IMP: Integrative Multi-species Prediction

Drosophila melanogaster

157 known processes

smo (Dmel_CG11561)

smoothened

(Aliases: SMO,Smo,dSmo,Dmel\CG11561,CG11561)

FLYBASE: FBgn0003444
Entrez: 33196
UniProtKB: P91682

Process Predictions
Disease Predictions

smo biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of cell communication	GO:0010648	223	0.978
forebrain development	GO:0030900	2	0.975	Zebrafish Mouse
tube morphogenesis	GO:0035239	191	0.973	Zebrafish Mouse
post embryonic appendage morphogenesis	GO:0035120	385	0.972
epithelial cell differentiation	GO:0030855	322	0.967
negative regulation of wnt signaling pathway	GO:0030178	28	0.954
wing disc morphogenesis	GO:0007472	344	0.954
gastrulation	GO:0007369	70	0.954
appendage morphogenesis	GO:0035107	397	0.953	Zebrafish
cellular protein modification process	GO:0006464	438	0.937
ameboidal type cell migration	GO:0001667	151	0.916	Mouse
meiotic cell cycle process	GO:1903046	132	0.907
imaginal disc derived wing morphogenesis	GO:0007476	337	0.900
negative regulation of response to stimulus	GO:0048585	258	0.887
negative regulation of signal transduction	GO:0009968	206	0.826
nuclear division	GO:0000280	332	0.825
negative regulation of developmental growth	GO:0048640	64	0.823
negative regulation of cellular metabolic process	GO:0031324	382	0.820	Mouse
regulation of ras gtpase activity	GO:0032318	38	0.817
convergent extension	GO:0060026	2	0.802
regulation of developmental growth	GO:0048638	174	0.764
heart development	GO:0007507	82	0.747	Zebrafish Mouse
open tracheal system development	GO:0007424	204	0.741
respiratory system development	GO:0060541	213	0.737
muscle structure development	GO:0061061	224	0.719	Zebrafish Mouse
negative regulation of multicellular organismal process	GO:0051241	142	0.714	Mouse
digestive tract development	GO:0048565	149	0.711	Zebrafish Mouse
head development	GO:0060322	135	0.711	Zebrafish Mouse
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.694
programmed cell death	GO:0012501	257	0.690
meiotic cell cycle	GO:0051321	171	0.685
cell motility	GO:0048870	251	0.679	Zebrafish Mouse
morphogenesis of a branching structure	GO:0001763	45	0.676	Mouse
columnar cuboidal epithelial cell development	GO:0002066	249	0.663
muscle cell differentiation	GO:0042692	103	0.663	Zebrafish Mouse
negative regulation of cell differentiation	GO:0045596	143	0.660
endodermal cell fate commitment	GO:0001711	3	0.648
tissue migration	GO:0090130	155	0.642
digestive system development	GO:0055123	149	0.626	Zebrafish Mouse
regionalization	GO:0003002	416	0.622
regulation of catabolic process	GO:0009894	170	0.619
localization of cell	GO:0051674	257	0.612	Zebrafish Mouse
meiotic nuclear division	GO:0007126	151	0.610
endocytosis	GO:0006897	310	0.607
peripheral nervous system development	GO:0007422	52	0.601
proteolysis	GO:0006508	192	0.592
intracellular transport	GO:0046907	228	0.591	Mouse
regulation of neurogenesis	GO:0050767	158	0.589	Mouse
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.588
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.585
regulation of multicellular organismal development	GO:2000026	414	0.576	Mouse
protein localization to nucleus	GO:0034504	55	0.573	Mouse
epithelial tube morphogenesis	GO:0060562	88	0.571	Zebrafish Mouse
regulation of cell proliferation	GO:0042127	163	0.559	Mouse
negative regulation of developmental process	GO:0051093	201	0.556
sulfur compound metabolic process	GO:0006790	59	0.540
protein modification process	GO:0036211	438	0.533
retinal ganglion cell axon guidance	GO:0031290	12	0.531	Zebrafish
muscle tissue development	GO:0060537	30	0.519	Zebrafish Mouse
regulation of cellular catabolic process	GO:0031329	157	0.519
appendage development	GO:0048736	401	0.518	Zebrafish
imaginal disc pattern formation	GO:0007447	91	0.510
ovarian follicle cell migration	GO:0007297	121	0.493
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.489
central nervous system development	GO:0007417	201	0.486	Zebrafish Mouse Rat
cell division	GO:0051301	248	0.482
ubiquitin dependent protein catabolic process	GO:0006511	78	0.480
