IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

HLHm3 (Dmel_CG8346)

E(spl) region transcript m3

(Aliases: CG8346,E(spl)M3,E(spl)-m3,Dmel\CG8346,E(spl)C,E(spl)C m3,E(spl)m3/m4,E(Spl)-HLH-m3,HLH-m3,bHLHc14,E(spl)m3,m3,HLHM3)

Entrez: 43156
FLYBASE: FBgn0002609
UniProtKB: Q01068

Process Predictions
Disease Predictions

HLHm3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
neuron fate determination	GO:0048664	1	0.954	Mouse
r7 cell differentiation	GO:0045466	43	0.954	Fly
neuronal stem cell maintenance	GO:0097150	4	0.787	Human Mouse Rat
sex determination	GO:0007530	18	0.734	Fly
nephron epithelium morphogenesis	GO:0072088	3	0.722	Mouse
nephron epithelium development	GO:0072009	3	0.705	Mouse
regulation of cell differentiation	GO:0045595	302	0.650	Human Zebrafish Mouse Rat Fly
nephron morphogenesis	GO:0072028	3	0.631	Mouse
dosage compensation	GO:0007549	16	0.613	Fly
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.604	Zebrafish Mouse Rat Fly
sensory organ precursor cell fate determination	GO:0016360	19	0.604	Fly
embryonic morphogenesis	GO:0048598	206	0.588	Zebrafish Mouse
kidney epithelium development	GO:0072073	3	0.569	Mouse
open tracheal system development	GO:0007424	204	0.568	Fly
nephron development	GO:0072006	3	0.557	Mouse
larval behavior	GO:0030537	42	0.553	Fly
regulation of glial cell differentiation	GO:0045685	1	0.534	Mouse
glial cell fate commitment	GO:0021781	3	0.528	Mouse
nephron tubule development	GO:0072080	3	0.528	Mouse
axon ensheathment in central nervous system	GO:0032291	3	0.502	Mouse
sensory organ morphogenesis	GO:0090596	260	0.492	Fly
positive regulation of bmp signaling pathway	GO:0030513	5	0.484	Mouse
adult locomotory behavior	GO:0008344	76	0.477	Fly
tyrosine phosphorylation of stat protein	GO:0007260	1	0.467	Mouse
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.458	Zebrafish Mouse Rat Fly
sensory organ boundary specification	GO:0008052	22	0.457	Fly
tube morphogenesis	GO:0035239	191	0.456	Mouse Fly
regulation of cell development	GO:0060284	215	0.451	Zebrafish Mouse Rat Fly
kidney morphogenesis	GO:0060993	3	0.439	Mouse
cell fate determination involved in pattern specification	GO:0060582	19	0.436	Fly
stem cell proliferation	GO:0072089	88	0.430	Fly
anterior posterior pattern specification	GO:0009952	136	0.419	Zebrafish Mouse Worm
stem cell maintenance	GO:0019827	67	0.418	Human Mouse Rat
respiratory system development	GO:0060541	213	0.412	Fly
regulation of neuroblast proliferation	GO:1902692	34	0.411	Fly
embryonic epithelial tube formation	GO:0001838	6	0.408	Mouse
regulation of gene expression epigenetic	GO:0040029	128	0.396	Fly
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.394	Mouse
connective tissue development	GO:0061448	3	0.394	Human Mouse
nephron tubule morphogenesis	GO:0072078	3	0.390	Mouse
kidney development	GO:0001822	3	0.390	Mouse
nerve development	GO:0021675	6	0.368	Mouse
telencephalon development	GO:0021537	2	0.363	Mouse
eye morphogenesis	GO:0048592	260	0.350	Fly
formation of organ boundary	GO:0010160	30	0.345	Fly
nuclear division	GO:0000280	332	0.336	Fly
compound eye development	GO:0048749	307	0.331	Fly
tube formation	GO:0035148	21	0.331	Mouse
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.325	Zebrafish Mouse Rat Fly
gliogenesis	GO:0042063	80	0.325	Zebrafish Mouse Rat
r1 r6 cell differentiation	GO:0048052	4	0.322	Fly
camera type eye development	GO:0043010	4	0.318	Mouse
regulation of intracellular signal transduction	GO:1902531	236	0.316	Mouse
