IMP: Integrative Multi-species Prediction

Drosophila melanogaster

15 known processes

l(2)37Cc (Dmel_CG10691)

lethal (2) 37Cc

(Aliases: Cc,fs(2)HH32,l(2)Cc,CG10691,Dmel\CG10691)

FLYBASE: FBgn0002031
Entrez: 49168
UniProtKB: A0A023GQA5
UniProtKB: P24156

Process Predictions
Disease Predictions

l(2)37Cc biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
mitotic spindle organization	GO:0007052	220	0.666
cell death	GO:0008219	279	0.513
endocytosis	GO:0006897	310	0.341
spermatid development	GO:0007286	98	0.279
translation	GO:0006412	69	0.275
response to abiotic stimulus	GO:0009628	341	0.251
spindle organization	GO:0007051	253	0.246
microtubule organizing center organization	GO:0031023	168	0.243
embryo development ending in birth or egg hatching	GO:0009792	152	0.223	Worm
organonitrogen compound metabolic process	GO:1901564	318	0.206	Worm
immune response	GO:0006955	246	0.206
dna metabolic process	GO:0006259	227	0.205	Mouse
body morphogenesis	GO:0010171	2	0.201
immune system process	GO:0002376	347	0.199
apoptotic process	GO:0006915	159	0.191
ribonucleoside metabolic process	GO:0009119	127	0.188	Worm
oocyte development	GO:0048599	124	0.183
taxis	GO:0042330	304	0.171
regulation of localization	GO:0032879	275	0.155
nuclear division	GO:0000280	332	0.136
regulation of cell death	GO:0010941	173	0.136
response to organic substance	GO:0010033	284	0.130	Human
positive regulation of cellular biosynthetic process	GO:0031328	316	0.127	Human
cell proliferation	GO:0008283	299	0.126	Human
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.125	Worm
death	GO:0016265	284	0.124
regulation of protein metabolic process	GO:0051246	256	0.121
small molecule metabolic process	GO:0044281	305	0.116	Worm
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.114
oocyte differentiation	GO:0009994	145	0.110
posttranscriptional regulation of gene expression	GO:0010608	145	0.107
regulation of cellular protein metabolic process	GO:0032268	243	0.106
developmental maturation	GO:0021700	172	0.105
organelle fission	GO:0048285	340	0.105
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.100	Worm
biological adhesion	GO:0022610	138	0.098
single fertilization	GO:0007338	24	0.098
programmed cell death	GO:0012501	257	0.095
vesicle mediated transport	GO:0016192	381	0.094
protein complex biogenesis	GO:0070271	201	0.091
centrosome duplication	GO:0051298	121	0.091
oocyte construction	GO:0007308	112	0.090
trna aminoacylation for protein translation	GO:0006418	2	0.088
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.085	Worm
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.085
regulation of response to stress	GO:0080134	200	0.082
macromolecular complex assembly	GO:0065003	256	0.081
neuron projection guidance	GO:0097485	241	0.081
cellular response to chemical stimulus	GO:0070887	199	0.080
regulation of immune response	GO:0050776	118	0.079
regulation of mrna splicing via spliceosome	GO:0048024	64	0.079
regulation of cell cycle	GO:0051726	291	0.074
nucleoside triphosphate metabolic process	GO:0009141	120	0.072	Worm
response to radiation	GO:0009314	155	0.066
spermatid differentiation	GO:0048515	114	0.061
regulation of oocyte development	GO:0060281	27	0.061
nucleoside metabolic process	GO:0009116	127	0.060	Worm
regulation of catabolic process	GO:0009894	170	0.060
centrosome organization	GO:0051297	163	0.060
organophosphate metabolic process	GO:0019637	195	0.060	Worm
purine nucleoside catabolic process	GO:0006152	112	0.059
purine ribonucleoside metabolic process	GO:0046128	127	0.058	Worm
glycosyl compound metabolic process	GO:1901657	127	0.058	Worm
larval development	GO:0002164	104	0.058
reproductive system development	GO:0061458	74	0.056	Worm
nucleoside catabolic process	GO:0009164	112	0.056
protein transport	GO:0015031	155	0.055
axonogenesis	GO:0007409	290	0.054
mitotic nuclear division	GO:0007067	213	0.053
organonitrogen compound catabolic process	GO:1901565	128	0.052
innate immune response	GO:0045087	144	0.050
ncrna metabolic process	GO:0034660	43	0.049
positive regulation of molecular function	GO:0044093	136	0.048
regulation of translation	GO:0006417	56	0.046
atp metabolic process	GO:0046034	49	0.046	Worm
cell maturation	GO:0048469	144	0.045
positive regulation of protein metabolic process	GO:0051247	128	0.044
regulation of organelle organization	GO:0033043	196	0.043
