IMP: Integrative Multi-species Prediction

Drosophila melanogaster

72 known processes

Ptp69D (Dmel_CG10975)

Protein tyrosine phosphatase 69D

(Aliases: dptp69D,dptp69d,CT30751,R-PTP 69D,PTPase,DPTP69D,Dmel\CG10975,ptp69D,DPTP,Dptp69D,Ptp69d,ptp69d,CG10975,Ptp,PTP69D)

FLYBASE: FBgn0014007
Entrez: 39443
UniProtKB: P16620

Process Predictions
Disease Predictions

Ptp69D biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
axon development	GO:0061564	297	1.000
regulation of neurogenesis	GO:0050767	158	0.999	Rat
motor neuron axon guidance	GO:0008045	58	0.998
axonogenesis	GO:0007409	290	0.998
regulation of neuron projection development	GO:0010975	69	0.996
dendrite development	GO:0016358	204	0.992
taxis	GO:0042330	304	0.989
positive regulation of dendrite morphogenesis	GO:0050775	9	0.983
axon guidance	GO:0007411	233	0.980
regulation of cell projection organization	GO:0031344	92	0.975
regulation of nervous system development	GO:0051960	248	0.970	Rat
neuron projection guidance	GO:0097485	241	0.967
regulation of photoreceptor cell axon guidance	GO:2000289	5	0.965
olfactory bulb axon guidance	GO:0071678	3	0.962
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.953
dendrite morphogenesis	GO:0048813	199	0.951
retinal ganglion cell axon guidance	GO:0031290	12	0.937
regulation of axonogenesis	GO:0050770	32	0.921
regulation of axon extension involved in axon guidance	GO:0048841	4	0.917
axon target recognition	GO:0007412	16	0.900
regulation of dendrite morphogenesis	GO:0048814	28	0.890
regulation of axon guidance	GO:1902667	10	0.889
regulation of cell differentiation	GO:0045595	302	0.872	Mouse Rat
photoreceptor cell axon guidance	GO:0072499	23	0.867
regulation of neuron differentiation	GO:0045664	103	0.860
regulation of behavior	GO:0050795	75	0.828
regulation of cell development	GO:0060284	215	0.823	Rat
developmental growth involved in morphogenesis	GO:0060560	65	0.817
regulation of response to external stimulus	GO:0032101	115	0.809
regulation of cell morphogenesis	GO:0022604	163	0.788
cell migration	GO:0016477	238	0.782	Human
morphogenesis of an epithelium	GO:0002009	276	0.762	Zebrafish
regulation of chemotaxis	GO:0050920	12	0.728
positive regulation of cell development	GO:0010720	61	0.716	Rat
positive regulation of nervous system development	GO:0051962	69	0.711	Rat
defense response	GO:0006952	300	0.705	Mouse
neurological system process	GO:0050877	358	0.703
regulation of axon extension	GO:0030516	8	0.701
positive regulation of cell migration	GO:0030335	2	0.665	Human
digestive tract morphogenesis	GO:0048546	127	0.664	Zebrafish
regulation of cell migration	GO:0030334	22	0.662	Human
negative regulation of cellular component organization	GO:0051129	108	0.661
semaphorin plexin signaling pathway	GO:0071526	4	0.652
establishment or maintenance of cell polarity	GO:0007163	167	0.642
epithelium migration	GO:0090132	148	0.614
chemotaxis	GO:0006935	249	0.609
regulation of multicellular organismal development	GO:2000026	414	0.602	Mouse Rat
regulation of dendrite development	GO:0050773	37	0.599
regulation of localization	GO:0032879	275	0.594	Human Mouse
regulation of anatomical structure morphogenesis	GO:0022603	242	0.591
axon extension involved in axon guidance	GO:0048846	10	0.589
positive regulation of developmental process	GO:0051094	143	0.587	Mouse Rat
immune response	GO:0006955	246	0.585	Human Mouse
localization of cell	GO:0051674	257	0.582	Human
negative regulation of signaling	GO:0023057	219	0.573	Mouse Rat Worm
negative regulation of neurogenesis	GO:0050768	53	0.570
multi organism behavior	GO:0051705	175	0.541	Worm
regulation of anatomical structure size	GO:0090066	163	0.541
axon choice point recognition	GO:0016198	26	0.524
response to growth factor	GO:0070848	31	0.494	Worm
regulation of intracellular signal transduction	GO:1902531	236	0.492	Mouse
regulation of response to stress	GO:0080134	200	0.486
axon midline choice point recognition	GO:0016199	26	0.477
single organismal cell cell adhesion	GO:0016337	45	0.469	Mouse
axon extension	GO:0048675	32	0.464
