IMP: Integrative Multi-species Prediction

Drosophila melanogaster

111 known processes

Cyt-c-d (Dmel_CG13263)

Cytochrome c distal

(Aliases: cyt.c,Cyt c,Dmel\CG13263,cyt-c-d,CG13263,Cytc,Cytc-d,bs30f07.y1,Cyt-c1,cytochrome c,bln,pDMc02,cyt c-d,CytC-1,dc3,CytC1,ms(2)04445,DC3,cyt c)

FLYBASE: FBgn0086907
Entrez: 34995
UniProtKB: P04657
UniProtKB: M9PD22

Process Predictions
Disease Predictions

Cyt-c-d biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
spermatid development	GO:0007286	98	0.978
spermatid differentiation	GO:0048515	114	0.977
spermatogenesis	GO:0007283	200	0.789
male gamete generation	GO:0048232	201	0.413
cilium assembly	GO:0042384	38	0.396
positive regulation of peptidase activity	GO:0010952	29	0.334
positive regulation of proteolysis	GO:0045862	52	0.327
programmed cell death	GO:0012501	257	0.302
positive regulation of endopeptidase activity	GO:0010950	26	0.292
cilium morphogenesis	GO:0060271	39	0.283
axoneme assembly	GO:0035082	18	0.236
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.228
regulation of proteolysis	GO:0030162	87	0.192
localization of cell	GO:0051674	257	0.170
cellular component assembly involved in morphogenesis	GO:0010927	151	0.169
negative regulation of response to stimulus	GO:0048585	258	0.152
activation of cysteine type endopeptidase activity	GO:0097202	17	0.149
zymogen activation	GO:0031638	20	0.147
neurological system process	GO:0050877	358	0.147
positive regulation of programmed cell death	GO:0043068	62	0.142
sperm individualization	GO:0007291	48	0.141
cell motility	GO:0048870	251	0.141
apoptotic process	GO:0006915	159	0.123
regulation of cellular localization	GO:0060341	136	0.121
intracellular transport	GO:0046907	228	0.116
cell death	GO:0008219	279	0.113
intracellular signal transduction	GO:0035556	300	0.112	Mouse
regulation of programmed cell death	GO:0043067	152	0.110
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.107
regulation of apoptotic process	GO:0042981	130	0.106
protein modification process	GO:0036211	438	0.105
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.101
regulation of circadian rhythm	GO:0042752	49	0.099
negative regulation of signal transduction	GO:0009968	206	0.096
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.095
positive regulation of response to stimulus	GO:0048584	323	0.091	Mouse
proteolysis	GO:0006508	192	0.089
regulation of hydrolase activity	GO:0051336	97	0.086
regulation of protein metabolic process	GO:0051246	256	0.081
microtubule based transport	GO:0010970	42	0.081
microtubule bundle formation	GO:0001578	27	0.078
sperm axoneme assembly	GO:0007288	13	0.078
sperm motility	GO:0030317	12	0.078
negative regulation of signaling	GO:0023057	219	0.077
positive regulation of molecular function	GO:0044093	136	0.077
organelle assembly	GO:0070925	198	0.075
negative regulation of cell communication	GO:0010648	223	0.075
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.074	Mouse
establishment of localization in cell	GO:0051649	402	0.070
cellular protein modification process	GO:0006464	438	0.070
regulation of catalytic activity	GO:0050790	185	0.068
kidney development	GO:0001822	3	0.068
cilium organization	GO:0044782	41	0.066
positive regulation of hydrolase activity	GO:0051345	78	0.062
cellularization	GO:0007349	90	0.061
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.060
organic substance catabolic process	GO:1901575	308	0.059
regulation of localization	GO:0032879	275	0.059
positive regulation of cell death	GO:0010942	69	0.058
nucleus organization	GO:0006997	45	0.057
protein catabolic process	GO:0030163	101	0.056
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.056
regulation of cellular protein metabolic process	GO:0032268	243	0.055
death	GO:0016265	284	0.053
lateral inhibition	GO:0046331	206	0.053
regulation of peptidase activity	GO:0052547	39	0.048
regulation of response to stress	GO:0080134	200	0.048
regulation of multicellular organismal development	GO:2000026	414	0.046
positive regulation of macromolecule metabolic process	GO:0010604	405	0.046
response to glucose	GO:0009749	2	0.045
