IMP: Integrative Multi-species Prediction

Drosophila melanogaster

83 known processes

Ptpmeg (Dmel_CG1228)

CG1228 gene product from transcript CG1228-RD

(Aliases: Meg,ptpmeg,PTP-meg,dMEG1,scc,CG1228,Dmel\CG1228,MEG1,anon-WO0118547.211)

FLYBASE: FBgn0261985
Entrez: 38059
UniProtKB: Q9W0R3

Process Predictions
Disease Predictions

Ptpmeg biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
mushroom body development	GO:0016319	70	0.986
central nervous system development	GO:0007417	201	0.966
brain development	GO:0007420	120	0.789
head development	GO:0060322	135	0.765
growth	GO:0040007	359	0.598
exocrine system development	GO:0035272	162	0.478
negative regulation of response to stimulus	GO:0048585	258	0.446
organelle assembly	GO:0070925	198	0.373
chemotaxis	GO:0006935	249	0.370
cellular protein modification process	GO:0006464	438	0.361
detection of stimulus	GO:0051606	156	0.346
positive regulation of signal transduction	GO:0009967	223	0.345
gland morphogenesis	GO:0022612	145	0.311
protein modification process	GO:0036211	438	0.258
regulation of cell development	GO:0060284	215	0.235
organic substance catabolic process	GO:1901575	308	0.220
nucleoside triphosphate catabolic process	GO:0009143	108	0.213
nuclear division	GO:0000280	332	0.203
positive regulation of cell communication	GO:0010647	250	0.189
intracellular signal transduction	GO:0035556	300	0.186
cellular catabolic process	GO:0044248	372	0.185
transcription from rna polymerase ii promoter	GO:0006366	368	0.178
positive regulation of signaling	GO:0023056	243	0.176
positive regulation of cellular component biogenesis	GO:0044089	80	0.175
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.172
organelle fission	GO:0048285	340	0.171
catabolic process	GO:0009056	409	0.164
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.156
nucleoside phosphate catabolic process	GO:1901292	110	0.154
regulation of growth	GO:0040008	233	0.141
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.141
ribonucleoside metabolic process	GO:0009119	127	0.138
protein localization	GO:0008104	284	0.136
regulation of developmental growth	GO:0048638	174	0.136
chromatin modification	GO:0016568	147	0.135
muscle structure development	GO:0061061	224	0.127
organonitrogen compound catabolic process	GO:1901565	128	0.126
regulation of cell projection organization	GO:0031344	92	0.123
spermatogenesis	GO:0007283	200	0.120
regulation of phosphate metabolic process	GO:0019220	210	0.118
establishment of localization in cell	GO:0051649	402	0.116
developmental growth	GO:0048589	280	0.112
positive regulation of phosphorus metabolic process	GO:0010562	139	0.108
salivary gland development	GO:0007431	162	0.108
gland development	GO:0048732	191	0.107
ribonucleotide catabolic process	GO:0009261	109	0.104
negative regulation of cell communication	GO:0010648	223	0.103
positive regulation of phosphate metabolic process	GO:0045937	139	0.102
regulation of intracellular signal transduction	GO:1902531	236	0.098
cell migration	GO:0016477	238	0.098
aromatic compound catabolic process	GO:0019439	166	0.096
taxis	GO:0042330	304	0.093
regulation of cell death	GO:0010941	173	0.091
ras protein signal transduction	GO:0007265	88	0.089
cell motility	GO:0048870	251	0.089
positive regulation of response to stimulus	GO:0048584	323	0.087
proteolysis	GO:0006508	192	0.085
regulation of cell growth	GO:0001558	43	0.084
organonitrogen compound metabolic process	GO:1901564	318	0.083
peptidyl amino acid modification	GO:0018193	105	0.083
axon guidance	GO:0007411	233	0.082
neuron projection guidance	GO:0097485	241	0.081
positive regulation of gene expression	GO:0010628	290	0.077
response to organic substance	GO:0010033	284	0.076
glycosyl compound catabolic process	GO:1901658	112	0.075
small gtpase mediated signal transduction	GO:0007264	88	0.075
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.072
microtubule organizing center organization	GO:0031023	168	0.072