immune response regulating signaling pathway	GO:0002764	2	0.043
nucleoside monophosphate metabolic process	GO:0009123	52	0.041	Worm
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.040	Human
regulation of apoptotic process	GO:0042981	130	0.040
protein localization	GO:0008104	284	0.038
cellular nitrogen compound catabolic process	GO:0044270	165	0.038
regulation of cell maturation	GO:1903429	27	0.038
oocyte axis specification	GO:0007309	108	0.038
regulation of molecular function	GO:0065009	217	0.037
axon development	GO:0061564	297	0.037
establishment of protein localization	GO:0045184	163	0.037
single organism cellular localization	GO:1902580	180	0.036
ribose phosphate metabolic process	GO:0019693	145	0.036	Worm
purine nucleoside metabolic process	GO:0042278	127	0.036	Worm
cytoplasmic microtubule organization	GO:0031122	22	0.035
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.034	Human
response to extracellular stimulus	GO:0009991	116	0.034
negative regulation of cellular metabolic process	GO:0031324	382	0.034	Human Mouse
phagocytosis	GO:0006909	215	0.034
organelle assembly	GO:0070925	198	0.033
defense response	GO:0006952	300	0.033
cellular response to organic substance	GO:0071310	132	0.033	Human
regulation of rna splicing	GO:0043484	69	0.033
intracellular transport	GO:0046907	228	0.033
cell motility	GO:0048870	251	0.033
negative regulation of biosynthetic process	GO:0009890	277	0.032	Human Mouse
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.032
regulation of vesicle mediated transport	GO:0060627	59	0.031
cellular amino acid metabolic process	GO:0006520	61	0.031
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.030
meiotic cell cycle	GO:0051321	171	0.030
regulation of meiosis	GO:0040020	3	0.030
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.030
cell recognition	GO:0008037	102	0.030
embryonic pattern specification	GO:0009880	174	0.029
purine ribonucleotide metabolic process	GO:0009150	145	0.029	Worm
reproductive structure development	GO:0048608	74	0.029	Worm
immune response activating signal transduction	GO:0002757	2	0.029
regulation of immune system process	GO:0002682	176	0.028
regulation of mrna processing	GO:0050684	71	0.028
purine containing compound metabolic process	GO:0072521	155	0.027	Worm
protein complex assembly	GO:0006461	200	0.027
ribonucleotide metabolic process	GO:0009259	145	0.026	Worm
localization of cell	GO:0051674	257	0.026
endomembrane system organization	GO:0010256	119	0.026
response to external biotic stimulus	GO:0043207	293	0.026
fertilization	GO:0009566	26	0.025
immune effector process	GO:0002252	98	0.025
response to light stimulus	GO:0009416	124	0.025
axon guidance	GO:0007411	233	0.025
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.025	Human Mouse
oocyte anterior posterior axis specification	GO:0007314	72	0.025
single organism behavior	GO:0044708	391	0.024
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.024	Worm
organonitrogen compound biosynthetic process	GO:1901566	117	0.024
positive regulation of cellular component organization	GO:0051130	156	0.023
carbohydrate derivative metabolic process	GO:1901135	217	0.023	Worm
positive regulation of phosphate metabolic process	GO:0045937	139	0.023
nucleoside phosphate metabolic process	GO:0006753	162	0.023	Worm
negative regulation of protein metabolic process	GO:0051248	85	0.022
stem cell development	GO:0048864	79	0.022
glycosyl compound catabolic process	GO:1901658	112	0.022
pole plasm assembly	GO:0007315	61	0.022
organic cyclic compound catabolic process	GO:1901361	168	0.021
mitochondrion organization	GO:0007005	65	0.021	Worm
trna aminoacylation	GO:0043039	2	0.021
positive regulation of hydrolase activity	GO:0051345	78	0.021
regulation of defense response	GO:0031347	102	0.021
lipid storage	GO:0019915	38	0.021
cell migration	GO:0016477	238	0.021
nucleobase containing small molecule metabolic process	GO:0055086	174	0.020	Worm
spermatogenesis	GO:0007283	200	0.020	Worm
proteolysis	GO:0006508	192	0.020
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.020
dna biosynthetic process	GO:0071897	24	0.020	Mouse
chemotaxis	GO:0006935	249	0.019
cellular catabolic process	GO:0044248	372	0.019
negative regulation of rna metabolic process	GO:0051253	251	0.019	Human Mouse
ribonucleoprotein complex subunit organization	GO:0071826	28	0.018
pole plasm rna localization	GO:0007316	52	0.018
