IMP: Integrative Multi-species Prediction

Drosophila melanogaster

54 known processes

Crc (Dmel_CG9429)

Calreticulin

(Aliases: CG9429,anon-EST:Liang-2.17,clone 2.17,anon-EST:fe3D7,potp,anon-EST:Liang-2.11,eth,Dmel\CG9429,clone 2.11,Clr)

Entrez: 41166
FLYBASE: FBgn0005585
UniProtKB: P29413
UniProtKB: Q53YH3

Process Predictions
Disease Predictions

Crc biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
centrosome cycle	GO:0007098	137	0.631
centrosome organization	GO:0051297	163	0.520
cellular catabolic process	GO:0044248	372	0.346
microtubule organizing center organization	GO:0031023	168	0.329
negative regulation of gene expression	GO:0010629	387	0.318	Human Rat
aging	GO:0007568	143	0.305	Human
regulation of cell proliferation	GO:0042127	163	0.290	Human
spermatogenesis	GO:0007283	200	0.268	Rat
centrosome duplication	GO:0051298	121	0.264
catabolic process	GO:0009056	409	0.210
multicellular organismal aging	GO:0010259	140	0.197
cell death	GO:0008219	279	0.190
cell proliferation	GO:0008283	299	0.175	Human
regulation of intracellular signal transduction	GO:1902531	236	0.172
regulation of cellular response to stress	GO:0080135	89	0.167
negative regulation of rna metabolic process	GO:0051253	251	0.153	Human
death	GO:0016265	284	0.151
positive regulation of cellular biosynthetic process	GO:0031328	316	0.149	Human
determination of adult lifespan	GO:0008340	137	0.145
cellular protein modification process	GO:0006464	438	0.140
regulation of anatomical structure size	GO:0090066	163	0.127
regulation of response to stress	GO:0080134	200	0.122
protein complex assembly	GO:0006461	200	0.119
protein modification process	GO:0036211	438	0.112
intracellular signal transduction	GO:0035556	300	0.109
regulation of programmed cell death	GO:0043067	152	0.108
positive regulation of cell communication	GO:0010647	250	0.108
apoptotic process	GO:0006915	159	0.108
programmed cell death	GO:0012501	257	0.106
cellular protein localization	GO:0034613	160	0.104	Human
eye development	GO:0001654	323	0.093
response to organic substance	GO:0010033	284	0.088	Rat
positive regulation of biosynthetic process	GO:0009891	316	0.086	Human
sesquiterpenoid metabolic process	GO:0006714	3	0.079
protein complex biogenesis	GO:0070271	201	0.079
meiotic nuclear division	GO:0007126	151	0.076
positive regulation of response to stimulus	GO:0048584	323	0.075	Human
meiotic cell cycle	GO:0051321	171	0.070
male gamete generation	GO:0048232	201	0.067	Rat
proteolysis	GO:0006508	192	0.065
nucleosome assembly	GO:0006334	35	0.064
intracellular transport	GO:0046907	228	0.061	Human
inter male aggressive behavior	GO:0002121	60	0.061
notch signaling pathway	GO:0007219	120	0.059
cellular macromolecule localization	GO:0070727	220	0.058	Human
regulation of cell death	GO:0010941	173	0.057
organic substance catabolic process	GO:1901575	308	0.056
organonitrogen compound metabolic process	GO:1901564	318	0.056
appendage development	GO:0048736	401	0.054
regulation of anatomical structure morphogenesis	GO:0022603	242	0.052	Human
endocytosis	GO:0006897	310	0.052
response to biotic stimulus	GO:0009607	294	0.049
regulation of protein metabolic process	GO:0051246	256	0.048	Rat
phosphorylation	GO:0016310	294	0.048
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.046	Human
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.046
regulation of multicellular organismal development	GO:2000026	414	0.044	Human
appendage morphogenesis	GO:0035107	397	0.043
organic substance transport	GO:0071702	257	0.043	Human
regulation of cell morphogenesis	GO:0022604	163	0.042	Human
developmental pigmentation	GO:0048066	68	0.041
regulation of catalytic activity	GO:0050790	185	0.041
single organism biosynthetic process	GO:0044711	206	0.040
biological adhesion	GO:0022610	138	0.040	Human
single organism carbohydrate metabolic process	GO:0044723	72	0.039