regulation of cytoskeleton organization	GO:0051493	89	0.471
muscle organ development	GO:0007517	127	0.460	Zebrafish Mouse
gliogenesis	GO:0042063	80	0.458	Zebrafish Mouse
sensory organ morphogenesis	GO:0090596	260	0.456
regulation of protein catabolic process	GO:0042176	55	0.446
cardiovascular system development	GO:0072358	82	0.443	Zebrafish Mouse
protein catabolic process	GO:0030163	101	0.441
skeletal muscle organ development	GO:0060538	48	0.440	Zebrafish Mouse
ovarian follicle cell development	GO:0030707	248	0.438
homeostatic process	GO:0042592	199	0.437	Mouse
positive regulation of developmental process	GO:0051094	143	0.430	Mouse
gland development	GO:0048732	191	0.429	Zebrafish Mouse
negative regulation of signaling	GO:0023057	219	0.423
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.416	Mouse
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.415	Mouse
striated muscle tissue development	GO:0014706	27	0.409	Zebrafish Mouse
multi organism behavior	GO:0051705	175	0.403
brain development	GO:0007420	120	0.390	Zebrafish Mouse
eye development	GO:0001654	323	0.385
organelle fission	GO:0048285	340	0.382
epithelial cell development	GO:0002064	274	0.376
regulation of mitotic cell cycle	GO:0007346	190	0.373
regulation of immune system process	GO:0002682	176	0.370
positive regulation of molecular function	GO:0044093	136	0.364	Mouse
regulation of muscle organ development	GO:0048634	13	0.363
posttranscriptional regulation of gene expression	GO:0010608	145	0.362	Mouse
immune system process	GO:0002376	347	0.359
cellular protein catabolic process	GO:0044257	83	0.358
embryonic morphogenesis	GO:0048598	206	0.351	Zebrafish Mouse
taxis	GO:0042330	304	0.348	Zebrafish Rat
intracellular signal transduction	GO:0035556	300	0.346	Mouse
actin filament bundle organization	GO:0061572	28	0.341
positive regulation of pathway restricted smad protein phosphorylation	GO:0010862	1	0.340
epithelium migration	GO:0090132	148	0.332
imaginal disc derived appendage development	GO:0048737	399	0.328
regulation of intracellular signal transduction	GO:1902531	236	0.327
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.326
multicellular organismal reproductive behavior	GO:0033057	110	0.322
single organism intracellular transport	GO:1902582	207	0.319	Mouse
regulation of wnt signaling pathway	GO:0030111	68	0.314
regulation of microtubule based process	GO:0032886	49	0.314
regulation of epithelial cell proliferation	GO:0050678	4	0.311	Mouse
cytoplasmic transport	GO:0016482	130	0.310	Mouse
tissue morphogenesis	GO:0048729	297	0.310	Zebrafish Mouse
negative regulation of cellular biosynthetic process	GO:0031327	277	0.308	Mouse
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.303
neuroblast proliferation	GO:0007405	74	0.300	Mouse
regulation of growth	GO:0040008	233	0.298
modification dependent macromolecule catabolic process	GO:0043632	79	0.294
morphogenesis of an epithelium	GO:0002009	276	0.294	Zebrafish Mouse
lipid metabolic process	GO:0006629	121	0.290
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.283
mesenchymal cell differentiation	GO:0048762	1	0.281	Zebrafish Mouse
developmental growth	GO:0048589	280	0.279	Mouse Rat
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	13	0.272
regulation of phosphorus metabolic process	GO:0051174	210	0.267
compound eye photoreceptor cell differentiation	GO:0001751	140	0.264
epithelial cell migration	GO:0010631	148	0.264
regulation of nervous system development	GO:0051960	248	0.259	Mouse
striated muscle cell differentiation	GO:0051146	90	0.252	Zebrafish Mouse
regulation of protein metabolic process	GO:0051246	256	0.249
organic acid metabolic process	GO:0006082	103	0.247
camera type eye development	GO:0043010	4	0.244	Zebrafish
axon development	GO:0061564	297	0.232	Zebrafish Rat
wing disc pattern formation	GO:0035222	66	0.231
cell migration involved in gastrulation	GO:0042074	9	0.231
gtp metabolic process	GO:0046039	72	0.231
positive regulation of gtp catabolic process	GO:0033126	43	0.230
death	GO:0016265	284	0.229
positive regulation of catalytic activity	GO:0043085	118	0.227