protein modification by small protein conjugation or removal	GO:0070647	106	0.043
catabolic process	GO:0009056	409	0.042
protein processing	GO:0016485	68	0.041
axon cargo transport	GO:0008088	29	0.041
cell division	GO:0051301	248	0.041
sensory perception of mechanical stimulus	GO:0050954	72	0.040
regulation of transport	GO:0051049	181	0.040
positive regulation of protein metabolic process	GO:0051247	128	0.040
negative regulation of cellular metabolic process	GO:0031324	382	0.039
protein maturation	GO:0051604	71	0.039
regulation of catabolic process	GO:0009894	170	0.038
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.038
single organism intracellular transport	GO:1902582	207	0.038
positive regulation of transport	GO:0051050	92	0.038
vesicle mediated transport	GO:0016192	381	0.037
chromatin remodeling	GO:0006338	72	0.037
small molecule metabolic process	GO:0044281	305	0.036	Yeast
secretion by cell	GO:0032940	101	0.036
cellular macromolecule localization	GO:0070727	220	0.036
response to abiotic stimulus	GO:0009628	341	0.036
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.035
regulation of autophagy	GO:0010506	62	0.034
organic substance transport	GO:0071702	257	0.034
cell maturation	GO:0048469	144	0.033
protein transport	GO:0015031	155	0.032
camera type eye development	GO:0043010	4	0.031
sensory perception	GO:0007600	196	0.031
learning or memory	GO:0007611	141	0.031
synaptic transmission	GO:0007268	288	0.031
single organism catabolic process	GO:0044712	228	0.031
positive regulation of catalytic activity	GO:0043085	118	0.031
response to endogenous stimulus	GO:0009719	119	0.031
regulation of cellular protein catabolic process	GO:1903362	44	0.030
regulation of molecular function	GO:0065009	217	0.030
central nervous system development	GO:0007417	201	0.030
organic acid metabolic process	GO:0006082	103	0.030
positive regulation of cellular protein metabolic process	GO:0032270	118	0.029
protein localization	GO:0008104	284	0.029
secretion	GO:0046903	109	0.029
microtubule organizing center organization	GO:0031023	168	0.029
carboxylic acid metabolic process	GO:0019752	92	0.029
regulation of intracellular transport	GO:0032386	64	0.029
blastoderm segmentation	GO:0007350	159	0.029
sensory perception of sound	GO:0007605	56	0.028
cell migration	GO:0016477	238	0.028
regulation of microtubule based process	GO:0032886	49	0.028
regulation of cell death	GO:0010941	173	0.027
positive regulation of signal transduction	GO:0009967	223	0.027	Mouse
microtubule based movement	GO:0007018	51	0.027
protein modification by small protein conjugation	GO:0032446	79	0.027
protein ubiquitination	GO:0016567	70	0.027
learning	GO:0007612	75	0.027
response to oxidative stress	GO:0006979	86	0.027
response to monosaccharide	GO:0034284	4	0.027
positive regulation of signaling	GO:0023056	243	0.026	Mouse
cell projection assembly	GO:0030031	94	0.026
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.026
regulation of oocyte development	GO:0060281	27	0.026
cellular macromolecule catabolic process	GO:0044265	136	0.026
establishment of protein localization	GO:0045184	163	0.026
innate immune response	GO:0045087	144	0.025
single organism behavior	GO:0044708	391	0.025
phagocytosis	GO:0006909	215	0.025
mitotic spindle organization	GO:0007052	220	0.025
membrane organization	GO:0061024	112	0.025
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.025
regulation of wnt signaling pathway	GO:0030111	68	0.024
response to external biotic stimulus	GO:0043207	293	0.024
regulation of multi organism process	GO:0043900	131	0.024
positive regulation of cellular biosynthetic process	GO:0031328	316	0.024
stem cell division	GO:0017145	69	0.024
wnt signaling pathway	GO:0016055	98	0.023
nucleoside triphosphate metabolic process	GO:0009141	120	0.023	Yeast
exocrine system development	GO:0035272	162	0.023
sleep	GO:0030431	49	0.023
cellular response to dna damage stimulus	GO:0006974	223	0.023
immune system process	GO:0002376	347	0.023
regulation of proteasomal protein catabolic process	GO:0061136	39	0.023
