IMP: Integrative Multi-species Prediction

Drosophila melanogaster

202 known processes

barr (Dmel_CG10726)

barren

(Aliases: Cap-H,38B.3,CAP-H,Dmel\CG10726,Barren,CG10726,dCap-H)

Entrez: 35287
FLYBASE: FBgn0014127
UniProtKB: Q9VIP9

Process Predictions
Disease Predictions

barr biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.917
chromosome segregation	GO:0007059	157	0.898
negative regulation of cellular biosynthetic process	GO:0031327	277	0.894
negative regulation of rna metabolic process	GO:0051253	251	0.862
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.837
meiotic nuclear division	GO:0007126	151	0.834
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.780
embryo development ending in birth or egg hatching	GO:0009792	152	0.756
negative regulation of biosynthetic process	GO:0009890	277	0.736
negative regulation of rna biosynthetic process	GO:1902679	240	0.733
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.711
negative regulation of gene expression epigenetic	GO:0045814	77	0.659
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.646
mitotic nuclear division	GO:0007067	213	0.641
negative regulation of cellular metabolic process	GO:0031324	382	0.634
mitotic chromosome condensation	GO:0007076	22	0.618
meiotic cell cycle	GO:0051321	171	0.609
chromosome organization	GO:0051276	360	0.599
spindle assembly involved in mitosis	GO:0090307	50	0.592
hindgut morphogenesis	GO:0007442	58	0.569
sister chromatid segregation	GO:0000819	92	0.562
spindle organization	GO:0007051	253	0.551
mitotic cytokinesis	GO:0000281	50	0.500
organelle assembly	GO:0070925	198	0.498
mitotic spindle organization	GO:0007052	220	0.430
ubiquitin dependent protein catabolic process	GO:0006511	78	0.415
chromatin silencing	GO:0006342	76	0.380
cell cycle dna replication	GO:0044786	23	0.378
positive regulation of rna metabolic process	GO:0051254	271	0.359
regulation of gene expression epigenetic	GO:0040029	128	0.348
positive regulation of biosynthetic process	GO:0009891	316	0.338
negative regulation of gene expression	GO:0010629	387	0.312
regulation of cell cycle	GO:0051726	291	0.306
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.305
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.304
embryonic hindgut morphogenesis	GO:0048619	48	0.303
negative regulation of transcription dna templated	GO:0045892	237	0.299
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.280
single fertilization	GO:0007338	24	0.262
cellular protein catabolic process	GO:0044257	83	0.259
regulation of mitotic cell cycle	GO:0007346	190	0.258
tube development	GO:0035295	244	0.256
nuclear division	GO:0000280	332	0.252
female meiotic division	GO:0007143	70	0.247
positive regulation of gene expression	GO:0010628	290	0.246
transcription from rna polymerase ii promoter	GO:0006366	368	0.236
positive regulation of rna biosynthetic process	GO:1902680	266	0.236
hindgut development	GO:0061525	58	0.235
proteolysis	GO:0006508	192	0.226
dna replication	GO:0006260	48	0.220
dendrite development	GO:0016358	204	0.187
dendrite morphogenesis	GO:0048813	199	0.183
gene silencing	GO:0016458	138	0.183
positive regulation of metaphase anaphase transition of cell cycle	GO:1902101	10	0.182
chromosome condensation	GO:0030261	41	0.179
body morphogenesis	GO:0010171	2	0.178
modification dependent protein catabolic process	GO:0019941	78	0.178
cell proliferation	GO:0008283	299	0.174
malpighian tubule development	GO:0072002	64	0.172
mitotic sister chromatid segregation	GO:0000070	87	0.163
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.162
regulation of cell cycle phase transition	GO:1901987	130	0.152
regulation of organelle organization	GO:0033043	196	0.149
renal tubule development	GO:0061326	64	0.146
endocytosis	GO:0006897	310	0.145
covalent chromatin modification	GO:0016569	106	0.144
meiotic cell cycle process	GO:1903046	132	0.143
protein modification process	GO:0036211	438	0.142
chromatin organization	GO:0006325	207	0.138
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.135
negative regulation of mitotic cell cycle	GO:0045930	109	0.134
cellular protein modification process	GO:0006464	438	0.134
dna metabolic process	GO:0006259	227	0.130
regulation of cell cycle process	GO:0010564	181	0.127
positive regulation of transcription dna templated	GO:0045893	266	0.126
cellular macromolecule catabolic process	GO:0044265	136	0.125
regulation of protein metabolic process	GO:0051246	256	0.125
protein catabolic process	GO:0030163	101	0.122
