IMP: Integrative Multi-species Prediction

Drosophila melanogaster

305 known processes

arm (Dmel_CG11579)

armadillo

(Aliases: l(1)G0234,Dmel\CG11579,beta-cat-arm,CG11579,beta-cat,l(1)2Bv,l(1)G0192,ARM,betacat,t12687 ALR Dm,l(1)G0410,l(1)arm,beta-Cat,EG:86E4.6,Arm)

FLYBASE: FBgn0000117
Entrez: 31151
UniProtKB: P18824
UniProtKB: M9PGG4

Process Predictions
Disease Predictions

arm biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
germarium derived egg chamber formation	GO:0007293	101	1.000
tube development	GO:0035295	244	1.000
tube morphogenesis	GO:0035239	191	0.999
respiratory system development	GO:0060541	213	0.999
oocyte differentiation	GO:0009994	145	0.999	Mouse
ovarian follicle cell migration	GO:0007297	121	0.999
embryonic morphogenesis	GO:0048598	206	0.999
border follicle cell migration	GO:0007298	113	0.998
digestive tract development	GO:0048565	149	0.997
sensory organ morphogenesis	GO:0090596	260	0.997
anterior posterior axis specification	GO:0009948	109	0.997	Mouse
regulation of anatomical structure morphogenesis	GO:0022603	242	0.997
protein complex assembly	GO:0006461	200	0.997
cell motility	GO:0048870	251	0.997	Human Mouse Worm
embryonic development via the syncytial blastoderm	GO:0001700	148	0.996
oocyte construction	GO:0007308	112	0.996
meiotic nuclear division	GO:0007126	151	0.994
meiotic cell cycle	GO:0051321	171	0.994
branching morphogenesis of an epithelial tube	GO:0048754	45	0.993
morphogenesis of a branching epithelium	GO:0061138	45	0.992
neurological system process	GO:0050877	358	0.988
multicellular organismal reproductive behavior	GO:0033057	110	0.988	Worm
open tracheal system development	GO:0007424	204	0.988
oocyte axis specification	GO:0007309	108	0.987
appendage morphogenesis	GO:0035107	397	0.985
anterior posterior pattern specification	GO:0009952	136	0.985	Mouse
embryo development ending in birth or egg hatching	GO:0009792	152	0.983
sex differentiation	GO:0007548	81	0.982	Mouse Worm
axis specification	GO:0009798	167	0.981	Zebrafish Mouse Worm
protein complex biogenesis	GO:0070271	201	0.979
spermatid differentiation	GO:0048515	114	0.979
embryonic pattern specification	GO:0009880	174	0.977	Zebrafish Mouse
biological adhesion	GO:0022610	138	0.976
muscle cell differentiation	GO:0042692	103	0.976	Mouse
germarium derived female germ line cyst formation	GO:0030727	42	0.976
dna metabolic process	GO:0006259	227	0.975	Mouse
cell division	GO:0051301	248	0.973
regulation of cell morphogenesis	GO:0022604	163	0.971
regulation of developmental growth	GO:0048638	174	0.970
forebrain development	GO:0030900	2	0.970	Mouse
female germ line cyst formation	GO:0048135	42	0.967
morphogenesis of an epithelium	GO:0002009	276	0.967
branching involved in open tracheal system development	GO:0060446	45	0.966
blastoderm segmentation	GO:0007350	159	0.966
tissue morphogenesis	GO:0048729	297	0.965
regulation of organ morphogenesis	GO:2000027	78	0.965
digestive tract morphogenesis	GO:0048546	127	0.962
r3 r4 cell fate commitment	GO:0007464	10	0.959
reproductive structure development	GO:0048608	74	0.955	Mouse Worm
cytoskeleton dependent cytokinesis	GO:0061640	81	0.955
appendage development	GO:0048736	401	0.953
actin cytoskeleton organization	GO:0030036	206	0.947	Worm
photoreceptor cell differentiation	GO:0046530	170	0.946
central nervous system development	GO:0007417	201	0.935	Mouse
positive regulation of developmental process	GO:0051094	143	0.929
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.928
gonad development	GO:0008406	50	0.923	Worm
ovarian follicle cell development	GO:0030707	248	0.922
cell migration	GO:0016477	238	0.917	Human Mouse Worm
body morphogenesis	GO:0010171	2	0.914	Worm
negative regulation of cardioblast differentiation	GO:0051892	7	0.910
larval development	GO:0002164	104	0.905
nuclear division	GO:0000280	332	0.899
heart induction	GO:0003129	3	0.889
embryonic organ development	GO:0048568	50	0.889	Mouse
