IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Nhe3 (Dmel_CG11328)

Na[+]/H[+] hydrogen exchanger 3

(Aliases: NHE3,nhe3,DmNHE3,CG11328,Dmel\CG11328)

Entrez: 33939
FLYBASE: FBgn0028703
UniProtKB: M9PB53
UniProtKB: A8DYW5
UniProtKB: Q9VM99
UniProtKB: B7Z029
UniProtKB: Q8IPJ4
UniProtKB: D5SHT8

Process Predictions
Disease Predictions

Nhe3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
death	GO:0016265	284	0.283
regulation of response to stress	GO:0080134	200	0.233
regulation of response to external stimulus	GO:0032101	115	0.227
negative regulation of signaling	GO:0023057	219	0.207
endocytosis	GO:0006897	310	0.170
intracellular signal transduction	GO:0035556	300	0.164
regulation of intracellular signal transduction	GO:1902531	236	0.163
response to abiotic stimulus	GO:0009628	341	0.159
vesicle mediated transport	GO:0016192	381	0.137
defense response to other organism	GO:0098542	225	0.135
response to other organism	GO:0051707	293	0.132
catabolic process	GO:0009056	409	0.132
organic substance catabolic process	GO:1901575	308	0.128
cell death	GO:0008219	279	0.121
single organism intracellular transport	GO:1902582	207	0.116
defense response	GO:0006952	300	0.116
cellular catabolic process	GO:0044248	372	0.110
regulation of phosphate metabolic process	GO:0019220	210	0.106
response to radiation	GO:0009314	155	0.105
negative regulation of signal transduction	GO:0009968	206	0.101
response to biotic stimulus	GO:0009607	294	0.101
organophosphate metabolic process	GO:0019637	195	0.101
organonitrogen compound metabolic process	GO:1901564	318	0.096
organic substance transport	GO:0071702	257	0.094
programmed cell death	GO:0012501	257	0.093
establishment of localization in cell	GO:0051649	402	0.093
heterocycle catabolic process	GO:0046700	166	0.092
single organism behavior	GO:0044708	391	0.089
regulation of localization	GO:0032879	275	0.085
negative regulation of response to stimulus	GO:0048585	258	0.080
regulation of transport	GO:0051049	181	0.080
meiotic nuclear division	GO:0007126	151	0.080
apoptotic process	GO:0006915	159	0.078
cell division	GO:0051301	248	0.077
positive regulation of cellular component organization	GO:0051130	156	0.076
response to light stimulus	GO:0009416	124	0.076
regulation of cell death	GO:0010941	173	0.076
activation of innate immune response	GO:0002218	4	0.076
homeostatic process	GO:0042592	199	0.074	Human
lipid metabolic process	GO:0006629	121	0.073
protein modification process	GO:0036211	438	0.073
regulation of catabolic process	GO:0009894	170	0.072
cellular lipid metabolic process	GO:0044255	83	0.069
glycosyl compound metabolic process	GO:1901657	127	0.068
adult behavior	GO:0030534	137	0.067
pattern recognition receptor signaling pathway	GO:0002221	2	0.066
negative regulation of cellular metabolic process	GO:0031324	382	0.066
neuron recognition	GO:0008038	101	0.065
regulation of cellular catabolic process	GO:0031329	157	0.064
phosphorylation	GO:0016310	294	0.063
positive regulation of cell communication	GO:0010647	250	0.063
cellular protein modification process	GO:0006464	438	0.063
response to external biotic stimulus	GO:0043207	293	0.062
single organism catabolic process	GO:0044712	228	0.062
negative regulation of cell communication	GO:0010648	223	0.062
nucleobase containing compound catabolic process	GO:0034655	165	0.061
protein localization	GO:0008104	284	0.060
phagocytosis	GO:0006909	215	0.059
protein transport	GO:0015031	155	0.059
organic cyclic compound catabolic process	GO:1901361	168	0.058
regulation of phosphorus metabolic process	GO:0051174	210	0.057
mapk cascade	GO:0000165	107	0.056
small molecule metabolic process	GO:0044281	305	0.055
innate immune response activating signal transduction	GO:0002758	2	0.053
meiotic chromosome segregation	GO:0045132	59	0.053
cellular nitrogen compound catabolic process	GO:0044270	165	0.052
positive regulation of response to stimulus	GO:0048584	323	0.051
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.050
purine nucleoside metabolic process	GO:0042278	127	0.050
aromatic compound catabolic process	GO:0019439	166	0.048
single organism carbohydrate metabolic process	GO:0044723	72	0.047