notch signaling pathway	GO:0007219	120	0.313	Human Zebrafish Mouse Fly
regulation of nervous system development	GO:0051960	248	0.309	Zebrafish Mouse Rat Fly
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.307	Mouse
positive regulation of transcription dna templated	GO:0045893	266	0.300	Mouse
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.300	Zebrafish Mouse Rat Fly
negative regulation of developmental process	GO:0051093	201	0.296	Human Zebrafish Mouse Rat
positive regulation of cellular amine metabolic process	GO:0033240	0	0.296
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.292	Zebrafish Mouse Rat Fly
negative regulation of stem cell differentiation	GO:2000737	8	0.291	Human
small molecule metabolic process	GO:0044281	305	0.290
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.284	Mouse
regulation of timing of cell differentiation	GO:0048505	1	0.282	Mouse
compound eye morphogenesis	GO:0001745	249	0.282	Fly
positive regulation of macromolecule metabolic process	GO:0010604	405	0.277	Zebrafish Mouse
positive regulation of rna metabolic process	GO:0051254	271	0.277	Mouse
sex determination establishment of x a ratio	GO:0007540	1	0.275	Fly
neuron fate commitment	GO:0048663	50	0.274	Mouse
regulation of neurogenesis	GO:0050767	158	0.269	Zebrafish Mouse Rat Fly
transcription from rna polymerase ii promoter	GO:0006366	368	0.269	Mouse Rat Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.269	Mouse Rat Fly
bmp signaling pathway	GO:0030509	27	0.268	Mouse
negative regulation of rna metabolic process	GO:0051253	251	0.266	Zebrafish Mouse Rat Fly
tube development	GO:0035295	244	0.264	Zebrafish Mouse Fly
imaginal disc pattern formation	GO:0007447	91	0.263	Fly
regulation of organelle organization	GO:0033043	196	0.260	Fly
hindbrain development	GO:0030902	2	0.260	Mouse
primary sex determination soma	GO:0007539	2	0.259	Fly
eye development	GO:0001654	323	0.258	Zebrafish Mouse Fly
single organism behavior	GO:0044708	391	0.253	Fly
rhythmic process	GO:0048511	106	0.248	Mouse
peripheral nervous system development	GO:0007422	52	0.248	Zebrafish
regulation of response to dna damage stimulus	GO:2001020	23	0.245	Fly
nephron tubule formation	GO:0072079	3	0.241	Mouse
negative regulation of cellular metabolic process	GO:0031324	382	0.240	Zebrafish Mouse Rat Fly
morphogenesis of an epithelium	GO:0002009	276	0.240	Mouse
adult behavior	GO:0030534	137	0.238	Fly
regulation of multicellular organismal development	GO:2000026	414	0.235	Zebrafish Mouse Rat Fly
negative regulation of rna biosynthetic process	GO:1902679	240	0.234	Zebrafish Mouse Rat Fly
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	9	0.229	Mouse
regulation of mitosis	GO:0007088	56	0.222	Fly
neuroblast proliferation	GO:0007405	74	0.220	Fly
positive regulation of molecular function	GO:0044093	136	0.215	Zebrafish
negative regulation of cell development	GO:0010721	62	0.215	Zebrafish Mouse Rat
regulation of tyrosine phosphorylation of stat protein	GO:0042509	1	0.214	Mouse
hair cell differentiation	GO:0035315	47	0.214	Mouse
somatic sex determination	GO:0018993	2	0.213	Fly
jak stat cascade	GO:0007259	49	0.212	Mouse
lateral inhibition	GO:0046331	206	0.211
positive regulation of rna biosynthetic process	GO:1902680	266	0.211	Mouse
locomotory behavior	GO:0007626	176	0.210	Fly
photoreceptor cell differentiation	GO:0046530	170	0.209	Fly
forebrain development	GO:0030900	2	0.209	Mouse Rat
positive regulation of signaling	GO:0023056	243	0.208	Mouse
