Drosophila melanogaster

133 known processes

Hand (Dmel_CG18144)

CG18144 gene product from transcript CG18144-RA

(Aliases: hand-C,bHLHa28,Dmel\CG18144,CG18144,HAND,dHand,Dhand,hand,dHAND)

Hand biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
embryonic organ developmentGO:0048568500.798
heart developmentGO:0007507820.648
cardiocyte differentiationGO:0035051290.502
Zebrafish Mouse
positive regulation of rna metabolic processGO:00512542710.451
positive regulation of nucleobase containing compound metabolic processGO:00459353320.450
locomotory behaviorGO:00076261760.450
positive regulation of nitrogen compound metabolic processGO:00511733540.444
positive regulation of macromolecule metabolic processGO:00106044050.422
dendrite developmentGO:00163582040.373
cardioblast differentiationGO:0010002200.351
Zebrafish
circulatory system developmentGO:0072359820.338
cardiovascular system developmentGO:0072358820.329
digestive tract developmentGO:00485651490.323
Zebrafish Mouse Fly
positive regulation of nucleic acid templated transcriptionGO:19035082660.315
tube developmentGO:00352952440.280
transcription from rna polymerase ii promoterGO:00063663680.270
regulation of transcription from rna polymerase ii promoterGO:00063573780.244
single organism behaviorGO:00447083910.220
dendrite morphogenesisGO:00488131990.201
cell motilityGO:00488702510.190
Mouse
positive regulation of rna biosynthetic processGO:19026802660.183
embryonic heart tube developmentGO:0035050220.177
cellular catabolic processGO:00442483720.172
negative regulation of rna metabolic processGO:00512532510.172
Mouse
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.170
response to starvationGO:0042594970.160
circulatory system processGO:0003013370.153
Zebrafish
lymph gland developmentGO:0048542280.137
protein acetylationGO:0006473390.135
positive regulation of macromolecule biosynthetic processGO:00105572830.133
positive regulation of multicellular organismal processGO:00512401430.131
Mouse
larval developmentGO:00021641040.129
outflow tract morphogenesisGO:000315140.120
Mouse
blood circulationGO:0008015260.118
Zebrafish
forebrain developmentGO:003090020.114
regulation of synapse organizationGO:00508071100.111
gland developmentGO:00487321910.111
Zebrafish Mouse Fly
negative regulation of transcription dna templatedGO:00458922370.111
Mouse
response to growth factorGO:0070848310.110
positive regulation of transcription dna templatedGO:00458932660.108
multi organism reproductive behaviorGO:00447051210.105
tube morphogenesisGO:00352391910.104
Zebrafish Mouse Fly
embryo development ending in birth or egg hatchingGO:00097921520.104
Zebrafish Mouse Worm
positive regulation of cellular biosynthetic processGO:00313283160.101
positive regulation of response to stimulusGO:00485843230.100
Mouse
regulation of localizationGO:00328792750.099
cell migrationGO:00164772380.098
Mouse
regulation of dendrite morphogenesisGO:0048814280.096
cellular response to chemical stimulusGO:00708871990.095
localization of cellGO:00516742570.094
Mouse
organonitrogen compound metabolic processGO:19015643180.092
Mouse
head developmentGO:00603221350.090
immune system developmentGO:0002520570.088
embryonic ectodermal digestive tract developmentGO:004861140.085
cellular response to endogenous stimulusGO:0071495800.084
negative regulation of gene expressionGO:00106293870.083
Mouse Fly
positive regulation of biosynthetic processGO:00098913160.082
lateral inhibitionGO:00463312060.080
protein modification processGO:00362114380.079
negative regulation of developmental processGO:00510932010.079
Mouse
catabolic processGO:00090564090.079
catecholamine biosynthetic processGO:004242330.078
Mouse
stem cell differentiationGO:00488631170.077
Zebrafish Mouse
negative regulation of nitrogen compound metabolic processGO:00511722650.076
Mouse
small molecule metabolic processGO:00442813050.075
renal filtrationGO:009720570.075
cell cell signaling involved in cell fate commitmentGO:00451682100.074
vesicle mediated transportGO:00161923810.074
negative regulation of biosynthetic processGO:00098902770.071