growth	GO:0040007	359	0.038
carbohydrate derivative metabolic process	GO:1901135	217	0.038
posttranscriptional regulation of gene expression	GO:0010608	145	0.038	Rat
pigmentation	GO:0043473	75	0.038
small molecule metabolic process	GO:0044281	305	0.037
post embryonic appendage morphogenesis	GO:0035120	385	0.036
anatomical structure homeostasis	GO:0060249	97	0.034
wing disc morphogenesis	GO:0007472	344	0.034
positive regulation of intracellular signal transduction	GO:1902533	116	0.034
cellular response to nutrient levels	GO:0031669	62	0.034
single organism intracellular transport	GO:1902582	207	0.033	Human
positive regulation of signal transduction	GO:0009967	223	0.033
cytoplasmic transport	GO:0016482	130	0.033	Human
regulation of rna splicing	GO:0043484	69	0.031
carbohydrate derivative catabolic process	GO:1901136	118	0.030
macromolecular complex assembly	GO:0065003	256	0.030
cellular response to starvation	GO:0009267	61	0.030
positive regulation of signaling	GO:0023056	243	0.030
organelle fission	GO:0048285	340	0.029
cell aging	GO:0007569	2	0.029	Human
chaeta development	GO:0022416	97	0.029
regulation of organelle organization	GO:0033043	196	0.028
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.028	Human
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.027	Human
nuclear division	GO:0000280	332	0.027
regulation of cellular protein metabolic process	GO:0032268	243	0.027	Rat
aggressive behavior	GO:0002118	63	0.027
regulation of transport	GO:0051049	181	0.027
regulation of molecular function	GO:0065009	217	0.026
salivary gland morphogenesis	GO:0007435	145	0.026
response to other organism	GO:0051707	293	0.026
dna metabolic process	GO:0006259	227	0.026	Human
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.026	Human Rat
negative regulation of cellular metabolic process	GO:0031324	382	0.025	Human Rat
cell adhesion	GO:0007155	136	0.024	Human
monocarboxylic acid metabolic process	GO:0032787	29	0.024
regulation of phosphorus metabolic process	GO:0051174	210	0.024
primary alcohol metabolic process	GO:0034308	2	0.024
response to metal ion	GO:0010038	23	0.023	Rat
macromolecule catabolic process	GO:0009057	161	0.023
regulation of growth	GO:0040008	233	0.023
lipid localization	GO:0010876	54	0.023
hydrogen peroxide metabolic process	GO:0042743	6	0.022
meiotic cell cycle process	GO:1903046	132	0.022
regionalization	GO:0003002	416	0.022
single organism cellular localization	GO:1902580	180	0.022
protein localization	GO:0008104	284	0.022	Human
response to oxidative stress	GO:0006979	86	0.021
regulation of catabolic process	GO:0009894	170	0.021
central nervous system development	GO:0007417	201	0.021
androgen metabolic process	GO:0008209	1	0.021
response to abiotic stimulus	GO:0009628	341	0.021
vesicle mediated transport	GO:0016192	381	0.021
heart development	GO:0007507	82	0.020	Rat
dendrite development	GO:0016358	204	0.020
spermatid differentiation	GO:0048515	114	0.020
regulation of apoptotic process	GO:0042981	130	0.019
morphogenesis of an epithelium	GO:0002009	276	0.019
positive regulation of macromolecule metabolic process	GO:0010604	405	0.019	Human
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.018
positive regulation of cellular protein metabolic process	GO:0032270	118	0.018
cellular macromolecular complex assembly	GO:0034622	153	0.018
maintenance of location	GO:0051235	73	0.017
establishment of protein localization to organelle	GO:0072594	62	0.017
endomembrane system organization	GO:0010256	119	0.017
intrinsic apoptotic signaling pathway	GO:0097193	16	0.017
regulation of immune system process	GO:0002682	176	0.017	Human
developmental programmed cell death	GO:0010623	138	0.017
embryo development ending in birth or egg hatching	GO:0009792	152	0.017
phagocytosis	GO:0006909	215	0.017
dna conformation change	GO:0071103	105	0.017