glycosyl compound catabolic process	GO:1901658	112	0.044
meiotic cell cycle process	GO:1903046	132	0.044
cytokinesis	GO:0000910	90	0.043
positive regulation of signal transduction	GO:0009967	223	0.043
chemical homeostasis	GO:0048878	92	0.043	Human
post embryonic appendage morphogenesis	GO:0035120	385	0.042
negative regulation of intracellular signal transduction	GO:1902532	57	0.042
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.041
establishment of protein localization	GO:0045184	163	0.040
axon cargo transport	GO:0008088	29	0.040
synapse organization	GO:0050808	196	0.040
signal transduction by phosphorylation	GO:0023014	107	0.039
nucleobase containing small molecule metabolic process	GO:0055086	174	0.039
ribonucleoside catabolic process	GO:0042454	112	0.039
carbohydrate derivative metabolic process	GO:1901135	217	0.038
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.038
organelle localization	GO:0051640	148	0.038
nucleoside triphosphate metabolic process	GO:0009141	120	0.038
organonitrogen compound catabolic process	GO:1901565	128	0.037
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.037
ras protein signal transduction	GO:0007265	88	0.037
regulation of protein metabolic process	GO:0051246	256	0.036
guanosine containing compound metabolic process	GO:1901068	74	0.035
regulation of nucleotide catabolic process	GO:0030811	48	0.035
organophosphate catabolic process	GO:0046434	112	0.035
gtp metabolic process	GO:0046039	72	0.035
nucleoside phosphate metabolic process	GO:0006753	162	0.035
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.035
nucleotide metabolic process	GO:0009117	161	0.034
regulation of cell cycle	GO:0051726	291	0.034
regulation of phosphorylation	GO:0042325	147	0.034
small gtpase mediated signal transduction	GO:0007264	88	0.034
immune response regulating signaling pathway	GO:0002764	2	0.034
neurological system process	GO:0050877	358	0.034
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.033
regulation of mapk cascade	GO:0043408	92	0.033
eye morphogenesis	GO:0048592	260	0.032
nucleoside phosphate catabolic process	GO:1901292	110	0.032
positive regulation of transport	GO:0051050	92	0.032
intracellular protein transport	GO:0006886	104	0.032
intracellular transport	GO:0046907	228	0.032
positive regulation of phosphate metabolic process	GO:0045937	139	0.032
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.031
nucleotide catabolic process	GO:0009166	109	0.031
locomotory behavior	GO:0007626	176	0.031
carbohydrate derivative catabolic process	GO:1901136	118	0.031
regulation of cellular response to stress	GO:0080135	89	0.031
defense response to bacterium	GO:0042742	178	0.031
nuclear import	GO:0051170	51	0.031
nucleoside triphosphate catabolic process	GO:0009143	108	0.031
regulation of multi organism process	GO:0043900	131	0.031
cellular macromolecule localization	GO:0070727	220	0.030
body morphogenesis	GO:0010171	2	0.030
purine ribonucleotide catabolic process	GO:0009154	109	0.030
positive regulation of multicellular organismal process	GO:0051240	143	0.030
regulation of synapse structure and activity	GO:0050803	128	0.029
nucleoside catabolic process	GO:0009164	112	0.029
negative regulation of defense response	GO:0031348	35	0.029
purine nucleotide metabolic process	GO:0006163	146	0.029
purine ribonucleoside metabolic process	GO:0046128	127	0.029
nuclear division	GO:0000280	332	0.029
cell motility	GO:0048870	251	0.029
organelle fission	GO:0048285	340	0.029
purine nucleoside catabolic process	GO:0006152	112	0.029
multi multicellular organism process	GO:0044706	123	0.029
regulation of multicellular organismal development	GO:2000026	414	0.028
taxis	GO:0042330	304	0.028
cellular response to dna damage stimulus	GO:0006974	223	0.028
positive regulation of nucleotide metabolic process	GO:0045981	55	0.028
embryonic pattern specification	GO:0009880	174	0.028
purine containing compound catabolic process	GO:0072523	112	0.028
dendrite development	GO:0016358	204	0.028
ribose phosphate metabolic process	GO:0019693	145	0.027
regulation of catalytic activity	GO:0050790	185	0.027
purine ribonucleotide metabolic process	GO:0009150	145	0.027
response to bacterium	GO:0009617	198	0.027