epidermal cell differentiation	GO:0009913	51	0.226
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.223
protein modification by small protein conjugation or removal	GO:0070647	106	0.223
imaginal disc derived wing vein specification	GO:0007474	48	0.222
growth	GO:0040007	359	0.219	Mouse Rat
camera type eye morphogenesis	GO:0048593	2	0.216
guanosine containing compound catabolic process	GO:1901069	74	0.216
proteoglycan biosynthetic process	GO:0030166	10	0.216
response to external biotic stimulus	GO:0043207	293	0.206
ectodermal placode formation	GO:0060788	4	0.205
regulation of anatomical structure morphogenesis	GO:0022603	242	0.198	Mouse
positive regulation of cellular component biogenesis	GO:0044089	80	0.196
multi multicellular organism process	GO:0044706	123	0.195
synaptic growth at neuromuscular junction	GO:0051124	119	0.194
positive regulation of macromolecule metabolic process	GO:0010604	405	0.192	Mouse
organ growth	GO:0035265	56	0.192
neuromuscular junction development	GO:0007528	149	0.185
apoptotic process	GO:0006915	159	0.183
protein targeting	GO:0006605	64	0.181	Mouse
regulation of cellular protein catabolic process	GO:1903362	44	0.181
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.180
negative regulation of nervous system development	GO:0051961	92	0.180
organic substance transport	GO:0071702	257	0.175	Mouse
spindle organization	GO:0007051	253	0.170
cell fate commitment involved in formation of primary germ layer	GO:0060795	10	0.170
stem cell differentiation	GO:0048863	117	0.169
positive regulation of gtpase activity	GO:0043547	43	0.167
circulatory system development	GO:0072359	82	0.167	Zebrafish Mouse
axis specification	GO:0009798	167	0.163
leg disc development	GO:0035218	92	0.163
imaginal disc derived leg morphogenesis	GO:0007480	80	0.159
positive regulation of protein metabolic process	GO:0051247	128	0.157
epithelial cell proliferation	GO:0050673	15	0.156	Mouse
actin filament based process	GO:0030029	220	0.156	Zebrafish
cell proliferation	GO:0008283	299	0.155	Mouse Rat
mitotic nuclear division	GO:0007067	213	0.155
regulation of smoothened signaling pathway	GO:0008589	28	0.154	Zebrafish Mouse
oxoacid metabolic process	GO:0043436	103	0.152
glial cell differentiation	GO:0010001	35	0.151	Zebrafish Mouse
response to wounding	GO:0009611	94	0.149	Rat
vesicle mediated transport	GO:0016192	381	0.146
dorsal ventral pattern formation	GO:0009953	133	0.145	Zebrafish Mouse
positive regulation of developmental growth	GO:0048639	62	0.143
nucleocytoplasmic transport	GO:0006913	72	0.143	Mouse
heart morphogenesis	GO:0003007	32	0.143	Zebrafish Mouse
cell migration	GO:0016477	238	0.140	Zebrafish Mouse
skin development	GO:0043588	65	0.140	Mouse
regulation of cell substrate adhesion	GO:0010810	2	0.137
positive regulation of nucleoside metabolic process	GO:0045979	47	0.137
tube development	GO:0035295	244	0.136	Zebrafish Mouse
retina development in camera type eye	GO:0060041	4	0.135	Zebrafish
mesoderm formation	GO:0001707	21	0.134
negative regulation of epithelial cell proliferation	GO:0050680	4	0.133
limb morphogenesis	GO:0035108	1	0.133
morphogenesis of a branching epithelium	GO:0061138	45	0.133	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	316	0.133	Mouse
positive regulation of signaling	GO:0023056	243	0.132	Zebrafish Mouse
establishment of localization in cell	GO:0051649	402	0.131	Mouse
negative regulation of biosynthetic process	GO:0009890	277	0.129	Mouse
regulation of organ morphogenesis	GO:2000027	78	0.127	Mouse
response to other organism	GO:0051707	293	0.126
reproductive behavior	GO:0019098	122	0.124
determination of dorsal ventral asymmetry	GO:0048262	3	0.124
proteasomal protein catabolic process	GO:0010498	59	0.123
modification dependent protein catabolic process	GO:0019941	78	0.122
negative regulation of neurogenesis	GO:0050768	53	0.122
spermatid differentiation	GO:0048515	114	0.120
regulation of cellular protein metabolic process	GO:0032268	243	0.120
positive regulation of cellular protein metabolic process	GO:0032270	118	0.118