establishment of planar polarity	GO:0001736	87	0.884
reproductive behavior	GO:0019098	122	0.875	Worm
segmentation	GO:0035282	207	0.874
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.870
heart development	GO:0007507	82	0.870
epidermis development	GO:0008544	65	0.865	Mouse
skin development	GO:0043588	65	0.864	Mouse
negative regulation of cell development	GO:0010721	62	0.863	Mouse
cell proliferation	GO:0008283	299	0.859
pole plasm mrna localization	GO:0019094	49	0.858
digestive system development	GO:0055123	149	0.852
cellular macromolecular complex assembly	GO:0034622	153	0.839
epithelial tube morphogenesis	GO:0060562	88	0.836
glial cell migration	GO:0008347	31	0.836
gliogenesis	GO:0042063	80	0.834	Mouse
multicellular organism growth	GO:0035264	46	0.833
male gamete generation	GO:0048232	201	0.815
cell adhesion	GO:0007155	136	0.811
regulation of multicellular organismal development	GO:2000026	414	0.809
gastrulation	GO:0007369	70	0.797
germarium derived oocyte fate determination	GO:0007294	26	0.793
cardiovascular system development	GO:0072358	82	0.791
regulation of organelle organization	GO:0033043	196	0.784	Human Mouse Worm
establishment of tissue polarity	GO:0007164	87	0.783
muscle structure development	GO:0061061	224	0.778	Mouse
macromolecular complex assembly	GO:0065003	256	0.774
protein transport	GO:0015031	155	0.773	Human
protein targeting	GO:0006605	64	0.762	Human
cell junction assembly	GO:0034329	42	0.761
establishment of ommatidial planar polarity	GO:0042067	49	0.761
establishment of organelle localization	GO:0051656	122	0.761	Mouse
developmental growth	GO:0048589	280	0.759
motor neuron axon guidance	GO:0008045	58	0.758
positive regulation of cellular component organization	GO:0051130	156	0.758	Human
reproductive system development	GO:0061458	74	0.755	Mouse Worm
regulation of cell development	GO:0060284	215	0.755	Human Mouse
axon development	GO:0061564	297	0.755
regulation of membrane potential	GO:0042391	35	0.752	Human
dorsal closure elongation of leading edge cells	GO:0007394	10	0.750
negative regulation of neurogenesis	GO:0050768	53	0.748	Mouse
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.747	Mouse
ameboidal type cell migration	GO:0001667	151	0.746	Worm
pole plasm rna localization	GO:0007316	52	0.745
organelle fission	GO:0048285	340	0.732
renal system development	GO:0072001	72	0.730	Mouse
brain development	GO:0007420	120	0.727	Mouse
regulation of wnt signaling pathway	GO:0030111	68	0.726	Zebrafish
organelle localization	GO:0051640	148	0.720	Mouse
initiation of dorsal closure	GO:0007392	12	0.719
regulation of cell division	GO:0051302	72	0.719
positive regulation of macromolecule metabolic process	GO:0010604	405	0.717
response to oxygen containing compound	GO:1901700	200	0.713	Human
guanosine containing compound metabolic process	GO:1901068	74	0.709
regulation of heart induction	GO:0090381	3	0.709
negative regulation of cell differentiation	GO:0045596	143	0.705
multi organism behavior	GO:0051705	175	0.705	Worm
transcription from rna polymerase ii promoter	GO:0006366	368	0.700
establishment or maintenance of cell polarity	GO:0007163	167	0.690
positive regulation of cell proliferation	GO:0008284	47	0.684	Mouse
eggshell chorion assembly	GO:0007306	66	0.682
multicellular organismal aging	GO:0010259	140	0.680
axis elongation	GO:0003401	3	0.675
localization of cell	GO:0051674	257	0.673	Human Mouse Worm
regulation of intracellular signal transduction	GO:1902531	236	0.670	Mouse
actin filament based process	GO:0030029	220	0.666	Worm
morphogenesis of a polarized epithelium	GO:0001738	93	0.651
epithelial cell migration	GO:0010631	148	0.649
death	GO:0016265	284	0.648
epithelial cell differentiation	GO:0030855	322	0.638	Mouse
oocyte development	GO:0048599	124	0.636	Mouse
regulation of anatomical structure size	GO:0090066	163	0.635
cytokinesis	GO:0000910	90	0.632
germ line cyst formation	GO:0048134	44	0.627
genitalia development	GO:0048806	26	0.623	Mouse Worm