phosphorylation	GO:0016310	294	0.071
retina morphogenesis in camera type eye	GO:0060042	2	0.071
tube morphogenesis	GO:0035239	191	0.071
cytoskeleton dependent cytokinesis	GO:0061640	81	0.070
immune system process	GO:0002376	347	0.067
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.066
salivary gland morphogenesis	GO:0007435	145	0.066
glycosyl compound metabolic process	GO:1901657	127	0.065
cell division	GO:0051301	248	0.064
protein acylation	GO:0043543	42	0.063
guanosine containing compound catabolic process	GO:1901069	74	0.063
male gamete generation	GO:0048232	201	0.063
immune response	GO:0006955	246	0.062
nucleotide catabolic process	GO:0009166	109	0.062
positive regulation of molecular function	GO:0044093	136	0.061
regulation of hydrolase activity	GO:0051336	97	0.061
spindle assembly	GO:0051225	80	0.061
regulation of ras gtpase activity	GO:0032318	38	0.060
vesicle mediated transport	GO:0016192	381	0.060
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.060
positive regulation of catalytic activity	GO:0043085	118	0.059
detection of external stimulus	GO:0009581	66	0.059
regulation of cellular component size	GO:0032535	98	0.059
skeletal muscle organ development	GO:0060538	48	0.058
ribose phosphate metabolic process	GO:0019693	145	0.057
nucleoside metabolic process	GO:0009116	127	0.057
regulation of multi organism process	GO:0043900	131	0.056
cellular nitrogen compound catabolic process	GO:0044270	165	0.055
purine containing compound catabolic process	GO:0072523	112	0.055
chromosome organization	GO:0051276	360	0.055
organophosphate metabolic process	GO:0019637	195	0.055
regulation of organelle organization	GO:0033043	196	0.055
mitotic nuclear division	GO:0007067	213	0.055
positive regulation of gtp catabolic process	GO:0033126	43	0.055
regulation of cell morphogenesis	GO:0022604	163	0.055
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.055
positive regulation of developmental process	GO:0051094	143	0.054
response to oxygen containing compound	GO:1901700	200	0.054
actin cytoskeleton organization	GO:0030036	206	0.053
maintenance of location	GO:0051235	73	0.053
purine nucleoside catabolic process	GO:0006152	112	0.051
sensory perception	GO:0007600	196	0.051
purine nucleoside metabolic process	GO:0042278	127	0.051
cell death	GO:0008219	279	0.051
multicellular organism growth	GO:0035264	46	0.051
nucleobase containing compound catabolic process	GO:0034655	165	0.050
multi organism behavior	GO:0051705	175	0.048
purine ribonucleoside metabolic process	GO:0046128	127	0.048
positive regulation of nucleotide catabolic process	GO:0030813	46	0.047
open tracheal system development	GO:0007424	204	0.047
regulation of ras protein signal transduction	GO:0046578	93	0.047
regulation of phosphorus metabolic process	GO:0051174	210	0.046
carbohydrate derivative catabolic process	GO:1901136	118	0.046
tube development	GO:0035295	244	0.044
death	GO:0016265	284	0.044
purine ribonucleoside catabolic process	GO:0046130	112	0.044
dendrite morphogenesis	GO:0048813	199	0.044
immune effector process	GO:0002252	98	0.044
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.044
response to ecdysone	GO:0035075	34	0.044
heterocycle catabolic process	GO:0046700	166	0.043
regulation of tube size open tracheal system	GO:0035151	43	0.043
regulation of anatomical structure size	GO:0090066	163	0.043
nucleoside catabolic process	GO:0009164	112	0.043
localization of cell	GO:0051674	257	0.042
centrosome cycle	GO:0007098	137	0.041
inter male aggressive behavior	GO:0002121	60	0.041
organic cyclic compound catabolic process	GO:1901361	168	0.041
carbohydrate derivative metabolic process	GO:1901135	217	0.039
protein phosphorylation	GO:0006468	169	0.039
cellular macromolecule localization	GO:0070727	220	0.039
larval midgut histolysis	GO:0035069	22	0.038
positive regulation of transcription dna templated	GO:0045893	266	0.038