epithelial cell differentiation	GO:0030855	322	0.023
response to hexose	GO:0009746	3	0.023
ubiquitin dependent protein catabolic process	GO:0006511	78	0.023
positive regulation of cell communication	GO:0010647	250	0.023	Mouse
histolysis	GO:0007559	102	0.023
regulation of circadian sleep wake cycle sleep	GO:0045187	21	0.023
renal system development	GO:0072001	72	0.022
regionalization	GO:0003002	416	0.022
nucleoside phosphate metabolic process	GO:0006753	162	0.022	Yeast
response to biotic stimulus	GO:0009607	294	0.022
protein phosphorylation	GO:0006468	169	0.022
regulation of cell development	GO:0060284	215	0.022
actin filament based process	GO:0030029	220	0.022
immune effector process	GO:0002252	98	0.022
imaginal disc derived wing morphogenesis	GO:0007476	337	0.022
cellular catabolic process	GO:0044248	372	0.022
intracellular protein transport	GO:0006886	104	0.021
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.021
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.021
circadian sleep wake cycle process	GO:0022410	24	0.021
regulation of cellular response to oxidative stress	GO:1900407	4	0.021
gland development	GO:0048732	191	0.021
regulation of cell cycle phase transition	GO:1901987	130	0.021
regulation of secretion	GO:0051046	44	0.020
compound eye morphogenesis	GO:0001745	249	0.020
phosphorylation	GO:0016310	294	0.020	Yeast
male courtship behavior veined wing extension	GO:0048065	22	0.020
purine nucleoside metabolic process	GO:0042278	127	0.020	Yeast
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.020
purine ribonucleoside metabolic process	GO:0046128	127	0.020	Yeast
neuron maturation	GO:0042551	31	0.020
regulation of cellular response to stress	GO:0080135	89	0.020
cellular protein localization	GO:0034613	160	0.020
negative regulation of cell cycle process	GO:0010948	109	0.019
endocytosis	GO:0006897	310	0.019
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.019
mitotic cell cycle phase transition	GO:0044772	138	0.019
regulation of cell cycle	GO:0051726	291	0.019
response to ionizing radiation	GO:0010212	32	0.019
chromosome organization	GO:0051276	360	0.019
positive regulation of gene expression	GO:0010628	290	0.019
oxoacid metabolic process	GO:0043436	103	0.019
embryonic pattern specification	GO:0009880	174	0.018
positive regulation of apoptotic process	GO:0043065	47	0.018
cytoplasmic transport	GO:0016482	130	0.018
sensory organ morphogenesis	GO:0090596	260	0.018
signal release	GO:0023061	49	0.018
segmentation	GO:0035282	207	0.018
regulation of intracellular signal transduction	GO:1902531	236	0.018	Mouse
cellular protein catabolic process	GO:0044257	83	0.018
response to lipopolysaccharide	GO:0032496	4	0.018
defense response	GO:0006952	300	0.018
centrosome duplication	GO:0051298	121	0.018
endomembrane system organization	GO:0010256	119	0.018
cell cycle phase transition	GO:0044770	140	0.018
immune response	GO:0006955	246	0.018
negative regulation of cellular biosynthetic process	GO:0031327	277	0.017
developmental pigmentation	GO:0048066	68	0.017
cytoskeleton dependent intracellular transport	GO:0030705	44	0.017
macromolecular complex assembly	GO:0065003	256	0.017
organonitrogen compound metabolic process	GO:1901564	318	0.017	Yeast
cell proliferation	GO:0008283	299	0.017
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.017	Yeast
insemination	GO:0007320	22	0.017
dna packaging	GO:0006323	91	0.017
regulation of protein catabolic process	GO:0042176	55	0.017
response to wounding	GO:0009611	94	0.017
autophagic cell death	GO:0048102	83	0.017
mitotic cell cycle checkpoint	GO:0007093	88	0.016
regulation of neurogenesis	GO:0050767	158	0.016
rna localization	GO:0006403	115	0.016
macromolecule catabolic process	GO:0009057	161	0.016
antimicrobial humoral response	GO:0019730	99	0.016
gland morphogenesis	GO:0022612	145	0.016
positive regulation of intracellular signal transduction	GO:1902533	116	0.016	Mouse
response to other organism	GO:0051707	293	0.016
single organism cellular localization	GO:1902580	180	0.016
positive regulation of catabolic process	GO:0009896	105	0.016