r3 r4 cell differentiation	GO:0048056	12	0.623
negative regulation of cellular metabolic process	GO:0031324	382	0.620	Human Mouse
wnt signaling pathway	GO:0016055	98	0.616
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.609	Human Mouse
purine ribonucleotide catabolic process	GO:0009154	109	0.605
spermatogenesis	GO:0007283	200	0.602
morphogenesis of embryonic epithelium	GO:0016331	94	0.594
protein localization to nucleus	GO:0034504	55	0.593	Human
regulation of cellular component biogenesis	GO:0044087	201	0.583
actin filament bundle organization	GO:0061572	28	0.580
spermatid development	GO:0007286	98	0.580
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.577
negative regulation of multicellular organismal process	GO:0051241	142	0.574
protein targeting to nucleus	GO:0044744	51	0.563	Human
negative regulation of nervous system development	GO:0051961	92	0.560	Mouse
regulation of notch signaling pathway	GO:0008593	100	0.559
regionalization	GO:0003002	416	0.554
regulation of cell shape	GO:0008360	113	0.554
regulation of tube size	GO:0035150	46	0.553
positive regulation of signal transduction	GO:0009967	223	0.545	Mouse
intracellular signal transduction	GO:0035556	300	0.545	Mouse Worm
dendrite regeneration	GO:0031104	2	0.544
positive regulation of nervous system development	GO:0051962	69	0.542	Mouse
morphogenesis of a branching structure	GO:0001763	45	0.541
organ induction	GO:0001759	3	0.541
convergent extension	GO:0060026	2	0.540	Zebrafish
ensheathment of neurons	GO:0007272	10	0.540	Mouse
oocyte morphogenesis	GO:0048601	3	0.539
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.537
regulation of establishment of planar polarity	GO:0090175	22	0.533
regulation of proteasomal protein catabolic process	GO:0061136	39	0.525
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.524
morphogenesis of follicular epithelium	GO:0016333	36	0.524
gland morphogenesis	GO:0022612	145	0.524
cell projection assembly	GO:0030031	94	0.517
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.514
mitotic cytokinesis	GO:0000281	50	0.495
eye morphogenesis	GO:0048592	260	0.495
dorsal closure	GO:0007391	79	0.493
axonogenesis	GO:0007409	290	0.493
negative regulation of signal transduction	GO:0009968	206	0.488	Zebrafish Mouse
regulation of dna metabolic process	GO:0051052	34	0.484	Mouse
non canonical wnt signaling pathway	GO:0035567	8	0.480
nucleotide catabolic process	GO:0009166	109	0.479
spindle organization	GO:0007051	253	0.479	Worm
determination of adult lifespan	GO:0008340	137	0.476
purine nucleoside catabolic process	GO:0006152	112	0.475
canonical wnt signaling pathway involved in heart development	GO:0061316	3	0.472
meiotic nuclear envelope disassembly	GO:0051078	2	0.464
cell fate specification	GO:0001708	71	0.463
compound eye photoreceptor cell differentiation	GO:0001751	140	0.462
heart field specification	GO:0003128	0	0.462
regulation of apoptotic process	GO:0042981	130	0.459	Human Mouse
regulation of cell death	GO:0010941	173	0.459	Human Mouse
establishment of protein localization	GO:0045184	163	0.454	Human
dorsal appendage formation	GO:0046843	47	0.454
mesenchymal cell differentiation	GO:0048762	1	0.454	Human
male meiosis	GO:0007140	52	0.451
anterior posterior axis specification embryo	GO:0008595	103	0.450
establishment of mitotic spindle localization	GO:0040001	17	0.443
carbohydrate derivative catabolic process	GO:1901136	118	0.440
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.435
salivary gland development	GO:0007431	162	0.433
striated muscle cell differentiation	GO:0051146	90	0.432
salivary gland morphogenesis	GO:0007435	145	0.430
embryonic axis specification	GO:0000578	107	0.427	Zebrafish Mouse
regulation of axonogenesis	GO:0050770	32	0.423
wnt signaling pathway planar cell polarity pathway	GO:0060071	6	0.422
regulation of cardioblast differentiation	GO:0051890	9	0.414
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.409
