IMP: Integrative Multi-species Prediction

Drosophila melanogaster

30 known processes

CG10267 (Dmel_CG10267)

CG10267 gene product from transcript CG10267-RB

(Aliases: Dmel\CG10267,anon-WO0118547.391)

FLYBASE: FBgn0037446
Entrez: 40795
UniProtKB: Q9VI24

Process Predictions
Disease Predictions

CG10267 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
programmed cell death	GO:0012501	257	0.679
negative regulation of gene expression	GO:0010629	387	0.669
dendrite morphogenesis	GO:0048813	199	0.643
macromolecular complex assembly	GO:0065003	256	0.598
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.572
asymmetric neuroblast division	GO:0055059	33	0.541
organelle fission	GO:0048285	340	0.534	Fly
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.509
meiotic cell cycle	GO:0051321	171	0.487	Fly
intracellular signal transduction	GO:0035556	300	0.454	Fly
protein complex biogenesis	GO:0070271	201	0.451
positive regulation of cellular biosynthetic process	GO:0031328	316	0.384
regulation of intracellular signal transduction	GO:1902531	236	0.381	Fly
dendrite development	GO:0016358	204	0.375
mitotic spindle organization	GO:0007052	220	0.322
spindle assembly	GO:0051225	80	0.306
dna metabolic process	GO:0006259	227	0.291	Fly
regulation of meiosis	GO:0040020	3	0.291
signal transduction by phosphorylation	GO:0023014	107	0.289	Fly
dna damage checkpoint	GO:0000077	78	0.282
meiotic cell cycle process	GO:1903046	132	0.282	Fly
organic substance transport	GO:0071702	257	0.262
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.246
death	GO:0016265	284	0.243
nuclear division	GO:0000280	332	0.236	Fly
stem cell proliferation	GO:0072089	88	0.228
regulation of organelle organization	GO:0033043	196	0.216
regulation of mapk cascade	GO:0043408	92	0.216	Fly
cell migration	GO:0016477	238	0.207
neuroblast proliferation	GO:0007405	74	0.200
establishment of localization in cell	GO:0051649	402	0.191
reproductive system development	GO:0061458	74	0.190
mitotic cell cycle checkpoint	GO:0007093	88	0.190
heterocycle catabolic process	GO:0046700	166	0.188
cellular macromolecular complex assembly	GO:0034622	153	0.184
cell death	GO:0008219	279	0.179
microtubule organizing center organization	GO:0031023	168	0.178
cell cycle checkpoint	GO:0000075	95	0.175
positive regulation of signaling	GO:0023056	243	0.173
response to temperature stimulus	GO:0009266	106	0.169
regulation of cell cycle	GO:0051726	291	0.169
embryo development ending in birth or egg hatching	GO:0009792	152	0.168
intracellular transport	GO:0046907	228	0.166
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.162
spindle organization	GO:0007051	253	0.161
cellular response to dna damage stimulus	GO:0006974	223	0.160
reproductive structure development	GO:0048608	74	0.157
apoptotic process	GO:0006915	159	0.155
cellular component disassembly	GO:0022411	46	0.151
small gtpase mediated signal transduction	GO:0007264	88	0.147	Fly
axon development	GO:0061564	297	0.140
positive regulation of rna metabolic process	GO:0051254	271	0.139
positive regulation of gene expression	GO:0010628	290	0.134
regulation of cell death	GO:0010941	173	0.131
development of primary sexual characteristics	GO:0045137	50	0.131
cell motility	GO:0048870	251	0.127
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.126
negative regulation of signal transduction	GO:0009968	206	0.124	Fly
single organism intracellular transport	GO:1902582	207	0.123
regulation of neural precursor cell proliferation	GO:2000177	35	0.120
cytoplasmic transport	GO:0016482	130	0.120
positive regulation of macromolecule metabolic process	GO:0010604	405	0.119
gene silencing	GO:0016458	138	0.118
posttranscriptional gene silencing	GO:0016441	46	0.116