Mouse
peptidyl lysine acetylationGO:0018394390.069
defense response to bacteriumGO:00427421780.069
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.068
Mouse
regulation of blood circulationGO:1903522210.067
regulation of cellular catabolic processGO:00313291570.066
cellular response to extracellular stimulusGO:0031668640.066
regulation of molecular functionGO:00650092170.065
Human Mouse
cell deathGO:00082192790.064
notch signaling pathwayGO:00072191200.064
regulation of anatomical structure morphogenesisGO:00226032420.064
Mouse
cardiac cell fate commitmentGO:0060911170.064
peptidyl lysine modificationGO:0018205570.063
positive regulation of gene expressionGO:00106282900.062
developmental maturationGO:00217001720.062
cellular amino acid metabolic processGO:0006520610.062
positive regulation of developmental growthGO:0048639620.062
digestive system developmentGO:00551231490.061
Zebrafish Mouse Fly
response to extracellular stimulusGO:00099911160.061
intracellular signal transductionGO:00355563000.058
chaeta developmentGO:0022416970.058
immune effector processGO:0002252980.057
regulation of phosphate metabolic processGO:00192202100.056
cellular response to growth factor stimulusGO:0071363300.056
actin filament based processGO:00300292200.056
Fly
multicellular organismal agingGO:00102591400.056
heterocycle catabolic processGO:00467001660.055
programmed cell deathGO:00125012570.054
cellular protein modification processGO:00064644380.054
actin cytoskeleton organizationGO:00300362060.053
Fly
regulation of developmental growthGO:00486381740.053
organic substance catabolic processGO:19015753080.052
sensory organ boundary specificationGO:0008052220.051
Fly
internal protein amino acid acetylationGO:0006475380.051
embryonic pattern specificationGO:00098801740.051
renal system developmentGO:0072001720.050
Fly
regulation of synapse structure and activityGO:00508031280.049
embryonic morphogenesisGO:00485982060.048
Zebrafish Mouse Fly
organelle assemblyGO:00709251980.048
muscle cell differentiationGO:00426921030.047
Fly
telencephalon developmentGO:002153720.046
histone acetylationGO:0016573380.046
regulation of dendrite developmentGO:0050773370.044
negative regulation of nucleobase containing compound metabolic processGO:00459342610.044
Mouse
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.044
Mouse
multicellular organismal reproductive behaviorGO:00330571100.044
heart processGO:0003015370.043
Zebrafish
cuticle pigmentationGO:0048067220.043
cellular lipid metabolic processGO:0044255830.042
single organism catabolic processGO:00447122280.041
response to organic substanceGO:00100332840.041
dna damage checkpointGO:0000077780.041
endocytosisGO:00068973100.040
regulation of protein acetylationGO:190198370.040
establishment of localization in cellGO:00516494020.040
catechol containing compound biosynthetic processGO:000971330.040
Mouse
regulation of protein metabolic processGO:00512462560.038
regulation of multicellular organismal developmentGO:20000264140.038
Mouse Fly
peptide metabolic processGO:0006518800.038
positive regulation of cell communicationGO:00106472500.038
Mouse
regulation of cell cycleGO:00517262910.038
regulation of notch signaling pathwayGO:00085931000.037
cell fate determinationGO:0001709910.037
Fly
autophagyGO:00069141080.037
developmental growthGO:00485892800.037
brain developmentGO:00074201200.037
post embryonic hemopoiesisGO:0035166170.037
response to biotic stimulusGO:00096072940.036
response to other organismGO:00517072930.036
lipid metabolic processGO:00066291210.036
regulation of cellular amine metabolic processGO:003323830.036
regulation of catalytic activityGO:00507901850.036
adult behaviorGO:00305341370.036
organophosphate metabolic processGO:00196371950.035
extracellular structure organizationGO:0043062460.035
embryonic hindgut morphogenesisGO:0048619480.034
Fly
positive regulation of signalingGO:00230562430.034
Mouse
regulation of cell deathGO:00109411730.034
renal system processGO:0003014120.034
central nervous system developmentGO:00074172010.034