forebrain development	GO:0030900	2	0.038
spindle organization	GO:0007051	253	0.037
positive regulation of multicellular organismal process	GO:0051240	143	0.037
response to sterol	GO:0036314	34	0.037
establishment of organelle localization	GO:0051656	122	0.037
respiratory system development	GO:0060541	213	0.037
mitotic cell cycle embryonic	GO:0045448	38	0.036
endocytosis	GO:0006897	310	0.036
nucleoside phosphate metabolic process	GO:0006753	162	0.036
mitotic spindle organization	GO:0007052	220	0.035
sensory perception of mechanical stimulus	GO:0050954	72	0.035
digestive system development	GO:0055123	149	0.035
ribonucleoside catabolic process	GO:0042454	112	0.035
nucleobase containing small molecule metabolic process	GO:0055086	174	0.035
positive regulation of cellular protein metabolic process	GO:0032270	118	0.035
modification dependent protein catabolic process	GO:0019941	78	0.035
positive regulation of hydrolase activity	GO:0051345	78	0.035
positive regulation of rna metabolic process	GO:0051254	271	0.034
negative regulation of signal transduction	GO:0009968	206	0.034
regulation of nucleoside metabolic process	GO:0009118	50	0.034
negative regulation of signaling	GO:0023057	219	0.033
gtp catabolic process	GO:0006184	72	0.033
regulation of response to external stimulus	GO:0032101	115	0.033
cellular response to chemical stimulus	GO:0070887	199	0.033
nucleus localization	GO:0051647	34	0.033
regulation of neurogenesis	GO:0050767	158	0.032
negative regulation of cellular component organization	GO:0051129	108	0.031
post embryonic appendage morphogenesis	GO:0035120	385	0.031
cellular protein localization	GO:0034613	160	0.030
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.029
autophagic cell death	GO:0048102	83	0.029
regionalization	GO:0003002	416	0.029
regulation of axonogenesis	GO:0050770	32	0.029
regulation of cell proliferation	GO:0042127	163	0.029
protein dna complex subunit organization	GO:0071824	86	0.029
negative regulation of intracellular signal transduction	GO:1902532	57	0.029
axonogenesis	GO:0007409	290	0.028
covalent chromatin modification	GO:0016569	106	0.028
dendrite development	GO:0016358	204	0.028
purine nucleotide catabolic process	GO:0006195	109	0.028
locomotory behavior	GO:0007626	176	0.028
retina development in camera type eye	GO:0060041	4	0.028
regulation of localization	GO:0032879	275	0.028
appendage development	GO:0048736	401	0.027
regulation of cellular amino acid metabolic process	GO:0006521	0	0.027
regulation of mitotic cell cycle	GO:0007346	190	0.027
protein ubiquitination	GO:0016567	70	0.026
positive regulation of proteolysis	GO:0045862	52	0.026
larval midgut cell programmed cell death	GO:0035096	19	0.026
positive regulation of catabolic process	GO:0009896	105	0.026
response to organic cyclic compound	GO:0014070	89	0.026
negative regulation of apoptotic process	GO:0043066	63	0.026
regulation of response to stress	GO:0080134	200	0.026
cellular macromolecule catabolic process	GO:0044265	136	0.026
positive regulation of rna biosynthetic process	GO:1902680	266	0.025
muscle attachment	GO:0016203	36	0.025
axis elongation	GO:0003401	3	0.025
positive regulation of phosphorylation	GO:0042327	87	0.025
regulation of gtp catabolic process	GO:0033124	44	0.025
single organism catabolic process	GO:0044712	228	0.025
positive regulation of intracellular signal transduction	GO:1902533	116	0.025
imaginal disc derived appendage development	GO:0048737	399	0.025
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.025
negative regulation of growth	GO:0045926	84	0.024
negative regulation of gene expression	GO:0010629	387	0.024
intracellular transport	GO:0046907	228	0.024
convergent extension involved in gastrulation	GO:0060027	2	0.024
regulation of cytoskeleton organization	GO:0051493	89	0.024
negative regulation of neurogenesis	GO:0050768	53	0.024
phagocytosis	GO:0006909	215	0.024
