Drosophila melanogaster

70 known processes

Ext2 (Dmel_CG8433)

CG8433 gene product from transcript CG8433-RA

(Aliases: DEXT2,DExt2,BcDNA:GH02288,Dmel\CG8433,CG8433,CG33038,Sotv,sotv)

Ext2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
chondroitin sulfate metabolic processGO:003020421.000
cellular carbohydrate biosynthetic processGO:003463771.000
cellular polysaccharide biosynthetic processGO:003369270.999
heparan sulfate proteoglycan biosynthetic processGO:0015012100.997
polysaccharide biosynthetic processGO:000027170.997
glycosaminoglycan biosynthetic processGO:000602470.996
chondroitin sulfate proteoglycan metabolic processGO:005065430.988
sulfur compound biosynthetic processGO:0044272160.988
aminoglycan metabolic processGO:0006022180.980
heparan sulfate proteoglycan metabolic processGO:0030201100.962
heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic processGO:001501450.958
chondroitin sulfate proteoglycan biosynthetic processGO:005065030.953
sulfur compound metabolic processGO:0006790590.944
chondroitin sulfate biosynthetic processGO:003020620.921
heparin metabolic processGO:003020240.917
aminoglycan biosynthetic processGO:0006023110.906
retinal ganglion cell axon guidanceGO:0031290120.904
Zebrafish
proteoglycan biosynthetic processGO:0030166100.882
positive regulation of fibroblast growth factor receptor signaling pathwayGO:004574350.814
Zebrafish
glycoprotein metabolic processGO:0009100410.808
synaptic vesicle endocytosisGO:0048488280.799
Fly
mitochondrion distributionGO:0048311100.765
Fly
glycoprotein biosynthetic processGO:0009101410.765
glycosaminoglycan metabolic processGO:0030203110.730
imaginal disc derived wing vein specificationGO:0007474480.721
regionalizationGO:00030024160.700
post embryonic appendage morphogenesisGO:00351203850.589
synaptic vesicle transportGO:0048489500.539
Fly
intracellular distribution of mitochondriaGO:004831250.530
Fly
wing disc morphogenesisGO:00074723440.527
cellular polysaccharide metabolic processGO:0044264110.516
cellular carbohydrate metabolic processGO:0044262220.500
appendage morphogenesisGO:00351073970.491
Zebrafish
imaginal disc derived wing morphogenesisGO:00074763370.487
establishment of vesicle localizationGO:0051650510.476
Fly
cellular response to fibroblast growth factor stimulusGO:0044344100.462
Zebrafish
segmentationGO:00352822070.426
carbohydrate derivative biosynthetic processGO:1901137850.386
neuron projection guidanceGO:00974852410.379
Zebrafish Fly
smoothened signaling pathwayGO:0007224490.361
response to fibroblast growth factorGO:0071774100.347
Zebrafish
proteoglycan metabolic processGO:0006029100.322
imaginal disc derived wing margin morphogenesisGO:0008587410.306
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.297
mucopolysaccharide metabolic processGO:190351050.268
regulation of neuron differentiationGO:00456641030.266
Zebrafish
synaptic vesicle localizationGO:0097479530.254
Fly
synapse organizationGO:00508081960.251
Fly
axon guidanceGO:00074112330.240
Zebrafish Fly
pharynx developmentGO:006046510.240
mitochondrion organizationGO:0007005650.239
Fly
germ cell migrationGO:0008354430.236
Fly
positive regulation of response to stimulusGO:00485843230.215
Zebrafish
axonogenesisGO:00074092900.213
Zebrafish Fly
single organism carbohydrate metabolic processGO:0044723720.210
positive regulation of signal transductionGO:00099672230.200
Zebrafish
fibroblast growth factor receptor signaling pathwayGO:0008543100.198
Zebrafish
imaginal disc derived appendage morphogenesisGO:00351143950.194
mitochondrion localizationGO:0051646170.189
Fly
polysaccharide metabolic processGO:0005976110.186
carbohydrate biosynthetic processGO:0016051170.186
regulation of smoothened signaling pathwayGO:0008589280.167
Fly
oxoacid metabolic processGO:00434361030.161
