IMP: Integrative Multi-species Prediction

Drosophila melanogaster

7 known processes

Dgkepsilon (Dmel_CG8657)

Diacyl glycerol kinase epsilon

(Aliases: DGKepsilon,Dmel\CG8657,CG8657,DGKe)

Entrez: 36408
FLYBASE: FBgn0020930
UniProtKB: Q7K579

Process Predictions
Disease Predictions

Dgkepsilon biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.182
lateral inhibition	GO:0046331	206	0.125
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.084
protein modification process	GO:0036211	438	0.053
organic substance catabolic process	GO:1901575	308	0.052
negative regulation of cellular metabolic process	GO:0031324	382	0.051
macromolecule catabolic process	GO:0009057	161	0.050
catabolic process	GO:0009056	409	0.047
cellular catabolic process	GO:0044248	372	0.041
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.041
positive regulation of macromolecule metabolic process	GO:0010604	405	0.040
positive regulation of transcription dna templated	GO:0045893	266	0.039
positive regulation of rna metabolic process	GO:0051254	271	0.037
cellular macromolecule catabolic process	GO:0044265	136	0.035
cellular protein modification process	GO:0006464	438	0.033
positive regulation of cellular biosynthetic process	GO:0031328	316	0.033
regionalization	GO:0003002	416	0.031
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.030
positive regulation of biosynthetic process	GO:0009891	316	0.029
homeostatic process	GO:0042592	199	0.028
establishment of localization in cell	GO:0051649	402	0.027
positive regulation of gene expression	GO:0010628	290	0.026
chaeta development	GO:0022416	97	0.026
negative regulation of gene expression	GO:0010629	387	0.026
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.025
positive regulation of signaling	GO:0023056	243	0.025
response to nutrient levels	GO:0031667	114	0.025
transcription from rna polymerase ii promoter	GO:0006366	368	0.025
protein localization	GO:0008104	284	0.024
positive regulation of rna biosynthetic process	GO:1902680	266	0.024
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.024
cytoskeleton dependent cytokinesis	GO:0061640	81	0.024
regulation of catabolic process	GO:0009894	170	0.024
response to organic substance	GO:0010033	284	0.024
positive regulation of response to stimulus	GO:0048584	323	0.024
regulation of cellular protein metabolic process	GO:0032268	243	0.024
cellular nitrogen compound catabolic process	GO:0044270	165	0.023
heterocycle catabolic process	GO:0046700	166	0.023
protein catabolic process	GO:0030163	101	0.023
secretion	GO:0046903	109	0.022
cellular response to extracellular stimulus	GO:0031668	64	0.022
posttranscriptional regulation of gene expression	GO:0010608	145	0.022
organic substance transport	GO:0071702	257	0.021
programmed cell death	GO:0012501	257	0.021
vesicle mediated transport	GO:0016192	381	0.020
phosphorylation	GO:0016310	294	0.020
protein transport	GO:0015031	155	0.020
single organism catabolic process	GO:0044712	228	0.020
regulation of localization	GO:0032879	275	0.020
response to abiotic stimulus	GO:0009628	341	0.020
positive regulation of cell communication	GO:0010647	250	0.019
developmental maturation	GO:0021700	172	0.019
negative regulation of rna metabolic process	GO:0051253	251	0.019
cell division	GO:0051301	248	0.019
mitotic nuclear division	GO:0007067	213	0.019
compound eye development	GO:0048749	307	0.019
carbohydrate derivative metabolic process	GO:1901135	217	0.019
small molecule metabolic process	GO:0044281	305	0.019
immune system process	GO:0002376	347	0.018
cellular response to starvation	GO:0009267	61	0.018
endocytosis	GO:0006897	310	0.017
defense response to other organism	GO:0098542	225	0.017
organelle fission	GO:0048285	340	0.017
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.017
detection of stimulus	GO:0051606	156	0.017
secretion by cell	GO:0032940	101	0.017
