IMP: Integrative Multi-species Prediction

Drosophila melanogaster

194 known processes

Top2 (Dmel_CG10223)

Topoisomerase 2

(Aliases: TOPOII,TopoII,dCHRAC,TOP2,top2,CHRAC,topoII,topo II,dTopoII,CG10223,Topo II,Dmel\CG10223,TopII)

FLYBASE: FBgn0003732
Entrez: 35225
UniProtKB: M9PDQ1
UniProtKB: P15348

Process Predictions
Disease Predictions

Top2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of biosynthetic process	GO:0009890	277	0.952
aging	GO:0007568	143	0.950
multicellular organismal aging	GO:0010259	140	0.950
chromatin organization	GO:0006325	207	0.943
embryo development ending in birth or egg hatching	GO:0009792	152	0.893	Worm
regulation of gene expression epigenetic	GO:0040029	128	0.878
central nervous system development	GO:0007417	201	0.874	Mouse
chromosome organization	GO:0051276	360	0.853
response to oxygen containing compound	GO:1901700	200	0.786
determination of adult lifespan	GO:0008340	137	0.771
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.704
negative regulation of cellular biosynthetic process	GO:0031327	277	0.678
larval development	GO:0002164	104	0.661
dna metabolic process	GO:0006259	227	0.630
regulation of multicellular organism growth	GO:0040014	40	0.601
head development	GO:0060322	135	0.590	Mouse
cellular catabolic process	GO:0044248	372	0.583
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.580
centrosome organization	GO:0051297	163	0.573
growth	GO:0040007	359	0.567
cellular response to organic substance	GO:0071310	132	0.550
regulation of cell death	GO:0010941	173	0.549	Human
microtubule organizing center organization	GO:0031023	168	0.549
reproductive structure development	GO:0048608	74	0.544
cell death	GO:0008219	279	0.538	Human
cognition	GO:0050890	141	0.531
dendrite development	GO:0016358	204	0.519
response to abiotic stimulus	GO:0009628	341	0.478
positive regulation of rna biosynthetic process	GO:1902680	266	0.465
positive regulation of transcription dna templated	GO:0045893	266	0.460
regulation of cell development	GO:0060284	215	0.459
programmed cell death	GO:0012501	257	0.443	Human
apoptotic process	GO:0006915	159	0.423	Human
regulation of mitotic cell cycle	GO:0007346	190	0.418
nucleocytoplasmic transport	GO:0006913	72	0.415
brain development	GO:0007420	120	0.396	Mouse
stem cell differentiation	GO:0048863	117	0.387
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.384
heterochromatin organization	GO:0070828	25	0.382
negative regulation of cell cycle phase transition	GO:1901988	103	0.377
response to organic substance	GO:0010033	284	0.376
death	GO:0016265	284	0.361	Human
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.351
protein localization	GO:0008104	284	0.347
dna conformation change	GO:0071103	105	0.345
chromatin modification	GO:0016568	147	0.342
regulation of developmental growth	GO:0048638	174	0.340
centrosome cycle	GO:0007098	137	0.336
chromatin assembly or disassembly	GO:0006333	52	0.335
chromatin remodeling	GO:0006338	72	0.329
neuron projection guidance	GO:0097485	241	0.323	Zebrafish
covalent chromatin modification	GO:0016569	106	0.313
innate immune response	GO:0045087	144	0.312
nucleolus organization	GO:0007000	4	0.311
macromolecular complex assembly	GO:0065003	256	0.309
stem cell development	GO:0048864	79	0.309
dna replication	GO:0006260	48	0.303
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.290
cell proliferation	GO:0008283	299	0.284
cell cycle checkpoint	GO:0000075	95	0.284
positive regulation of gene expression	GO:0010628	290	0.280
mitotic cell cycle phase transition	GO:0044772	138	0.280
negative regulation of gene expression	GO:0010629	387	0.271
protein targeting to nucleus	GO:0044744	51	0.262
axon guidance	GO:0007411	233	0.262	Zebrafish
reproductive system development	GO:0061458	74	0.256
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.250
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.242
regulation of defense response	GO:0031347	102	0.238
multicellular organism growth	GO:0035264	46	0.236
gene silencing by rna	GO:0031047	57	0.227	Worm
negative regulation of rna biosynthetic process	GO:1902679	240	0.224
tissue morphogenesis	GO:0048729	297	0.224	Zebrafish
negative regulation of cellular metabolic process	GO:0031324	382	0.222
