IMP: Integrative Multi-species Prediction

Drosophila melanogaster

10 known processes

unc-119 (Dmel_CG1659)

CG1659 gene product from transcript CG1659-RA

(Aliases: Dmel\CG1659,dm unc-119,Unc119,Unc-119,anon-EST:Posey123,DmUNC-119,CG1659)

Entrez: 31664
FLYBASE: FBgn0025549
UniProtKB: Q540Y4
UniProtKB: Q9XYQ2

Process Predictions
Disease Predictions

unc-119 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
defense response	GO:0006952	300	0.249
embryo development ending in birth or egg hatching	GO:0009792	152	0.229
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.228
negative regulation of cellular biosynthetic process	GO:0031327	277	0.212
negative regulation of transcription dna templated	GO:0045892	237	0.196
positive regulation of rna metabolic process	GO:0051254	271	0.192
cellular response to chemical stimulus	GO:0070887	199	0.191
apoptotic process	GO:0006915	159	0.185
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.183
single organism behavior	GO:0044708	391	0.182
neurological system process	GO:0050877	358	0.173
adult behavior	GO:0030534	137	0.150
embryonic development via the syncytial blastoderm	GO:0001700	148	0.146
positive regulation of biosynthetic process	GO:0009891	316	0.142
central nervous system development	GO:0007417	201	0.141
nucleocytoplasmic transport	GO:0006913	72	0.138
positive regulation of transcription dna templated	GO:0045893	266	0.137
rna splicing via transesterification reactions	GO:0000375	73	0.130
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.115
digestive system development	GO:0055123	149	0.114
negative regulation of gene expression	GO:0010629	387	0.109
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.109
multi organism reproductive behavior	GO:0044705	121	0.106
spermatogenesis	GO:0007283	200	0.105
tube morphogenesis	GO:0035239	191	0.099
reproductive behavior	GO:0019098	122	0.098
positive regulation of gene expression	GO:0010628	290	0.096
regulation of cell shape	GO:0008360	113	0.093
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.091
multi organism behavior	GO:0051705	175	0.089
positive regulation of rna biosynthetic process	GO:1902680	266	0.088
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.084
neuron projection guidance	GO:0097485	241	0.083
protein localization	GO:0008104	284	0.081
regulation of localization	GO:0032879	275	0.080
positive regulation of macromolecule metabolic process	GO:0010604	405	0.079
axon development	GO:0061564	297	0.076
imaginal disc derived wing morphogenesis	GO:0007476	337	0.073
programmed cell death	GO:0012501	257	0.073
death	GO:0016265	284	0.072
chromosome organization	GO:0051276	360	0.072
transcription from rna polymerase ii promoter	GO:0006366	368	0.070
regulation of cell development	GO:0060284	215	0.069
regulation of phosphate metabolic process	GO:0019220	210	0.067
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.066
epithelial tube morphogenesis	GO:0060562	88	0.066
cell death	GO:0008219	279	0.065
positive regulation of cellular biosynthetic process	GO:0031328	316	0.064
taxis	GO:0042330	304	0.064
cellular catabolic process	GO:0044248	372	0.062
chemotaxis	GO:0006935	249	0.060
oxoacid metabolic process	GO:0043436	103	0.059
chemosensory behavior	GO:0007635	106	0.058
response to oxygen containing compound	GO:1901700	200	0.057
negative regulation of cellular metabolic process	GO:0031324	382	0.057
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.056
digestive tract development	GO:0048565	149	0.056
single organism catabolic process	GO:0044712	228	0.056
sensory perception	GO:0007600	196	0.055
regulation of cell differentiation	GO:0045595	302	0.054
muscle cell differentiation	GO:0042692	103	0.054
locomotory behavior	GO:0007626	176	0.054
negative regulation of rna biosynthetic process	GO:1902679	240	0.054
appendage morphogenesis	GO:0035107	397	0.053
regulation of cell cycle	GO:0051726	291	0.050
cellular protein modification process	GO:0006464	438	0.050
tube development	GO:0035295	244	0.050
