048285	340	0.277
chromatin organization	GO:0006325	207	0.271
regulation of multicellular organismal development	GO:2000026	414	0.265
meiotic cell cycle process	GO:1903046	132	0.263
positive regulation of wnt signaling pathway	GO:0030177	25	0.262
negative regulation of rna biosynthetic process	GO:1902679	240	0.262
protein modification process	GO:0036211	438	0.258
positive regulation of signaling	GO:0023056	243	0.244
regulation of organelle organization	GO:0033043	196	0.241
post embryonic appendage morphogenesis	GO:0035120	385	0.238
cell proliferation	GO:0008283	299	0.227
appendage development	GO:0048736	401	0.210
memory	GO:0007613	94	0.209
chromosome condensation	GO:0030261	41	0.208
positive regulation of cell communication	GO:0010647	250	0.208
dendrite morphogenesis	GO:0048813	199	0.202
developmental growth	GO:0048589	280	0.190
regulation of wnt signaling pathway	GO:0030111	68	0.188
negative regulation of mitotic cell cycle	GO:0045930	109	0.182
establishment or maintenance of cell polarity	GO:0007163	167	0.175
regulation of mitotic cell cycle	GO:0007346	190	0.164
protein transport	GO:0015031	155	0.160
male gamete generation	GO:0048232	201	0.160
negative regulation of cell cycle phase transition	GO:1901988	103	0.157
single organism cellular localization	GO:1902580	180	0.156
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.154
organic substance catabolic process	GO:1901575	308	0.153	Human
eye morphogenesis	GO:0048592	260	0.153
regulation of cell cycle	GO:0051726	291	0.151
gliogenesis	GO:0042063	80	0.150
negative regulation of cell cycle	GO:0045786	116	0.149
compound eye morphogenesis	GO:0001745	249	0.148
histolysis	GO:0007559	102	0.147
regionalization	GO:0003002	416	0.147
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.146
sensory organ morphogenesis	GO:0090596	260	0.145
chromatin remodeling	GO:0006338	72	0.144
regulation of nervous system development	GO:0051960	248	0.138
positive regulation of transcription dna templated	GO:0045893	266	0.138
sister chromatid segregation	GO:0000819	92	0.134
tissue morphogenesis	GO:0048729	297	0.131
dephosphorylation	GO:0016311	51	0.129
regulation of cell cycle phase transition	GO:1901987	130	0.127
epithelial cell differentiation	GO:0030855	322	0.121
posttranscriptional regulation of gene expression	GO:0010608	145	0.120
regulation of neurogenesis	GO:0050767	158	0.120
regulation of transport	GO:0051049	181	0.119
regulation of cell cycle process	GO:0010564	181	0.118
programmed cell death	GO:0012501	257	0.118
positive regulation of signal transduction	GO:0009967	223	0.116
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.114
positive regulation of developmental process	GO:0051094	143	0.110
negative regulation of cellular biosynthetic process	GO:0031327	277	0.106
dna packaging	GO:0006323	91	0.103
locomotory behavior	GO:0007626	176	0.103
g2 dna damage checkpoint	GO:0031572	69	0.102
central nervous system development	GO:0007417	201	0.100
chromatin modification	GO:0016568	147	0.099
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.098
ovarian follicle cell development	GO:0030707	248	0.095
spermatogenesis	GO:0007283	200	0.094
positive regulation of cellular protein metabolic process	GO:0032270	118	0.091
mitotic dna integrity checkpoint	GO:0044774	75	0.090
response to organic substance	GO:0010033	284	0.089
neuronal stem cell division	GO:0036445	35	0.088
mitotic g2 m transition checkpoint	GO:0044818	70	0.087
chromosome segregation	GO:0007059	157	0.084
negative regulation of cellular metabolic process	GO:0031324	382	0.084	Human
macromolecular complex assembly	GO:0065003	256	0.084
tissue death	GO:0016271	102	0.082
exocrine system development	GO:0035272	162	0.082
positive regulation of multicellular organismal process	GO:0051240	143	0.081
dna damage checkpoint	GO:0000077	78	0.081