stem cell division	GO:0017145	69	0.115
cell proliferation	GO:0008283	299	0.115
protein localization	GO:0008104	284	0.114
dna replication	GO:0006260	48	0.101
oocyte differentiation	GO:0009994	145	0.101
protein complex assembly	GO:0006461	200	0.101
positive regulation of response to stimulus	GO:0048584	323	0.100
regulation of gene expression epigenetic	GO:0040029	128	0.099
meiotic nuclear division	GO:0007126	151	0.099	Fly
response to abiotic stimulus	GO:0009628	341	0.099
response to other organism	GO:0051707	293	0.099
head development	GO:0060322	135	0.098
regulation of cellular response to stress	GO:0080135	89	0.095
regulation of programmed cell death	GO:0043067	152	0.092
reproductive behavior	GO:0019098	122	0.092
chemotaxis	GO:0006935	249	0.090
chromosome organization	GO:0051276	360	0.090
response to organic substance	GO:0010033	284	0.089
positive regulation of intracellular signal transduction	GO:1902533	116	0.088
cellular catabolic process	GO:0044248	372	0.084
neuron projection guidance	GO:0097485	241	0.083
axon guidance	GO:0007411	233	0.083
organelle assembly	GO:0070925	198	0.081
positive regulation of signal transduction	GO:0009967	223	0.080
erk1 and erk2 cascade	GO:0070371	39	0.079	Fly
positive regulation of programmed cell death	GO:0043068	62	0.078
multi organism behavior	GO:0051705	175	0.078
localization of cell	GO:0051674	257	0.077
central nervous system development	GO:0007417	201	0.076
negative regulation of transcription dna templated	GO:0045892	237	0.075
sex differentiation	GO:0007548	81	0.075
negative regulation of cell cycle phase transition	GO:1901988	103	0.074
negative regulation of biosynthetic process	GO:0009890	277	0.073
taxis	GO:0042330	304	0.073
transcription from rna polymerase ii promoter	GO:0006366	368	0.072
regulation of phosphate metabolic process	GO:0019220	210	0.071	Fly
cell division	GO:0051301	248	0.070
regionalization	GO:0003002	416	0.068
mitotic dna damage checkpoint	GO:0044773	74	0.067
mapk cascade	GO:0000165	107	0.067	Fly
aromatic compound catabolic process	GO:0019439	166	0.066
regulation of erk1 and erk2 cascade	GO:0070372	39	0.066	Fly
positive regulation of cell communication	GO:0010647	250	0.065
gonad development	GO:0008406	50	0.065
negative regulation of cellular biosynthetic process	GO:0031327	277	0.063
regulation of cell cycle process	GO:0010564	181	0.060
negative regulation of erk1 and erk2 cascade	GO:0070373	3	0.059	Fly
protein modification process	GO:0036211	438	0.058
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.056
positive regulation of apoptotic process	GO:0043065	47	0.056
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.054
regulation of dna dependent dna replication	GO:0090329	6	0.054
positive regulation of biosynthetic process	GO:0009891	316	0.054
negative regulation of rna biosynthetic process	GO:1902679	240	0.053
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.052
histone acetylation	GO:0016573	38	0.052
centrosome organization	GO:0051297	163	0.051
negative regulation of cell cycle	GO:0045786	116	0.049
regulation of cell development	GO:0060284	215	0.048
negative regulation of rna metabolic process	GO:0051253	251	0.047
cellular protein complex disassembly	GO:0043624	35	0.047
internal peptidyl lysine acetylation	GO:0018393	38	0.046
multicellular organismal reproductive behavior	GO:0033057	110	0.046
negative regulation of cell communication	GO:0010648	223	0.045	Fly
actin cytoskeleton organization	GO:0030036	206	0.045
regulation of nervous system development	GO:0051960	248	0.045
neuroblast division	GO:0055057	35	0.044
asymmetric protein localization	GO:0008105	33	0.042
synapse assembly	GO:0007416	143	0.042
catabolic process	GO:0009056	409	0.042