axon guidance	GO:0007411	233	0.050
chromatin silencing	GO:0006342	76	0.049
response to other organism	GO:0051707	293	0.048
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.047
organic substance catabolic process	GO:1901575	308	0.046
wing disc morphogenesis	GO:0007472	344	0.046
post embryonic appendage morphogenesis	GO:0035120	385	0.046
circulatory system development	GO:0072359	82	0.045
protein modification process	GO:0036211	438	0.045
regulation of intracellular signal transduction	GO:1902531	236	0.045
negative regulation of biosynthetic process	GO:0009890	277	0.044
catabolic process	GO:0009056	409	0.043
dendrite development	GO:0016358	204	0.043
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.042
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.042
organonitrogen compound metabolic process	GO:1901564	318	0.041
negative regulation of rna metabolic process	GO:0051253	251	0.040
digestive tract morphogenesis	GO:0048546	127	0.040
learning	GO:0007612	75	0.040
response to bacterium	GO:0009617	198	0.040
cell adhesion	GO:0007155	136	0.040
immune response	GO:0006955	246	0.039
carbohydrate derivative metabolic process	GO:1901135	217	0.039
negative regulation of multicellular organismal process	GO:0051241	142	0.038
biological adhesion	GO:0022610	138	0.038
intracellular signal transduction	GO:0035556	300	0.038
regulation of transport	GO:0051049	181	0.038
organonitrogen compound biosynthetic process	GO:1901566	117	0.037
regulation of cellular localization	GO:0060341	136	0.037
muscle attachment	GO:0016203	36	0.036
regulation of multi organism process	GO:0043900	131	0.036
negative regulation of gene expression epigenetic	GO:0045814	77	0.036
germarium derived egg chamber formation	GO:0007293	101	0.035
organelle assembly	GO:0070925	198	0.035
actin filament based process	GO:0030029	220	0.035
regulation of immune system process	GO:0002682	176	0.035
negative regulation of developmental process	GO:0051093	201	0.034
defense response to bacterium	GO:0042742	178	0.034
imaginal disc derived appendage development	GO:0048737	399	0.034
aromatic compound catabolic process	GO:0019439	166	0.033
negative regulation of signal transduction	GO:0009968	206	0.033
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.032
cell cycle checkpoint	GO:0000075	95	0.032
organic cyclic compound catabolic process	GO:1901361	168	0.032
chromosome separation	GO:0051304	42	0.032
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.032
response to ethanol	GO:0045471	59	0.032
growth	GO:0040007	359	0.031
positive regulation of molecular function	GO:0044093	136	0.030
male gamete generation	GO:0048232	201	0.030
dendrite morphogenesis	GO:0048813	199	0.030
phagocytosis	GO:0006909	215	0.030
regulation of programmed cell death	GO:0043067	152	0.030
regulation of molecular function	GO:0065009	217	0.029
renal tubule development	GO:0061326	64	0.029
response to organic substance	GO:0010033	284	0.029
larval development	GO:0002164	104	0.029
regulation of compound eye cone cell fate specification	GO:0042682	4	0.029
eye development	GO:0001654	323	0.029
mrna processing	GO:0006397	104	0.029
male courtship behavior veined wing generated song production	GO:0045433	20	0.028
cell division	GO:0051301	248	0.028
nucleoside phosphate metabolic process	GO:0006753	162	0.028
axonogenesis	GO:0007409	290	0.027
vesicle mediated transport	GO:0016192	381	0.027
organelle fission	GO:0048285	340	0.027
camera type eye development	GO:0043010	4	0.027
response to abiotic stimulus	GO:0009628	341	0.027
defense response to other organism	GO:0098542	225	0.027
response to nutrient levels	GO:0031667	114	0.027
regulation of cell death	GO:0010941	173	0.027
regulation of protein metabolic process	GO:0051246	256	0.026
negative regulation of protein metabolic process	GO:0051248	85	0.026
chromatin organization	GO:0006325	207	0.026
small molecule metabolic process	GO:0044281	305	0.026
regulation of organelle organization	GO:0033043	196	0.026
nuclear transport	GO:0051169	72	0.026