axonogenesis	GO:0007409	290	0.118	Zebrafish Rat
extracellular structure organization	GO:0043062	46	0.117
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.115	Mouse
heparan sulfate proteoglycan metabolic process	GO:0030201	10	0.114
regulation of cell cycle phase transition	GO:1901987	130	0.114
blastoderm segmentation	GO:0007350	159	0.113
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.112
single organismal cell cell adhesion	GO:0016337	45	0.111
small gtpase mediated signal transduction	GO:0007264	88	0.111
positive regulation of ras gtpase activity	GO:0032320	36	0.110
regulation of protein serine threonine kinase activity	GO:0071900	25	0.109
positive regulation of phosphorus metabolic process	GO:0010562	139	0.108
somatic stem cell maintenance	GO:0035019	14	0.107
negative regulation of growth	GO:0045926	84	0.106
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.106
cell junction assembly	GO:0034329	42	0.105
hematopoietic or lymphoid organ development	GO:0048534	57	0.104
formation of primary germ layer	GO:0001704	24	0.103
regulation of glial cell differentiation	GO:0045685	1	0.101
gtp catabolic process	GO:0006184	72	0.100
cell elongation involved in imaginal disc derived wing morphogenesis	GO:0090254	5	0.099
cell fate specification	GO:0001708	71	0.099	Zebrafish Mouse
digestive tract morphogenesis	GO:0048546	127	0.098	Zebrafish
cell adhesion	GO:0007155	136	0.097
regulation of nucleoside metabolic process	GO:0009118	50	0.097
positive regulation of signal transduction	GO:0009967	223	0.096	Zebrafish Mouse
multi organism reproductive behavior	GO:0044705	121	0.096
imaginal disc growth	GO:0007446	37	0.094
cellular macromolecule catabolic process	GO:0044265	136	0.093
response to biotic stimulus	GO:0009607	294	0.093	Human
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.092	Mouse
female meiotic division	GO:0007143	70	0.092
sensory organ precursor cell division	GO:0045035	10	0.091
single organism biosynthetic process	GO:0044711	206	0.091
negative regulation of cellular protein metabolic process	GO:0032269	85	0.090
protein import into nucleus	GO:0006606	51	0.090	Mouse
regulation of proteolysis	GO:0030162	87	0.089
neuron projection guidance	GO:0097485	241	0.089	Zebrafish Rat
positive regulation of mitotic cell cycle	GO:0045931	34	0.088
positive regulation of ribosome biogenesis	GO:0090070	3	0.087
convergent extension involved in gastrulation	GO:0060027	2	0.087
catabolic process	GO:0009056	409	0.086
cellular protein localization	GO:0034613	160	0.086
embryonic foregut morphogenesis	GO:0048617	3	0.085
organic substance catabolic process	GO:1901575	308	0.084
cation homeostasis	GO:0055080	51	0.083
endodermal cell differentiation	GO:0035987	3	0.082
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.082
positive regulation of response to stimulus	GO:0048584	323	0.082	Zebrafish Mouse
membrane protein ectodomain proteolysis	GO:0006509	5	0.082
protein import	GO:0017038	55	0.082	Mouse
single organism nuclear import	GO:1902593	51	0.081	Mouse
wnt signaling pathway	GO:0016055	98	0.080
stem cell maintenance	GO:0019827	67	0.080
protein localization	GO:0008104	284	0.078
regulation of ras protein signal transduction	GO:0046578	93	0.078
notch signaling pathway	GO:0007219	120	0.078
cellular catabolic process	GO:0044248	372	0.078
specification of symmetry	GO:0009799	13	0.078	Zebrafish Mouse
germ cell migration	GO:0008354	43	0.077
canonical wnt signaling pathway involved in heart development	GO:0061316	3	0.077
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.076
skeletal muscle tissue development	GO:0007519	13	0.076	Zebrafish Mouse
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.076
hemopoiesis	GO:0030097	46	0.074
cellular hormone metabolic process	GO:0034754	23	0.074
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.073
actin cytoskeleton organization	GO:0030036	206	0.072	Zebrafish
regulation of catalytic activity	GO:0050790	185	0.072
positive regulation of phosphate metabolic process	GO:0045937	139	0.070
negative regulation of intracellular signal transduction	GO:1902532	57	0.070