cellular response to organic substance	GO:0071310	132	0.042
multi organism reproductive behavior	GO:0044705	121	0.042
muscle cell differentiation	GO:0042692	103	0.041
negative regulation of ras protein signal transduction	GO:0046580	13	0.040	Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.040
regulation of neurogenesis	GO:0050767	158	0.040
negative regulation of cell cycle process	GO:0010948	109	0.040
carbohydrate derivative metabolic process	GO:1901135	217	0.040
endocytosis	GO:0006897	310	0.040
asymmetric stem cell division	GO:0098722	49	0.039
organic substance catabolic process	GO:1901575	308	0.039
cellular nitrogen compound catabolic process	GO:0044270	165	0.039
mitotic dna integrity checkpoint	GO:0044774	75	0.039
meiotic dna double strand break formation involved in reciprocal meiotic recombination	GO:0010780	1	0.039	Fly
multi multicellular organism process	GO:0044706	123	0.038
regulation of growth	GO:0040008	233	0.038
regulation of phosphorus metabolic process	GO:0051174	210	0.037	Fly
cellular macromolecule catabolic process	GO:0044265	136	0.037
positive regulation of cellular component organization	GO:0051130	156	0.036
meiosis i	GO:0007127	59	0.036	Fly
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.034
cytokinesis	GO:0000910	90	0.034
meiotic dna double strand break formation	GO:0042138	1	0.034	Fly
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.033
response to oxygen containing compound	GO:1901700	200	0.033
regulation of ras protein signal transduction	GO:0046578	93	0.033	Fly
cell cycle arrest	GO:0007050	4	0.033
cellular macromolecule localization	GO:0070727	220	0.033
neural precursor cell proliferation	GO:0061351	75	0.032
positive regulation of phosphorylation	GO:0042327	87	0.032
posttranscriptional gene silencing by rna	GO:0035194	45	0.032
ras protein signal transduction	GO:0007265	88	0.031	Fly
larval development	GO:0002164	104	0.031
appendage development	GO:0048736	401	0.031
spermatogenesis	GO:0007283	200	0.031
nitrogen compound transport	GO:0071705	85	0.031
histone exchange	GO:0043486	21	0.030
mitochondrion organization	GO:0007005	65	0.030
regulation of apoptotic process	GO:0042981	130	0.030
regulation of stem cell proliferation	GO:0072091	40	0.029
negative regulation of organelle organization	GO:0010639	56	0.029
dna integrity checkpoint	GO:0031570	81	0.029
brain development	GO:0007420	120	0.028
g2 dna damage checkpoint	GO:0031572	69	0.028
negative regulation of phosphate metabolic process	GO:0045936	45	0.027	Fly
covalent chromatin modification	GO:0016569	106	0.027
organic cyclic compound catabolic process	GO:1901361	168	0.027
cellular response to chemical stimulus	GO:0070887	199	0.027
stem cell differentiation	GO:0048863	117	0.026
axonogenesis	GO:0007409	290	0.026
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.026
regulation of localization	GO:0032879	275	0.026
nucleobase containing compound catabolic process	GO:0034655	165	0.026
positive regulation of developmental process	GO:0051094	143	0.025
purine containing compound metabolic process	GO:0072521	155	0.025
internal protein amino acid acetylation	GO:0006475	38	0.025
regulation of cell proliferation	GO:0042127	163	0.025
mushroom body development	GO:0016319	70	0.025
regulation of cell division	GO:0051302	72	0.025
purine nucleotide metabolic process	GO:0006163	146	0.025
positive regulation of transcription dna templated	GO:0045893	266	0.025
imaginal disc derived leg morphogenesis	GO:0007480	80	0.024
regulation of phosphorylation	GO:0042325	147	0.024	Fly
genitalia development	GO:0048806	26	0.024
purine ribonucleotide catabolic process	GO:0009154	109	0.024
protein k48 linked ubiquitination	GO:0070936	3	0.024
regulation of dendrite development	GO:0050773	37	0.023