regulation of multicellular organism growth	GO:0040014	40	0.407
purine ribonucleoside catabolic process	GO:0046130	112	0.406
secondary metabolic process	GO:0019748	75	0.406
aging	GO:0007568	143	0.404
eye photoreceptor cell differentiation	GO:0001754	145	0.403
positive regulation of proteolysis	GO:0045862	52	0.401
protein localization	GO:0008104	284	0.397
purine ribonucleoside metabolic process	GO:0046128	127	0.393
microtubule organizing center organization	GO:0031023	168	0.392	Human
regulation of centriole centriole cohesion	GO:0030997	1	0.391	Human
cardiac cell fate commitment	GO:0060911	17	0.390
ribonucleoside catabolic process	GO:0042454	112	0.390
vesicle mediated transport	GO:0016192	381	0.389	Mouse Worm
compound eye morphogenesis	GO:0001745	249	0.387
eggshell formation	GO:0030703	105	0.386
development of primary sexual characteristics	GO:0045137	50	0.382	Worm
compound eye development	GO:0048749	307	0.382
nucleoside triphosphate catabolic process	GO:0009143	108	0.380
epithelial cell cell adhesion	GO:0090136	6	0.376
programmed cell death	GO:0012501	257	0.376
endodermal cell differentiation	GO:0035987	3	0.373	Mouse Worm
cell fate determination	GO:0001709	91	0.369
negative regulation of gene expression	GO:0010629	387	0.367	Human Mouse
chorion containing eggshell formation	GO:0007304	105	0.366
cell junction organization	GO:0034330	57	0.363
determination of left right symmetry	GO:0007368	9	0.363
tripartite regional subdivision	GO:0007351	103	0.361
oviposition	GO:0018991	19	0.357	Worm
positive regulation of developmental growth	GO:0048639	62	0.355
oocyte fate commitment	GO:0048600	2	0.354
regulation of eye pigmentation	GO:0048073	7	0.352
chromosome segregation	GO:0007059	157	0.343	Human Mouse
growth	GO:0040007	359	0.343
cell activation	GO:0001775	9	0.341	Mouse
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	2	0.340
ribose phosphate metabolic process	GO:0019693	145	0.329
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.325
nucleoside triphosphate metabolic process	GO:0009141	120	0.322
negative regulation of heart induction by canonical wnt signaling pathway	GO:0003136	3	0.322
regulation of molecular function	GO:0065009	217	0.321	Human Mouse Worm
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.321
dendrite development	GO:0016358	204	0.314
regulation of neurogenesis	GO:0050767	158	0.302	Mouse
regulation of glial cell differentiation	GO:0045685	1	0.299	Mouse
establishment of localization in cell	GO:0051649	402	0.298	Human Mouse
positive regulation of phosphorylation	GO:0042327	87	0.297	Mouse Worm
chemotaxis	GO:0006935	249	0.294
organophosphate metabolic process	GO:0019637	195	0.289
meiotic spindle checkpoint	GO:0044779	1	0.287
camera type eye development	GO:0043010	4	0.286	Mouse
neuronal action potential	GO:0019228	10	0.282
developmental induction	GO:0031128	3	0.271
negative regulation of terminal cell fate specification open tracheal system	GO:0035155	2	0.270
cell death	GO:0008219	279	0.269
gland development	GO:0048732	191	0.269	Zebrafish Mouse
positive regulation of cell differentiation	GO:0045597	64	0.266	Human Mouse
myotube differentiation	GO:0014902	46	0.266
cardiac cell fate specification	GO:0060912	10	0.265
dendrite morphogenesis	GO:0048813	199	0.261
compound eye retinal cell programmed cell death	GO:0046667	23	0.259
asymmetric protein localization	GO:0008105	33	0.258	Worm
tissue migration	GO:0090130	155	0.256
regulation of programmed cell death	GO:0043067	152	0.253	Human Mouse
regulation of cell cycle	GO:0051726	291	0.253	Human Mouse
endocytosis	GO:0006897	310	0.251	Worm
glycosyl compound metabolic process	GO:1901657	127	0.248
positive regulation of multicellular organism growth	GO:0040018	21	0.247
cellular macromolecule localization	GO:0070727	220	0.244
receptor mediated endocytosis	GO:0006898	21	0.243	Worm
axon guidance	GO:0007411	233	0.241
regeneration	GO:0031099	16	0.240
nucleoside catabolic process	GO:0009164	112	0.240