epidermis development	GO:0008544	65	0.070	Mouse
neuron recognition	GO:0008038	101	0.069
regulation of dna metabolic process	GO:0051052	34	0.069
regulation of cell differentiation	GO:0045595	302	0.069
determination of ventral identity	GO:0048264	1	0.069
regulation of organelle organization	GO:0033043	196	0.069
positive regulation of fibroblast growth factor receptor signaling pathway	GO:0045743	5	0.069
regulation of map kinase activity	GO:0043405	17	0.068
cellular chemical homeostasis	GO:0055082	40	0.068
positive regulation of catabolic process	GO:0009896	105	0.068
adherens junction organization	GO:0034332	27	0.067
axon guidance	GO:0007411	233	0.067	Zebrafish Rat
regulation of tube architecture open tracheal system	GO:0035152	68	0.066
macromolecule catabolic process	GO:0009057	161	0.066
chromosome segregation	GO:0007059	157	0.066
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.066
regulation of phosphate metabolic process	GO:0019220	210	0.066
eye antennal disc development	GO:0035214	60	0.066
positive regulation of cell adhesion	GO:0045785	10	0.066
neural precursor cell proliferation	GO:0061351	75	0.064	Mouse
positive regulation of rna biosynthetic process	GO:1902680	266	0.063	Mouse
cell fate determination	GO:0001709	91	0.063
biological adhesion	GO:0022610	138	0.063
eye morphogenesis	GO:0048592	260	0.063
negative regulation of catabolic process	GO:0009895	36	0.062
positive regulation of cell communication	GO:0010647	250	0.061	Zebrafish Mouse
protein targeting to nucleus	GO:0044744	51	0.061	Mouse
guanosine containing compound metabolic process	GO:1901068	74	0.061
imaginal disc derived wing hair organization	GO:0035317	45	0.061
negative regulation of protein metabolic process	GO:0051248	85	0.061
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.061	Mouse
enteroendocrine cell differentiation	GO:0035883	1	0.060	Mouse
sex determination	GO:0007530	18	0.059
carbohydrate derivative biosynthetic process	GO:1901137	85	0.057
regulation of defense response	GO:0031347	102	0.057
regulation of synapse structure and activity	GO:0050803	128	0.056
negative regulation of rna metabolic process	GO:0051253	251	0.055	Mouse
stem cell division	GO:0017145	69	0.054
smoothened signaling pathway involved in ventral spinal cord patterning	GO:0021910	0	0.054	Mouse
regulation of proteasomal protein catabolic process	GO:0061136	39	0.053
i kappab phosphorylation	GO:0007252	3	0.053
negative regulation of nucleotide metabolic process	GO:0045980	4	0.053
mushroom body development	GO:0016319	70	0.053
protein palmitoylation	GO:0018345	2	0.052
hindbrain development	GO:0030902	2	0.051	Zebrafish Mouse
amine metabolic process	GO:0009308	12	0.051
dna integration	GO:0015074	1	0.051
limb development	GO:0060173	1	0.051
compound eye development	GO:0048749	307	0.051
regulation of sister chromatid cohesion	GO:0007063	2	0.050
salivary gland development	GO:0007431	162	0.050
neurological system process	GO:0050877	358	0.049
protein complex biogenesis	GO:0070271	201	0.049
protein localization to organelle	GO:0033365	82	0.049	Mouse
regulation of gliogenesis	GO:0014013	11	0.048
cellular homeostasis	GO:0019725	80	0.048
anterior posterior pattern specification	GO:0009952	136	0.048	Zebrafish Mouse
positive regulation of multicellular organism growth	GO:0040018	21	0.047
regulation of rho protein signal transduction	GO:0035023	20	0.046
chemical homeostasis	GO:0048878	92	0.046
mitotic sister chromatid segregation	GO:0000070	87	0.046
segmentation	GO:0035282	207	0.045
spinal cord dorsal ventral patterning	GO:0021513	1	0.045	Mouse
single organism carbohydrate metabolic process	GO:0044723	72	0.045
regulation of immune response	GO:0050776	118	0.045
compound eye morphogenesis	GO:0001745	249	0.045
glycoprotein biosynthetic process	GO:0009101	41	0.044
dorsal closure leading edge cell differentiation	GO:0046663	2	0.044
wnt signaling pathway involved in heart development	GO:0003306	3	0.044
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.043
proteoglycan metabolic process	GO:0006029	10	0.043