rna processing	GO:0006396	147	0.219
organelle fission	GO:0048285	340	0.218
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.217	Human
positive regulation of response to stimulus	GO:0048584	323	0.214
regulation of cell cycle phase transition	GO:1901987	130	0.209
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.205
regulation of meiosis	GO:0040020	3	0.201
cell migration	GO:0016477	238	0.201	Mouse
regulation of immune system process	GO:0002682	176	0.196
regulation of cell cycle	GO:0051726	291	0.196
cellular macromolecule localization	GO:0070727	220	0.195
taxis	GO:0042330	304	0.192	Zebrafish
dendrite morphogenesis	GO:0048813	199	0.189
carbohydrate derivative catabolic process	GO:1901136	118	0.182
digestive tract morphogenesis	GO:0048546	127	0.181
intracellular transport	GO:0046907	228	0.178
chromatin assembly	GO:0031497	48	0.174
positive regulation of signal transduction	GO:0009967	223	0.169
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.168
cellular response to chemical stimulus	GO:0070887	199	0.166
regulation of programmed cell death	GO:0043067	152	0.165	Human
peptidyl amino acid modification	GO:0018193	105	0.165
meiotic cell cycle process	GO:1903046	132	0.161
macromolecule methylation	GO:0043414	45	0.161
digestive system development	GO:0055123	149	0.160
cell cycle phase transition	GO:0044770	140	0.158
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.157
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.157
cellular protein modification process	GO:0006464	438	0.154
immune response	GO:0006955	246	0.152
chemotaxis	GO:0006935	249	0.150	Zebrafish
ribonucleoprotein complex assembly	GO:0022618	23	0.150
oocyte differentiation	GO:0009994	145	0.143
single organism behavior	GO:0044708	391	0.140
negative regulation of developmental process	GO:0051093	201	0.137
response to light stimulus	GO:0009416	124	0.137
dna endoreduplication	GO:0042023	22	0.136
gonad development	GO:0008406	50	0.133
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.132
atp metabolic process	GO:0046034	49	0.132
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.131
meiotic nuclear division	GO:0007126	151	0.128
positive regulation of rna metabolic process	GO:0051254	271	0.128	Human
regulation of chromatin organization	GO:1902275	32	0.128
negative regulation of cell cycle	GO:0045786	116	0.127
regulation of cell proliferation	GO:0042127	163	0.125
regulation of multicellular organismal development	GO:2000026	414	0.124
regionalization	GO:0003002	416	0.122
mitotic nuclear division	GO:0007067	213	0.122
digestive tract development	GO:0048565	149	0.121
dna packaging	GO:0006323	91	0.121
cell motility	GO:0048870	251	0.121	Mouse
sex differentiation	GO:0007548	81	0.120
meiotic cell cycle	GO:0051321	171	0.119
positive regulation of biosynthetic process	GO:0009891	316	0.116
regulation of response to stress	GO:0080134	200	0.113
negative regulation of cellular component organization	GO:0051129	108	0.113
nucleosome mobilization	GO:0042766	9	0.111
organophosphate catabolic process	GO:0046434	112	0.111
immune system process	GO:0002376	347	0.110
regulation of establishment of protein localization	GO:0070201	61	0.109
negative regulation of transcription dna templated	GO:0045892	237	0.109
small molecule metabolic process	GO:0044281	305	0.109
nucleobase containing small molecule metabolic process	GO:0055086	174	0.108
single organism biosynthetic process	GO:0044711	206	0.107
nuclear transport	GO:0051169	72	0.104
development of primary sexual characteristics	GO:0045137	50	0.100
atp catabolic process	GO:0006200	38	0.100
locomotory behavior	GO:0007626	176	0.097
positive regulation of cellular component biogenesis	GO:0044089	80	0.096
translation	GO:0006412	69	0.095
purine nucleotide catabolic process	GO:0006195	109	0.094
negative regulation of gene expression epigenetic	GO:0045814	77	0.092
epithelial cell differentiation	GO:0030855	322	0.092
positive regulation of signaling	GO:0023056	243	0.091
positive regulation of cellular biosynthetic process	GO:0031328	316	0.091
centrosome duplication	GO:0051298	121	0.089
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.089
body morphogenesis	GO:0010171	2	0.088
ribose phosphate metabolic process	GO:0019693	145	0.088