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.207	Zebrafish
cell fate specification	GO:0001708	71	0.204	Worm
tissue morphogenesis	GO:0048729	297	0.202	Mouse
dendrite development	GO:0016358	204	0.201	Fly
epidermis development	GO:0008544	65	0.200	Mouse Worm
formation of anatomical boundary	GO:0048859	37	0.200	Fly
regulation of cellular amino acid metabolic process	GO:0006521	0	0.198
neural precursor cell proliferation	GO:0061351	75	0.197	Fly
organ formation	GO:0048645	39	0.195	Fly
segmentation	GO:0035282	207	0.194	Zebrafish Mouse
epithelial tube morphogenesis	GO:0060562	88	0.192	Mouse
head development	GO:0060322	135	0.189	Zebrafish Mouse Rat Fly
axonogenesis	GO:0007409	290	0.189	Zebrafish
positive regulation of developmental process	GO:0051094	143	0.189	Fly
dorsal ventral pattern formation	GO:0009953	133	0.186	Fly
intracellular signal transduction	GO:0035556	300	0.186	Mouse
epithelial tube formation	GO:0072175	7	0.183	Mouse
larval locomotory behavior	GO:0008345	27	0.181	Fly
hematopoietic progenitor cell differentiation	GO:0002244	1	0.181	Rat
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.180
morphogenesis of embryonic epithelium	GO:0016331	94	0.180	Mouse
cellular amine metabolic process	GO:0044106	12	0.178
regulation of cellular amine metabolic process	GO:0033238	3	0.176
epidermal cell differentiation	GO:0009913	51	0.176	Mouse Worm
eye photoreceptor cell differentiation	GO:0001754	145	0.175	Fly
peptidyl tyrosine phosphorylation	GO:0018108	24	0.174	Mouse
proximal distal pattern formation	GO:0009954	15	0.174	Mouse
gland development	GO:0048732	191	0.173	Fly
cellular response to dna damage stimulus	GO:0006974	223	0.172	Fly
regulation of cell proliferation	GO:0042127	163	0.172	Human Fly
positive regulation of phosphate metabolic process	GO:0045937	139	0.170	Zebrafish Mouse
embryonic organ development	GO:0048568	50	0.169	Zebrafish
startle response	GO:0001964	16	0.168	Fly
regulation of cellular ketone metabolic process	GO:0010565	3	0.167
regulation of bmp signaling pathway	GO:0030510	23	0.166	Mouse
regulation of neuron differentiation	GO:0045664	103	0.166	Mouse Rat
compound eye photoreceptor cell differentiation	GO:0001751	140	0.165	Fly
mitotic nuclear division	GO:0007067	213	0.164	Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.158	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	316	0.156	Mouse
segment specification	GO:0007379	33	0.156	Zebrafish Mouse
transmission of nerve impulse	GO:0019226	12	0.155	Mouse
negative regulation of cell differentiation	GO:0045596	143	0.154	Human Zebrafish Mouse Rat
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.154	Mouse
organelle fission	GO:0048285	340	0.153	Fly
regulation of peptidyl tyrosine phosphorylation	GO:0050730	10	0.153	Mouse
salivary gland development	GO:0007431	162	0.151	Fly
regionalization	GO:0003002	416	0.150	Zebrafish Mouse Worm Fly
regulation of gliogenesis	GO:0014013	11	0.149	Mouse
negative regulation of immune system process	GO:0002683	50	0.148	Rat
regulation of stem cell proliferation	GO:0072091	40	0.146	Fly
negative regulation of neurogenesis	GO:0050768	53	0.146	Zebrafish Mouse Rat
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.143	Fly
negative regulation of cellular biosynthetic process	GO:0031327	277	0.143	Zebrafish Mouse Rat Fly
carboxylic acid metabolic process	GO:0019752	92	0.143
gland morphogenesis	GO:0022612	145	0.142	Fly
cell fate determination	GO:0001709	91	0.140	Mouse Fly
positive regulation of cellular component organization	GO:0051130	156	0.139	Fly
