IMP: Integrative Multi-species Prediction

Drosophila melanogaster

70 known processes

Ext2 (Dmel_CG8433)

CG8433 gene product from transcript CG8433-RA

(Aliases: DEXT2,DExt2,BcDNA:GH02288,Dmel\CG8433,CG8433,CG33038,Sotv,sotv)

FLYBASE: FBgn0029175
Entrez: 3772101
UniProtKB: Q9Y169
UniProtKB: A4UZJ2

Process Predictions
Disease Predictions

Ext2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
chondroitin sulfate metabolic process	GO:0030204	2	1.000
cellular carbohydrate biosynthetic process	GO:0034637	7	1.000
cellular polysaccharide biosynthetic process	GO:0033692	7	0.999
heparan sulfate proteoglycan biosynthetic process	GO:0015012	10	0.997
polysaccharide biosynthetic process	GO:0000271	7	0.997
glycosaminoglycan biosynthetic process	GO:0006024	7	0.996
chondroitin sulfate proteoglycan metabolic process	GO:0050654	3	0.988
sulfur compound biosynthetic process	GO:0044272	16	0.988
aminoglycan metabolic process	GO:0006022	18	0.980
heparan sulfate proteoglycan metabolic process	GO:0030201	10	0.962
heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process	GO:0015014	5	0.958
chondroitin sulfate proteoglycan biosynthetic process	GO:0050650	3	0.953
sulfur compound metabolic process	GO:0006790	59	0.944
chondroitin sulfate biosynthetic process	GO:0030206	2	0.921
heparin metabolic process	GO:0030202	4	0.917
aminoglycan biosynthetic process	GO:0006023	11	0.906
retinal ganglion cell axon guidance	GO:0031290	12	0.904	Zebrafish
proteoglycan biosynthetic process	GO:0030166	10	0.882
positive regulation of fibroblast growth factor receptor signaling pathway	GO:0045743	5	0.814	Zebrafish
glycoprotein metabolic process	GO:0009100	41	0.808
synaptic vesicle endocytosis	GO:0048488	28	0.799	Fly
mitochondrion distribution	GO:0048311	10	0.765	Fly
glycoprotein biosynthetic process	GO:0009101	41	0.765
glycosaminoglycan metabolic process	GO:0030203	11	0.730
imaginal disc derived wing vein specification	GO:0007474	48	0.721
regionalization	GO:0003002	416	0.700
post embryonic appendage morphogenesis	GO:0035120	385	0.589
synaptic vesicle transport	GO:0048489	50	0.539	Fly
intracellular distribution of mitochondria	GO:0048312	5	0.530	Fly
wing disc morphogenesis	GO:0007472	344	0.527
cellular polysaccharide metabolic process	GO:0044264	11	0.516
cellular carbohydrate metabolic process	GO:0044262	22	0.500
appendage morphogenesis	GO:0035107	397	0.491	Zebrafish
imaginal disc derived wing morphogenesis	GO:0007476	337	0.487
establishment of vesicle localization	GO:0051650	51	0.476	Fly
cellular response to fibroblast growth factor stimulus	GO:0044344	10	0.462	Zebrafish
segmentation	GO:0035282	207	0.426
carbohydrate derivative biosynthetic process	GO:1901137	85	0.386
neuron projection guidance	GO:0097485	241	0.379	Zebrafish Fly
smoothened signaling pathway	GO:0007224	49	0.361
response to fibroblast growth factor	GO:0071774	10	0.347	Zebrafish
proteoglycan metabolic process	GO:0006029	10	0.322
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.306
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.297
mucopolysaccharide metabolic process	GO:1903510	5	0.268
regulation of neuron differentiation	GO:0045664	103	0.266	Zebrafish
synaptic vesicle localization	GO:0097479	53	0.254	Fly
synapse organization	GO:0050808	196	0.251	Fly
axon guidance	GO:0007411	233	0.240	Zebrafish Fly
pharynx development	GO:0060465	1	0.240
mitochondrion organization	GO:0007005	65	0.239	Fly
germ cell migration	GO:0008354	43	0.236	Fly
positive regulation of response to stimulus	GO:0048584	323	0.215	Zebrafish
axonogenesis	GO:0007409	290	0.213	Zebrafish Fly
single organism carbohydrate metabolic process	GO:0044723	72	0.210
positive regulation of signal transduction	GO:0009967	223	0.200	Zebrafish
fibroblast growth factor receptor signaling pathway	GO:0008543	10	0.198	Zebrafish
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.194
mitochondrion localization	GO:0051646	17	0.189	Fly
polysaccharide metabolic process	GO:0005976	11	0.186
carbohydrate biosynthetic process	GO:0016051	17	0.186