regulation of cell differentiation	GO:0045595	302	0.087
mrna transport	GO:0051028	15	0.086
memory	GO:0007613	94	0.085
carbohydrate derivative metabolic process	GO:1901135	217	0.085
cellular response to hormone stimulus	GO:0032870	44	0.083
negative regulation of cell cycle process	GO:0010948	109	0.083
response to temperature stimulus	GO:0009266	106	0.082
regulation of intracellular signal transduction	GO:1902531	236	0.082
negative regulation of mitotic cell cycle	GO:0045930	109	0.081
purine nucleoside metabolic process	GO:0042278	127	0.081
regulation of growth	GO:0040008	233	0.080
spindle organization	GO:0007051	253	0.079
ribonucleoprotein complex biogenesis	GO:0022613	31	0.078
cellular response to heat	GO:0034605	24	0.078
methylation	GO:0032259	47	0.078
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.078
chromosome segregation	GO:0007059	157	0.077
cellular macromolecular complex assembly	GO:0034622	153	0.077
response to radiation	GO:0009314	155	0.077
positive regulation of multicellular organism growth	GO:0040018	21	0.076
induction of programmed cell death by ecdysone	GO:0035078	12	0.076
positive regulation of macromolecule metabolic process	GO:0010604	405	0.076	Human
nuclear import	GO:0051170	51	0.076
regulation of cell cycle process	GO:0010564	181	0.076
cellular ketone metabolic process	GO:0042180	24	0.075
macromolecule catabolic process	GO:0009057	161	0.074
axon development	GO:0061564	297	0.074	Zebrafish Mouse
ecdysone mediated induction of salivary gland cell autophagic cell death	GO:0035072	12	0.074
regulation of protein metabolic process	GO:0051246	256	0.073
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.071
heterocycle catabolic process	GO:0046700	166	0.069
glycosyl compound metabolic process	GO:1901657	127	0.068
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.068
genitalia development	GO:0048806	26	0.068
double strand break repair	GO:0006302	26	0.065
positive regulation of cell communication	GO:0010647	250	0.065
nuclear pore organization	GO:0006999	1	0.065
response to external biotic stimulus	GO:0043207	293	0.064
female germ line cyst formation	GO:0048135	42	0.064
histone acetylation	GO:0016573	38	0.063
positive regulation of growth	GO:0045927	75	0.063
tube development	GO:0035295	244	0.062
histone modification	GO:0016570	106	0.062
cell cycle dna replication	GO:0044786	23	0.061
regulation of neurogenesis	GO:0050767	158	0.061
organonitrogen compound metabolic process	GO:1901564	318	0.060
learning or memory	GO:0007611	141	0.060
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.059
aromatic compound catabolic process	GO:0019439	166	0.059
regulation of localization	GO:0032879	275	0.058
ribonucleotide metabolic process	GO:0009259	145	0.058
catabolic process	GO:0009056	409	0.058
nuclear envelope organization	GO:0006998	7	0.057
positive regulation of mitotic cell cycle	GO:0045931	34	0.056
homeostatic process	GO:0042592	199	0.056
tube morphogenesis	GO:0035239	191	0.055
regulation of actin filament based process	GO:0032970	42	0.054
regulation of nervous system development	GO:0051960	248	0.053
nucleoside phosphate metabolic process	GO:0006753	162	0.053
glycosyl compound catabolic process	GO:1901658	112	0.052
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.052
defense response	GO:0006952	300	0.052
nucleoside metabolic process	GO:0009116	127	0.051
regulation of cellular localization	GO:0060341	136	0.051
regulation of cellular component biogenesis	GO:0044087	201	0.050
positive regulation of developmental growth	GO:0048639	62	0.050
protein import into nucleus	GO:0006606	51	0.050
stem cell maintenance	GO:0019827	67	0.049
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.049
developmental growth	GO:0048589	280	0.049
response to sterol	GO:0036314	34	0.048
single organism nuclear import	GO:1902593	51	0.048
negative regulation of cell proliferation	GO:0008285	69	0.048
mrna processing	GO:0006397	104	0.048
forebrain development	GO:0030900	2	0.047	Mouse
nucleosome organization	GO:0034728	59	0.047
dna damage checkpoint	GO:0000077	78	0.047
negative regulation of apoptotic process	GO:0043066	63	0.047
telencephalon development	GO:0021537	2	0.046
protein modification process	GO:0036211	438	0.046