regulation of hematopoietic progenitor cell differentiation	GO:1901532	1	0.139	Rat
cranial nerve development	GO:0021545	1	0.139	Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.138	Mouse Rat Fly
dendrite morphogenesis	GO:0048813	199	0.137	Fly
negative regulation of gliogenesis	GO:0014014	6	0.133	Mouse
regulation of stem cell differentiation	GO:2000736	14	0.130	Human
negative regulation of gene expression	GO:0010629	387	0.130	Zebrafish Mouse Rat Worm Fly
regulation of transferase activity	GO:0051338	58	0.130	Zebrafish
stem cell differentiation	GO:0048863	117	0.128	Human Mouse Rat
immune system development	GO:0002520	57	0.128	Rat
positive regulation of intracellular signal transduction	GO:1902533	116	0.127	Mouse
wing disc pattern formation	GO:0035222	66	0.126	Fly
organic acid metabolic process	GO:0006082	103	0.124
regulation of notch signaling pathway	GO:0008593	100	0.124	Mouse
response to hypoxia	GO:0001666	53	0.123	Fly
neuronal action potential	GO:0019228	10	0.122	Mouse
salivary gland morphogenesis	GO:0007435	145	0.121	Fly
mesoderm development	GO:0007498	78	0.121	Fly
protein complex biogenesis	GO:0070271	201	0.120	Mouse
cellular ketone metabolic process	GO:0042180	24	0.119
renal tubule development	GO:0061326	64	0.119	Mouse
hemopoiesis	GO:0030097	46	0.117	Rat
positive regulation of gene expression	GO:0010628	290	0.117	Mouse
positive regulation of signal transduction	GO:0009967	223	0.117	Mouse
positive regulation of biosynthetic process	GO:0009891	316	0.116	Mouse
response to abiotic stimulus	GO:0009628	341	0.116	Fly
cell proliferation	GO:0008283	299	0.115	Human Fly
protein modification process	GO:0036211	438	0.115	Zebrafish Mouse
regulation of response to stress	GO:0080134	200	0.114	Fly
negative regulation of nervous system development	GO:0051961	92	0.114	Zebrafish Mouse Rat
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.114
regulation of catalytic activity	GO:0050790	185	0.112	Zebrafish
neurological system process	GO:0050877	358	0.112	Mouse Fly
regulation of molecular function	GO:0065009	217	0.112	Zebrafish
positive regulation of cell differentiation	GO:0045597	64	0.111	Fly
positive regulation of cell communication	GO:0010647	250	0.110	Mouse
positive regulation of multicellular organismal process	GO:0051240	143	0.110	Fly
central nervous system development	GO:0007417	201	0.110	Zebrafish Mouse Rat Fly
negative regulation of multicellular organismal process	GO:0051241	142	0.109	Zebrafish Mouse Rat
immune system process	GO:0002376	347	0.109	Rat
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.108	Mouse
axon development	GO:0061564	297	0.107	Zebrafish
regulation of phosphate metabolic process	GO:0019220	210	0.107	Zebrafish Mouse
cellular protein modification process	GO:0006464	438	0.106	Zebrafish Mouse
peripheral nervous system neuron development	GO:0048935	8	0.106	Zebrafish
peptidyl tyrosine modification	GO:0018212	24	0.105	Mouse
cell division	GO:0051301	248	0.103	Fly
regulation of mitotic cell cycle	GO:0007346	190	0.103	Fly
protein complex assembly	GO:0006461	200	0.102	Mouse
neuromuscular process	GO:0050905	21	0.100	Fly
positive regulation of cellular protein metabolic process	GO:0032270	118	0.100	Zebrafish Mouse
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.098	Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.098	Mouse
response to decreased oxygen levels	GO:0036293	58	0.098	Fly
oxoacid metabolic process	GO:0043436	103	0.096