spindle elongation	GO:0051231	83	0.461
reproductive behavior	GO:0019098	122	0.455	Worm
developmental maturation	GO:0021700	172	0.449
single organism behavior	GO:0044708	391	0.439
positive regulation of macromolecule metabolic process	GO:0010604	405	0.438	Mouse
positive regulation of response to stimulus	GO:0048584	323	0.435	Human Mouse
positive regulation of biosynthetic process	GO:0009891	316	0.431
transcription from rna polymerase ii promoter	GO:0006366	368	0.429
cell motility	GO:0048870	251	0.426	Human
determination of adult lifespan	GO:0008340	137	0.422
embryonic organ development	GO:0048568	50	0.422
gastrulation	GO:0007369	70	0.418	Zebrafish
digestive system development	GO:0055123	149	0.414	Zebrafish
positive regulation of cell motility	GO:2000147	3	0.407	Human
negative regulation of cell differentiation	GO:0045596	143	0.406
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.400
substrate dependent cell migration	GO:0006929	3	0.395	Human
locomotory behavior	GO:0007626	176	0.383
reproductive system development	GO:0061458	74	0.380
positive regulation of cellular biosynthetic process	GO:0031328	316	0.375
neuron recognition	GO:0008038	101	0.375
histone deubiquitination	GO:0016578	8	0.366
positive regulation of signal transduction	GO:0009967	223	0.363	Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.351
intracellular signal transduction	GO:0035556	300	0.350	Mouse
negative regulation of response to external stimulus	GO:0032102	22	0.345
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.344	Mouse
embryo development ending in birth or egg hatching	GO:0009792	152	0.340
formation of organ boundary	GO:0010160	30	0.338
regulation of cellular component movement	GO:0051270	42	0.336	Human
phosphorylation	GO:0016310	294	0.333	Human Zebrafish Mouse
positive regulation of cell projection organization	GO:0031346	29	0.328
semaphorin plexin signaling pathway involved in regulation of photoreceptor cell axon guidance	GO:2000305	2	0.328
cell recognition	GO:0008037	102	0.326
protein localization	GO:0008104	284	0.320
tube development	GO:0035295	244	0.309	Zebrafish
respiratory system development	GO:0060541	213	0.304
regulation of developmental growth	GO:0048638	174	0.296
positive regulation of neuron projection development	GO:0010976	14	0.293
response to wounding	GO:0009611	94	0.293
developmental cell growth	GO:0048588	52	0.288
formation of anatomical boundary	GO:0048859	37	0.282
regulation of cellular response to stress	GO:0080135	89	0.280
neuron projection extension	GO:1990138	32	0.273
adherens junction organization	GO:0034332	27	0.271
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.268
positive regulation of neuron differentiation	GO:0045666	26	0.259
negative regulation of phosphorus metabolic process	GO:0010563	45	0.259	Human Mouse
eye antennal disc development	GO:0035214	60	0.258
actin cytoskeleton reorganization	GO:0031532	22	0.256
kidney development	GO:0001822	3	0.249
cell maturation	GO:0048469	144	0.247
response to external biotic stimulus	GO:0043207	293	0.246	Mouse
protein modification process	GO:0036211	438	0.244
regulation of canonical wnt signaling pathway	GO:0060828	15	0.243
dorsal ventral axon guidance	GO:0033563	2	0.236
oocyte maturation	GO:0001556	3	0.232
cellular protein modification process	GO:0006464	438	0.227
body morphogenesis	GO:0010171	2	0.226	Worm
neuron remodeling	GO:0016322	29	0.220
negative regulation of response to stimulus	GO:0048585	258	0.217	Mouse Rat Worm
sensory organ morphogenesis	GO:0090596	260	0.212
defense response to bacterium	GO:0042742	178	0.208
regulation of cellular component size	GO:0032535	98	0.201
innate immune response	GO:0045087	144	0.198
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.198
collateral sprouting	GO:0048668	3	0.194
cellular response to chemical stimulus	GO:0070887	199	0.192	Mouse Rat Worm
negative regulation of multicellular organismal process	GO:0051241	142	0.191
cell cycle phase transition	GO:0044770	140	0.191	Human
positive regulation of transcription dna templated	GO:0045893	266	0.190