imaginal disc derived appendage development	GO:0048737	399	0.017
nucleotide metabolic process	GO:0009117	161	0.017
regulation of cell shape	GO:0008360	113	0.017
positive regulation of gene expression	GO:0010628	290	0.016
mitotic spindle elongation	GO:0000022	81	0.015
reactive oxygen species metabolic process	GO:0072593	22	0.015
organic cyclic compound catabolic process	GO:1901361	168	0.015
positive regulation of cell differentiation	GO:0045597	64	0.015	Human
peptidyl amino acid modification	GO:0018193	105	0.015
negative regulation of transcription dna templated	GO:0045892	237	0.014	Human
epithelial cell differentiation	GO:0030855	322	0.014
spermatid development	GO:0007286	98	0.014
single organism catabolic process	GO:0044712	228	0.014
regulation of protein modification process	GO:0031399	112	0.014
cellular ketone metabolic process	GO:0042180	24	0.014
gtp catabolic process	GO:0006184	72	0.014
regulation of neurogenesis	GO:0050767	158	0.013	Human
cellular response to oxidative stress	GO:0034599	28	0.013
respiratory system development	GO:0060541	213	0.013
positive regulation of molecular function	GO:0044093	136	0.013
nucleobase containing small molecule metabolic process	GO:0055086	174	0.013
positive regulation of rna biosynthetic process	GO:1902680	266	0.013
reproductive system development	GO:0061458	74	0.013
ribonucleotide catabolic process	GO:0009261	109	0.013
forebrain development	GO:0030900	2	0.013
regulation of viral genome replication	GO:0045069	4	0.012
nucleocytoplasmic transport	GO:0006913	72	0.012	Human
response to radiation	GO:0009314	155	0.012
regulation of notch signaling pathway	GO:0008593	100	0.012
regulation of localization	GO:0032879	275	0.012	Human
cellular protein catabolic process	GO:0044257	83	0.012
regulation of cell differentiation	GO:0045595	302	0.012	Human
dendrite morphogenesis	GO:0048813	199	0.012
membrane organization	GO:0061024	112	0.012
regulation of hormone levels	GO:0010817	40	0.012
establishment of protein localization	GO:0045184	163	0.012	Human
regulation of phosphorylation	GO:0042325	147	0.012
intracellular protein transport	GO:0006886	104	0.012	Human
positive regulation of cell proliferation	GO:0008284	47	0.012	Human
regulation of phosphate metabolic process	GO:0019220	210	0.012
brain development	GO:0007420	120	0.012
gland morphogenesis	GO:0022612	145	0.012
protein localization to organelle	GO:0033365	82	0.012	Human
actin cytoskeleton organization	GO:0030036	206	0.012
maintenance of cell polarity	GO:0030011	18	0.012
protein phosphorylation	GO:0006468	169	0.011
rna splicing	GO:0008380	83	0.011
cellular macromolecule catabolic process	GO:0044265	136	0.011
golgi organization	GO:0007030	66	0.011
organic hydroxy compound catabolic process	GO:1901616	4	0.011
stem cell differentiation	GO:0048863	117	0.011
exocrine system development	GO:0035272	162	0.011
protein targeting	GO:0006605	64	0.011
cellular response to reactive oxygen species	GO:0034614	14	0.011
regulation of cellular catabolic process	GO:0031329	157	0.011
salivary gland development	GO:0007431	162	0.011
nucleoside phosphate metabolic process	GO:0006753	162	0.010
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.010	Human
ubiquitin dependent protein catabolic process	GO:0006511	78	0.010
larval development	GO:0002164	104	0.010
inorganic cation transmembrane transport	GO:0098662	61	0.010
response to endoplasmic reticulum stress	GO:0034976	28	0.010
regulation of nervous system development	GO:0051960	248	0.010	Human

Crc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
bone marrow cancer	DOID:4960	0.012	Human
organ system cancer	DOID:0050686	0.012	Human
disease of cellular proliferation	DOID:14566	0.012	Human
hematologic cancer	DOID:2531	0.012	Human
cancer	DOID:162	0.012	Human
immune system cancer	DOID:0060083	0.012	Human

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