regulation of smoothened signaling pathway	GO:0008589	28	0.167	Fly
oxoacid metabolic process	GO:0043436	103	0.161
localization of cell	GO:0051674	257	0.145	Fly
vesicle localization	GO:0051648	55	0.143	Fly
peptidyl threonine phosphorylation	GO:0018107	2	0.141
regulation of multicellular organismal development	GO:2000026	414	0.133	Zebrafish
imaginal disc derived appendage development	GO:0048737	399	0.125
organelle localization	GO:0051640	148	0.124	Fly
cell motility	GO:0048870	251	0.123	Fly
carbohydrate metabolic process	GO:0005975	82	0.120
digestive tract development	GO:0048565	149	0.119	Mouse
cellular protein modification process	GO:0006464	438	0.119
chemotaxis	GO:0006935	249	0.115	Zebrafish Fly
regulation of neurogenesis	GO:0050767	158	0.105	Zebrafish
protein ubiquitination	GO:0016567	70	0.105
synaptic transmission	GO:0007268	288	0.104	Fly
segment polarity determination	GO:0007367	25	0.098
digestive system development	GO:0055123	149	0.093	Mouse
carbohydrate derivative metabolic process	GO:1901135	217	0.091
embryonic morphogenesis	GO:0048598	206	0.090	Zebrafish Mouse
organonitrogen compound biosynthetic process	GO:1901566	117	0.089
small molecule metabolic process	GO:0044281	305	0.088
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.087	Zebrafish
appendage development	GO:0048736	401	0.085	Zebrafish
chromosome segregation	GO:0007059	157	0.083
endocytosis	GO:0006897	310	0.083	Fly
regulation of cell morphogenesis	GO:0022604	163	0.081	Zebrafish
wnt signaling pathway	GO:0016055	98	0.080
epithelium migration	GO:0090132	148	0.076
periodic partitioning	GO:0007365	29	0.076
embryonic organ development	GO:0048568	50	0.073
single organism intracellular transport	GO:1902582	207	0.072
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.069
connective tissue development	GO:0061448	3	0.068	Zebrafish
leg disc development	GO:0035218	92	0.068
protein catabolic process	GO:0030163	101	0.063
cell migration	GO:0016477	238	0.061	Fly
single organism cellular localization	GO:1902580	180	0.058	Fly
vesicle mediated transport	GO:0016192	381	0.055	Fly
apposition of dorsal and ventral imaginal disc derived wing surfaces	GO:0007475	15	0.055
regulation of epithelial cell proliferation	GO:0050678	4	0.054
cardiovascular system development	GO:0072358	82	0.051
positive regulation of signaling	GO:0023056	243	0.051	Zebrafish
macromolecular complex assembly	GO:0065003	256	0.050
regulation of cellular amino acid metabolic process	GO:0006521	0	0.049
regulation of cell differentiation	GO:0045595	302	0.049	Zebrafish
regulation of cell projection organization	GO:0031344	92	0.047	Zebrafish
protein localization	GO:0008104	284	0.044
segment specification	GO:0007379	33	0.044
synaptic vesicle recycling	GO:0036465	28	0.044	Fly
regulation of cellular amine metabolic process	GO:0033238	3	0.043
protein palmitoylation	GO:0018345	2	0.042
lipid metabolic process	GO:0006629	121	0.041
positive regulation of cell communication	GO:0010647	250	0.041	Zebrafish
negative regulation of gene expression	GO:0010629	387	0.040
protein modification by small protein conjugation or removal	GO:0070647	106	0.040
regulation of nervous system development	GO:0051960	248	0.040	Zebrafish
chromosome organization	GO:0051276	360	0.039
forebrain development	GO:0030900	2	0.039
cuticle development	GO:0042335	86	0.039
tissue morphogenesis	GO:0048729	297	0.038	Mouse
chromatin organization	GO:0006325	207	0.038
tissue migration	GO:0090130	155	0.037
blastoderm segmentation	GO:0007350	159	0.037
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.037
ubiquitin dependent protein catabolic process	GO:0006511	78	0.036
erbb signaling pathway	GO:0038127	58	0.035
single organism biosynthetic process	GO:0044711	206	0.035
axon development	GO:0061564	297	0.034	Zebrafish Fly
regulation of fibroblast growth factor receptor signaling pathway	GO:0040036	7	0.032	Zebrafish
regulation of reproductive process	GO:2000241	54	0.032
imaginal disc derived leg morphogenesis	GO:0007480	80	0.031