cellular nitrogen compound catabolic processGO:00442701650.034
positive regulation of growthGO:0045927750.033
digestive tract morphogenesisGO:00485461270.033
Mouse Fly
immune system processGO:00023763470.033
chromatin modificationGO:00165681470.033
appendage morphogenesisGO:00351073970.033
Zebrafish Mouse
response to abiotic stimulusGO:00096283410.033
regulation of cell morphogenesis involved in differentiationGO:0010769610.033
urogenital system developmentGO:0001655720.033
Fly
pigment granule organizationGO:0048753120.032
negative regulation of cellular component organizationGO:00511291080.031
cardioblast cell fate determinationGO:000751030.031
larval lymph gland hemopoiesisGO:0035167170.031
synapse organizationGO:00508081960.031
epithelial cell developmentGO:00020642740.030
camera type eye developmentGO:004301040.030
morphogenesis of an epitheliumGO:00020092760.030
Zebrafish Mouse Fly
cardioblast cell fate commitmentGO:0042684140.030
regulation of cell differentiationGO:00455953020.030
Mouse
columnar cuboidal epithelial cell developmentGO:00020662490.028
agingGO:00075681430.028
regulation of catabolic processGO:00098941700.028
cellular response to dna damage stimulusGO:00069742230.028
oxoacid metabolic processGO:00434361030.028
negative regulation of cell communicationGO:00106482230.027
determination of adult lifespanGO:00083401370.027
tissue morphogenesisGO:00487292970.027
Zebrafish Mouse Fly
hindgut morphogenesisGO:0007442580.027
Fly
phagocytosisGO:00069092150.027
positive regulation of cellular component organizationGO:00511301560.027
deathGO:00162652840.027
cell adhesionGO:00071551360.027
cellular response to starvationGO:0009267610.027
proteolysisGO:00065081920.027
reproductive structure developmentGO:0048608740.026
Mouse Worm
regulation of cellular protein metabolic processGO:00322682430.026
regulation of transportGO:00510491810.026
regulation of synaptic growth at neuromuscular junctionGO:0008582890.026
cell recognitionGO:00080371020.026
appendage developmentGO:00487364010.026
Zebrafish Mouse
positive regulation of intracellular signal transductionGO:19025331160.026
negative regulation of macromolecule biosynthetic processGO:00105582700.026
Mouse
regulation of neurogenesisGO:00507671580.026
regulation of nervous system developmentGO:00519602480.026
defense responseGO:00069523000.026
spermatid developmentGO:0007286980.026
purine containing compound metabolic processGO:00725211550.025
columnar cuboidal epithelial cell differentiationGO:00020652560.025
regulation of cell proliferationGO:00421271630.025
Mouse
epithelial tube morphogenesisGO:0060562880.025
Zebrafish Mouse Fly
cardiac cell fate determinationGO:006091330.024
anion homeostasisGO:005508130.024
retina development in camera type eyeGO:006004140.024
regulation of circadian rhythmGO:0042752490.024
circadian rhythmGO:00076231050.024
negative regulation of nucleic acid templated transcriptionGO:19035072400.024
Mouse
sensory organ precursor cell fate determinationGO:0016360190.023
Fly
response to oxygen radicalGO:000030530.023
homeostatic processGO:00425921990.023
alcohol biosynthetic processGO:0046165140.023
cellular pigmentationGO:0033059120.023
cellular ketone metabolic processGO:0042180240.023
protein acylationGO:0043543420.023
carbohydrate derivative metabolic processGO:19011352170.023
kidney developmentGO:000182230.023
regulation of phosphorus metabolic processGO:00511742100.023
defense response to other organismGO:00985422250.023
taxisGO:00423303040.023
positive regulation of dendrite morphogenesisGO:005077590.023
cell divisionGO:00513012480.023
protein transportGO:00150311550.022
pharynx developmentGO:006046510.022
formation of organ boundaryGO:0010160300.022
Fly
salivary gland developmentGO:00074311620.022
Fly
negative regulation of rna biosynthetic processGO:19026792400.022
Mouse
single organism cell adhesionGO:0098602470.022
hemopoiesisGO:0030097460.022
macromolecule catabolic processGO:00090571610.022
striated muscle cell developmentGO:0055002500.021
Fly
epithelial cell migrationGO:00106311480.021