axis elongation	GO:0003401	3	0.189
positive regulation of protein metabolic process	GO:0051247	128	0.186	Mouse
positive regulation of cellular component organization	GO:0051130	156	0.185
cardiovascular system development	GO:0072358	82	0.184
regulation of mapk cascade	GO:0043408	92	0.180	Mouse
actin filament based process	GO:0030029	220	0.179
tissue morphogenesis	GO:0048729	297	0.177	Zebrafish
hemopoiesis	GO:0030097	46	0.174	Human Mouse
regulation of protein metabolic process	GO:0051246	256	0.173	Human Zebrafish Mouse
regulation of cytoskeleton organization	GO:0051493	89	0.172
nucleus localization	GO:0051647	34	0.171
defense response to other organism	GO:0098542	225	0.165	Mouse
regulation of defense response	GO:0031347	102	0.165
camera type eye development	GO:0043010	4	0.165	Zebrafish
cell junction organization	GO:0034330	57	0.164
eye morphogenesis	GO:0048592	260	0.162
establishment of monopolar cell polarity	GO:0061162	15	0.161
tube morphogenesis	GO:0035239	191	0.161	Zebrafish
negative regulation of phosphate metabolic process	GO:0045936	45	0.160	Human Mouse
gliogenesis	GO:0042063	80	0.160	Rat
response to bacterium	GO:0009617	198	0.159
cell matrix adhesion	GO:0007160	6	0.158
morphogenesis of embryonic epithelium	GO:0016331	94	0.157
regulation of protein kinase activity	GO:0045859	51	0.157	Human Zebrafish Mouse
embryonic morphogenesis	GO:0048598	206	0.153	Zebrafish
biological adhesion	GO:0022610	138	0.153	Human Mouse
regulation of apoptotic process	GO:0042981	130	0.153	Mouse
regulation of cell death	GO:0010941	173	0.152	Mouse
tissue migration	GO:0090130	155	0.151
dephosphorylation	GO:0016311	51	0.150
canonical wnt signaling pathway	GO:0060070	21	0.150
developmental growth	GO:0048589	280	0.145
positive regulation of cell communication	GO:0010647	250	0.144	Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.142	Mouse
regulation of protein modification process	GO:0031399	112	0.142	Human Zebrafish Mouse
positive regulation of intracellular signal transduction	GO:1902533	116	0.142	Mouse
central nervous system development	GO:0007417	201	0.141	Rat
morphogenesis of a branching epithelium	GO:0061138	45	0.140
protein modification by small protein conjugation or removal	GO:0070647	106	0.138
synapse assembly	GO:0007416	143	0.138
immune system process	GO:0002376	347	0.137	Human Mouse
epithelial cell differentiation	GO:0030855	322	0.137
convergent extension	GO:0060026	2	0.136	Zebrafish
branching morphogenesis of an epithelial tube	GO:0048754	45	0.132
mapk cascade	GO:0000165	107	0.131	Mouse
positive regulation of multicellular organismal process	GO:0051240	143	0.130	Mouse Rat
establishment of localization in cell	GO:0051649	402	0.129	Mouse
regulation of organ morphogenesis	GO:2000027	78	0.128
regulation of actin filament length	GO:0030832	27	0.128
negative regulation of cellular protein metabolic process	GO:0032269	85	0.126	Human Mouse
multi multicellular organism process	GO:0044706	123	0.126	Worm
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.124
negative regulation of nervous system development	GO:0051961	92	0.123
response to other organism	GO:0051707	293	0.123	Mouse
gonad development	GO:0008406	50	0.122
neuron maturation	GO:0042551	31	0.120
blastoderm segmentation	GO:0007350	159	0.119
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.118
regulation of cell size	GO:0008361	63	0.116
male gonad development	GO:0008584	9	0.115
epithelial cell migration	GO:0010631	148	0.115
maintenance of location	GO:0051235	73	0.114	Mouse
cell cycle checkpoint	GO:0000075	95	0.113
sensory perception	GO:0007600	196	0.112
protein polymerization	GO:0051258	42	0.110
regulation of organelle organization	GO:0033043	196	0.108
spindle organization	GO:0007051	253	0.108
cell fate specification	GO:0001708	71	0.107
protein depolymerization	GO:0051261	31	0.103
centrosome localization	GO:0051642	14	0.102
negative regulation of cell communication	GO:0010648	223	0.102	Mouse Rat Worm
open tracheal system development	GO:0007424	204	0.102