localization of cellGO:00516742570.145
Fly
vesicle localizationGO:0051648550.143
Fly
peptidyl threonine phosphorylationGO:001810720.141
regulation of multicellular organismal developmentGO:20000264140.133
Zebrafish
imaginal disc derived appendage developmentGO:00487373990.125
organelle localizationGO:00516401480.124
Fly
cell motilityGO:00488702510.123
Fly
carbohydrate metabolic processGO:0005975820.120
digestive tract developmentGO:00485651490.119
Mouse
cellular protein modification processGO:00064644380.119
chemotaxisGO:00069352490.115
Zebrafish Fly
regulation of neurogenesisGO:00507671580.105
Zebrafish
protein ubiquitinationGO:0016567700.105
synaptic transmissionGO:00072682880.104
Fly
segment polarity determinationGO:0007367250.098
digestive system developmentGO:00551231490.093
Mouse
carbohydrate derivative metabolic processGO:19011352170.091
embryonic morphogenesisGO:00485982060.090
Zebrafish Mouse
organonitrogen compound biosynthetic processGO:19015661170.089
small molecule metabolic processGO:00442813050.088
regulation of cell morphogenesis involved in differentiationGO:0010769610.087
Zebrafish
appendage developmentGO:00487364010.085
Zebrafish
chromosome segregationGO:00070591570.083
endocytosisGO:00068973100.083
Fly
regulation of cell morphogenesisGO:00226041630.081
Zebrafish
wnt signaling pathwayGO:0016055980.080
epithelium migrationGO:00901321480.076
periodic partitioningGO:0007365290.076
embryonic organ developmentGO:0048568500.073
single organism intracellular transportGO:19025822070.072
positive regulation of nucleobase containing compound metabolic processGO:00459353320.069
connective tissue developmentGO:006144830.068
Zebrafish
leg disc developmentGO:0035218920.068
protein catabolic processGO:00301631010.063
cell migrationGO:00164772380.061
Fly
single organism cellular localizationGO:19025801800.058
Fly
vesicle mediated transportGO:00161923810.055
Fly
apposition of dorsal and ventral imaginal disc derived wing surfacesGO:0007475150.055
regulation of epithelial cell proliferationGO:005067840.054
cardiovascular system developmentGO:0072358820.051
positive regulation of signalingGO:00230562430.051
Zebrafish
macromolecular complex assemblyGO:00650032560.050
regulation of cellular amino acid metabolic processGO:000652100.049
regulation of cell differentiationGO:00455953020.049
Zebrafish
regulation of cell projection organizationGO:0031344920.047
Zebrafish
protein localizationGO:00081042840.044
segment specificationGO:0007379330.044
synaptic vesicle recyclingGO:0036465280.044
Fly
regulation of cellular amine metabolic processGO:003323830.043
protein palmitoylationGO:001834520.042
lipid metabolic processGO:00066291210.041
positive regulation of cell communicationGO:00106472500.041
Zebrafish
negative regulation of gene expressionGO:00106293870.040
protein modification by small protein conjugation or removalGO:00706471060.040
regulation of nervous system developmentGO:00519602480.040
Zebrafish
chromosome organizationGO:00512763600.039
forebrain developmentGO:003090020.039
cuticle developmentGO:0042335860.039
tissue morphogenesisGO:00487292970.038
Mouse
chromatin organizationGO:00063252070.038
tissue migrationGO:00901301550.037
blastoderm segmentationGO:00073501590.037
enzyme linked receptor protein signaling pathwayGO:00071671790.037
ubiquitin dependent protein catabolic processGO:0006511780.036
erbb signaling pathwayGO:0038127580.035
single organism biosynthetic processGO:00447112060.035
axon developmentGO:00615642970.034
Zebrafish Fly
regulation of fibroblast growth factor receptor signaling pathwayGO:004003670.032
Zebrafish
regulation of reproductive processGO:2000241540.032
imaginal disc derived leg morphogenesisGO:0007480800.031
positive regulation of protein secretionGO:005071490.028