regulation of cellular response to stress	GO:0080135	89	0.096	Fly
regulation of nuclear division	GO:0051783	58	0.094	Fly
macromolecular complex assembly	GO:0065003	256	0.089	Mouse
axon ensheathment	GO:0008366	10	0.085	Mouse
positive regulation of neural precursor cell proliferation	GO:2000179	8	0.084	Fly
regulation of cell cycle process	GO:0010564	181	0.084	Fly
organonitrogen compound metabolic process	GO:1901564	318	0.083
stem cell development	GO:0048864	79	0.083	Human Mouse Rat
positive regulation of cell proliferation	GO:0008284	47	0.083	Human Fly
smoothened signaling pathway	GO:0007224	49	0.083	Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.080	Mouse
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.079	Zebrafish
negative regulation of transcription dna templated	GO:0045892	237	0.079	Zebrafish Mouse Rat Fly
peripheral nervous system neuron differentiation	GO:0048934	8	0.078	Zebrafish
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.077
positive regulation of phosphorus metabolic process	GO:0010562	139	0.076	Zebrafish Mouse
positive regulation of catalytic activity	GO:0043085	118	0.076	Zebrafish
regulation of protein kinase activity	GO:0045859	51	0.073	Zebrafish
positive regulation of response to stimulus	GO:0048584	323	0.073	Mouse
cell maturation	GO:0048469	144	0.073	Mouse
protein phosphorylation	GO:0006468	169	0.072	Zebrafish Mouse
developmental maturation	GO:0021700	172	0.072	Mouse
negative regulation of biosynthetic process	GO:0009890	277	0.071	Zebrafish Mouse Rat Fly
exocrine system development	GO:0035272	162	0.071	Fly
positive regulation of mitotic cell cycle	GO:0045931	34	0.070	Fly
regulation of cell cycle	GO:0051726	291	0.070	Zebrafish Fly
positive regulation of neurogenesis	GO:0050769	41	0.069	Fly
cell adhesion	GO:0007155	136	0.069	Mouse
glial cell differentiation	GO:0010001	35	0.069	Mouse Rat
cell fate commitment involved in pattern specification	GO:0060581	31	0.067	Fly
regulation of cell division	GO:0051302	72	0.067	Fly
renal tubule morphogenesis	GO:0061333	44	0.065	Mouse
positive regulation of notch signaling pathway	GO:0045747	34	0.065	Mouse
multicellular organismal signaling	GO:0035637	12	0.064	Mouse
urogenital system development	GO:0001655	72	0.064	Mouse
regulation of neural precursor cell proliferation	GO:2000177	35	0.064	Fly
glial cell development	GO:0021782	27	0.064	Mouse
humoral immune response	GO:0006959	117	0.064
neuron projection guidance	GO:0097485	241	0.064
skin development	GO:0043588	65	0.063	Mouse Worm
spinal cord development	GO:0021510	1	0.063
brain development	GO:0007420	120	0.059	Zebrafish Mouse Rat Fly
cellular amino acid metabolic process	GO:0006520	61	0.059
biological adhesion	GO:0022610	138	0.059	Mouse
positive regulation of cell development	GO:0010720	61	0.059	Fly
regulation of anatomical structure size	GO:0090066	163	0.056
positive regulation of nervous system development	GO:0051962	69	0.056	Fly
hematopoietic or lymphoid organ development	GO:0048534	57	0.056	Rat
peptidyl amino acid modification	GO:0018193	105	0.055	Mouse
regulation of membrane potential	GO:0042391	35	0.055	Mouse
action potential	GO:0001508	13	0.055	Mouse
phosphorylation	GO:0016310	294	0.054	Zebrafish Mouse
ensheathment of neurons	GO:0007272	10	0.050	Mouse
amine metabolic process	GO:0009308	12	0.047
epithelial cell differentiation	GO:0030855	322	0.047	Mouse Worm
positive regulation of cell cycle process	GO:0090068	28	0.047	Fly
response to oxygen levels	GO:0070482	59	0.045	Fly