negative regulation of developmental process	GO:0051093	201	0.099
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.099
cell death	GO:0008219	279	0.099	Mouse
larval development	GO:0002164	104	0.098	Worm
regulation of phosphorylation	GO:0042325	147	0.097	Human Zebrafish Mouse
apoptotic process	GO:0006915	159	0.096	Mouse
negative regulation of gene expression	GO:0010629	387	0.094
mitotic dna integrity checkpoint	GO:0044774	75	0.094
regulation of immune response	GO:0050776	118	0.093	Human Mouse
positive regulation of signaling	GO:0023056	243	0.092	Mouse
regulation of actin filament polymerization	GO:0030833	25	0.091
regulation of actin cytoskeleton organization	GO:0032956	42	0.091
morphogenesis of a branching structure	GO:0001763	45	0.089
positive regulation of rna metabolic process	GO:0051254	271	0.088
adult locomotory behavior	GO:0008344	76	0.088
spinal cord development	GO:0021510	1	0.087
actin polymerization or depolymerization	GO:0008154	31	0.087
regulation of immune system process	GO:0002682	176	0.087	Human Mouse
limb development	GO:0060173	1	0.086
actin filament polymerization	GO:0030041	27	0.085
reproductive structure development	GO:0048608	74	0.084
regionalization	GO:0003002	416	0.084
regulation of cellular amine metabolic process	GO:0033238	3	0.084
immune system development	GO:0002520	57	0.082	Human Mouse
regulation of extent of cell growth	GO:0061387	8	0.082
negative regulation of immune system process	GO:0002683	50	0.082	Mouse
positive regulation of immune system process	GO:0002684	68	0.081	Human Mouse
convergent extension involved in gastrulation	GO:0060027	2	0.081	Zebrafish
regulation of actin polymerization or depolymerization	GO:0008064	27	0.079
positive regulation of protein modification process	GO:0031401	58	0.079	Mouse
neuron migration	GO:0001764	5	0.078
eye development	GO:0001654	323	0.078	Zebrafish
peripheral nervous system development	GO:0007422	52	0.077
renal system development	GO:0072001	72	0.077
signal transduction by phosphorylation	GO:0023014	107	0.075	Mouse
actin cytoskeleton organization	GO:0030036	206	0.075
regulation of cell adhesion	GO:0030155	27	0.075	Human
lipid storage	GO:0019915	38	0.074
regulation of response to wounding	GO:1903034	19	0.074
negative regulation of cell cycle phase transition	GO:1901988	103	0.073
adult behavior	GO:0030534	137	0.073
negative regulation of axon extension	GO:0030517	3	0.072
positive regulation of response to external stimulus	GO:0032103	44	0.072
positive regulation of gene expression	GO:0010628	290	0.072
protein dephosphorylation	GO:0006470	27	0.071
urogenital system development	GO:0001655	72	0.070
negative regulation of molecular function	GO:0044092	51	0.069	Human Mouse
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.069
circulatory system development	GO:0072359	82	0.068
regulation of catalytic activity	GO:0050790	185	0.068	Human Zebrafish Mouse
neuron projection extension involved in neuron projection guidance	GO:1902284	10	0.067
dendrite guidance	GO:0070983	21	0.067
glial cell differentiation	GO:0010001	35	0.067	Rat
regulation of cellular component biogenesis	GO:0044087	201	0.067
regulation of molecular function	GO:0065009	217	0.066	Human Zebrafish Mouse
forebrain development	GO:0030900	2	0.066
positive regulation of apoptotic process	GO:0043065	47	0.065	Mouse
response to oxygen containing compound	GO:1901700	200	0.065	Mouse Rat
mitotic sister chromatid separation	GO:0051306	30	0.065
heart development	GO:0007507	82	0.065
single organism catabolic process	GO:0044712	228	0.064
protein phosphorylation	GO:0006468	169	0.064	Human Zebrafish Mouse
ubiquitin dependent protein catabolic process	GO:0006511	78	0.064
amine metabolic process	GO:0009308	12	0.063
multicellular organismal aging	GO:0010259	140	0.063
immune effector process	GO:0002252	98	0.062	Mouse
mitotic cell cycle checkpoint	GO:0007093	88	0.062
exocrine system development	GO:0035272	162	0.062
negative regulation of cell death	GO:0060548	81	0.061
compound eye development	GO:0048749	307	0.061