regulation of mitotic spindle organization	GO:0060236	9	0.120
nuclear dna replication	GO:0033260	1	0.117
negative regulation of cell cycle	GO:0045786	116	0.113
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.113
small molecule metabolic process	GO:0044281	305	0.112
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.111
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.110
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.108
mitotic sister chromatid separation	GO:0051306	30	0.108
multicellular organismal aging	GO:0010259	140	0.108
larval development	GO:0002164	104	0.102
chromatin modification	GO:0016568	147	0.101
organelle fission	GO:0048285	340	0.098
meiosis i	GO:0007127	59	0.095
spermatogenesis	GO:0007283	200	0.093
cellular response to dna damage stimulus	GO:0006974	223	0.092
protein dna complex subunit organization	GO:0071824	86	0.089
digestive system development	GO:0055123	149	0.089
positive regulation of macromolecule metabolic process	GO:0010604	405	0.088
cell cycle phase transition	GO:0044770	140	0.088
negative regulation of cell cycle process	GO:0010948	109	0.088
fertilization	GO:0009566	26	0.088
reproductive system development	GO:0061458	74	0.086
protein complex assembly	GO:0006461	200	0.081
sex differentiation	GO:0007548	81	0.080
macromolecule catabolic process	GO:0009057	161	0.080
proteasomal protein catabolic process	GO:0010498	59	0.078
determination of adult lifespan	GO:0008340	137	0.078
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.076
development of primary sexual characteristics	GO:0045137	50	0.074
regulation of chromatin silencing	GO:0031935	36	0.073
internal protein amino acid acetylation	GO:0006475	38	0.073
histone h4 acetylation	GO:0043967	13	0.071
cellular catabolic process	GO:0044248	372	0.070
positive regulation of cellular biosynthetic process	GO:0031328	316	0.070
spindle assembly	GO:0051225	80	0.069
regulation of chromosome organization	GO:0033044	64	0.067
phagocytosis	GO:0006909	215	0.064
histone h4 k20 methylation	GO:0034770	4	0.063
catabolic process	GO:0009056	409	0.063
pronuclear migration	GO:0035046	4	0.063
protein complex biogenesis	GO:0070271	201	0.062
regulation of cell differentiation	GO:0045595	302	0.061
central nervous system development	GO:0007417	201	0.060
oocyte maturation	GO:0001556	3	0.058
negative regulation of cellular component organization	GO:0051129	108	0.057
positive regulation of mitotic metaphase anaphase transition	GO:0045842	10	0.057
positive regulation of mitotic sister chromatid separation	GO:1901970	10	0.054
mitotic cell cycle phase transition	GO:0044772	138	0.052
regulation of heterochromatin assembly	GO:0031445	8	0.051
appendage morphogenesis	GO:0035107	397	0.051
meiotic chromosome segregation	GO:0045132	59	0.050
rna processing	GO:0006396	147	0.050
mitotic spindle stabilization	GO:0043148	6	0.048
dna integrity checkpoint	GO:0031570	81	0.048
dna conformation change	GO:0071103	105	0.048
negative regulation of cell communication	GO:0010648	223	0.047
regulation of meiosis	GO:0040020	3	0.047
cell death	GO:0008219	279	0.045
response to external biotic stimulus	GO:0043207	293	0.045
cytoskeleton dependent cytokinesis	GO:0061640	81	0.045
dna packaging	GO:0006323	91	0.044
regulation of catabolic process	GO:0009894	170	0.043
head involution	GO:0008258	35	0.043
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.043
mitotic spindle elongation	GO:0000022	81	0.042
postreplication repair	GO:0006301	2	0.042
multicellular organism growth	GO:0035264	46	0.041
post embryonic appendage morphogenesis	GO:0035120	385	0.040
centrosome duplication	GO:0051298	121	0.040
modification dependent macromolecule catabolic process	GO:0043632	79	0.040
peptidyl amino acid modification	GO:0018193	105	0.039
morphogenesis of an epithelium	GO:0002009	276	0.039
regulation of cell division	GO:0051302	72	0.039
vesicle mediated transport	GO:0016192	381	0.039
regulation of dna metabolic process	GO:0051052	34	0.038
mitotic sister chromatid cohesion	GO:0007064	6	0.037
telomere capping	GO:0016233	11	0.036
reproductive structure development	GO:0048608	74	0.036
histone modification	GO:0016570	106	0.036
embryonic morphogenesis	GO:0048598	206	0.035
organic substance catabolic process	GO:1901575	308	0.035
negative regulation of organelle organization	GO:0010639	56	0.034
negative regulation of signal transduction	GO:0009968	206	0.033
regulation of proteasomal protein catabolic process	GO:0061136	39	0.033