positive regulation of protein phosphorylation	GO:0001934	34	0.044	Zebrafish Mouse
glandular epithelial cell differentiation	GO:0002067	1	0.044
regulation of protein serine threonine kinase activity	GO:0071900	25	0.044	Zebrafish
digestive tract morphogenesis	GO:0048546	127	0.043
brain morphogenesis	GO:0048854	16	0.042	Fly
negative regulation of cell cycle process	GO:0010948	109	0.041
positive regulation of protein kinase activity	GO:0045860	25	0.041	Zebrafish
regulation of protein metabolic process	GO:0051246	256	0.040	Zebrafish Mouse
wing disc dorsal ventral pattern formation	GO:0048190	47	0.040	Fly
neuron fate specification	GO:0048665	12	0.039
embryonic organ morphogenesis	GO:0048562	5	0.039	Zebrafish
positive regulation of protein metabolic process	GO:0051247	128	0.039	Zebrafish Mouse
appendage development	GO:0048736	401	0.038
regulation of protein phosphorylation	GO:0001932	64	0.037	Zebrafish Mouse
regulation of phosphorylation	GO:0042325	147	0.036	Zebrafish Mouse
positive regulation of phosphorylation	GO:0042327	87	0.036	Zebrafish Mouse
positive regulation of neuroblast proliferation	GO:0002052	7	0.035	Fly
regulation of immune system process	GO:0002682	176	0.035	Rat
cell death	GO:0008219	279	0.034
regulation of cell death	GO:0010941	173	0.034
regulation of neuron projection development	GO:0010975	69	0.034
glial cell proliferation	GO:0014009	13	0.034
regulation of epithelial cell differentiation	GO:0030856	4	0.034
imaginal disc derived appendage development	GO:0048737	399	0.034
anterior posterior axis specification	GO:0009948	109	0.033
muscle structure development	GO:0061061	224	0.033
central nervous system neuron differentiation	GO:0021953	8	0.033	Rat
regulation of phosphorus metabolic process	GO:0051174	210	0.033	Zebrafish Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.033
positive regulation of organelle organization	GO:0010638	65	0.032	Fly
positive regulation of stem cell proliferation	GO:2000648	8	0.032	Fly
neuroblast fate specification	GO:0014018	2	0.032
positive regulation of protein modification process	GO:0031401	58	0.031	Zebrafish Mouse
regulation of protein modification process	GO:0031399	112	0.031	Zebrafish Mouse
regulation of cell morphogenesis	GO:0022604	163	0.030
single organism cellular localization	GO:1902580	180	0.030
endoderm development	GO:0007492	6	0.030	Zebrafish
regulation of reproductive process	GO:2000241	54	0.029
negative regulation of neuron differentiation	GO:0045665	16	0.028	Mouse Rat
immune response	GO:0006955	246	0.028
regulation of cellular protein metabolic process	GO:0032268	243	0.028	Zebrafish Mouse
establishment of localization in cell	GO:0051649	402	0.027
negative regulation of notch signaling pathway	GO:0045746	41	0.027
regulation of kinase activity	GO:0043549	53	0.027	Zebrafish
developmental cell growth	GO:0048588	52	0.027
organelle localization	GO:0051640	148	0.027
spinal cord patterning	GO:0021511	1	0.026
stem cell fate determination	GO:0048867	15	0.026
macromolecule catabolic process	GO:0009057	161	0.026
taxis	GO:0042330	304	0.025
negative regulation of cell communication	GO:0010648	223	0.025
positive regulation of kinase activity	GO:0033674	25	0.025	Zebrafish
renal system development	GO:0072001	72	0.025	Mouse
axon guidance	GO:0007411	233	0.024
regulation of glial cell proliferation	GO:0060251	11	0.023
death	GO:0016265	284	0.023
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.023
apoptotic process involved in morphogenesis	GO:0060561	3	0.023