regulation of dna metabolic process	GO:0051052	34	0.046	Human
ribonucleoprotein complex subunit organization	GO:0071826	28	0.046
cellular response to oxygen containing compound	GO:1901701	79	0.046
gene silencing	GO:0016458	138	0.046
negative regulation of response to stimulus	GO:0048585	258	0.045
cellular response to peptide hormone stimulus	GO:0071375	28	0.045
purine ribonucleoside metabolic process	GO:0046128	127	0.045
protein localization to organelle	GO:0033365	82	0.045
regulation of cellular protein metabolic process	GO:0032268	243	0.045
establishment of localization in cell	GO:0051649	402	0.044
single organism catabolic process	GO:0044712	228	0.044
intracellular signal transduction	GO:0035556	300	0.044
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.044
morphogenesis of an epithelium	GO:0002009	276	0.043
sister chromatid segregation	GO:0000819	92	0.043
mitotic cell cycle checkpoint	GO:0007093	88	0.043
rna catabolic process	GO:0006401	37	0.042
regulation of apoptotic process	GO:0042981	130	0.042	Human
protein complex biogenesis	GO:0070271	201	0.042
posttranscriptional gene silencing	GO:0016441	46	0.042	Worm
ribonucleoside catabolic process	GO:0042454	112	0.042
organic acid metabolic process	GO:0006082	103	0.041
meiotic chromosome segregation	GO:0045132	59	0.041
purine nucleoside catabolic process	GO:0006152	112	0.041
mrna metabolic process	GO:0016071	124	0.041
nucleoside catabolic process	GO:0009164	112	0.041
heterochromatin organization involved in chromatin silencing	GO:0070868	9	0.041
cellular amine metabolic process	GO:0044106	12	0.040
positive regulation of programmed cell death	GO:0043068	62	0.040	Human
negative regulation of programmed cell death	GO:0043069	72	0.039
mitotic spindle organization	GO:0007052	220	0.039
establishment of protein localization	GO:0045184	163	0.039
response to organic cyclic compound	GO:0014070	89	0.039
nucleoside triphosphate metabolic process	GO:0009141	120	0.038
nucleosome positioning	GO:0016584	3	0.037
ncrna metabolic process	GO:0034660	43	0.037
dna repair	GO:0006281	54	0.037
protein transport	GO:0015031	155	0.036
negative regulation of cell differentiation	GO:0045596	143	0.036
negative regulation of cell death	GO:0060548	81	0.036
cytoplasmic transport	GO:0016482	130	0.036
positive regulation of organelle organization	GO:0010638	65	0.036
nucleotide catabolic process	GO:0009166	109	0.035
regulation of cytoskeleton organization	GO:0051493	89	0.035
purine nucleotide metabolic process	GO:0006163	146	0.035
single organism cellular localization	GO:1902580	180	0.035
regulation of transcription by chromatin organization	GO:0034401	3	0.034
protein catabolic process	GO:0030163	101	0.034
negative regulation of cell communication	GO:0010648	223	0.034
positive regulation of cellular component organization	GO:0051130	156	0.034
regulation of organelle organization	GO:0033043	196	0.032
localization of cell	GO:0051674	257	0.031	Mouse
production of small rna involved in gene silencing by rna	GO:0070918	15	0.031
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.031	Human
organonitrogen compound catabolic process	GO:1901565	128	0.030
determination of dorsal ventral asymmetry	GO:0048262	3	0.030
mushroom body development	GO:0016319	70	0.030
mitotic cell cycle embryonic	GO:0045448	38	0.030
establishment of organelle localization	GO:0051656	122	0.030
male gamete generation	GO:0048232	201	0.030
regulation of dendrite morphogenesis	GO:0048814	28	0.030
regulation of protein localization	GO:0032880	76	0.030
protein complex assembly	GO:0006461	200	0.030
eye development	GO:0001654	323	0.029	Zebrafish
defense response to bacterium	GO:0042742	178	0.029
cellular response to nitrogen compound	GO:1901699	51	0.029
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.028
cellular protein localization	GO:0034613	160	0.028
response to heat	GO:0009408	63	0.028
nucleobase containing compound catabolic process	GO:0034655	165	0.027
mrna catabolic process	GO:0006402	33	0.027
response to other organism	GO:0051707	293	0.026
chromatin silencing	GO:0006342	76	0.026
regulation of mrna metabolic process	GO:1903311	72	0.026
carboxylic acid metabolic process	GO:0019752	92	0.026
protein targeting	GO:0006605	64	0.026