negative regulation of phosphate metabolic process	GO:0045936	45	0.240
regulation of neuron differentiation	GO:0045664	103	0.239
organonitrogen compound catabolic process	GO:1901565	128	0.239
positive regulation of transcription involved in g2 m transition of mitotic cell cycle	GO:0090282	1	0.238
phosphorylation	GO:0016310	294	0.237	Mouse Worm
photoreceptor cell development	GO:0042461	96	0.234
synaptic growth at neuromuscular junction	GO:0051124	119	0.229
establishment of spindle orientation	GO:0051294	18	0.228
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.228
embryonic hemopoiesis	GO:0035162	26	0.225
olfactory behavior	GO:0042048	97	0.223
purine containing compound catabolic process	GO:0072523	112	0.223
specification of segmental identity antennal segment	GO:0007383	2	0.222
ribonucleoside metabolic process	GO:0009119	127	0.221
wound healing	GO:0042060	75	0.219
regulation of protein complex assembly	GO:0043254	42	0.219
protein import into nucleus	GO:0006606	51	0.219	Human
cell substrate adhesion	GO:0031589	10	0.218	Mouse
cardioblast cell fate specification	GO:0042685	9	0.212
cellular component assembly involved in morphogenesis	GO:0010927	151	0.212
positive regulation of cell cycle process	GO:0090068	28	0.211
regulation of protein serine threonine kinase activity	GO:0071900	25	0.207
regulation of cell fate commitment	GO:0010453	29	0.205
negative regulation of dna templated transcription initiation	GO:2000143	1	0.204
purine ribonucleotide metabolic process	GO:0009150	145	0.203
establishment of mitotic spindle orientation	GO:0000132	13	0.203
cellular protein modification process	GO:0006464	438	0.201	Human Worm
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.200
meiotic cell cycle process	GO:1903046	132	0.200
positive regulation of organelle organization	GO:0010638	65	0.198
oocyte anterior posterior axis specification	GO:0007314	72	0.198
cellular response to dna damage stimulus	GO:0006974	223	0.197
response to organic substance	GO:0010033	284	0.195	Human Mouse
epidermal cell differentiation	GO:0009913	51	0.194
response to alcohol	GO:0097305	95	0.194	Human
dna templated transcriptional start site selection	GO:0001173	1	0.194
epithelium migration	GO:0090132	148	0.193
negative regulation of signaling	GO:0023057	219	0.192
protein modification process	GO:0036211	438	0.192	Human Worm
protein localization to organelle	GO:0033365	82	0.191	Human
regulation of proteolysis	GO:0030162	87	0.189
actin filament bundle assembly	GO:0051017	26	0.185
cardiocyte differentiation	GO:0035051	29	0.183
stem cell differentiation	GO:0048863	117	0.183
epithelial cell development	GO:0002064	274	0.183	Mouse
regulation of wound healing	GO:0061041	13	0.181
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded	GO:0008070	2	0.181
negative regulation of epithelial cell migration	GO:0010633	1	0.180
nucleotide metabolic process	GO:0009117	161	0.179
ribonucleotide catabolic process	GO:0009261	109	0.178
cellular catabolic process	GO:0044248	372	0.178
negative regulation of phosphorus metabolic process	GO:0010563	45	0.178
purine nucleoside metabolic process	GO:0042278	127	0.176
regulation of ran gtpase activity	GO:0032316	1	0.174
mesoderm development	GO:0007498	78	0.174
regulation of hemocyte differentiation	GO:0045610	22	0.169
regulation of embryonic development	GO:0045995	68	0.169	Mouse Worm
nephron development	GO:0072006	3	0.168	Mouse
response to red light	GO:0010114	2	0.164
glycosyl compound catabolic process	GO:1901658	112	0.163
endoderm formation	GO:0001706	3	0.161	Mouse Worm
ovarian nurse cell to oocyte transport	GO:0007300	27	0.159
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0017055	1	0.157
mitotic nuclear division	GO:0007067	213	0.155
oxoacid metabolic process	GO:0043436	103	0.154	Human
exocytosis	GO:0006887	28	0.154
regulation of mapk cascade	GO:0043408	92	0.154	Mouse
positive regulation of protein transport	GO:0051222	37	0.154	Human