regulation of dna replication	GO:0006275	13	0.023
positive regulation of phosphate metabolic process	GO:0045937	139	0.023
negative regulation of cellular component organization	GO:0051129	108	0.023
negative regulation of meiotic cell cycle	GO:0051447	2	0.023
atp dependent chromatin remodeling	GO:0043044	22	0.023
intracellular protein transport	GO:0006886	104	0.023
mitotic g2 m transition checkpoint	GO:0044818	70	0.023
salivary gland development	GO:0007431	162	0.023
vesicle mediated transport	GO:0016192	381	0.022
positive regulation of dna metabolic process	GO:0051054	12	0.022
negative regulation of phosphorus metabolic process	GO:0010563	45	0.022	Fly
dna dependent dna replication	GO:0006261	17	0.022
macromolecular complex disassembly	GO:0032984	37	0.022
negative regulation of programmed cell death	GO:0043069	72	0.022
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.022
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.022	Fly
regulation of protein localization	GO:0032880	76	0.022
embryonic development via the syncytial blastoderm	GO:0001700	148	0.021
cell cycle phase transition	GO:0044770	140	0.021
negative regulation of cellular metabolic process	GO:0031324	382	0.021	Fly
growth	GO:0040007	359	0.021
positive regulation of developmental growth	GO:0048639	62	0.021
regulation of protein serine threonine kinase activity	GO:0071900	25	0.021
mrna processing	GO:0006397	104	0.021
male gamete generation	GO:0048232	201	0.021
chromatin silencing	GO:0006342	76	0.020
positive regulation of phosphorus metabolic process	GO:0010562	139	0.020
regulation of nucleotide metabolic process	GO:0006140	62	0.020
mitotic nuclear division	GO:0007067	213	0.020
exocrine system development	GO:0035272	162	0.020
tube morphogenesis	GO:0035239	191	0.019
establishment of chromosome localization	GO:0051303	20	0.019
nuclear migration	GO:0007097	20	0.019
developmental maturation	GO:0021700	172	0.019
guanosine containing compound catabolic process	GO:1901069	74	0.019
regulation of intracellular transport	GO:0032386	64	0.019
peptidyl lysine acetylation	GO:0018394	39	0.018
negative regulation of cytoskeleton organization	GO:0051494	30	0.018
ribonucleotide metabolic process	GO:0009259	145	0.018
purine ribonucleotide metabolic process	GO:0009150	145	0.018
negative regulation of gene expression epigenetic	GO:0045814	77	0.018
spindle assembly involved in mitosis	GO:0090307	50	0.018
nucleotide catabolic process	GO:0009166	109	0.018
protein ubiquitination	GO:0016567	70	0.017
purine nucleotide catabolic process	GO:0006195	109	0.017
phagocytosis	GO:0006909	215	0.017
regulation of protein complex assembly	GO:0043254	42	0.017
ribonucleotide catabolic process	GO:0009261	109	0.017
regulation of establishment of protein localization	GO:0070201	61	0.017
oviposition	GO:0018991	19	0.017
response to external biotic stimulus	GO:0043207	293	0.017
gene silencing by rna	GO:0031047	57	0.017
establishment or maintenance of cell polarity	GO:0007163	167	0.017
protein phosphorylation	GO:0006468	169	0.016
negative regulation of signaling	GO:0023057	219	0.016	Fly
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.016
imaginal disc derived appendage development	GO:0048737	399	0.016
regulation of response to stress	GO:0080134	200	0.016
regulation of nuclear division	GO:0051783	58	0.016
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.016
gtp catabolic process	GO:0006184	72	0.016
protein localization to organelle	GO:0033365	82	0.016
posttranscriptional regulation of gene expression	GO:0010608	145	0.016
ribonucleoprotein complex biogenesis	GO:0022613	31	0.016
rna interference	GO:0016246	27	0.015
post embryonic appendage morphogenesis	GO:0035120	385	0.015