retina development in camera type eye	GO:0060041	4	0.061	Zebrafish
regulation of cell proliferation	GO:0042127	163	0.061	Human Mouse
nucleoside triphosphate metabolic process	GO:0009141	120	0.061
kidney epithelium development	GO:0072073	3	0.060
negative regulation of phosphorylation	GO:0042326	35	0.060	Human Mouse
segmentation	GO:0035282	207	0.060
mitotic cell cycle phase transition	GO:0044772	138	0.060
actin filament organization	GO:0007015	126	0.060
regulation of cellular protein metabolic process	GO:0032268	243	0.059	Human Zebrafish Mouse
negative chemotaxis	GO:0050919	15	0.059
establishment of tissue polarity	GO:0007164	87	0.059
muscle structure development	GO:0061061	224	0.059
regulation of axon regeneration	GO:0048679	4	0.058
positive regulation of cell differentiation	GO:0045597	64	0.058	Mouse Rat
notch signaling pathway	GO:0007219	120	0.057
negative regulation of signal transduction	GO:0009968	206	0.056	Mouse Rat Worm
central nervous system projection neuron axonogenesis	GO:0021952	6	0.056
protein processing	GO:0016485	68	0.056
anterior posterior pattern specification	GO:0009952	136	0.055
growth	GO:0040007	359	0.055
apoptotic signaling pathway	GO:0097190	27	0.055	Mouse
synaptic growth at neuromuscular junction	GO:0051124	119	0.054
synapse organization	GO:0050808	196	0.053
single organism cell adhesion	GO:0098602	47	0.053	Mouse
regulation of chromosome segregation	GO:0051983	32	0.053
cell adhesion	GO:0007155	136	0.053	Human Mouse
regulation of growth	GO:0040008	233	0.052
negative regulation of transcription dna templated	GO:0045892	237	0.052
eye antennal disc morphogenesis	GO:0007455	34	0.051
stem cell development	GO:0048864	79	0.051	Human
glial cell migration	GO:0008347	31	0.051
cellular amino acid metabolic process	GO:0006520	61	0.051
negative regulation of biosynthetic process	GO:0009890	277	0.050
positive regulation of neurogenesis	GO:0050769	41	0.050	Rat
r7 cell development	GO:0045467	14	0.050
positive regulation of locomotion	GO:0040017	8	0.049	Human
cell cell junction organization	GO:0045216	55	0.048
hair cell differentiation	GO:0035315	47	0.048
mitotic dna damage checkpoint	GO:0044773	74	0.048
organonitrogen compound metabolic process	GO:1901564	318	0.048
regulation of phosphate metabolic process	GO:0019220	210	0.047	Human Zebrafish Mouse
establishment of ommatidial planar polarity	GO:0042067	49	0.047
regulation of mitotic cell cycle	GO:0007346	190	0.047
protein deubiquitination	GO:0016579	17	0.047
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.047
eye photoreceptor cell differentiation	GO:0001754	145	0.047
negative regulation of cell development	GO:0010721	62	0.046
chromosome organization	GO:0051276	360	0.046
regulation of cellular protein catabolic process	GO:1903362	44	0.046
unidimensional cell growth	GO:0009826	15	0.044
posttranscriptional gene silencing by rna	GO:0035194	45	0.044
cellular response to organic substance	GO:0071310	132	0.044	Mouse Rat Worm
negative regulation of intracellular signal transduction	GO:1902532	57	0.043
maintenance of protein location in cell	GO:0032507	26	0.042
eye photoreceptor cell development	GO:0042462	81	0.042
regulation of programmed cell death	GO:0043067	152	0.042	Mouse
positive regulation of rna biosynthetic process	GO:1902680	266	0.042
regulation of transport	GO:0051049	181	0.042
organic acid metabolic process	GO:0006082	103	0.041
negative regulation of programmed cell death	GO:0043069	72	0.041
negative regulation of cell migration	GO:0030336	5	0.041
positive regulation of cell adhesion	GO:0045785	10	0.041
regulation of cell substrate adhesion	GO:0010810	2	0.040
wound healing	GO:0042060	75	0.040
regulation of binding	GO:0051098	16	0.039
negative regulation of cell cycle process	GO:0010948	109	0.039
cellular response to oxygen containing compound	GO:1901701	79	0.039	Mouse Rat
regulation of cell motility	GO:2000145	23	0.039	Human
positive regulation of axon extension	GO:0045773	2	0.039
chromatin modification	GO:0016568	147	0.039
germ cell migration	GO:0008354	43	0.039