protein modification by small protein conjugation	GO:0032446	79	0.043
germarium derived female germ line cyst formation	GO:0030727	42	0.043
chemotaxis	GO:0006935	249	0.043	Zebrafish Rat
branching involved in open tracheal system development	GO:0060446	45	0.042
heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process	GO:0015014	5	0.042
carbohydrate metabolic process	GO:0005975	82	0.042
positive regulation of transcription dna templated	GO:0045893	266	0.042	Mouse
metal ion homeostasis	GO:0055065	44	0.042
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.041
positive regulation of nucleotide metabolic process	GO:0045981	55	0.041
positive regulation of cellular catabolic process	GO:0031331	95	0.041
positive regulation of rho gtpase activity	GO:0032321	19	0.041
associative learning	GO:0008306	65	0.041
protein ubiquitination	GO:0016567	70	0.041
maintenance of protein location in cell	GO:0032507	26	0.041
oocyte morphogenesis	GO:0048601	3	0.041
establishment or maintenance of cell polarity	GO:0007163	167	0.040
regulation of neuron differentiation	GO:0045664	103	0.040
cellular lipid metabolic process	GO:0044255	83	0.040
positive regulation of protein catabolic process	GO:0045732	34	0.040
regulation of gtpase activity	GO:0043087	44	0.039
endoderm formation	GO:0001706	3	0.039
cell junction organization	GO:0034330	57	0.038
synapse organization	GO:0050808	196	0.038
single organism cellular localization	GO:1902580	180	0.038
regulation of synapse organization	GO:0050807	110	0.037
rho protein signal transduction	GO:0007266	14	0.037
regulation of organ growth	GO:0046620	42	0.037
regulation of cell cycle	GO:0051726	291	0.037
transcription from rna polymerase ii promoter	GO:0006366	368	0.037	Mouse
cellular macromolecule localization	GO:0070727	220	0.037
small molecule metabolic process	GO:0044281	305	0.036
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.036
negative regulation of transcription dna templated	GO:0045892	237	0.036	Mouse
telencephalon development	GO:0021537	2	0.036	Zebrafish Mouse
regulation of imaginal disc growth	GO:0045570	26	0.036
phagocytosis	GO:0006909	215	0.036
ribonucleoside catabolic process	GO:0042454	112	0.035
retina morphogenesis in camera type eye	GO:0060042	2	0.035
smoothened signaling pathway	GO:0007224	49	0.035
regulation of gtp catabolic process	GO:0033124	44	0.034
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.034
regulation of mapk cascade	GO:0043408	92	0.034
unidimensional cell growth	GO:0009826	15	0.034
ras protein signal transduction	GO:0007265	88	0.034
defense response to gram negative bacterium	GO:0050829	94	0.034
maintenance of location in cell	GO:0051651	28	0.034
germ line cyst formation	GO:0048134	44	0.034
positive regulation of nervous system development	GO:0051962	69	0.034	Mouse
regulation of mitosis	GO:0007088	56	0.033
negative regulation of cellular catabolic process	GO:0031330	34	0.033
regulation of gene expression epigenetic	GO:0040029	128	0.033
regulation of intracellular protein transport	GO:0033157	46	0.033	Mouse
regulation of synapse assembly	GO:0051963	94	0.033
response to bacterium	GO:0009617	198	0.033
spinal cord development	GO:0021510	1	0.033	Zebrafish Mouse
regulation of molecular function	GO:0065009	217	0.033	Mouse
carbohydrate biosynthetic process	GO:0016051	17	0.032
regulation of apoptotic process	GO:0042981	130	0.032
embryonic pattern specification	GO:0009880	174	0.032
epithelial cell migration open tracheal system	GO:0007427	32	0.032
germarium derived egg chamber formation	GO:0007293	101	0.032
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.032
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.032
organonitrogen compound metabolic process	GO:1901564	318	0.032
glial cell migration	GO:0008347	31	0.032
wound healing	GO:0042060	75	0.031
protein phosphorylation	GO:0006468	169	0.031
regulation of protein import into nucleus	GO:0042306	28	0.031	Mouse
heart field specification	GO:0003128	0	0.031
synapse assembly	GO:0007416	143	0.031
positive regulation of kinase activity	GO:0033674	25	0.031
chromosome separation	GO:0051304	42	0.030