neuron projection guidance	GO:0097485	241	0.033
cellular macromolecular complex assembly	GO:0034622	153	0.033
positive regulation of catabolic process	GO:0009896	105	0.032
regulation of cellular component biogenesis	GO:0044087	201	0.032
regulation of chromatin organization	GO:1902275	32	0.032
malpighian tubule morphogenesis	GO:0007443	44	0.032
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.032
mitotic dna damage checkpoint	GO:0044773	74	0.031
positive regulation of signaling	GO:0023056	243	0.031
response to abiotic stimulus	GO:0009628	341	0.031
neuroblast fate commitment	GO:0014017	19	0.030
developmental maturation	GO:0021700	172	0.030
negative regulation of neuroblast proliferation	GO:0007406	27	0.030
regulation of mitotic sister chromatid separation	GO:0010965	28	0.030
axon guidance	GO:0007411	233	0.030
spindle midzone assembly	GO:0051255	4	0.029
regulation of neurogenesis	GO:0050767	158	0.029
macromolecular complex assembly	GO:0065003	256	0.028
organic hydroxy compound metabolic process	GO:1901615	83	0.028
mitotic spindle midzone assembly	GO:0051256	1	0.028
regulation of neuroblast proliferation	GO:1902692	34	0.028
programmed cell death	GO:0012501	257	0.028
male gamete generation	GO:0048232	201	0.027
homeostatic process	GO:0042592	199	0.027
renal tubule morphogenesis	GO:0061333	44	0.027
open tracheal system development	GO:0007424	204	0.027
embryonic development via the syncytial blastoderm	GO:0001700	148	0.026
g2 m transition of mitotic cell cycle	GO:0000086	19	0.026
dna replication initiation	GO:0006270	6	0.026
chromosome organization involved in meiosis	GO:0070192	10	0.026
nuclear migration	GO:0007097	20	0.026
appendage development	GO:0048736	401	0.026
regulation of neuron differentiation	GO:0045664	103	0.026
molting cycle	GO:0042303	56	0.025
regulation of cellular ketone metabolic process	GO:0010565	3	0.025
cell division	GO:0051301	248	0.025
positive regulation of protein modification process	GO:0031401	58	0.024
gonad development	GO:0008406	50	0.023
negative regulation of signaling	GO:0023057	219	0.023
regulation of nuclear division	GO:0051783	58	0.023
positive regulation of signal transduction	GO:0009967	223	0.023
response to temperature stimulus	GO:0009266	106	0.023
regulation of dna replication	GO:0006275	13	0.023
dna damage checkpoint	GO:0000077	78	0.023
forebrain development	GO:0030900	2	0.022
regulation of proteolysis	GO:0030162	87	0.022
regulation of cytoskeleton organization	GO:0051493	89	0.022
cell cycle checkpoint	GO:0000075	95	0.022
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.022
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.022
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.022
negative regulation of cell cycle phase transition	GO:1901988	103	0.022
gonad morphogenesis	GO:0035262	7	0.021
taxis	GO:0042330	304	0.021
protein modification by small protein conjugation or removal	GO:0070647	106	0.021
phosphorylation	GO:0016310	294	0.021
immune response	GO:0006955	246	0.021
spermatid differentiation	GO:0048515	114	0.021
embryonic organ development	GO:0048568	50	0.021
respiratory system development	GO:0060541	213	0.021
aging	GO:0007568	143	0.021
ras protein signal transduction	GO:0007265	88	0.021
dna dependent dna replication	GO:0006261	17	0.020
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.020
digestive tract development	GO:0048565	149	0.020
eye photoreceptor cell differentiation	GO:0001754	145	0.019
positive regulation of cell communication	GO:0010647	250	0.019
genitalia development	GO:0048806	26	0.019
regulation of localization	GO:0032879	275	0.019
response to organonitrogen compound	GO:0010243	75	0.018
immune system process	GO:0002376	347	0.018
regulation of protein catabolic process	GO:0042176	55	0.018
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.018
peripheral nervous system development	GO:0007422	52	0.018
chromosome separation	GO:0051304	42	0.018
regulation of cellular protein catabolic process	GO:1903362	44	0.018
kinetochore organization	GO:0051383	9	0.018
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.018
tissue morphogenesis	GO:0048729	297	0.018
sister chromatid cohesion	GO:0007062	18	0.018
regulation of gene silencing	GO:0060968	63	0.018
meiotic sister chromatid segregation	GO:0045144	6	0.018
cellular amine metabolic process	GO:0044106	12	0.017
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.017
cell projection assembly	GO:0030031	94	0.017
negative regulation of proteolysis	GO:0045861	31	0.017