positive regulation of programmed cell death	GO:0043068	62	0.023
ubiquitin dependent protein catabolic process	GO:0006511	78	0.023
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.022
detection of light stimulus	GO:0009583	58	0.022
purine containing compound metabolic process	GO:0072521	155	0.022
protein transport	GO:0015031	155	0.022
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.022
nucleoside triphosphate metabolic process	GO:0009141	120	0.022
regulation of phosphorylation	GO:0042325	147	0.021
regulation of catalytic activity	GO:0050790	185	0.021
cellular component assembly involved in morphogenesis	GO:0010927	151	0.021
positive regulation of macromolecule metabolic process	GO:0010604	405	0.021
regulation of neuron differentiation	GO:0045664	103	0.021
chromatin organization	GO:0006325	207	0.021
single organism intracellular transport	GO:1902582	207	0.020
regulation of programmed cell death	GO:0043067	152	0.020
organophosphate catabolic process	GO:0046434	112	0.020
muscle organ development	GO:0007517	127	0.020
regulation of cell cycle	GO:0051726	291	0.020
response to other organism	GO:0051707	293	0.019
innate immune response	GO:0045087	144	0.019
positive regulation of cell differentiation	GO:0045597	64	0.019
cellular protein complex assembly	GO:0043623	71	0.019
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.019
tissue morphogenesis	GO:0048729	297	0.019
sensory organ morphogenesis	GO:0090596	260	0.019
homeostatic process	GO:0042592	199	0.019
telencephalon development	GO:0021537	2	0.019
aggressive behavior	GO:0002118	63	0.018
regulation of immune system process	GO:0002682	176	0.018
regulation of apoptotic process	GO:0042981	130	0.018
secretion by cell	GO:0032940	101	0.018
induction of programmed cell death by ecdysone	GO:0035078	12	0.018
centrosome organization	GO:0051297	163	0.018
regulation of proteolysis	GO:0030162	87	0.018
regulation of cellular catabolic process	GO:0031329	157	0.018
regulation of cellular component biogenesis	GO:0044087	201	0.018
regulation of phosphatase activity	GO:0010921	3	0.018
central nervous system segmentation	GO:0035283	5	0.017
regulation of anatomical structure morphogenesis	GO:0022603	242	0.017
induction of programmed cell death	GO:0012502	12	0.017
positive regulation of ras gtpase activity	GO:0032320	36	0.017
detection of stimulus involved in sensory perception	GO:0050906	92	0.017
mrna metabolic process	GO:0016071	124	0.017
purine nucleotide metabolic process	GO:0006163	146	0.017
regulation of mapk cascade	GO:0043408	92	0.017
camera type eye development	GO:0043010	4	0.017
macromolecular complex assembly	GO:0065003	256	0.017
embryo development ending in birth or egg hatching	GO:0009792	152	0.016
positive regulation of protein metabolic process	GO:0051247	128	0.016
cellularization	GO:0007349	90	0.016
carboxylic acid metabolic process	GO:0019752	92	0.016
regulation of catabolic process	GO:0009894	170	0.016
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.016
regulation of neuron projection development	GO:0010975	69	0.016
negative regulation of small gtpase mediated signal transduction	GO:0051058	13	0.016
wnt signaling pathway	GO:0016055	98	0.015
defense response to other organism	GO:0098542	225	0.015
chromatin remodeling	GO:0006338	72	0.015
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.015
positive regulation of cellular biosynthetic process	GO:0031328	316	0.015
signal transduction by phosphorylation	GO:0023014	107	0.015
regulation of purine nucleotide metabolic process	GO:1900542	62	0.015
rna phosphodiester bond hydrolysis exonucleolytic	GO:0090503	4	0.015
cytoplasmic transport	GO:0016482	130	0.015
intracellular protein transport	GO:0006886	104	0.015
regulation of gtpase activity	GO:0043087	44	0.015
female meiotic division	GO:0007143	70	0.015
digestive tract morphogenesis	GO:0048546	127	0.014
rhodopsin mediated signaling pathway	GO:0016056	21	0.014
programmed cell death	GO:0012501	257	0.014