phagocytosisGO:00069092150.027
mitotic spindle organizationGO:00070522200.027
cellular amino acid metabolic processGO:0006520610.027
regulation of anatomical structure morphogenesisGO:00226032420.026
Zebrafish
eye developmentGO:00016543230.025
developmental growth involved in morphogenesisGO:0060560650.025
Zebrafish
amine metabolic processGO:0009308120.025
regulation of notch signaling pathwayGO:00085931000.025
regulation of extent of cell growthGO:006138780.025
Zebrafish
positive regulation of cellular component organizationGO:00511301560.024
proteolysisGO:00065081920.024
positive regulation of cell motilityGO:200014730.024
establishment of synaptic vesicle localizationGO:0097480500.024
Fly
single organism membrane organizationGO:0044802930.024
organic acid metabolic processGO:00060821030.024
protein modification by small protein conjugationGO:0032446790.024
cellular response to growth factor stimulusGO:0071363300.024
Zebrafish
macromolecule catabolic processGO:00090571610.024
homeostatic processGO:00425921990.023
protein modification processGO:00362114380.023
tube morphogenesisGO:00352391910.023
Mouse
regulation of protein localizationGO:0032880760.022
anterior posterior axis specificationGO:00099481090.022
peptidyl amino acid modificationGO:00181931050.022
histone h3 k4 methylationGO:0051568160.021
spindle organizationGO:00070512530.021
nucleocytoplasmic transportGO:0006913720.021
proteasomal protein catabolic processGO:0010498590.021
chaeta developmentGO:0022416970.021
morphogenesis of embryonic epitheliumGO:0016331940.021
regulation of cellular component movementGO:0051270420.021
methylationGO:0032259470.020
regulation of anatomical structure sizeGO:00900661630.020
Zebrafish
organonitrogen compound metabolic processGO:19015643180.020
cellular macromolecule localizationGO:00707272200.020
positive regulation of cellular amino acid metabolic processGO:004576400.020
cell recognitionGO:00080371020.020
positive regulation of wnt signaling pathwayGO:0030177250.020
golgi organizationGO:0007030660.020
mitotic sister chromatid segregationGO:0000070870.020
cell adhesionGO:00071551360.020
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.019
Zebrafish
mitotic cell cycle phase transitionGO:00447721380.019
cellular protein catabolic processGO:0044257830.019
regulation of developmental growthGO:00486381740.019
Zebrafish
regulation of axon extensionGO:003051680.019
Zebrafish
negative regulation of cell cycle processGO:00109481090.019
regulation of ras gtpase activityGO:0032318380.018
taxisGO:00423303040.018
Zebrafish Fly
intracellular transportGO:00469072280.018
response to endogenous stimulusGO:00097191190.018
Zebrafish
modification dependent macromolecule catabolic processGO:0043632790.018
mesoderm morphogenesisGO:0048332220.017
Mouse
phosphorylationGO:00163102940.017
cellular amine metabolic processGO:0044106120.017
protein secretionGO:0009306450.017
establishment of localization in cellGO:00516494020.017
Fly
lipid storageGO:0019915380.017
imaginal disc derived wing vein morphogenesisGO:0008586440.017
protein phosphorylationGO:00064681690.017
cellular macromolecule catabolic processGO:00442651360.016
sister chromatid segregationGO:0000819920.016
establishment of organelle localizationGO:00516561220.016
Fly
negative regulation of signal transductionGO:00099682060.016
organic substance transportGO:00717022570.016
endomembrane system organizationGO:00102561190.016
chaeta morphogenesisGO:0008407420.016
regulation of histone modificationGO:0031056200.016
cellular response to endogenous stimulusGO:0071495800.016
Zebrafish
negative regulation of cell divisionGO:0051782170.015
transcription from rna polymerase ii promoterGO:00063663680.015
regulation of mitotic cell cycleGO:00073461900.015