segmentationGO:00352822070.021
epithelial cell differentiationGO:00308553220.021
Zebrafish
mitotic nuclear divisionGO:00070672130.021
single organism biosynthetic processGO:00447112060.021
response to inorganic substanceGO:0010035440.021
adult locomotory behaviorGO:0008344760.020
exocrine system developmentGO:00352721620.020
Fly
synapse assemblyGO:00074161430.020
growthGO:00400073590.020
purine nucleotide metabolic processGO:00061631460.020
response to external biotic stimulusGO:00432072930.020
regulation of immune system processGO:00026821760.020
biological adhesionGO:00226101380.020
response to oxidative stressGO:0006979860.020
embryonic hemopoiesisGO:0035162260.020
camera type eye morphogenesisGO:004859320.020
body morphogenesisGO:001017120.020
Worm
pigmentationGO:0043473750.020
mitotic dna damage checkpointGO:0044773740.020
organic cyclic compound catabolic processGO:19013611680.020
post embryonic appendage morphogenesisGO:00351203850.020
positive regulation of molecular functionGO:00440931360.019
Human
regulation of system processGO:0044057360.019
muscle tissue morphogenesisGO:006041520.019
Mouse
male mating behaviorGO:0060179700.019
developmental programmed cell deathGO:00106231380.019
Mouse
determination of digestive tract left right asymmetryGO:007190760.019
Zebrafish
larval locomotory behaviorGO:0008345270.019
positive regulation of nervous system developmentGO:0051962690.019
nephron developmentGO:007200630.019
neuroblast differentiationGO:0014016290.019
gland morphogenesisGO:00226121450.019
Fly
malpighian tubule morphogenesisGO:0007443440.019
Fly
eye morphogenesisGO:00485922600.018
cell fate commitment involved in pattern specificationGO:0060581310.018
Fly
positive regulation of catabolic processGO:00098961050.018
hemocyte differentiationGO:0042386380.018
cellular component assembly involved in morphogenesisGO:00109271510.018
cellular response to decreased oxygen levelsGO:0036294300.018
glial cell migrationGO:0008347310.018
feeding behaviorGO:0007631500.018
Mouse
small molecule biosynthetic processGO:0044283370.018
cellular amine metabolic processGO:0044106120.018
regulation of intracellular signal transductionGO:19025312360.018
nucleobase containing small molecule metabolic processGO:00550861740.018
intracellular transportGO:00469072280.018
cell proliferationGO:00082832990.018
Mouse
protein prenylationGO:001834230.018
cellular response to oxygen levelsGO:0071453300.018
organic acid metabolic processGO:00060821030.018
purine nucleoside catabolic processGO:00061521120.018
synaptic growth at neuromuscular junctionGO:00511241190.018
positive regulation of catalytic activityGO:00430851180.018
response to superoxideGO:000030330.018
heart contractionGO:0060047260.018
Zebrafish
axon developmentGO:00615642970.017
regulation of protein modification processGO:00313991120.017
chromatin organizationGO:00063252070.017
negative regulation of synapse assemblyGO:0051964390.017
ribonucleoside catabolic processGO:00424541120.017
anatomical structure homeostasisGO:0060249970.017
lipid biosynthetic processGO:0008610460.017
salivary gland morphogenesisGO:00074351450.017
Fly
negative regulation of cellular metabolic processGO:00313243820.017
Mouse
mitochondrion organizationGO:0007005650.017
reproductive behaviorGO:00190981220.017
reactive oxygen species metabolic processGO:0072593220.017
response to oxygen levelsGO:0070482590.017
cellular response to organic substanceGO:00713101320.017
hindgut developmentGO:0061525580.017
Fly
enzyme linked receptor protein signaling pathwayGO:00071671790.016
mitotic dna integrity checkpointGO:0044774750.016
positive regulation of cell developmentGO:0010720610.016
regulation of proteolysisGO:0030162870.016
cardiac muscle tissue developmentGO:004873890.016
Mouse
organophosphate catabolic processGO:00464341120.016
organic hydroxy compound biosynthetic processGO:1901617210.016
Mouse
hematopoietic or lymphoid organ developmentGO:0048534570.016
regulation of programmed cell deathGO:00430671520.016
positive regulation of protein metabolic processGO:00512471280.016