cellular ketone metabolic process	GO:0042180	24	0.016
regulation of mitotic spindle elongation	GO:0032888	1	0.016
neuron recognition	GO:0008038	101	0.016
g2 dna damage checkpoint	GO:0031572	69	0.016
chromatin remodeling	GO:0006338	72	0.016
negative regulation of meiotic cell cycle	GO:0051447	2	0.016
ecdysone mediated induction of salivary gland cell autophagic cell death	GO:0035072	12	0.015
regulation of multicellular organism growth	GO:0040014	40	0.015
protein complex disassembly	GO:0043241	36	0.015
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.015
spindle assembly involved in female meiosis	GO:0007056	14	0.015
response to uv	GO:0009411	24	0.015
positive regulation of protein catabolic process	GO:0045732	34	0.015
compound eye development	GO:0048749	307	0.015
meiotic sister chromatid cohesion	GO:0051177	6	0.014
positive regulation of cellular catabolic process	GO:0031331	95	0.014
peptidyl lysine trimethylation	GO:0018023	6	0.014
regulation of microtubule based process	GO:0032886	49	0.014
imaginal disc derived appendage development	GO:0048737	399	0.014
cellular response to chemical stimulus	GO:0070887	199	0.014
regulation of cellular amino acid metabolic process	GO:0006521	0	0.014
growth	GO:0040007	359	0.014
negative regulation of protein complex disassembly	GO:0043242	23	0.014
regulation of cellular amine metabolic process	GO:0033238	3	0.014
mitotic spindle assembly checkpoint	GO:0007094	11	0.014
positive regulation of response to stimulus	GO:0048584	323	0.014
protein maturation	GO:0051604	71	0.014
wnt signaling pathway	GO:0016055	98	0.014
axon development	GO:0061564	297	0.014
regulation of phosphate metabolic process	GO:0019220	210	0.013
response to nitrogen compound	GO:1901698	90	0.013
nucleosome positioning	GO:0016584	3	0.013
signal transduction by phosphorylation	GO:0023014	107	0.013
negative regulation of stem cell proliferation	GO:2000647	30	0.013
regulation of embryonic development	GO:0045995	68	0.013
regulation of dendrite development	GO:0050773	37	0.013
response to organic substance	GO:0010033	284	0.013
positive regulation of developmental process	GO:0051094	143	0.013
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.013
regulation of chromatin binding	GO:0035561	3	0.013
axonogenesis	GO:0007409	290	0.013
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.013
dorsal closure	GO:0007391	79	0.013
positive regulation of cell cycle	GO:0045787	43	0.013
innate immune response	GO:0045087	144	0.013
meiotic chromosome condensation	GO:0010032	3	0.012
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.012
regulation of mitosis	GO:0007088	56	0.012
regulation of intracellular signal transduction	GO:1902531	236	0.012
positive regulation of cellular protein metabolic process	GO:0032270	118	0.012
single organism biosynthetic process	GO:0044711	206	0.012
positive regulation of proteolysis	GO:0045862	52	0.012
axonal fasciculation	GO:0007413	12	0.012
dna templated transcription elongation	GO:0006354	18	0.012
single organism intracellular transport	GO:1902582	207	0.012
chemotaxis	GO:0006935	249	0.012
regulation of cellular catabolic process	GO:0031329	157	0.011
response to biotic stimulus	GO:0009607	294	0.011
molting cycle chitin based cuticle	GO:0007591	56	0.011
protein alkylation	GO:0008213	43	0.011
negative regulation of mitotic sister chromatid separation	GO:2000816	13	0.011
regulation of phosphatase activity	GO:0010921	3	0.011
reactive oxygen species biosynthetic process	GO:1903409	0	0.011
microtubule based movement	GO:0007018	51	0.011
regulation of cellular protein metabolic process	GO:0032268	243	0.011
negative regulation of neurogenesis	GO:0050768	53	0.011
regulation of cellular response to stress	GO:0080135	89	0.011
eye development	GO:0001654	323	0.011
oxoacid metabolic process	GO:0043436	103	0.011
negative regulation of protein metabolic process	GO:0051248	85	0.011
embryonic heart tube development	GO:0035050	22	0.011
carboxylic acid metabolic process	GO:0019752	92	0.011
cytoplasmic microtubule organization	GO:0031122	22	0.010
leg disc morphogenesis	GO:0007478	80	0.010
negative regulation of wnt signaling pathway	GO:0030178	28	0.010
spermatid development	GO:0007286	98	0.010
histone h4 k12 acetylation	GO:0043983	2	0.010
tube morphogenesis	GO:0035239	191	0.010
metaphase anaphase transition of cell cycle	GO:0044784	28	0.010

barr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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