posttranscriptional gene silencingGO:0016441460.015
chitin based cuticle developmentGO:0040003490.015
mitotic nuclear divisionGO:00070672130.015
protein heterooligomerizationGO:005129140.015
regulation of wnt signaling pathwayGO:0030111680.015
proteolysis involved in cellular protein catabolic processGO:0051603830.015
rna localizationGO:00064031150.014
positive regulation of phosphorylationGO:0042327870.014
regulation of localizationGO:00328792750.014
positive regulation of organelle organizationGO:0010638650.014
regulation of axonogenesisGO:0050770320.014
Zebrafish
regulation of catalytic activityGO:00507901850.014
positive regulation of cellular amine metabolic processGO:003324000.014
stem cell divisionGO:0017145690.014
single organism membrane buddingGO:190259120.014
axon extensionGO:0048675320.013
Zebrafish
formation of primary germ layerGO:0001704240.013
Mouse
purine containing compound catabolic processGO:00725231120.013
hematopoietic or lymphoid organ developmentGO:0048534570.013
negative regulation of cellular component organizationGO:00511291080.013
pigment biosynthetic processGO:0046148360.013
leg disc morphogenesisGO:0007478800.013
phosphatidylinositol mediated signalingGO:004801540.013
positive regulation of molecular functionGO:00440931360.013
endodermal cell fate commitmentGO:000171130.013
notch signaling pathwayGO:00072191200.013
regulation of intracellular transportGO:0032386640.012
nitrogen compound transportGO:0071705850.012
dna metabolic processGO:00062592270.012
positive regulation of nitrogen compound metabolic processGO:00511733540.012
synaptic target recognitionGO:0008039450.012
positive regulation of gene expressionGO:00106282900.012
protein transportGO:00150311550.012
inter male aggressive behaviorGO:0002121600.012
limb developmentGO:006017310.012
regulation of microtubule cytoskeleton organizationGO:0070507410.012
protein glycosylationGO:0006486320.012
eye pigmentationGO:0048069430.012
mesenchymal cell differentiationGO:004876210.012
response to organic substanceGO:00100332840.012
Zebrafish
regulation of cellular ketone metabolic processGO:001056530.011
muscle cell fate commitmentGO:0042693140.011
modification dependent protein catabolic processGO:0019941780.011
morphogenesis of a branching structureGO:0001763450.011
negative regulation of cell cycleGO:00457861160.011
ovipositionGO:0018991190.011
carboxylic acid metabolic processGO:0019752920.011
negative regulation of organelle organizationGO:0010639560.011
pigment metabolic processGO:0042440840.011
regulation of immune system processGO:00026821760.011
positive regulation of macromolecule biosynthetic processGO:00105572830.011
cellular lipid metabolic processGO:0044255830.011
positive regulation of mapk cascadeGO:0043410630.011
secretion by cellGO:00329401010.011
pigmentationGO:0043473750.011
decapentaplegic signaling pathwayGO:0008101190.011
brain developmentGO:00074201200.011
peptidyl threonine modificationGO:001821030.011
limb morphogenesisGO:003510810.011
cell fate specificationGO:0001708710.011
cytoplasmic transportGO:00164821300.010
negative regulation of catabolic processGO:0009895360.010
epithelial cell migrationGO:00106311480.010
spinal cord developmentGO:002151010.010
cation transportGO:00068121100.010
ameboidal type cell migrationGO:00016671510.010
cell cycle checkpointGO:0000075950.010
protein maturationGO:0051604710.010
positive regulation of catalytic activityGO:00430851180.010

Ext2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.070
disease of cellular proliferationDOID:1456600.039
cancerDOID:16200.032
musculoskeletal system diseaseDOID:1700.025
connective tissue diseaseDOID:6500.025
bone diseaseDOID:008000100.025
cardiovascular system diseaseDOID:128700.023
organ system cancerDOID:005068600.022