spindle organization	GO:0007051	253	0.017
regulation of cell cycle	GO:0051726	291	0.017
modification dependent protein catabolic process	GO:0019941	78	0.017
chromosome organization	GO:0051276	360	0.017
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.016
nuclear division	GO:0000280	332	0.016
spermatid development	GO:0007286	98	0.016
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.016
male gamete generation	GO:0048232	201	0.015
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.015
eye development	GO:0001654	323	0.015
appendage development	GO:0048736	401	0.015
regulation of protein metabolic process	GO:0051246	256	0.015
regulation of multi organism process	GO:0043900	131	0.015
regulation of epithelial cell proliferation	GO:0050678	4	0.015
regulation of response to stress	GO:0080134	200	0.015
mitotic cytokinesis	GO:0000281	50	0.015
body morphogenesis	GO:0010171	2	0.015
actin filament organization	GO:0007015	126	0.014
carboxylic acid metabolic process	GO:0019752	92	0.014
negative regulation of cellular biosynthetic process	GO:0031327	277	0.014
camera type eye development	GO:0043010	4	0.014
cytoplasmic transport	GO:0016482	130	0.014
regulation of notch signaling pathway	GO:0008593	100	0.014
regulation of multicellular organismal development	GO:2000026	414	0.014
establishment of protein localization	GO:0045184	163	0.014
regulation of molecular function	GO:0065009	217	0.014
response to extracellular stimulus	GO:0009991	116	0.014
peptide metabolic process	GO:0006518	80	0.014
organic cyclic compound catabolic process	GO:1901361	168	0.014
regulation of cell cycle process	GO:0010564	181	0.014
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.014
compound eye morphogenesis	GO:0001745	249	0.014
defense response	GO:0006952	300	0.014
mitotic cell cycle phase transition	GO:0044772	138	0.014
single organism carbohydrate metabolic process	GO:0044723	72	0.014
chemical homeostasis	GO:0048878	92	0.014
negative regulation of biosynthetic process	GO:0009890	277	0.014
imaginal disc derived appendage development	GO:0048737	399	0.014
proteolysis	GO:0006508	192	0.014
regulation of cellular ketone metabolic process	GO:0010565	3	0.014
mrna metabolic process	GO:0016071	124	0.013
organic acid metabolic process	GO:0006082	103	0.013
response to other organism	GO:0051707	293	0.013
cellular homeostasis	GO:0019725	80	0.013
death	GO:0016265	284	0.013
regulation of programmed cell death	GO:0043067	152	0.013
nucleobase containing compound catabolic process	GO:0034655	165	0.013
cellular response to nutrient levels	GO:0031669	62	0.013
cytokinesis	GO:0000910	90	0.013
wing disc pattern formation	GO:0035222	66	0.013
cellular macromolecule localization	GO:0070727	220	0.013
regulation of cell death	GO:0010941	173	0.013
cell maturation	GO:0048469	144	0.013
detection of external stimulus	GO:0009581	66	0.013
proteasomal protein catabolic process	GO:0010498	59	0.013
phagocytosis	GO:0006909	215	0.013
protein secretion	GO:0009306	45	0.013
endomembrane system organization	GO:0010256	119	0.013
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.013
negative regulation of cellular protein metabolic process	GO:0032269	85	0.013
positive regulation of proteolysis	GO:0045862	52	0.013
response to biotic stimulus	GO:0009607	294	0.013
cellularization	GO:0007349	90	0.013
ion transport	GO:0006811	145	0.013
embryonic pattern specification	GO:0009880	174	0.013
cellular protein catabolic process	GO:0044257	83	0.013
segmentation	GO:0035282	207	0.012
negative regulation of protein metabolic process	GO:0051248	85	0.012
immune response	GO:0006955	246	0.012
mitotic spindle organization	GO:0007052	220	0.012
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.012
organonitrogen compound metabolic process	GO:1901564	318	0.012
connective tissue development	GO:0061448	3	0.012
cell death	GO:0008219	279	0.012