germ cell migration	GO:0008354	43	0.154
establishment of spindle localization	GO:0051293	22	0.151
pole plasm assembly	GO:0007315	61	0.149
single organism nuclear import	GO:1902593	51	0.148	Human
pole plasm oskar mrna localization	GO:0045451	46	0.147
negative regulation of mrna 3 end processing	GO:0031441	3	0.146
regulation of cellular component size	GO:0032535	98	0.145
purine containing compound metabolic process	GO:0072521	155	0.144
epithelial cell morphogenesis	GO:0003382	25	0.143	Mouse
cell type specific apoptotic process	GO:0097285	38	0.143
regulation of actin filament based process	GO:0032970	42	0.143	Human Worm
regulation of response to stress	GO:0080134	200	0.139
dephosphorylation	GO:0016311	51	0.139
guanosine containing compound catabolic process	GO:1901069	74	0.137
release of cytoplasmic sequestered nf kappab	GO:0008588	1	0.137
malpighian tubule development	GO:0072002	64	0.136
actin filament organization	GO:0007015	126	0.134
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.134	Mouse
positive regulation of response to stimulus	GO:0048584	323	0.133	Mouse
regulation of embryonic cell shape	GO:0016476	30	0.133
purine nucleotide catabolic process	GO:0006195	109	0.132
stem cell division	GO:0017145	69	0.132
cellular response to chemical stimulus	GO:0070887	199	0.132	Human Mouse
regulation of cell proliferation	GO:0042127	163	0.131	Human Mouse
wnt signaling pathway involved in heart development	GO:0003306	3	0.131
regulation of cell cycle process	GO:0010564	181	0.131	Human Mouse
negative regulation of developmental process	GO:0051093	201	0.130
germarium derived oocyte differentiation	GO:0030706	29	0.129
dna integration	GO:0015074	1	0.129
maintenance of location in cell	GO:0051651	28	0.129
asymmetric neuroblast division resulting in ganglion mother cell formation	GO:0055060	2	0.128
meiotic dna repair synthesis	GO:0000711	3	0.128
negative regulation of apoptotic signaling pathway	GO:2001234	5	0.128	Mouse
fusion cell fate specification	GO:0035156	4	0.127
regulation of actin cytoskeleton organization	GO:0032956	42	0.126	Worm
regulation of protein localization	GO:0032880	76	0.126	Human Worm
endodermal cell fate commitment	GO:0001711	3	0.126	Mouse Worm
organelle assembly	GO:0070925	198	0.125
single organismal cell cell adhesion	GO:0016337	45	0.123
sensory perception of mechanical stimulus	GO:0050954	72	0.121
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.121
exocrine system development	GO:0035272	162	0.121
retinal cell programmed cell death	GO:0046666	25	0.121
regulation of cellular catabolic process	GO:0031329	157	0.120
nucleoside phosphate catabolic process	GO:1901292	110	0.118
cellular protein complex assembly	GO:0043623	71	0.118
epithelial cell type specification open tracheal system	GO:0035153	11	0.118
vesicle localization	GO:0051648	55	0.118	Mouse
regulation of cellular response to stress	GO:0080135	89	0.118
muscle organ development	GO:0007517	127	0.117
negative regulation of mitotic anaphase promoting complex activity	GO:0060564	2	0.117
organophosphate catabolic process	GO:0046434	112	0.116
positive regulation of phosphorus metabolic process	GO:0010562	139	0.114	Mouse Worm
cell morphogenesis involved in malpighian tubule morphogenesis	GO:0061336	1	0.113
protein import	GO:0017038	55	0.112	Human
cardiac muscle tissue development	GO:0048738	9	0.112
specification of symmetry	GO:0009799	13	0.112	Zebrafish Mouse
regulation of cell differentiation	GO:0045595	302	0.111
leaf development	GO:0048366	3	0.111
hindbrain development	GO:0030902	2	0.110
centripetally migrating follicle cell migration	GO:0060269	1	0.110
stem cell maintenance	GO:0019827	67	0.110
ganglion mother cell fate determination	GO:0007402	2	0.109
nucleoside metabolic process	GO:0009116	127	0.109
p granule organization	GO:0030719	4	0.109
regulation of phosphorylation	GO:0042325	147	0.108	Mouse Worm
positive regulation of cell death	GO:0010942	69	0.107	Human