regulation of response to external stimulusGO:00321011150.016
mesoderm formationGO:0001707210.016
Mouse Fly
skeletal muscle fiber developmentGO:004874130.016
regulation of mitotic cell cycle phase transitionGO:19019901300.016
protein processingGO:0016485680.016
regulation of cell developmentGO:00602842150.016
eye antennal disc developmentGO:0035214600.016
response to temperature stimulusGO:00092661060.015
cell cycle phase transitionGO:00447701400.015
regulation of multi organism processGO:00439001310.015
detection of stimulusGO:00516061560.015
carboxylic acid metabolic processGO:0019752920.015
carbohydrate metabolic processGO:0005975820.015
regulation of response to stressGO:00801342000.015
regulation of cell cycle processGO:00105641810.015
protein localizationGO:00081042840.015
purine ribonucleoside metabolic processGO:00461281270.015
positive regulation of ras protein signal transductionGO:0046579430.015
cellular amide metabolic processGO:0043603800.015
negative regulation of response to stimulusGO:00485852580.015
imaginal disc derived appendage morphogenesisGO:00351143950.014
secretionGO:00469031090.014
wing disc morphogenesisGO:00074723440.014
appendage segmentationGO:0035285260.014
establishment of protein localizationGO:00451841630.014
blastoderm segmentationGO:00073501590.014
ovarian follicle cell developmentGO:00307072480.014
neuron fate commitmentGO:0048663500.014
ameboidal type cell migrationGO:00016671510.014
Mouse
negative regulation of programmed cell deathGO:0043069720.014
regulation of hydrolase activityGO:0051336970.014
organonitrogen compound biosynthetic processGO:19015661170.014
Mouse
chromosome organizationGO:00512763600.014
organic substance transportGO:00717022570.014
nephrocyte filtrationGO:009720670.014
cholesterol transportGO:003030120.014
larval heart developmentGO:000750860.014
sensory perceptionGO:00076001960.013
midgut developmentGO:0007494230.013
ribonucleoside metabolic processGO:00091191270.013
open tracheal system developmentGO:00074242040.013
glycosyl compound metabolic processGO:19016571270.013
embryonic development via the syncytial blastodermGO:00017001480.013
stem cell proliferationGO:0072089880.013
Mouse
muscle organ developmentGO:00075171270.013
Mouse Fly
ventral furrow formationGO:0007370170.013
Fly
regulation of neuron projection developmentGO:0010975690.013
amine metabolic processGO:0009308120.013
regulation of peptidyl lysine acetylationGO:200075670.013
positive regulation of synapse assemblyGO:0051965290.013
cellular response to transforming growth factor beta stimulusGO:0071560180.013
regulation of growthGO:00400082330.013
response to bacteriumGO:00096171980.013
organonitrogen compound catabolic processGO:19015651280.013
negative regulation of protein metabolic processGO:0051248850.013
limb developmentGO:006017310.013
Mouse
neural retina developmentGO:000340740.013
organ formationGO:0048645390.013
Mouse Fly
rna localizationGO:00064031150.013
stem cell developmentGO:0048864790.013
Mouse
neuron recognitionGO:00080381010.013
malpighian tubule developmentGO:0072002640.013
Fly
dna templated transcription elongationGO:0006354180.013
anterior posterior axis specification embryoGO:00085951030.013
aromatic compound catabolic processGO:00194391660.013
developmental pigmentationGO:0048066680.013
phosphorylationGO:00163102940.012
positive regulation of cellular protein metabolic processGO:00322701180.012
secretion by cellGO:00329401010.012
glycerolipid metabolic processGO:0046486340.012
positive regulation of reactive oxygen species metabolic processGO:200037900.012
mitotic cell cycle phase transitionGO:00447721380.012
pigment metabolic processGO:0042440840.012
detection of light stimulusGO:0009583580.012
regulation of autophagyGO:0010506620.012
sex differentiationGO:0007548810.012
Worm
embryonic digestive tract developmentGO:004856650.012
regulation of cellular localizationGO:00603411360.012
leg disc developmentGO:0035218920.012
positive regulation of phosphorus metabolic processGO:00105621390.012
regulation of cell projection organizationGO:0031344920.012