positive regulation of signaling	GO:0023056	243	0.027
head development	GO:0060322	135	0.026
ribonucleotide metabolic process	GO:0009259	145	0.026
endosomal transport	GO:0016197	44	0.026
regulation of intracellular protein transport	GO:0033157	46	0.026
positive regulation of macromolecule metabolic process	GO:0010604	405	0.026
ribonucleoside metabolic process	GO:0009119	127	0.026
guanosine containing compound catabolic process	GO:1901069	74	0.026
protein catabolic process	GO:0030163	101	0.025
localization of cell	GO:0051674	257	0.025
salivary gland development	GO:0007431	162	0.025
nucleoside metabolic process	GO:0009116	127	0.025
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.025
regulation of defense response	GO:0031347	102	0.024
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.024
o glycan processing	GO:0016266	3	0.024
positive regulation of phosphorus metabolic process	GO:0010562	139	0.024
purine nucleotide catabolic process	GO:0006195	109	0.024
single organism biosynthetic process	GO:0044711	206	0.024
immune system process	GO:0002376	347	0.024
regulation of response to biotic stimulus	GO:0002831	63	0.024
chromosome segregation	GO:0007059	157	0.024
cellular macromolecule catabolic process	GO:0044265	136	0.024
developmental maturation	GO:0021700	172	0.023
regulation of nervous system development	GO:0051960	248	0.023
positive regulation of catalytic activity	GO:0043085	118	0.023
defense response to virus	GO:0051607	23	0.023
positive regulation of endopeptidase activity	GO:0010950	26	0.023
cell recognition	GO:0008037	102	0.023
ribonucleotide catabolic process	GO:0009261	109	0.023
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.022
spindle organization	GO:0007051	253	0.022
positive regulation of catabolic process	GO:0009896	105	0.022
central nervous system development	GO:0007417	201	0.022
positive regulation of intracellular signal transduction	GO:1902533	116	0.022
spermatid differentiation	GO:0048515	114	0.022
multicellular organismal reproductive behavior	GO:0033057	110	0.022
positive regulation of molecular function	GO:0044093	136	0.021
negative regulation of immune system process	GO:0002683	50	0.021
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.021
glycerolipid metabolic process	GO:0046486	34	0.021
organelle assembly	GO:0070925	198	0.021
positive regulation of cellular catabolic process	GO:0031331	95	0.021
purine ribonucleoside catabolic process	GO:0046130	112	0.021
positive regulation of developmental process	GO:0051094	143	0.021
brain development	GO:0007420	120	0.021
forebrain development	GO:0030900	2	0.021
regulation of ras protein signal transduction	GO:0046578	93	0.021
protein targeting	GO:0006605	64	0.020
meiotic cell cycle	GO:0051321	171	0.020
regulation of protein localization	GO:0032880	76	0.020
regulation of gtp catabolic process	GO:0033124	44	0.020
regulation of vesicle mediated transport	GO:0060627	59	0.020
negative regulation of cellular biosynthetic process	GO:0031327	277	0.020
protein phosphorylation	GO:0006468	169	0.019
g protein coupled receptor signaling pathway	GO:0007186	136	0.019
macromolecule catabolic process	GO:0009057	161	0.019
secretion	GO:0046903	109	0.019
tissue morphogenesis	GO:0048729	297	0.019
lipid modification	GO:0030258	24	0.019
generation of precursor metabolites and energy	GO:0006091	42	0.019
positive regulation of cell death	GO:0010942	69	0.019
single organism membrane organization	GO:0044802	93	0.018
adult locomotory behavior	GO:0008344	76	0.018
regulation of apoptotic process	GO:0042981	130	0.018
molting cycle	GO:0042303	56	0.018
regulation of nucleoside metabolic process	GO:0009118	50	0.018
compound eye photoreceptor development	GO:0042051	78	0.018
purine containing compound metabolic process	GO:0072521	155	0.018
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.018
positive regulation of programmed cell death	GO:0043068	62	0.018
immune response activating signal transduction	GO:0002757	2	0.018
regulation of synapse organization	GO:0050807	110	0.018
regulation of anatomical structure size	GO:0090066	163	0.017
protein ubiquitination	GO:0016567	70	0.017
amine metabolic process	GO:0009308	12	0.017