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.038
protein catabolic process	GO:0030163	101	0.038
telencephalon development	GO:0021537	2	0.037
epithelial tube morphogenesis	GO:0060562	88	0.037
oxoacid metabolic process	GO:0043436	103	0.037
regulation of protein serine threonine kinase activity	GO:0071900	25	0.037	Mouse
programmed cell death	GO:0012501	257	0.037	Mouse
positive regulation of axonogenesis	GO:0050772	2	0.037
regulation of transferase activity	GO:0051338	58	0.037	Human Zebrafish Mouse
negative regulation of epithelial cell migration	GO:0010633	1	0.037
multicellular organismal reproductive behavior	GO:0033057	110	0.035	Worm
modification dependent protein catabolic process	GO:0019941	78	0.035
protein ubiquitination	GO:0016567	70	0.035
neuromuscular junction development	GO:0007528	149	0.035
establishment of protein localization	GO:0045184	163	0.035
embryonic pattern specification	GO:0009880	174	0.035
secondary metabolic process	GO:0019748	75	0.034
histone h4 acetylation	GO:0043967	13	0.034
r3 r4 cell differentiation	GO:0048056	12	0.034
positive regulation of cellular amine metabolic process	GO:0033240	0	0.034
positive regulation of jun kinase activity	GO:0043507	4	0.033
cellular macromolecule localization	GO:0070727	220	0.033
negative regulation of chemotaxis	GO:0050922	1	0.033
gene silencing	GO:0016458	138	0.033
extracellular matrix organization	GO:0030198	32	0.033
protein complex assembly	GO:0006461	200	0.033
neural precursor cell proliferation	GO:0061351	75	0.033
camera type eye morphogenesis	GO:0048593	2	0.033
regulation of cell growth	GO:0001558	43	0.033
regulation of protein transport	GO:0051223	57	0.033
response to axon injury	GO:0048678	12	0.032
protein modification by small protein conjugation	GO:0032446	79	0.032
aging	GO:0007568	143	0.032
response to inorganic substance	GO:0010035	44	0.032
regulation of kinase activity	GO:0043549	53	0.032	Human Zebrafish Mouse
development of primary sexual characteristics	GO:0045137	50	0.031
response to alcohol	GO:0097305	95	0.031
regulation of protein localization	GO:0032880	76	0.031
actin filament bundle organization	GO:0061572	28	0.031
protein complex biogenesis	GO:0070271	201	0.031
cellular homeostasis	GO:0019725	80	0.031	Mouse
purine nucleotide metabolic process	GO:0006163	146	0.031
peptidyl tyrosine modification	GO:0018212	24	0.031	Mouse
central nervous system neuron differentiation	GO:0021953	8	0.030
regulation of protein phosphorylation	GO:0001932	64	0.030	Human Zebrafish Mouse
regulation of cell junction assembly	GO:1901888	2	0.030
mitotic g2 m transition checkpoint	GO:0044818	70	0.030
stress activated protein kinase signaling cascade	GO:0031098	55	0.030
g protein coupled receptor signaling pathway	GO:0007186	136	0.030
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.030
regulation of jnk cascade	GO:0046328	40	0.030
response to ketone	GO:1901654	34	0.030
regulation of microtubule depolymerization	GO:0031114	24	0.030
regulation of chromatin assembly	GO:0010847	9	0.030
mating behavior	GO:0007617	106	0.030
regulation of gene expression epigenetic	GO:0040029	128	0.030
courtship behavior	GO:0007619	68	0.030
hindbrain development	GO:0030902	2	0.029
cellular macromolecular complex assembly	GO:0034622	153	0.029
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.029
regulation of proteasomal protein catabolic process	GO:0061136	39	0.029
axonal defasciculation	GO:0007414	12	0.029
regulation of cell cell adhesion	GO:0022407	21	0.029
proteolysis	GO:0006508	192	0.029
regulation of cellular localization	GO:0060341	136	0.028
organic substance catabolic process	GO:1901575	308	0.028
nucleotide metabolic process	GO:0009117	161	0.028
regulation of embryonic cell shape	GO:0016476	30	0.028
regulation of proteolysis	GO:0030162	87	0.028
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.028
cognition	GO:0050890	141	0.028
regulation of cell cycle process	GO:0010564	181	0.028
negative regulation of neuron differentiation	GO:0045665	16	0.028
organic substance transport	GO:0071702	257	0.027