rna processingGO:00063961470.012
small gtpase mediated signal transductionGO:0007264880.012
tissue deathGO:00162711020.012
neuron apoptotic processGO:0051402170.012
purine nucleoside metabolic processGO:00422781270.012
myotube cell developmentGO:001490430.012
humoral immune responseGO:00069591170.012
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.012
positive regulation of cellular amine metabolic processGO:003324000.012
mesenchymal cell differentiationGO:004876210.012
Mouse
nucleoside metabolic processGO:00091161270.012
morphogenesis of embryonic epitheliumGO:0016331940.012
Zebrafish Mouse
eye developmentGO:00016543230.012
production of molecular mediator of immune responseGO:0002440460.012
compound eye developmentGO:00487493070.012
cellular response to hypoxiaGO:0071456280.012
negative regulation of cellular biosynthetic processGO:00313272770.012
Mouse
regulation of cell cycle phase transitionGO:19019871300.012
internal peptidyl lysine acetylationGO:0018393380.012
ras protein signal transductionGO:0007265880.012
pericardial nephrocyte differentiationGO:006132090.011
response to endogenous stimulusGO:00097191190.011
lipid homeostasisGO:0055088330.011
negative regulation of cell cycleGO:00457861160.011
regulation of purine nucleotide metabolic processGO:1900542620.011
toxin metabolic processGO:000940420.011
mesenchymal cell developmentGO:001403110.011
Mouse
cardiac muscle cell differentiationGO:005500740.011
multi organism behaviorGO:00517051750.011
Mouse
positive regulation of feeding behaviorGO:200025380.011
protein maturationGO:0051604710.011
regulation of transcription regulatory region dna bindingGO:200067730.011
Human
heart morphogenesisGO:0003007320.011
Zebrafish Mouse
sarcomere organizationGO:0045214260.011
apoptotic processGO:00069151590.011
regulation of neuron differentiationGO:00456641030.011
jak stat cascadeGO:0007259490.011
oxidation reduction processGO:00551141230.011
antennal morphogenesisGO:0048800140.011
anterior midgut ectodermal morphogenesisGO:000744140.011
regulation of protein localizationGO:0032880760.011
regulation of cellular component biogenesisGO:00440872010.011
ribonucleoside triphosphate metabolic processGO:00091991190.011
regulation of nucleotide metabolic processGO:0006140620.011
negative regulation of sequence specific dna binding transcription factor activityGO:004343340.011
Mouse
response to copper ionGO:004668840.011
neuron projection guidanceGO:00974852410.011
single organism carbohydrate metabolic processGO:0044723720.011
regulation of apoptotic processGO:00429811300.010
regulation of cellular amino acid metabolic processGO:000652100.010
regulation of epithelial cell proliferationGO:005067840.010
reproductive system developmentGO:0061458740.010
Mouse Worm
nucleoside catabolic processGO:00091641120.010
embryonic axis specificationGO:00005781070.010
negative regulation of molecular functionGO:0044092510.010
Mouse
regulation of response to oxidative stressGO:190288240.010
positive regulation of cell deathGO:0010942690.010
gonad developmentGO:0008406500.010
Worm
cellular response to oxygen containing compoundGO:1901701790.010
stem cell divisionGO:0017145690.010
phosphatidylinositol mediated signalingGO:004801540.010
regulation of cellular component sizeGO:0032535980.010
positive regulation of transportGO:0051050920.010
negative regulation of cellular response to oxidative stressGO:190040810.010
extrinsic apoptotic signaling pathwayGO:009719110.010
germ cell migrationGO:0008354430.010
matingGO:00076181200.010

Hand disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.512
nervous system diseaseDOID:86300.042
musculoskeletal system diseaseDOID:1700.041
connective tissue diseaseDOID:6500.036
cardiovascular system diseaseDOID:128700.030
bone diseaseDOID:008000100.030
disease of cellular proliferationDOID:1456600.018
cancerDOID:16200.017
central nervous system diseaseDOID:33100.015
organ system cancerDOID:005068600.014
disease of metabolismDOID:001466700.012
muscle tissue diseaseDOID:6600.011
muscular diseaseDOID:008000000.011