regulation of gtpase activity	GO:0043087	44	0.017
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.017
regulation of cellular protein metabolic process	GO:0032268	243	0.017
dendrite morphogenesis	GO:0048813	199	0.017
regulation of cell size	GO:0008361	63	0.017
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.017
positive regulation of biosynthetic process	GO:0009891	316	0.017
notch signaling pathway	GO:0007219	120	0.017
developmental programmed cell death	GO:0010623	138	0.017
detection of external stimulus	GO:0009581	66	0.017
single organism cellular localization	GO:1902580	180	0.016
regulation of ras gtpase activity	GO:0032318	38	0.016
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.016
modification dependent macromolecule catabolic process	GO:0043632	79	0.016
regulation of protein transport	GO:0051223	57	0.016
regulation of cell division	GO:0051302	72	0.016
gtp catabolic process	GO:0006184	72	0.016
cellular protein localization	GO:0034613	160	0.016
single organism nuclear import	GO:1902593	51	0.016
regulation of epithelial cell proliferation	GO:0050678	4	0.016
positive regulation of immune system process	GO:0002684	68	0.016
mitotic cytokinesis	GO:0000281	50	0.016
columnar cuboidal epithelial cell development	GO:0002066	249	0.016
carbohydrate metabolic process	GO:0005975	82	0.015
regulation of cell development	GO:0060284	215	0.015
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.015
regulation of intracellular transport	GO:0032386	64	0.015
appendage development	GO:0048736	401	0.015
regulation of cell differentiation	GO:0045595	302	0.015
transmembrane transport	GO:0055085	139	0.015	Human
cellular response to chemical stimulus	GO:0070887	199	0.015
positive regulation of gtpase activity	GO:0043547	43	0.015
cellular amine metabolic process	GO:0044106	12	0.015
regulation of establishment of protein localization	GO:0070201	61	0.015
macromolecular complex assembly	GO:0065003	256	0.015
positive regulation of cellular biosynthetic process	GO:0031328	316	0.015
regulation of notch signaling pathway	GO:0008593	100	0.015
mitotic spindle organization	GO:0007052	220	0.015
regulation of endocytosis	GO:0030100	37	0.015
cell adhesion	GO:0007155	136	0.015
protein targeting to nucleus	GO:0044744	51	0.014
peptidyl amino acid modification	GO:0018193	105	0.014
carboxylic acid metabolic process	GO:0019752	92	0.014
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.014
positive regulation of nucleotide catabolic process	GO:0030813	46	0.014
appendage morphogenesis	GO:0035107	397	0.014
salivary gland histolysis	GO:0035070	88	0.014
chemotaxis	GO:0006935	249	0.014
transcription from rna polymerase ii promoter	GO:0006366	368	0.014
regulation of cellular localization	GO:0060341	136	0.014
embryo development ending in birth or egg hatching	GO:0009792	152	0.014
negative regulation of response to external stimulus	GO:0032102	22	0.014
positive regulation of ras gtpase activity	GO:0032320	36	0.014
proteolysis	GO:0006508	192	0.014
biological adhesion	GO:0022610	138	0.013
regulation of purine nucleotide metabolic process	GO:1900542	62	0.013
regulation of response to nutrient levels	GO:0032107	18	0.013
digestive tract morphogenesis	GO:0048546	127	0.013
regulation of molecular function	GO:0065009	217	0.013
regulation of organelle organization	GO:0033043	196	0.013
positive regulation of apoptotic process	GO:0043065	47	0.013
olfactory behavior	GO:0042048	97	0.013
ovarian follicle cell development	GO:0030707	248	0.013
developmental pigmentation	GO:0048066	68	0.013
regulation of cell morphogenesis	GO:0022604	163	0.013
modification dependent protein catabolic process	GO:0019941	78	0.013
segmentation	GO:0035282	207	0.013
organic acid metabolic process	GO:0006082	103	0.013
response to organic substance	GO:0010033	284	0.013
microtubule based movement	GO:0007018	51	0.013
immune effector process	GO:0002252	98	0.013
positive regulation of nucleoside metabolic process	GO:0045979	47	0.013
wing disc morphogenesis	GO:0007472	344	0.013
dna metabolic process	GO:0006259	227	0.012
regulation of lipid transport	GO:0032368	3	0.012
single fertilization	GO:0007338	24	0.012