ribonucleotide metabolic process	GO:0009259	145	0.016	Yeast
cytokinesis	GO:0000910	90	0.016
somatic stem cell division	GO:0048103	37	0.016
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.016
positive regulation of rna biosynthetic process	GO:1902680	266	0.016
negative regulation of protein metabolic process	GO:0051248	85	0.016
positive regulation of secretion	GO:0051047	22	0.015
regulation of cellular amine metabolic process	GO:0033238	3	0.015
negative regulation of cellular protein metabolic process	GO:0032269	85	0.015
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.015
eye development	GO:0001654	323	0.015
developmental maturation	GO:0021700	172	0.015
regulation of cytoskeleton organization	GO:0051493	89	0.015
neuron remodeling	GO:0016322	29	0.015
regulation of cellular amino acid metabolic process	GO:0006521	0	0.015
regulation of mitochondrial fusion	GO:0010635	5	0.015
regulation of cellular ketone metabolic process	GO:0010565	3	0.015
regulation of protein localization	GO:0032880	76	0.015
regulation of anatomical structure morphogenesis	GO:0022603	242	0.015
nitrogen compound transport	GO:0071705	85	0.015
regulation of phosphorylation	GO:0042325	147	0.015
autophagy	GO:0006914	108	0.015
oocyte construction	GO:0007308	112	0.015
centrosome organization	GO:0051297	163	0.015
proteasomal protein catabolic process	GO:0010498	59	0.015
imaginal disc pattern formation	GO:0007447	91	0.014
eye morphogenesis	GO:0048592	260	0.014
nucleotide catabolic process	GO:0009166	109	0.014
nucleoside catabolic process	GO:0009164	112	0.014
tissue death	GO:0016271	102	0.014
regulation of synaptic transmission	GO:0050804	69	0.014
oocyte anterior posterior axis specification	GO:0007314	72	0.014
regulation of cellular component biogenesis	GO:0044087	201	0.014
cellular amino acid metabolic process	GO:0006520	61	0.014
positive regulation of cell development	GO:0010720	61	0.014
response to organic cyclic compound	GO:0014070	89	0.014
regulation of cell differentiation	GO:0045595	302	0.014
chromatin organization	GO:0006325	207	0.014
positive regulation of intracellular transport	GO:0032388	42	0.014
axis specification	GO:0009798	167	0.014
positive regulation of biosynthetic process	GO:0009891	316	0.014
compound eye development	GO:0048749	307	0.014
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.014
organonitrogen compound catabolic process	GO:1901565	128	0.014
response to bacterium	GO:0009617	198	0.014
defense response to other organism	GO:0098542	225	0.014
cell cycle checkpoint	GO:0000075	95	0.013
gtp catabolic process	GO:0006184	72	0.013
smoothened signaling pathway	GO:0007224	49	0.013
lipid storage	GO:0019915	38	0.013
modification dependent protein catabolic process	GO:0019941	78	0.013
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.013
retinal cell programmed cell death	GO:0046666	25	0.013
regulation of secretion by cell	GO:1903530	39	0.013
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.013
salivary gland cell autophagic cell death	GO:0035071	83	0.013
negative regulation of cell cycle phase transition	GO:1901988	103	0.013
imaginal disc derived appendage development	GO:0048737	399	0.013
nucleoside triphosphate catabolic process	GO:0009143	108	0.013
glycosyl compound metabolic process	GO:1901657	127	0.013	Yeast
positive regulation of transcription dna templated	GO:0045893	266	0.013
intracellular mrna localization	GO:0008298	66	0.013
memory	GO:0007613	94	0.013
response to oxygen containing compound	GO:1901700	200	0.013
dna metabolic process	GO:0006259	227	0.013
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.013
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.013
purine ribonucleotide catabolic process	GO:0009154	109	0.013
regulation of endopeptidase activity	GO:0052548	36	0.013
acid secretion	GO:0046717	1	0.013
heart contraction	GO:0060047	26	0.013
response to alcohol	GO:0097305	95	0.012
regulation of organelle organization	GO:0033043	196	0.012
wnt protein secretion	GO:0061355	5	0.012
vesicle localization	GO:0051648	55	0.012
centrosome cycle	GO:0007098	137	0.012
mitotic cytokinesis	GO:0000281	50	0.012