organic substance transport	GO:0071702	257	0.080
muscle structure development	GO:0061061	224	0.080
mitotic g2 dna damage checkpoint	GO:0007095	69	0.079
protein complex assembly	GO:0006461	200	0.075
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.074
cellular response to chemical stimulus	GO:0070887	199	0.073
intracellular signal transduction	GO:0035556	300	0.073
dna metabolic process	GO:0006259	227	0.072
cell cycle checkpoint	GO:0000075	95	0.072
endomembrane system organization	GO:0010256	119	0.071
cell junction assembly	GO:0034329	42	0.071
negative regulation of transcription dna templated	GO:0045892	237	0.071
multicellular organismal aging	GO:0010259	140	0.070
secretion	GO:0046903	109	0.068
epithelial cell development	GO:0002064	274	0.064
mitotic cell cycle checkpoint	GO:0007093	88	0.063
positive regulation of programmed cell death	GO:0043068	62	0.062
regulation of developmental growth	GO:0048638	174	0.060
embryo development ending in birth or egg hatching	GO:0009792	152	0.057
regulation of cell morphogenesis	GO:0022604	163	0.057
imaginal disc derived appendage development	GO:0048737	399	0.057
regulation of molecular function	GO:0065009	217	0.055
salivary gland development	GO:0007431	162	0.055
stem cell division	GO:0017145	69	0.055
cellular response to dna damage stimulus	GO:0006974	223	0.054
mitotic cell cycle phase transition	GO:0044772	138	0.052
mitotic nuclear division	GO:0007067	213	0.051
positive regulation of molecular function	GO:0044093	136	0.051
olfactory behavior	GO:0042048	97	0.051
wnt signaling pathway	GO:0016055	98	0.050
regulation of intracellular signal transduction	GO:1902531	236	0.048
positive regulation of cellular biosynthetic process	GO:0031328	316	0.048
microtubule organizing center organization	GO:0031023	168	0.048
translation	GO:0006412	69	0.045
rna interference	GO:0016246	27	0.044
eggshell formation	GO:0030703	105	0.044
cellular response to oxygen levels	GO:0071453	30	0.043
negative regulation of cell communication	GO:0010648	223	0.043
eye development	GO:0001654	323	0.042
salivary gland cell autophagic cell death	GO:0035071	83	0.042
histone h4 acetylation	GO:0043967	13	0.042
positive regulation of rna metabolic process	GO:0051254	271	0.041
dna integrity checkpoint	GO:0031570	81	0.041
transcription from rna polymerase ii promoter	GO:0006366	368	0.041
positive regulation of phosphorus metabolic process	GO:0010562	139	0.041
long term memory	GO:0007616	62	0.040
centrosome organization	GO:0051297	163	0.040
regulation of dendrite morphogenesis	GO:0048814	28	0.040
negative regulation of cell cycle process	GO:0010948	109	0.040
positive regulation of catalytic activity	GO:0043085	118	0.040
positive regulation of protein metabolic process	GO:0051247	128	0.040
morphogenesis of follicular epithelium	GO:0016333	36	0.040
endocytosis	GO:0006897	310	0.039
spermatid differentiation	GO:0048515	114	0.038
imaginal disc fusion	GO:0046528	19	0.037
notch signaling pathway	GO:0007219	120	0.036
head development	GO:0060322	135	0.036
heterocycle catabolic process	GO:0046700	166	0.036
rna splicing	GO:0008380	83	0.036
negative regulation of cell proliferation	GO:0008285	69	0.036
single organism catabolic process	GO:0044712	228	0.035
syncytial blastoderm mitotic cell cycle	GO:0035186	21	0.035
rna localization	GO:0006403	115	0.035
rhythmic process	GO:0048511	106	0.035
apposition of dorsal and ventral imaginal disc derived wing surfaces	GO:0007475	15	0.035
positive regulation of phosphate metabolic process	GO:0045937	139	0.034
regulation of cell proliferation	GO:0042127	163	0.034
negative regulation of organelle organization	GO:0010639	56	0.034
cellular macromolecule catabolic process	GO:0044265	136	0.033	Human
cytokinesis	GO:0000910	90	0.033
vesicle mediated transport	GO:0016192	381	0.032