instar larval development	GO:0002168	55	0.014
salivary gland histolysis	GO:0035070	88	0.014
synapse assembly	GO:0007416	143	0.014
single organism cellular localization	GO:1902580	180	0.014
regulation of cell division	GO:0051302	72	0.014
response to ketone	GO:1901654	34	0.014
actin filament organization	GO:0007015	126	0.014
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.014
organic substance transport	GO:0071702	257	0.014
regulation of cell size	GO:0008361	63	0.014
nucleotide metabolic process	GO:0009117	161	0.014
negative regulation of mitotic cell cycle	GO:0045930	109	0.014
mrna processing	GO:0006397	104	0.014
maintenance of protein location	GO:0045185	28	0.013
positive regulation of cellular component organization	GO:0051130	156	0.013
regulation of purine nucleotide catabolic process	GO:0033121	48	0.013
protein polymerization	GO:0051258	42	0.013
response to hypoxia	GO:0001666	53	0.013
positive regulation of axonogenesis	GO:0050772	2	0.013
defense response to virus	GO:0051607	23	0.013
response to oxidative stress	GO:0006979	86	0.013
regulation of molecular function	GO:0065009	217	0.013
regulation of protein stability	GO:0031647	43	0.013
phosphatidylinositol mediated signaling	GO:0048015	4	0.013
somatic muscle development	GO:0007525	66	0.012
flight behavior	GO:0007629	26	0.012
regulation of nucleotide metabolic process	GO:0006140	62	0.012
regulation of multicellular organismal development	GO:2000026	414	0.012
cation homeostasis	GO:0055080	51	0.012
synaptic growth at neuromuscular junction	GO:0051124	119	0.012
apoptotic process	GO:0006915	159	0.012
microtubule polymerization or depolymerization	GO:0031109	39	0.012
protein complex assembly	GO:0006461	200	0.012
ecdysone mediated induction of salivary gland cell autophagic cell death	GO:0035072	12	0.012
guanosine containing compound metabolic process	GO:1901068	74	0.012
organelle localization	GO:0051640	148	0.012
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.012
establishment of protein localization to organelle	GO:0072594	62	0.012
peptidyl lysine modification	GO:0018205	57	0.012
ribonucleotide metabolic process	GO:0009259	145	0.012
macromolecule catabolic process	GO:0009057	161	0.012
response to abiotic stimulus	GO:0009628	341	0.011
positive regulation of growth	GO:0045927	75	0.011
negative regulation of multicellular organismal process	GO:0051241	142	0.011
regulation of mitosis	GO:0007088	56	0.011
response to light stimulus	GO:0009416	124	0.011
purine ribonucleotide catabolic process	GO:0009154	109	0.011
cellular amine metabolic process	GO:0044106	12	0.011
regulation of cellular component movement	GO:0051270	42	0.011
cellular amino acid metabolic process	GO:0006520	61	0.011
regulation of cell differentiation	GO:0045595	302	0.011
cell migration involved in gastrulation	GO:0042074	9	0.011
positive regulation of cell proliferation	GO:0008284	47	0.011
proteasomal protein catabolic process	GO:0010498	59	0.011
imaginal disc derived wing morphogenesis	GO:0007476	337	0.011
protein targeting	GO:0006605	64	0.011
single organism behavior	GO:0044708	391	0.011
adult behavior	GO:0030534	137	0.011
actin filament based process	GO:0030029	220	0.011
cellular response to radiation	GO:0071478	52	0.010
regulation of nucleotide catabolic process	GO:0030811	48	0.010
neuromuscular process	GO:0050905	21	0.010
axon development	GO:0061564	297	0.010
imaginal disc growth	GO:0007446	37	0.010
oxoacid metabolic process	GO:0043436	103	0.010
regulation of mrna metabolic process	GO:1903311	72	0.010
activation of cysteine type endopeptidase activity	GO:0097202	17	0.010
negative regulation of ras protein signal transduction	GO:0046580	13	0.010
multi multicellular organism process	GO:0044706	123	0.010
asymmetric protein localization	GO:0008105	33	0.010

Ptpmeg disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.031

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