positive regulation of protein secretion	GO:0050714	9	0.028
phagocytosis	GO:0006909	215	0.027
mitotic spindle organization	GO:0007052	220	0.027
cellular amino acid metabolic process	GO:0006520	61	0.027
regulation of anatomical structure morphogenesis	GO:0022603	242	0.026	Zebrafish
eye development	GO:0001654	323	0.025
developmental growth involved in morphogenesis	GO:0060560	65	0.025	Zebrafish
amine metabolic process	GO:0009308	12	0.025
regulation of notch signaling pathway	GO:0008593	100	0.025
regulation of extent of cell growth	GO:0061387	8	0.025	Zebrafish
positive regulation of cellular component organization	GO:0051130	156	0.024
proteolysis	GO:0006508	192	0.024
positive regulation of cell motility	GO:2000147	3	0.024
establishment of synaptic vesicle localization	GO:0097480	50	0.024	Fly
single organism membrane organization	GO:0044802	93	0.024
organic acid metabolic process	GO:0006082	103	0.024
protein modification by small protein conjugation	GO:0032446	79	0.024
cellular response to growth factor stimulus	GO:0071363	30	0.024	Zebrafish
macromolecule catabolic process	GO:0009057	161	0.024
homeostatic process	GO:0042592	199	0.023
protein modification process	GO:0036211	438	0.023
tube morphogenesis	GO:0035239	191	0.023	Mouse
regulation of protein localization	GO:0032880	76	0.022
anterior posterior axis specification	GO:0009948	109	0.022
peptidyl amino acid modification	GO:0018193	105	0.022
histone h3 k4 methylation	GO:0051568	16	0.021
spindle organization	GO:0007051	253	0.021
nucleocytoplasmic transport	GO:0006913	72	0.021
proteasomal protein catabolic process	GO:0010498	59	0.021
chaeta development	GO:0022416	97	0.021
morphogenesis of embryonic epithelium	GO:0016331	94	0.021
regulation of cellular component movement	GO:0051270	42	0.021
methylation	GO:0032259	47	0.020
regulation of anatomical structure size	GO:0090066	163	0.020	Zebrafish
organonitrogen compound metabolic process	GO:1901564	318	0.020
cellular macromolecule localization	GO:0070727	220	0.020
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.020
cell recognition	GO:0008037	102	0.020
positive regulation of wnt signaling pathway	GO:0030177	25	0.020
golgi organization	GO:0007030	66	0.020
mitotic sister chromatid segregation	GO:0000070	87	0.020
cell adhesion	GO:0007155	136	0.020
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.019	Zebrafish
mitotic cell cycle phase transition	GO:0044772	138	0.019
cellular protein catabolic process	GO:0044257	83	0.019
regulation of developmental growth	GO:0048638	174	0.019	Zebrafish
regulation of axon extension	GO:0030516	8	0.019	Zebrafish
negative regulation of cell cycle process	GO:0010948	109	0.019
regulation of ras gtpase activity	GO:0032318	38	0.018
taxis	GO:0042330	304	0.018	Zebrafish Fly
intracellular transport	GO:0046907	228	0.018
response to endogenous stimulus	GO:0009719	119	0.018	Zebrafish
modification dependent macromolecule catabolic process	GO:0043632	79	0.018
mesoderm morphogenesis	GO:0048332	22	0.017	Mouse
phosphorylation	GO:0016310	294	0.017
cellular amine metabolic process	GO:0044106	12	0.017
protein secretion	GO:0009306	45	0.017
establishment of localization in cell	GO:0051649	402	0.017	Fly
lipid storage	GO:0019915	38	0.017
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.017
protein phosphorylation	GO:0006468	169	0.017
cellular macromolecule catabolic process	GO:0044265	136	0.016
sister chromatid segregation	GO:0000819	92	0.016
establishment of organelle localization	GO:0051656	122	0.016	Fly
negative regulation of signal transduction	GO:0009968	206	0.016
organic substance transport	GO:0071702	257	0.016
endomembrane system organization	GO:0010256	119	0.016
chaeta morphogenesis	GO:0008407	42	0.016
regulation of histone modification	GO:0031056	20	0.016
cellular response to endogenous stimulus	GO:0071495	80	0.016	Zebrafish
negative regulation of cell division	GO:0051782	17	0.015
transcription from rna polymerase ii promoter	GO:0006366	368	0.015
regulation of mitotic cell cycle	GO:0007346	190	0.015