regulation of translation	GO:0006417	56	0.032
regulation of rna splicing	GO:0043484	69	0.032
muscle organ development	GO:0007517	127	0.032
secretion by cell	GO:0032940	101	0.032
regulation of transferase activity	GO:0051338	58	0.032
meiotic nuclear division	GO:0007126	151	0.031
stem cell development	GO:0048864	79	0.031
aromatic compound catabolic process	GO:0019439	166	0.031
gland development	GO:0048732	191	0.031
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.031
humoral immune response	GO:0006959	117	0.030
negative regulation of translation	GO:0017148	28	0.030
photoreceptor cell differentiation	GO:0046530	170	0.030
intercellular bridge organization	GO:0043063	14	0.030
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.029
forebrain development	GO:0030900	2	0.029
cell division	GO:0051301	248	0.028
autophagic cell death	GO:0048102	83	0.028
small molecule metabolic process	GO:0044281	305	0.028
posttranscriptional gene silencing by rna	GO:0035194	45	0.028
cell cycle phase transition	GO:0044770	140	0.028
positive regulation of growth	GO:0045927	75	0.028
death	GO:0016265	284	0.027
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.026
regulation of malpighian tubule diameter	GO:0035297	3	0.026
mitotic sister chromatid segregation	GO:0000070	87	0.025
mitotic dna damage checkpoint	GO:0044773	74	0.025
generation of precursor metabolites and energy	GO:0006091	42	0.025
regulation of dendrite development	GO:0050773	37	0.025
cellular catabolic process	GO:0044248	372	0.024	Human
regulation of actin cytoskeleton organization	GO:0032956	42	0.024
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.024
positive regulation of cell death	GO:0010942	69	0.024
regulation of neuron differentiation	GO:0045664	103	0.023
mrna processing	GO:0006397	104	0.023
protein phosphorylation	GO:0006468	169	0.023
positive regulation of nervous system development	GO:0051962	69	0.022
regulation of defense response	GO:0031347	102	0.022
cognition	GO:0050890	141	0.022
golgi organization	GO:0007030	66	0.021
regulation of proteolysis	GO:0030162	87	0.021
mitotic cell cycle embryonic	GO:0045448	38	0.021
mrna metabolic process	GO:0016071	124	0.021
nuclear transport	GO:0051169	72	0.021
germline ring canal formation	GO:0030725	13	0.021
cell death	GO:0008219	279	0.021
developmental maturation	GO:0021700	172	0.021
regulation of catalytic activity	GO:0050790	185	0.020
negative regulation of rna metabolic process	GO:0051253	251	0.020
chemosensory behavior	GO:0007635	106	0.020
protein localization	GO:0008104	284	0.020
brain development	GO:0007420	120	0.020
organic acid metabolic process	GO:0006082	103	0.020
positive regulation of cell development	GO:0010720	61	0.020
chromosome separation	GO:0051304	42	0.019
regulation of synapse structure and activity	GO:0050803	128	0.019
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.019
heart development	GO:0007507	82	0.019
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.018
mitotic spindle organization	GO:0007052	220	0.018
spermatid development	GO:0007286	98	0.018
chitin based cuticle development	GO:0040003	49	0.018
protein complex biogenesis	GO:0070271	201	0.018
antimicrobial humoral response	GO:0019730	99	0.018
cardiovascular system development	GO:0072358	82	0.017
developmental programmed cell death	GO:0010623	138	0.017
nucleus localization	GO:0051647	34	0.017
cellular nitrogen compound catabolic process	GO:0044270	165	0.017
extrinsic apoptotic signaling pathway	GO:0097191	1	0.017
nucleotide catabolic process	GO:0009166	109	0.017
positive regulation of developmental growth	GO:0048639	62	0.016
signal release	GO:0023061	49	0.016
neuroblast division	GO:0055057	35	0.016
immune response	GO:0006955	246	0.016
regulation of cell size	GO:0008361	63	0.016
oocyte maturation	GO:0001556	3	0.016