sister chromatid segregation	GO:0000819	92	0.030
positive regulation of intracellular signal transduction	GO:1902533	116	0.030
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.030
regulation of phosphorylation	GO:0042325	147	0.030
positive regulation of cell proliferation	GO:0008284	47	0.030	Mouse
cortical cytoskeleton organization	GO:0030865	29	0.030
protein transport	GO:0015031	155	0.030	Mouse
defense response to other organism	GO:0098542	225	0.030
regeneration	GO:0031099	16	0.030	Rat
mating	GO:0007618	120	0.029
purine nucleoside metabolic process	GO:0042278	127	0.029
positive regulation of protein phosphorylation	GO:0001934	34	0.029
canonical wnt signaling pathway	GO:0060070	21	0.029
cellular response to chemical stimulus	GO:0070887	199	0.029	Mouse
negative regulation of protein modification process	GO:0031400	29	0.029
phosphorylation	GO:0016310	294	0.028
establishment of protein localization to organelle	GO:0072594	62	0.028	Mouse
positive regulation of nucleotide catabolic process	GO:0030813	46	0.028
dorsal closure	GO:0007391	79	0.028
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.028
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.028
cation transport	GO:0006812	110	0.028
jak stat cascade	GO:0007259	49	0.028
defense response to bacterium	GO:0042742	178	0.028
regulation of cell division	GO:0051302	72	0.027
organelle assembly	GO:0070925	198	0.027	Zebrafish
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.027	Mouse
negative regulation of phosphate metabolic process	GO:0045936	45	0.027
receptor mediated endocytosis	GO:0006898	21	0.027
multicellular organism growth	GO:0035264	46	0.027	Mouse
renal system development	GO:0072001	72	0.026	Human Mouse
malpighian tubule development	GO:0072002	64	0.026
negative regulation of peptidyl tyrosine phosphorylation	GO:0050732	6	0.026
maintenance of location	GO:0051235	73	0.026
learning or memory	GO:0007611	141	0.026
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.026
regulation of transmembrane transport	GO:0034762	27	0.026
branching morphogenesis of an epithelial tube	GO:0048754	45	0.026	Mouse
regulation of stem cell proliferation	GO:0072091	40	0.026	Mouse
response to red or far red light	GO:0009639	2	0.026
peptidyl amino acid modification	GO:0018193	105	0.026
sensory perception	GO:0007600	196	0.026
regulation of protein localization to nucleus	GO:1900180	29	0.026	Mouse
regulation of notch signaling pathway	GO:0008593	100	0.026
leg disc morphogenesis	GO:0007478	80	0.026
regulation of epithelial cell migration	GO:0010632	12	0.025
purine ribonucleotide catabolic process	GO:0009154	109	0.025
cell cycle g1 s phase transition	GO:0044843	31	0.025
activation of anaphase promoting complex activity	GO:0051488	1	0.025
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.025
stem cell proliferation	GO:0072089	88	0.025	Mouse
regulation of innate immune response	GO:0045088	71	0.024
negative regulation of synapse assembly	GO:0051964	39	0.024
negative regulation of gene expression	GO:0010629	387	0.024	Mouse
aging	GO:0007568	143	0.024
muscle cell development	GO:0055001	50	0.024	Zebrafish Mouse
muscle cell fate specification	GO:0042694	7	0.024
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.024
cell cycle phase transition	GO:0044770	140	0.023
regulation of nuclear division	GO:0051783	58	0.023
organelle localization	GO:0051640	148	0.023
dendrite regeneration	GO:0031104	2	0.023

smo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.137
cancer	DOID:162	0.137
organ system cancer	DOID:0050686	0.137
musculoskeletal system disease	DOID:17	0.098
disease of anatomical entity	DOID:7	0.098
large intestine cancer	DOID:5672	0.056
colorectal cancer	DOID:9256	0.056
intestinal cancer	DOID:10155	0.056
gastrointestinal system cancer	DOID:3119	0.056
colon cancer	DOID:219	0.031
cardiovascular system disease	DOID:1287	0.030
aortic disease	DOID:520	0.030
artery disease	DOID:0050828	0.030
vascular disease	DOID:178	0.030
aortic aneurysm	DOID:3627	0.030
connective tissue disease	DOID:65	0.029

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