negative regulation of glial cell proliferation	GO:0060253	6	0.023
negative regulation of response to stimulus	GO:0048585	258	0.022
regulation of antimicrobial peptide production	GO:0002784	44	0.022
stem cell fate specification	GO:0048866	2	0.021
negative regulation of cell cycle	GO:0045786	116	0.021
wing disc morphogenesis	GO:0007472	344	0.021
positive regulation of transferase activity	GO:0051347	26	0.021	Zebrafish
spinal cord dorsal ventral patterning	GO:0021513	1	0.020
stem cell fate commitment	GO:0048865	25	0.020
response to lipopolysaccharide	GO:0032496	4	0.020
carbohydrate derivative metabolic process	GO:1901135	217	0.020
cellular catabolic process	GO:0044248	372	0.020
programmed cell death	GO:0012501	257	0.020
regulation of multi organism process	GO:0043900	131	0.020
body morphogenesis	GO:0010171	2	0.020
single organism biosynthetic process	GO:0044711	206	0.019
camera type eye morphogenesis	GO:0048593	2	0.019
digestive system development	GO:0055123	149	0.019
organic substance transport	GO:0071702	257	0.019
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.019
defense response to other organism	GO:0098542	225	0.018
neuroblast fate commitment	GO:0014017	19	0.018
cell migration	GO:0016477	238	0.018
epithelial cell development	GO:0002064	274	0.018
anterior posterior axis specification embryo	GO:0008595	103	0.017
response to wounding	GO:0009611	94	0.017
muscle cell development	GO:0055001	50	0.017
eye photoreceptor cell fate commitment	GO:0042706	37	0.017
regulation of cellular catabolic process	GO:0031329	157	0.017
positive regulation of cell cycle	GO:0045787	43	0.017	Zebrafish Fly
regulation of catabolic process	GO:0009894	170	0.017
regulation of cellular amide metabolic process	GO:0034248	39	0.017
somatic stem cell division	GO:0048103	37	0.017
embryonic hindgut morphogenesis	GO:0048619	48	0.017
digestive tract development	GO:0048565	149	0.016
mesenchymal cell differentiation	GO:0048762	1	0.016
compound eye photoreceptor fate commitment	GO:0001752	36	0.016
negative regulation of signal transduction	GO:0009968	206	0.016
retina development in camera type eye	GO:0060041	4	0.016
organic substance catabolic process	GO:1901575	308	0.015
hindgut morphogenesis	GO:0007442	58	0.015
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.015
post embryonic appendage morphogenesis	GO:0035120	385	0.015
negative regulation of signaling	GO:0023057	219	0.015
regulation of programmed cell death	GO:0043067	152	0.015
response to oxygen containing compound	GO:1901700	200	0.015
chaeta development	GO:0022416	97	0.014
vesicle mediated transport	GO:0016192	381	0.014
localization of cell	GO:0051674	257	0.014
intracellular transport	GO:0046907	228	0.014
cellular macromolecule catabolic process	GO:0044265	136	0.014
neuroepithelial cell differentiation	GO:0060563	6	0.014
rna localization	GO:0006403	115	0.014
regulation of hydrolase activity	GO:0051336	97	0.014
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.014
regulation of anatomical structure morphogenesis	GO:0022603	242	0.014	Mouse
axis specification	GO:0009798	167	0.014
regulation of jak stat cascade	GO:0046425	43	0.014	Mouse
neuroblast fate determination	GO:0007400	12	0.014
bolwig s organ development	GO:0055034	8	0.014
cellular macromolecule localization	GO:0070727	220	0.014
regulation of cell cycle phase transition	GO:1901987	130	0.014
antimicrobial peptide biosynthetic process	GO:0002777	38	0.013
neuroblast differentiation	GO:0014016	29	0.013
locomotor rhythm	GO:0045475	56	0.013