spermatogenesis	GO:0007283	200	0.012
post embryonic appendage morphogenesis	GO:0035120	385	0.012
carbohydrate metabolic process	GO:0005975	82	0.012
limb morphogenesis	GO:0035108	1	0.012
anterior posterior pattern specification	GO:0009952	136	0.012
golgi organization	GO:0007030	66	0.012
cell motility	GO:0048870	251	0.012
cellular response to external stimulus	GO:0071496	66	0.012
cellular amide metabolic process	GO:0043603	80	0.012
regulation of transport	GO:0051049	181	0.012
small gtpase mediated signal transduction	GO:0007264	88	0.012
cell aging	GO:0007569	2	0.012
dendrite development	GO:0016358	204	0.012
single organism cellular localization	GO:1902580	180	0.011
regulation of cellular catabolic process	GO:0031329	157	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
eye photoreceptor cell differentiation	GO:0001754	145	0.011
limb development	GO:0060173	1	0.011
regulation of cellular localization	GO:0060341	136	0.011
negative regulation of cell cycle	GO:0045786	116	0.011
negative regulation of mitotic cell cycle	GO:0045930	109	0.011
wing disc morphogenesis	GO:0007472	344	0.011
oocyte construction	GO:0007308	112	0.011
negative regulation of response to stimulus	GO:0048585	258	0.011
protein complex assembly	GO:0006461	200	0.011
dorsal ventral pattern formation	GO:0009953	133	0.011
microtubule based movement	GO:0007018	51	0.011
regulation of response to external stimulus	GO:0032101	115	0.011
regulation of protein catabolic process	GO:0042176	55	0.011
regulation of mitotic cell cycle	GO:0007346	190	0.011
salivary gland development	GO:0007431	162	0.011
regulation of phosphorus metabolic process	GO:0051174	210	0.011
notch signaling pathway	GO:0007219	120	0.011
positive regulation of signal transduction	GO:0009967	223	0.011
response to hexose	GO:0009746	3	0.011
nitrogen compound transport	GO:0071705	85	0.011
aromatic compound catabolic process	GO:0019439	166	0.011
negative regulation of cell cycle process	GO:0010948	109	0.011
embryonic axis specification	GO:0000578	107	0.011
detection of chemical stimulus	GO:0009593	93	0.011
positive regulation of transport	GO:0051050	92	0.011
regulation of proteolysis	GO:0030162	87	0.011
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.011
response to starvation	GO:0042594	97	0.011
cell cycle phase transition	GO:0044770	140	0.011
mesenchymal cell differentiation	GO:0048762	1	0.010
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.010
regulation of apoptotic process	GO:0042981	130	0.010
oocyte differentiation	GO:0009994	145	0.010
response to glucose	GO:0009749	2	0.010
anterior posterior axis specification embryo	GO:0008595	103	0.010
regulation of catalytic activity	GO:0050790	185	0.010
cellular response to organic substance	GO:0071310	132	0.010
blastoderm segmentation	GO:0007350	159	0.010
regulation of phosphate metabolic process	GO:0019220	210	0.010
regulation of cell cycle phase transition	GO:1901987	130	0.010
negative regulation of cell communication	GO:0010648	223	0.010
response to radiation	GO:0009314	155	0.010
defense response to bacterium	GO:0042742	178	0.010
synaptic growth at neuromuscular junction	GO:0051124	119	0.010
negative regulation of signal transduction	GO:0009968	206	0.010
regulation of gene expression epigenetic	GO:0040029	128	0.010

Dgkepsilon disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.038
disease of metabolism	DOID:0014667	0.026
nervous system disease	DOID:863	0.021
inherited metabolic disorder	DOID:655	0.021
diabetes mellitus	DOID:9351	0.018
acquired metabolic disease	DOID:0060158	0.018
carbohydrate metabolism disease	DOID:0050013	0.018
glucose metabolism disease	DOID:4194	0.018
central nervous system disease	DOID:331	0.016
neurodegenerative disease	DOID:1289	0.016
type 2 diabetes mellitus	DOID:9352	0.014
cardiovascular system disease	DOID:1287	0.010

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