meiotic chromosome segregation	GO:0045132	59	0.016
negative regulation of developmental process	GO:0051093	201	0.015
regulation of phosphorus metabolic process	GO:0051174	210	0.015
macromolecule catabolic process	GO:0009057	161	0.015	Human
regulation of cellular localization	GO:0060341	136	0.015
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.015
sex differentiation	GO:0007548	81	0.015
positive regulation of transport	GO:0051050	92	0.015
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.015
single organism behavior	GO:0044708	391	0.015
nucleocytoplasmic transport	GO:0006913	72	0.015
instar larval development	GO:0002168	55	0.014
positive regulation of neurogenesis	GO:0050769	41	0.014
segmentation	GO:0035282	207	0.014
purine nucleotide catabolic process	GO:0006195	109	0.014
oocyte development	GO:0048599	124	0.014
salivary gland histolysis	GO:0035070	88	0.014
regulation of meiosis	GO:0040020	3	0.014
organ growth	GO:0035265	56	0.014
larval development	GO:0002164	104	0.013
positive regulation of protein kinase activity	GO:0045860	25	0.013
regulation of protein modification process	GO:0031399	112	0.013	Human
oocyte differentiation	GO:0009994	145	0.013
phagocytosis	GO:0006909	215	0.013
positive regulation of transferase activity	GO:0051347	26	0.013
rna catabolic process	GO:0006401	37	0.013
regulation of cytoskeleton organization	GO:0051493	89	0.013
positive regulation of gene expression	GO:0010628	290	0.013
positive regulation of catabolic process	GO:0009896	105	0.013
regulation of hydrolase activity	GO:0051336	97	0.012
positive regulation of cell cycle process	GO:0090068	28	0.012
cellular macromolecule localization	GO:0070727	220	0.012
carbohydrate metabolic process	GO:0005975	82	0.012
regulation of muscle organ development	GO:0048634	13	0.012
cuticle development	GO:0042335	86	0.012
respiratory system development	GO:0060541	213	0.012
immune system process	GO:0002376	347	0.012
posttranscriptional gene silencing	GO:0016441	46	0.012
aging	GO:0007568	143	0.012
positive regulation of r7 cell differentiation	GO:0045678	7	0.012
rhythmic behavior	GO:0007622	76	0.012
chaeta development	GO:0022416	97	0.012
negative regulation of cell differentiation	GO:0045596	143	0.011
negative regulation of neuron apoptotic process	GO:0043524	14	0.011
receptor clustering	GO:0043113	3	0.011
covalent chromatin modification	GO:0016569	106	0.011
cytoskeleton dependent cytokinesis	GO:0061640	81	0.011
positive regulation of protein modification process	GO:0031401	58	0.011
mrna splicing via spliceosome	GO:0000398	73	0.011
regulation of mrna splicing via spliceosome	GO:0048024	64	0.011
actin filament organization	GO:0007015	126	0.011
histone h3 acetylation	GO:0043966	11	0.011
blastoderm segmentation	GO:0007350	159	0.011
regulation of eye photoreceptor cell development	GO:0042478	13	0.011
regulation of immune response	GO:0050776	118	0.011
response to oxidative stress	GO:0006979	86	0.011
muscle tissue development	GO:0060537	30	0.011
positive regulation of immune response	GO:0050778	63	0.011
morphogenesis of an epithelium	GO:0002009	276	0.010
regulation of protein localization	GO:0032880	76	0.010
negative regulation of organ growth	GO:0046621	15	0.010
cellular component assembly involved in morphogenesis	GO:0010927	151	0.010
regulation of kinase activity	GO:0043549	53	0.010
regulation of cytoplasmic transport	GO:1903649	47	0.010
regulation of sister chromatid segregation	GO:0033045	28	0.010
negative regulation of intracellular signal transduction	GO:1902532	57	0.010
neuroblast proliferation	GO:0007405	74	0.010
body morphogenesis	GO:0010171	2	0.010
synaptic transmission	GO:0007268	288	0.010
regulation of cell shape	GO:0008360	113	0.010

rdx disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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