response to wounding	GO:0009611	94	0.026
head development	GO:0060322	135	0.026
regulation of phosphorylation	GO:0042325	147	0.026
olfactory behavior	GO:0042048	97	0.026
proteolysis	GO:0006508	192	0.026
developmental growth	GO:0048589	280	0.025
regulation of response to stress	GO:0080134	200	0.025
embryonic organ development	GO:0048568	50	0.025
response to external biotic stimulus	GO:0043207	293	0.025
cytoplasmic transport	GO:0016482	130	0.025
cell proliferation	GO:0008283	299	0.025
rhythmic behavior	GO:0007622	76	0.025
gland development	GO:0048732	191	0.024
sensory perception of chemical stimulus	GO:0007606	116	0.024
organic substance transport	GO:0071702	257	0.024
gliogenesis	GO:0042063	80	0.024
mrna splicing via spliceosome	GO:0000398	73	0.023
actin cytoskeleton organization	GO:0030036	206	0.023
negative regulation of cell death	GO:0060548	81	0.023
regulation of response to external stimulus	GO:0032101	115	0.023
regulation of catalytic activity	GO:0050790	185	0.023
negative regulation of signaling	GO:0023057	219	0.023
translation	GO:0006412	69	0.023
neural precursor cell proliferation	GO:0061351	75	0.023
regulation of neurogenesis	GO:0050767	158	0.023
gene silencing	GO:0016458	138	0.023
cellular component assembly involved in morphogenesis	GO:0010927	151	0.022
mating behavior	GO:0007617	106	0.022
phosphorylation	GO:0016310	294	0.022
positive regulation of signal transduction	GO:0009967	223	0.022
heart process	GO:0003015	37	0.022
positive regulation of cell communication	GO:0010647	250	0.022
stem cell division	GO:0017145	69	0.022
immune system process	GO:0002376	347	0.022
negative regulation of cellular component organization	GO:0051129	108	0.021
regulation of developmental growth	GO:0048638	174	0.021
nucleoside phosphate catabolic process	GO:1901292	110	0.021
mating	GO:0007618	120	0.021
organonitrogen compound catabolic process	GO:1901565	128	0.021
homeostatic process	GO:0042592	199	0.021
respiratory system development	GO:0060541	213	0.020
localization of cell	GO:0051674	257	0.020
lateral inhibition	GO:0046331	206	0.020
protein catabolic process	GO:0030163	101	0.020
cellular response to organic substance	GO:0071310	132	0.020
regulation of cytoplasmic transport	GO:1903649	47	0.020
multi multicellular organism process	GO:0044706	123	0.020
cellular homeostasis	GO:0019725	80	0.020
tissue morphogenesis	GO:0048729	297	0.020
protein transport	GO:0015031	155	0.020
regionalization	GO:0003002	416	0.020
photoreceptor cell development	GO:0042461	96	0.020
male courtship behavior veined wing vibration	GO:0016545	21	0.020
negative regulation of translation	GO:0017148	28	0.020
regulation of protein localization	GO:0032880	76	0.019
response to light stimulus	GO:0009416	124	0.019
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.019
regulation of apoptotic process	GO:0042981	130	0.019
ribonucleoside catabolic process	GO:0042454	112	0.019
feeding behavior	GO:0007631	50	0.019
learning or memory	GO:0007611	141	0.018
response to alcohol	GO:0097305	95	0.018
cell migration	GO:0016477	238	0.018
oocyte differentiation	GO:0009994	145	0.018
circadian rhythm	GO:0007623	105	0.018
positive regulation of phosphate metabolic process	GO:0045937	139	0.018
protein k48 linked ubiquitination	GO:0070936	3	0.018
muscle structure development	GO:0061061	224	0.018
organophosphate metabolic process	GO:0019637	195	0.018
negative regulation of cellular protein metabolic process	GO:0032269	85	0.018
single organism carbohydrate metabolic process	GO:0044723	72	0.018
regulation of protein modification process	GO:0031399	112	0.017
cell type specific apoptotic process	GO:0097285	38	0.017
cellular ketone metabolic process	GO:0042180	24	0.017
cell motility	GO:0048870	251	0.017
macromolecular complex assembly	GO:0065003	256	0.017
protein complex assembly	GO:0006461	200	0.017
actin filament organization	GO:0007015	126	0.017
positive regulation of phosphorus metabolic process	GO:0010562	139	0.017