posttranscriptional gene silencing	GO:0016441	46	0.015
chitin based cuticle development	GO:0040003	49	0.015
mitotic nuclear division	GO:0007067	213	0.015
protein heterooligomerization	GO:0051291	4	0.015
regulation of wnt signaling pathway	GO:0030111	68	0.015
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.015
rna localization	GO:0006403	115	0.014
positive regulation of phosphorylation	GO:0042327	87	0.014
regulation of localization	GO:0032879	275	0.014
positive regulation of organelle organization	GO:0010638	65	0.014
regulation of axonogenesis	GO:0050770	32	0.014	Zebrafish
regulation of catalytic activity	GO:0050790	185	0.014
positive regulation of cellular amine metabolic process	GO:0033240	0	0.014
stem cell division	GO:0017145	69	0.014
single organism membrane budding	GO:1902591	2	0.014
axon extension	GO:0048675	32	0.013	Zebrafish
formation of primary germ layer	GO:0001704	24	0.013	Mouse
purine containing compound catabolic process	GO:0072523	112	0.013
hematopoietic or lymphoid organ development	GO:0048534	57	0.013
negative regulation of cellular component organization	GO:0051129	108	0.013
pigment biosynthetic process	GO:0046148	36	0.013
leg disc morphogenesis	GO:0007478	80	0.013
phosphatidylinositol mediated signaling	GO:0048015	4	0.013
positive regulation of molecular function	GO:0044093	136	0.013
endodermal cell fate commitment	GO:0001711	3	0.013
notch signaling pathway	GO:0007219	120	0.013
regulation of intracellular transport	GO:0032386	64	0.012
nitrogen compound transport	GO:0071705	85	0.012
dna metabolic process	GO:0006259	227	0.012
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.012
synaptic target recognition	GO:0008039	45	0.012
positive regulation of gene expression	GO:0010628	290	0.012
protein transport	GO:0015031	155	0.012
inter male aggressive behavior	GO:0002121	60	0.012
limb development	GO:0060173	1	0.012
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.012
protein glycosylation	GO:0006486	32	0.012
eye pigmentation	GO:0048069	43	0.012
mesenchymal cell differentiation	GO:0048762	1	0.012
response to organic substance	GO:0010033	284	0.012	Zebrafish
regulation of cellular ketone metabolic process	GO:0010565	3	0.011
muscle cell fate commitment	GO:0042693	14	0.011
modification dependent protein catabolic process	GO:0019941	78	0.011
morphogenesis of a branching structure	GO:0001763	45	0.011
negative regulation of cell cycle	GO:0045786	116	0.011
oviposition	GO:0018991	19	0.011
carboxylic acid metabolic process	GO:0019752	92	0.011
negative regulation of organelle organization	GO:0010639	56	0.011
pigment metabolic process	GO:0042440	84	0.011
regulation of immune system process	GO:0002682	176	0.011
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.011
cellular lipid metabolic process	GO:0044255	83	0.011
positive regulation of mapk cascade	GO:0043410	63	0.011
secretion by cell	GO:0032940	101	0.011
pigmentation	GO:0043473	75	0.011
decapentaplegic signaling pathway	GO:0008101	19	0.011
brain development	GO:0007420	120	0.011
peptidyl threonine modification	GO:0018210	3	0.011
limb morphogenesis	GO:0035108	1	0.011
cell fate specification	GO:0001708	71	0.011
cytoplasmic transport	GO:0016482	130	0.010
negative regulation of catabolic process	GO:0009895	36	0.010
epithelial cell migration	GO:0010631	148	0.010
spinal cord development	GO:0021510	1	0.010
cation transport	GO:0006812	110	0.010
ameboidal type cell migration	GO:0001667	151	0.010
cell cycle checkpoint	GO:0000075	95	0.010
protein maturation	GO:0051604	71	0.010
positive regulation of catalytic activity	GO:0043085	118	0.010

Ext2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.070
disease of cellular proliferation	DOID:14566	0.039
cancer	DOID:162	0.032
musculoskeletal system disease	DOID:17	0.025
connective tissue disease	DOID:65	0.025
bone disease	DOID:0080001	0.025
cardiovascular system disease	DOID:1287	0.023
organ system cancer	DOID:0050686	0.022

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