regulation of mrna processing	GO:0050684	71	0.025
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.025
purine containing compound metabolic process	GO:0072521	155	0.025
purine ribonucleoside catabolic process	GO:0046130	112	0.025
response to organonitrogen compound	GO:0010243	75	0.024
positive regulation of developmental process	GO:0051094	143	0.024
protein alkylation	GO:0008213	43	0.024
cellular response to dna damage stimulus	GO:0006974	223	0.024
protein localization to nucleus	GO:0034504	55	0.024
imaginal disc growth	GO:0007446	37	0.024
cellular response to sterol depletion	GO:0071501	3	0.024
intracellular protein transport	GO:0006886	104	0.024
positive regulation of multicellular organismal process	GO:0051240	143	0.024
organic substance catabolic process	GO:1901575	308	0.023
positive regulation of phosphorylation	GO:0042327	87	0.023
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.023
positive regulation of protein metabolic process	GO:0051247	128	0.023
regulation of phosphorylation	GO:0042325	147	0.023
chromatin maintenance	GO:0070827	2	0.022
regulation of cellular response to stress	GO:0080135	89	0.022
regulation of protein complex assembly	GO:0043254	42	0.022
small gtpase mediated signal transduction	GO:0007264	88	0.022
multi multicellular organism process	GO:0044706	123	0.022
regulation of innate immune response	GO:0045088	71	0.021
maintenance of location	GO:0051235	73	0.021
nuclear export	GO:0051168	24	0.021
endocytosis	GO:0006897	310	0.021
regulation of neuron differentiation	GO:0045664	103	0.021
protein import	GO:0017038	55	0.021
germ line stem cell maintenance	GO:0030718	50	0.021
cell division	GO:0051301	248	0.021
chromosome separation	GO:0051304	42	0.021
protein phosphorylation	GO:0006468	169	0.020
nucleoside triphosphate catabolic process	GO:0009143	108	0.020
induction of programmed cell death	GO:0012502	12	0.020
cellular response to lipid	GO:0071396	20	0.020
amine metabolic process	GO:0009308	12	0.020
positive regulation of intracellular signal transduction	GO:1902533	116	0.020
embryonic morphogenesis	GO:0048598	206	0.019
regulation of cellular amino acid metabolic process	GO:0006521	0	0.019
positive regulation of cell cycle process	GO:0090068	28	0.019
response to alcohol	GO:0097305	95	0.019
organophosphate metabolic process	GO:0019637	195	0.019
organic substance transport	GO:0071702	257	0.019
regulation of protein modification process	GO:0031399	112	0.019
negative regulation of protein export from nucleus	GO:0046826	2	0.019
response to dsrna	GO:0043331	15	0.018
induction of programmed cell death by hormones	GO:0035081	12	0.018
nucleotide metabolic process	GO:0009117	161	0.018
regulation of ras protein signal transduction	GO:0046578	93	0.018
regulation of intracellular protein transport	GO:0033157	46	0.018
establishment of nucleus localization	GO:0040023	26	0.018
response to endogenous stimulus	GO:0009719	119	0.017
defense response to other organism	GO:0098542	225	0.017
positive regulation of mrna processing	GO:0050685	4	0.017
defense response to gram negative bacterium	GO:0050829	94	0.017
lipid localization	GO:0010876	54	0.017
heterochromatin assembly	GO:0031507	13	0.017
regulation of anatomical structure morphogenesis	GO:0022603	242	0.017
negative regulation of imaginal disc growth	GO:0045571	8	0.017
dorsal ventral axis specification	GO:0009950	66	0.017
negative regulation of multicellular organismal process	GO:0051241	142	0.017
response to lipid	GO:0033993	38	0.017
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.017
production of mirnas involved in gene silencing by mirna	GO:0035196	10	0.016
posttranscriptional regulation of gene expression	GO:0010608	145	0.016	Worm
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.016
synapse assembly	GO:0007416	143	0.016
phosphorylation	GO:0016310	294	0.016
regulation of chromatin modification	GO:1903308	28	0.016
regulation of phosphorus metabolic process	GO:0051174	210	0.016
instar larval development	GO:0002168	55	0.016
dorsal ventral pattern formation	GO:0009953	133	0.016
post embryonic appendage morphogenesis	GO:0035120	385	0.016
positive regulation of dna endoreduplication	GO:0032877	4	0.016
dendritic spine development	GO:0060996	4	0.016