regulation of gene expression epigenetic	GO:0040029	128	0.017
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.017
positive regulation of multicellular organismal process	GO:0051240	143	0.017
gastrulation with mouth forming first	GO:0001703	36	0.017
ribonucleoside metabolic process	GO:0009119	127	0.017
fertilization	GO:0009566	26	0.016
regulation of cellular protein metabolic process	GO:0032268	243	0.016
positive regulation of cell death	GO:0010942	69	0.016
regulation of anatomical structure morphogenesis	GO:0022603	242	0.016
regulation of cellular component biogenesis	GO:0044087	201	0.016
morphogenesis of a branching structure	GO:0001763	45	0.016
positive regulation of catalytic activity	GO:0043085	118	0.016
compound eye cone cell differentiation	GO:0042675	13	0.016
regulation of nervous system development	GO:0051960	248	0.016
positive regulation of signaling	GO:0023056	243	0.016
cellular nitrogen compound catabolic process	GO:0044270	165	0.016
hindgut morphogenesis	GO:0007442	58	0.016
modification dependent protein catabolic process	GO:0019941	78	0.016
histone lysine demethylation	GO:0070076	6	0.016
cellular protein localization	GO:0034613	160	0.016
mrna metabolic process	GO:0016071	124	0.016
behavioral response to ethanol	GO:0048149	49	0.016
oocyte development	GO:0048599	124	0.016
response to biotic stimulus	GO:0009607	294	0.015
positive regulation of transferase activity	GO:0051347	26	0.015
regulation of anatomical structure size	GO:0090066	163	0.015
regulation of erk1 and erk2 cascade	GO:0070372	39	0.015
synapse assembly	GO:0007416	143	0.015
negative regulation of nervous system development	GO:0051961	92	0.015
hindgut development	GO:0061525	58	0.015
positive regulation of phosphorylation	GO:0042327	87	0.015
regulation of synapse structure and activity	GO:0050803	128	0.015
compound eye photoreceptor development	GO:0042051	78	0.015
mesoderm development	GO:0007498	78	0.015
heterocycle catabolic process	GO:0046700	166	0.015
reproductive system development	GO:0061458	74	0.015
regulation of chromosome organization	GO:0033044	64	0.015
regulation of cellular amino acid metabolic process	GO:0006521	0	0.015
regulation of phosphorus metabolic process	GO:0051174	210	0.014
gastrulation	GO:0007369	70	0.014
carboxylic acid metabolic process	GO:0019752	92	0.014
mapk cascade	GO:0000165	107	0.014
proteasomal protein catabolic process	GO:0010498	59	0.014
rhythmic process	GO:0048511	106	0.014
eye photoreceptor cell development	GO:0042462	81	0.014
purine containing compound catabolic process	GO:0072523	112	0.014
mitotic cell cycle phase transition	GO:0044772	138	0.014
synapse organization	GO:0050808	196	0.014
embryonic pattern specification	GO:0009880	174	0.014
intracellular transport	GO:0046907	228	0.014
metaphase anaphase transition of cell cycle	GO:0044784	28	0.014
regulation of cell morphogenesis	GO:0022604	163	0.014
regulation of growth	GO:0040008	233	0.014
cell fate specification	GO:0001708	71	0.014
response to extracellular stimulus	GO:0009991	116	0.014
determination of adult lifespan	GO:0008340	137	0.014
mitotic sister chromatid separation	GO:0051306	30	0.014
negative regulation of intracellular signal transduction	GO:1902532	57	0.014
chromatin modification	GO:0016568	147	0.014
ras protein signal transduction	GO:0007265	88	0.013
compound eye development	GO:0048749	307	0.013
oocyte axis specification	GO:0007309	108	0.013
regulation of mrna splicing via spliceosome	GO:0048024	64	0.013
embryonic hindgut morphogenesis	GO:0048619	48	0.013
intrinsic apoptotic signaling pathway	GO:0097193	16	0.013
neuron recognition	GO:0008038	101	0.013
neuronal stem cell division	GO:0036445	35	0.013
glial cell differentiation	GO:0010001	35	0.013
carbohydrate metabolic process	GO:0005975	82	0.013
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.013
amine metabolic process	GO:0009308	12	0.013
response to endogenous stimulus	GO:0009719	119	0.013
brain development	GO:0007420	120	0.013
regulation of nucleocytoplasmic transport	GO:0046822	35	0.013