actin filament based process	GO:0030029	220	0.015
regulation of mitotic cell cycle	GO:0007346	190	0.015
regulation of transport	GO:0051049	181	0.015
regulation of catalytic activity	GO:0050790	185	0.015
positive regulation of cellular amine metabolic process	GO:0033240	0	0.015
response to heat	GO:0009408	63	0.015
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.015
regulation of mitosis	GO:0007088	56	0.015
dna templated transcription initiation	GO:0006352	25	0.015
mitotic sister chromatid segregation	GO:0000070	87	0.014
regulation of cytoskeleton organization	GO:0051493	89	0.014
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.014
organonitrogen compound catabolic process	GO:1901565	128	0.014
spinal cord development	GO:0021510	1	0.014
negative regulation of protein depolymerization	GO:1901880	23	0.014
response to ecdysone	GO:0035075	34	0.014
nucleoside phosphate catabolic process	GO:1901292	110	0.014
chromatin remodeling	GO:0006338	72	0.014
establishment of spindle orientation	GO:0051294	18	0.014
chromatin modification	GO:0016568	147	0.014
establishment or maintenance of neuroblast polarity	GO:0045196	8	0.014
regulation of intracellular protein transport	GO:0033157	46	0.013
nucleoside catabolic process	GO:0009164	112	0.013
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.013
regulation of cellular localization	GO:0060341	136	0.013
protein complex disassembly	GO:0043241	36	0.013
mitotic g2 dna damage checkpoint	GO:0007095	69	0.013
regulation of dna metabolic process	GO:0051052	34	0.013
cellular protein localization	GO:0034613	160	0.013
glycosyl compound metabolic process	GO:1901657	127	0.012
body morphogenesis	GO:0010171	2	0.012
single organism catabolic process	GO:0044712	228	0.012
organic acid metabolic process	GO:0006082	103	0.012
regulation of cellular ketone metabolic process	GO:0010565	3	0.012
peptidyl amino acid modification	GO:0018193	105	0.012
establishment of nucleus localization	GO:0040023	26	0.012
regulation of protein transport	GO:0051223	57	0.012
protein acylation	GO:0043543	42	0.012
rna catabolic process	GO:0006401	37	0.012
hematopoietic stem cell differentiation	GO:0060218	1	0.012
rna localization	GO:0006403	115	0.012
regulation of gtp catabolic process	GO:0033124	44	0.012
nitric oxide metabolic process	GO:0046209	1	0.012
forebrain development	GO:0030900	2	0.011
regulation of transferase activity	GO:0051338	58	0.011
rna processing	GO:0006396	147	0.011
positive regulation of mapk cascade	GO:0043410	63	0.011
regulation of molecular function	GO:0065009	217	0.011
chromatin organization	GO:0006325	207	0.011
gland development	GO:0048732	191	0.011
establishment of cell polarity	GO:0030010	40	0.011
regulation of cell cycle phase transition	GO:1901987	130	0.011
positive regulation of multicellular organismal process	GO:0051240	143	0.011
histone modification	GO:0016570	106	0.011
negative regulation of intracellular signal transduction	GO:1902532	57	0.011	Fly
tissue death	GO:0016271	102	0.011
phosphorylation	GO:0016310	294	0.011	Fly
regulation of multicellular organismal development	GO:2000026	414	0.011
negative regulation of phosphorylation	GO:0042326	35	0.011	Fly
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.010
plasma membrane organization	GO:0007009	26	0.010
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.010
regulation of protein secretion	GO:0050708	13	0.010
regulation of cellular protein metabolic process	GO:0032268	243	0.010

CG10267 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.010
neurodegenerative disease	DOID:1289	0.010
synucleinopathy	DOID:0050890	0.010
central nervous system disease	DOID:331	0.010
disease of anatomical entity	DOID:7	0.010

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