alternative mrna splicing via spliceosome	GO:0000380	60	0.013
reproductive system development	GO:0061458	74	0.013
mitotic dna damage checkpoint	GO:0044773	74	0.013
axon extension involved in axon guidance	GO:0048846	10	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.013
developmental programmed cell death	GO:0010623	138	0.013
mitochondrion organization	GO:0007005	65	0.013
mitotic cell cycle checkpoint	GO:0007093	88	0.013
central nervous system neuron development	GO:0021954	8	0.012
apoptotic process	GO:0006915	159	0.012
gastrulation	GO:0007369	70	0.012
catabolic process	GO:0009056	409	0.012
neuron projection extension	GO:1990138	32	0.012
small gtpase mediated signal transduction	GO:0007264	88	0.012
regulation of localization	GO:0032879	275	0.012
heart development	GO:0007507	82	0.012
single organism membrane organization	GO:0044802	93	0.012
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.012
regulation of developmental growth	GO:0048638	174	0.012
establishment of protein localization	GO:0045184	163	0.011
posttranscriptional gene silencing	GO:0016441	46	0.011
regulation of axonogenesis	GO:0050770	32	0.011
regulation of mapk cascade	GO:0043408	92	0.011
regulation of cellular component size	GO:0032535	98	0.011
positive regulation of neuron differentiation	GO:0045666	26	0.011
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.011
embryonic pattern specification	GO:0009880	174	0.011	Zebrafish
steroid catabolic process	GO:0006706	1	0.011
response to other organism	GO:0051707	293	0.011
organonitrogen compound biosynthetic process	GO:1901566	117	0.011
antimicrobial humoral response	GO:0019730	99	0.011
regulation of embryonic development	GO:0045995	68	0.011	Mouse
rna processing	GO:0006396	147	0.011
neuroblast division	GO:0055057	35	0.011
negative regulation of cell cycle phase transition	GO:1901988	103	0.011
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.011
nucleus organization	GO:0006997	45	0.011
proteolysis	GO:0006508	192	0.011
imaginal disc derived wing morphogenesis	GO:0007476	337	0.011
cell cycle arrest	GO:0007050	4	0.011
neuron recognition	GO:0008038	101	0.011
wound healing	GO:0042060	75	0.011
photoreceptor cell fate commitment	GO:0046552	41	0.011
response to alcohol	GO:0097305	95	0.011
muscle organ development	GO:0007517	127	0.010
positive regulation of cell division	GO:0051781	16	0.010	Fly
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.010
ribonucleotide metabolic process	GO:0009259	145	0.010
regulation of axon extension	GO:0030516	8	0.010
protein localization	GO:0008104	284	0.010
dna metabolic process	GO:0006259	227	0.010
epithelial cell proliferation involved in malpighian tubule morphogenesis	GO:0061331	11	0.010
neural retina development	GO:0003407	4	0.010
embryonic axis specification	GO:0000578	107	0.010
meiotic cell cycle process	GO:1903046	132	0.010
meiotic nuclear division	GO:0007126	151	0.010
membrane organization	GO:0061024	112	0.010

HLHm3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
bone development disease	DOID:0080006	0.569	Human
bone disease	DOID:0080001	0.569	Human
disease of anatomical entity	DOID:7	0.569	Human
dysostosis	DOID:1934	0.569	Human
musculoskeletal system disease	DOID:17	0.569	Human
connective tissue disease	DOID:65	0.569	Human
spondylocostal dysostosis	DOID:0050568	0.164	Human
eye and adnexa disease	DOID:1492	0.010
sensory system disease	DOID:0050155	0.010
nervous system disease	DOID:863	0.010

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