embryonic hemopoiesis	GO:0035162	26	0.027
negative regulation of cell cycle	GO:0045786	116	0.027
tripartite regional subdivision	GO:0007351	103	0.026
meiotic cell cycle process	GO:1903046	132	0.026
microtubule depolymerization	GO:0007019	25	0.026
neuromuscular process	GO:0050905	21	0.026
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.026
imaginal disc derived wing hair organization	GO:0035317	45	0.026
response to virus	GO:0009615	28	0.025	Mouse
brain morphogenesis	GO:0048854	16	0.025
regulation of gene silencing	GO:0060968	63	0.025
regulation of phosphorus metabolic process	GO:0051174	210	0.025	Human Zebrafish Mouse
appendage development	GO:0048736	401	0.025
central nervous system neuron axonogenesis	GO:0021955	7	0.025
stem cell proliferation	GO:0072089	88	0.025	Human
salivary gland development	GO:0007431	162	0.025
mesenchyme development	GO:0060485	9	0.024
negative regulation of cellular response to oxidative stress	GO:1900408	1	0.024
histone modification	GO:0016570	106	0.024
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.024
carboxylic acid metabolic process	GO:0019752	92	0.024
sensory organ boundary specification	GO:0008052	22	0.024
response to light stimulus	GO:0009416	124	0.024
regulation of epithelial cell migration	GO:0010632	12	0.024
negative regulation of apoptotic process	GO:0043066	63	0.024
regeneration	GO:0031099	16	0.024
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.024
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.024
axon regeneration	GO:0031103	8	0.024
regulation of locomotion	GO:0040012	42	0.023	Human
regulation of wnt signaling pathway	GO:0030111	68	0.023
male courtship behavior	GO:0008049	63	0.023
positive regulation of cell death	GO:0010942	69	0.023	Mouse
cellular amine metabolic process	GO:0044106	12	0.023
cell substrate adhesion	GO:0031589	10	0.023
cellular protein localization	GO:0034613	160	0.023
positive regulation of mitotic metaphase anaphase transition	GO:0045842	10	0.023
cell junction assembly	GO:0034329	42	0.023
response to organonitrogen compound	GO:0010243	75	0.023	Mouse Rat
macromolecular complex assembly	GO:0065003	256	0.023
regulation of cell matrix adhesion	GO:0001952	1	0.023
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.022
mesenchymal cell differentiation	GO:0048762	1	0.022
response to nitrogen compound	GO:1901698	90	0.022	Mouse Rat
startle response	GO:0001964	16	0.022
positive regulation of axon guidance	GO:1902669	1	0.022
dna damage checkpoint	GO:0000077	78	0.022
response to abiotic stimulus	GO:0009628	341	0.022	Rat
small molecule metabolic process	GO:0044281	305	0.022
regulation of protein complex assembly	GO:0043254	42	0.022
microtubule anchoring	GO:0034453	11	0.021
melanin metabolic process	GO:0006582	47	0.021
regulation of cellular ketone metabolic process	GO:0010565	3	0.021
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.021
stress activated mapk cascade	GO:0051403	52	0.021
response to organic cyclic compound	GO:0014070	89	0.021
presynaptic membrane organization	GO:0097090	4	0.021
dna endoreduplication	GO:0042023	22	0.021
establishment of epithelial cell apical basal polarity	GO:0045198	10	0.021
establishment of apical basal cell polarity	GO:0035089	12	0.021
regulation of notch signaling pathway	GO:0008593	100	0.020
muscle organ development	GO:0007517	127	0.020
skin development	GO:0043588	65	0.020
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.020
synaptic target recognition	GO:0008039	45	0.020
border follicle cell migration	GO:0007298	113	0.020
multi organism reproductive behavior	GO:0044705	121	0.020	Worm
mitotic spindle organization	GO:0007052	220	0.020
anterior commissure morphogenesis	GO:0021960	2	0.019

Ptp69D disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.110
eye disease	DOID:5614	0.070
nervous system disease	DOID:863	0.070
eye and adnexa disease	DOID:1492	0.070
sensory system disease	DOID:0050155	0.070
disease of cellular proliferation	DOID:14566	0.021
cancer	DOID:162	0.021

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