negative regulation of epithelial cell proliferation	GO:0050680	4	0.018
nucleobase containing compound catabolic process	GO:0034655	165	0.017
positive regulation of catalytic activity	GO:0043085	118	0.017
phosphorylation	GO:0016310	294	0.017	Worm
positive regulation of developmental process	GO:0051094	143	0.017	Worm
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.017
regulation of meiotic cell cycle	GO:0051445	9	0.017
single organism membrane organization	GO:0044802	93	0.017
intracellular signal transduction	GO:0035556	300	0.016
organic substance transport	GO:0071702	257	0.016
response to other organism	GO:0051707	293	0.016
actin filament based process	GO:0030029	220	0.015
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.015
negative regulation of transcription dna templated	GO:0045892	237	0.015	Human Mouse
actin cytoskeleton organization	GO:0030036	206	0.015
pigmentation	GO:0043473	75	0.015
centrosome cycle	GO:0007098	137	0.015
regulation of programmed cell death	GO:0043067	152	0.015
segmentation	GO:0035282	207	0.015
spindle assembly involved in mitosis	GO:0090307	50	0.015
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.015	Human Mouse
cellular lipid metabolic process	GO:0044255	83	0.015
regulation of cell development	GO:0060284	215	0.015
positive regulation of developmental growth	GO:0048639	62	0.014	Worm
membrane organization	GO:0061024	112	0.014
cytoplasmic transport	GO:0016482	130	0.014
positive regulation of response to stimulus	GO:0048584	323	0.014
development of primary sexual characteristics	GO:0045137	50	0.014	Worm
response to biotic stimulus	GO:0009607	294	0.014
amino acid activation	GO:0043038	3	0.014
cell adhesion	GO:0007155	136	0.014
regulation of lipid metabolic process	GO:0019216	15	0.014
gonad development	GO:0008406	50	0.014	Worm
protein targeting	GO:0006605	64	0.014
cellular component assembly involved in morphogenesis	GO:0010927	151	0.014
positive regulation of immune response	GO:0050778	63	0.014
negative regulation of multi organism process	GO:0043901	29	0.013
nucleotide catabolic process	GO:0009166	109	0.013
regulation of cell proliferation	GO:0042127	163	0.013	Human
pole plasm mrna localization	GO:0019094	49	0.013
positive regulation of cellular protein metabolic process	GO:0032270	118	0.013
pattern recognition receptor signaling pathway	GO:0002221	2	0.013
regulation of hydrolase activity	GO:0051336	97	0.013
purine ribonucleotide catabolic process	GO:0009154	109	0.012
lipid metabolic process	GO:0006629	121	0.012
regulation of endopeptidase activity	GO:0052548	36	0.012
regulation of cell differentiation	GO:0045595	302	0.012
activation of innate immune response	GO:0002218	4	0.012
positive regulation of immune system process	GO:0002684	68	0.012
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.012	Worm
regulation of nucleoside metabolic process	GO:0009118	50	0.012	Worm
regulation of catalytic activity	GO:0050790	185	0.012
meiotic cell cycle process	GO:1903046	132	0.012
growth	GO:0040007	359	0.012	Human Worm
trna metabolic process	GO:0006399	5	0.012
activation of cysteine type endopeptidase activity	GO:0097202	17	0.012
regulation of transport	GO:0051049	181	0.011
lipid localization	GO:0010876	54	0.011
oxidative phosphorylation	GO:0006119	9	0.011	Worm
catabolic process	GO:0009056	409	0.011
purine ribonucleoside catabolic process	GO:0046130	112	0.011
heterocycle catabolic process	GO:0046700	166	0.011
cytoplasmic translation	GO:0002181	0	0.011
apoptotic signaling pathway	GO:0097190	27	0.011
regulation of phosphorus metabolic process	GO:0051174	210	0.011	Worm
cellular response to oxygen containing compound	GO:1901701	79	0.011
maintenance of location	GO:0051235	73	0.011
stem cell differentiation	GO:0048863	117	0.011
establishment of localization in cell	GO:0051649	402	0.010
negative regulation of cell death	GO:0060548	81	0.010
response to nutrient levels	GO:0031667	114	0.010
spindle assembly	GO:0051225	80	0.010
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.010
axis specification	GO:0009798	167	0.010
cell cycle checkpoint	GO:0000075	95	0.010
positive regulation of growth	GO:0045927	75	0.010	Worm

l(2)37Cc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.039
inherited metabolic disorder	DOID:655	0.023
disease of anatomical entity	DOID:7	0.018
integumentary system disease	DOID:16	0.018

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