ubiquitin dependent protein catabolic process	GO:0006511	78	0.012
positive regulation of nervous system development	GO:0051962	69	0.012
axon guidance	GO:0007411	233	0.012
telencephalon development	GO:0021537	2	0.012
salivary gland cell autophagic cell death	GO:0035071	83	0.012
cation homeostasis	GO:0055080	51	0.012	Human
reproductive behavior	GO:0019098	122	0.012
epithelial cell migration	GO:0010631	148	0.012
rho protein signal transduction	GO:0007266	14	0.012
innate immune response	GO:0045087	144	0.012
nucleus organization	GO:0006997	45	0.012
regulation of nucleotide metabolic process	GO:0006140	62	0.012
morphogenesis of an epithelium	GO:0002009	276	0.012
jnk cascade	GO:0007254	50	0.012
regulation of protein import into nucleus	GO:0042306	28	0.012
cytoskeleton dependent intracellular transport	GO:0030705	44	0.012
regulation of purine nucleotide catabolic process	GO:0033121	48	0.012
regulation of stress activated mapk cascade	GO:0032872	41	0.012
regulation of synaptic transmission	GO:0050804	69	0.012
positive regulation of phosphorylation	GO:0042327	87	0.012
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.012
circadian rhythm	GO:0007623	105	0.012
exocrine system development	GO:0035272	162	0.011
autophagic cell death	GO:0048102	83	0.011
positive regulation of cell development	GO:0010720	61	0.011
glycoprotein metabolic process	GO:0009100	41	0.011
response to oxygen containing compound	GO:1901700	200	0.011
gland development	GO:0048732	191	0.011
imaginal disc derived leg morphogenesis	GO:0007480	80	0.011
membrane organization	GO:0061024	112	0.011
rhythmic process	GO:0048511	106	0.011
secretion by cell	GO:0032940	101	0.011
negative regulation of phosphate metabolic process	GO:0045936	45	0.011
nucleocytoplasmic transport	GO:0006913	72	0.011
detection of light stimulus	GO:0009583	58	0.011
cellular protein catabolic process	GO:0044257	83	0.011
courtship behavior	GO:0007619	68	0.011
imaginal disc derived wing morphogenesis	GO:0007476	337	0.011
regulation of cellular amine metabolic process	GO:0033238	3	0.011
positive regulation of hydrolase activity	GO:0051345	78	0.011
protein import into nucleus	GO:0006606	51	0.011
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.011
hindbrain development	GO:0030902	2	0.011
embryonic morphogenesis	GO:0048598	206	0.011
eye photoreceptor cell differentiation	GO:0001754	145	0.011
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.011
intracellular receptor signaling pathway	GO:0030522	19	0.011
mitochondrion distribution	GO:0048311	10	0.011
oocyte construction	GO:0007308	112	0.011
positive regulation of neuron apoptotic process	GO:0043525	1	0.011
regionalization	GO:0003002	416	0.011
regulation of kinase activity	GO:0043549	53	0.011
axon development	GO:0061564	297	0.011	Human
establishment or maintenance of cell polarity	GO:0007163	167	0.011
learning or memory	GO:0007611	141	0.010
microtubule based transport	GO:0010970	42	0.010
cellularization	GO:0007349	90	0.010
cellular macromolecular complex assembly	GO:0034622	153	0.010
nitrogen compound transport	GO:0071705	85	0.010
regulation of erk1 and erk2 cascade	GO:0070372	39	0.010
mesenchymal cell differentiation	GO:0048762	1	0.010
cellular ketone metabolic process	GO:0042180	24	0.010
compound eye development	GO:0048749	307	0.010
response to lipopolysaccharide	GO:0032496	4	0.010
positive regulation of cellular component biogenesis	GO:0044089	80	0.010
negative regulation of programmed cell death	GO:0043069	72	0.010
regulation of neurogenesis	GO:0050767	158	0.010
regulation of erbb signaling pathway	GO:1901184	42	0.010
imaginal disc derived appendage development	GO:0048737	399	0.010
negative regulation of mapk cascade	GO:0043409	23	0.010
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.010
cognition	GO:0050890	141	0.010
regulation of immune effector process	GO:0002697	52	0.010
regulation of cellular amino acid metabolic process	GO:0006521	0	0.010

Nhe3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.066
nervous system disease	DOID:863	0.029
disease of cellular proliferation	DOID:14566	0.017
organ system cancer	DOID:0050686	0.017
cancer	DOID:162	0.017

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network