negative regulation of cell development	GO:0010721	62	0.016
germarium derived female germ line cyst formation	GO:0030727	42	0.015
histone lysine demethylation	GO:0070076	6	0.015
nitrogen compound transport	GO:0071705	85	0.015
cellular macromolecule catabolic process	GO:0044265	136	0.015
female germ line stem cell maintenance	GO:0036099	8	0.015
rna 3 end processing	GO:0031123	45	0.015
eggshell chorion gene amplification	GO:0007307	9	0.015
regulation of immune response	GO:0050776	118	0.015
protein modification by small protein conjugation or removal	GO:0070647	106	0.015
nls bearing protein import into nucleus	GO:0006607	5	0.015
mrna splice site selection	GO:0006376	1	0.014
ribonucleoside metabolic process	GO:0009119	127	0.014
regulation of cellular ketone metabolic process	GO:0010565	3	0.014
gland development	GO:0048732	191	0.014
intermediate filament based process	GO:0045103	1	0.014
cell maturation	GO:0048469	144	0.014
protein methylation	GO:0006479	43	0.014
g2 dna damage checkpoint	GO:0031572	69	0.014
negative regulation of translation	GO:0017148	28	0.014
regulation of protein transport	GO:0051223	57	0.014
internal peptidyl lysine acetylation	GO:0018393	38	0.014
cytoplasmic mrna processing body assembly	GO:0033962	10	0.014
axonogenesis	GO:0007409	290	0.014	Zebrafish Mouse
purine ribonucleotide catabolic process	GO:0009154	109	0.014
spermatogenesis	GO:0007283	200	0.014
negative regulation of cellular protein metabolic process	GO:0032269	85	0.014
oocyte development	GO:0048599	124	0.013
camera type eye development	GO:0043010	4	0.013	Zebrafish
regulation of molecular function	GO:0065009	217	0.013
response to biotic stimulus	GO:0009607	294	0.013
cellular response to organic cyclic compound	GO:0071407	32	0.013
negative regulation of protein metabolic process	GO:0051248	85	0.013
regulation of dna templated transcription elongation	GO:0032784	17	0.013
synapse organization	GO:0050808	196	0.013
neuron maturation	GO:0042551	31	0.013
actin cytoskeleton organization	GO:0030036	206	0.013
cellular response to light stimulus	GO:0071482	37	0.013
cell fate determination	GO:0001709	91	0.012
unsaturated fatty acid biosynthetic process	GO:0006636	1	0.012
production of sirna involved in rna interference	GO:0030422	11	0.012
segmentation	GO:0035282	207	0.012
receptor mediated endocytosis	GO:0006898	21	0.012
regulation of nucleocytoplasmic transport	GO:0046822	35	0.012
positive regulation of apoptotic process	GO:0043065	47	0.012	Human
regulation of chromosome organization	GO:0033044	64	0.012
ribonucleotide catabolic process	GO:0009261	109	0.012
regulation of heterochromatin assembly	GO:0031445	8	0.012
exocrine system development	GO:0035272	162	0.012
cellular response to abiotic stimulus	GO:0071214	58	0.012
nucleoside monophosphate catabolic process	GO:0009125	39	0.012
oocyte maturation	GO:0001556	3	0.012
convergent extension	GO:0060026	2	0.011
multicellular organismal reproductive behavior	GO:0033057	110	0.011
regulation of mrna splicing via spliceosome	GO:0048024	64	0.011
negative regulation of rna metabolic process	GO:0051253	251	0.011
protein dna complex subunit organization	GO:0071824	86	0.011
cellular nitrogen compound catabolic process	GO:0044270	165	0.011
epithelial cell development	GO:0002064	274	0.011
germ line stem cell division	GO:0042078	25	0.011
jak stat cascade	GO:0007259	49	0.011
organic cyclic compound catabolic process	GO:1901361	168	0.011
histone methylation	GO:0016571	40	0.011
peptidyl threonine phosphorylation	GO:0018107	2	0.010
eye antennal disc development	GO:0035214	60	0.010
posttranscriptional gene silencing by rna	GO:0035194	45	0.010	Worm
compound eye development	GO:0048749	307	0.010
nucleoside phosphate catabolic process	GO:1901292	110	0.010
oxoacid metabolic process	GO:0043436	103	0.010
regulation of catalytic activity	GO:0050790	185	0.010
rna interference	GO:0016246	27	0.010	Worm
proteolysis	GO:0006508	192	0.010

Top2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.030
disease of cellular proliferation	DOID:14566	0.030
organ system cancer	DOID:0050686	0.029
connective tissue cancer	DOID:201	0.012
musculoskeletal system cancer	DOID:0060100	0.012
disease of anatomical entity	DOID:7	0.010

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