intercellular bridge organization	GO:0043063	14	0.012
guanosine containing compound catabolic process	GO:1901069	74	0.012
actin cytoskeleton organization	GO:0030036	206	0.012
regulation of establishment of protein localization	GO:0070201	61	0.012
response to organic substance	GO:0010033	284	0.012
regulation of nervous system development	GO:0051960	248	0.012
transcription from rna polymerase ii promoter	GO:0006366	368	0.012
humoral immune response	GO:0006959	117	0.012
developmental programmed cell death	GO:0010623	138	0.012
aromatic compound catabolic process	GO:0019439	166	0.012
negative regulation of cellular component organization	GO:0051129	108	0.012
positive regulation of protein catabolic process	GO:0045732	34	0.012
retina development in camera type eye	GO:0060041	4	0.012
ovarian follicle cell development	GO:0030707	248	0.012
cognition	GO:0050890	141	0.012
growth	GO:0040007	359	0.012
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.012	Yeast
anterior posterior pattern specification	GO:0009952	136	0.012
ras protein signal transduction	GO:0007265	88	0.012
salivary gland development	GO:0007431	162	0.011
gtp metabolic process	GO:0046039	72	0.011
purine nucleotide catabolic process	GO:0006195	109	0.011
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.011
response to organophosphorus	GO:0046683	2	0.011
purine nucleoside catabolic process	GO:0006152	112	0.011
negative regulation of gene expression	GO:0010629	387	0.011
ribonucleoside catabolic process	GO:0042454	112	0.011
positive regulation of rna metabolic process	GO:0051254	271	0.011
histone exchange	GO:0043486	21	0.011
leg disc development	GO:0035218	92	0.011
single organism membrane organization	GO:0044802	93	0.011
purine containing compound catabolic process	GO:0072523	112	0.011
monocarboxylic acid transport	GO:0015718	3	0.011
dna conformation change	GO:0071103	105	0.011
nucleoside phosphate catabolic process	GO:1901292	110	0.011
nucleotide metabolic process	GO:0009117	161	0.011	Yeast
cellular amide metabolic process	GO:0043603	80	0.011
nucleosome organization	GO:0034728	59	0.011
positive regulation of secretion by cell	GO:1903532	20	0.011
amine metabolic process	GO:0009308	12	0.011
small gtpase mediated signal transduction	GO:0007264	88	0.011
hemocyte differentiation	GO:0042386	38	0.011
positive regulation of cellular catabolic process	GO:0031331	95	0.011
ectopic germ cell programmed cell death	GO:0035234	8	0.011
circadian rhythm	GO:0007623	105	0.011
protein localization to organelle	GO:0033365	82	0.011
regulation of cell cycle process	GO:0010564	181	0.011
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:0070059	4	0.011
posttranscriptional gene silencing by rna	GO:0035194	45	0.011
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.010	Yeast
melanin metabolic process	GO:0006582	47	0.010
protein k48 linked ubiquitination	GO:0070936	3	0.010
post embryonic appendage morphogenesis	GO:0035120	385	0.010
single organism biosynthetic process	GO:0044711	206	0.010
glycosyl compound catabolic process	GO:1901658	112	0.010
epithelial cell development	GO:0002064	274	0.010
purine containing compound metabolic process	GO:0072521	155	0.010	Yeast
regulation of circadian sleep wake cycle	GO:0042749	25	0.010
pole plasm oskar mrna localization	GO:0045451	46	0.010
regulation of phosphorus metabolic process	GO:0051174	210	0.010
positive regulation of phosphate metabolic process	GO:0045937	139	0.010
cytoskeleton dependent cytokinesis	GO:0061640	81	0.010
negative regulation of cell cycle	GO:0045786	116	0.010
regulation of response to external stimulus	GO:0032101	115	0.010
dorsal ventral pattern formation	GO:0009953	133	0.010
rhythmic process	GO:0048511	106	0.010
ribose phosphate metabolic process	GO:0019693	145	0.010	Yeast

Cyt-c-d disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.062
nervous system disease	DOID:863	0.039
neurodegenerative disease	DOID:1289	0.019
central nervous system disease	DOID:331	0.019
musculoskeletal system disease	DOID:17	0.011

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