response to organic cyclic compound	GO:0014070	89	0.013
asymmetric stem cell division	GO:0098722	49	0.013
regulation of chromatin silencing	GO:0031935	36	0.013
signal transduction by phosphorylation	GO:0023014	107	0.013
organophosphate catabolic process	GO:0046434	112	0.013
regulation of neuron death	GO:1901214	26	0.012
ubiquitin dependent protein catabolic process	GO:0006511	78	0.012
dna templated transcription initiation	GO:0006352	25	0.012
segmentation	GO:0035282	207	0.012
establishment or maintenance of cell polarity	GO:0007163	167	0.012
negative regulation of cell differentiation	GO:0045596	143	0.012
renal tubule morphogenesis	GO:0061333	44	0.012
male meiosis chromosome segregation	GO:0007060	10	0.012
regulation of gene silencing	GO:0060968	63	0.012
macromolecule catabolic process	GO:0009057	161	0.012
cell maturation	GO:0048469	144	0.012
nuclear division	GO:0000280	332	0.012
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.012
regulation of multicellular organismal development	GO:2000026	414	0.012
blastoderm segmentation	GO:0007350	159	0.012
positive regulation of hydrolase activity	GO:0051345	78	0.012
endocytosis	GO:0006897	310	0.012
maintenance of protein location	GO:0045185	28	0.012
regulation of mrna processing	GO:0050684	71	0.012
head involution	GO:0008258	35	0.012
response to axon injury	GO:0048678	12	0.012
multicellular organismal aging	GO:0010259	140	0.012
histone modification	GO:0016570	106	0.011
germ line cyst formation	GO:0048134	44	0.011
glycosyl compound catabolic process	GO:1901658	112	0.011
epithelial cell development	GO:0002064	274	0.011
regulation of cellular ketone metabolic process	GO:0010565	3	0.011
regulation of intracellular transport	GO:0032386	64	0.011
dna replication	GO:0006260	48	0.011
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.011
regulation of translation	GO:0006417	56	0.011
response to decreased oxygen levels	GO:0036293	58	0.011
morphogenesis of embryonic epithelium	GO:0016331	94	0.011
negative regulation of proteolysis	GO:0045861	31	0.011
positive regulation of programmed cell death	GO:0043068	62	0.011
positive regulation of response to stimulus	GO:0048584	323	0.011
mitotic cell cycle checkpoint	GO:0007093	88	0.011
cellular macromolecule localization	GO:0070727	220	0.011
negative regulation of organelle organization	GO:0010639	56	0.011
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.011
cell aging	GO:0007569	2	0.011
neuromuscular junction development	GO:0007528	149	0.011
cellular response to dna damage stimulus	GO:0006974	223	0.011
regulation of rna splicing	GO:0043484	69	0.011
cellular macromolecule catabolic process	GO:0044265	136	0.011
axon midline choice point recognition	GO:0016199	26	0.011
nucleoside catabolic process	GO:0009164	112	0.011
nucleotide metabolic process	GO:0009117	161	0.011
positive regulation of developmental process	GO:0051094	143	0.010
regulation of response to wounding	GO:1903034	19	0.010
response to oxygen levels	GO:0070482	59	0.010
regulation of cellular catabolic process	GO:0031329	157	0.010
membrane depolarization	GO:0051899	4	0.010
developmental maturation	GO:0021700	172	0.010
oocyte construction	GO:0007308	112	0.010
nucleoside triphosphate metabolic process	GO:0009141	120	0.010
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.010
renal system development	GO:0072001	72	0.010
carbohydrate derivative catabolic process	GO:1901136	118	0.010
protein maturation	GO:0051604	71	0.010
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.010
negative regulation of response to stimulus	GO:0048585	258	0.010
g1 s transition of mitotic cell cycle	GO:0000082	31	0.010
cellular macromolecular complex assembly	GO:0034622	153	0.010
nucleoside triphosphate catabolic process	GO:0009143	108	0.010

unc-119 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.162
nervous system disease	DOID:863	0.036
sensory system disease	DOID:0050155	0.011

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