regulation of intracellular protein transport	GO:0033157	46	0.106	Human
endoderm development	GO:0007492	6	0.106	Mouse Worm
regulation of protein catabolic process	GO:0042176	55	0.106
neuron projection guidance	GO:0097485	241	0.106
negative regulation of wnt signaling pathway	GO:0030178	28	0.106	Zebrafish
segment polarity determination	GO:0007367	25	0.105
positive regulation of chromatin silencing at telomere	GO:0031940	2	0.103
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycle	GO:0051436	2	0.102
cell cell junction assembly	GO:0007043	38	0.102
regulation of hematopoietic stem cell differentiation	GO:1902036	1	0.102
gtp catabolic process	GO:0006184	72	0.102
dorsal vessel heart proper cell fate commitment	GO:0035053	2	0.100
synaptic vesicle budding from presynaptic membrane	GO:0016185	1	0.099
regulation of centriole replication	GO:0046599	2	0.098
positive regulation of phosphate metabolic process	GO:0045937	139	0.098	Mouse Worm
female meiotic division	GO:0007143	70	0.097
anterior posterior axis specification follicular epithelium	GO:0030714	2	0.096
spindle localization	GO:0051653	22	0.095
dorsal closure leading edge cell differentiation	GO:0046663	2	0.095
regulation of cellular localization	GO:0060341	136	0.095	Human
head development	GO:0060322	135	0.095	Mouse
gastrulation involving germ band extension	GO:0010004	36	0.094
meiotic sister chromatid cohesion centromeric	GO:0051754	2	0.091
positive regulation of cell maturation	GO:1903431	2	0.091
negative regulation of protein phosphorylation	GO:0001933	17	0.091
centrosome cycle	GO:0007098	137	0.090	Human
regulation of jnk cascade	GO:0046328	40	0.090
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.090
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.090
response to ketone	GO:1901654	34	0.089
positive regulation of intracellular protein transport	GO:0090316	30	0.089	Human
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.088

arm disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.880	Human
nervous system disease	DOID:863	0.678
reproductive organ cancer	DOID:193	0.523	Human
ovarian cancer	DOID:2394	0.523	Human
female reproductive organ cancer	DOID:120	0.523	Human
cancer	DOID:162	0.523	Human
disease of cellular proliferation	DOID:14566	0.523	Human
organ system cancer	DOID:0050686	0.523	Human
musculoskeletal system disease	DOID:17	0.507	Human
large intestine cancer	DOID:5672	0.338	Human
gastrointestinal system cancer	DOID:3119	0.338	Human
intestinal cancer	DOID:10155	0.338	Human
colorectal cancer	DOID:9256	0.338	Human
endocrine gland cancer	DOID:170	0.291
thyroid cancer	DOID:1781	0.291
hajdu cheney syndrome	DOID:2736	0.177
artery disease	DOID:0050828	0.164
vascular disease	DOID:178	0.164
cardiovascular system disease	DOID:1287	0.164	Human
aortic disease	DOID:520	0.164
organ system benign neoplasm	DOID:0060085	0.152	Human
pilomatrixoma	DOID:5374	0.152	Human
hair follicle neoplasm	DOID:5375	0.152	Human
benign neoplasm	DOID:0060072	0.152	Human
skin benign neoplasm	DOID:3165	0.152	Human
integumentary system benign neoplasm	DOID:0060121	0.152	Human
costello syndrome	DOID:0050469	0.123
disease of metabolism	DOID:0014667	0.119
hemochromatosis	DOID:2352	0.119
inherited metabolic disorder	DOID:655	0.119
metal metabolism disorder	DOID:896	0.119
hepatobiliary disease	DOID:3118	0.114
gastrointestinal system disease	DOID:77	0.114
liver disease	DOID:409	0.114
alagille syndrome	DOID:9245	0.114
myopathy	DOID:423	0.113	Human
muscular disease	DOID:0080000	0.113	Human
heart disease	DOID:114	0.113	Human
cardiomyopathy	DOID:0050700	0.113	Human
intrinsic cardiomyopathy	DOID:0060036	0.113	Human
arrhythmogenic right ventricular cardiomyopathy	DOID:0050431	0.113	Human
muscle tissue disease	DOID:66	0.113	Human
nervous system benign neoplasm	DOID:0060115	0.106
neuroma	DOID:2001	0.106
neurilemmoma	DOID:3192	0.106
neurilemmomatosis	DOID:3204	0.106
heart valve disease	DOID:4079	0.093

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