IMP: Integrative Multi-species Prediction

Drosophila melanogaster

26 known processes

Or22a (Dmel_CG12193)

Odorant receptor 22a

(Aliases: dor53,DOR22A.1,Dmel\CG12193,CG12193,Or22A.1,22a,22A.1,Dmel22a,DOR22a,AN11,Dmel Or22a,OR22a,DOR53,Or53,Dor53)

Entrez: 33335
FLYBASE: FBgn0026398
UniProtKB: P81909
UniProtKB: I6LU58

Process Predictions
Disease Predictions

Or22a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
peptide metabolic process	GO:0006518	80	0.864
detection of chemical stimulus involved in sensory perception of smell	GO:0050911	50	0.583
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.495
cellular amide metabolic process	GO:0043603	80	0.458
tissue morphogenesis	GO:0048729	297	0.438
neurological system process	GO:0050877	358	0.406
exocrine system development	GO:0035272	162	0.390
spermatid differentiation	GO:0048515	114	0.330
response to external biotic stimulus	GO:0043207	293	0.326
male gamete generation	GO:0048232	201	0.321
drinking behavior	GO:0042756	2	0.315
regulation of behavior	GO:0050795	75	0.309
appendage morphogenesis	GO:0035107	397	0.305
detection of chemical stimulus involved in sensory perception	GO:0050907	75	0.290
epithelial cell differentiation	GO:0030855	322	0.280
spermatid development	GO:0007286	98	0.263
sensory perception	GO:0007600	196	0.259
imaginal disc derived wing hair organization	GO:0035317	45	0.258
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.255
response to other organism	GO:0051707	293	0.253
spermatogenesis	GO:0007283	200	0.248
single organism behavior	GO:0044708	391	0.241	Fly
establishment of planar polarity	GO:0001736	87	0.239
appendage development	GO:0048736	401	0.235
cellular catabolic process	GO:0044248	372	0.235
salivary gland development	GO:0007431	162	0.227
skin development	GO:0043588	65	0.210
positive regulation of response to stimulus	GO:0048584	323	0.208
columnar cuboidal epithelial cell development	GO:0002066	249	0.194
response to bacterium	GO:0009617	198	0.193
response to pheromone	GO:0019236	19	0.190
response to biotic stimulus	GO:0009607	294	0.185
epithelial cell development	GO:0002064	274	0.183
proteolysis	GO:0006508	192	0.182
ovarian follicle cell development	GO:0030707	248	0.177
non sensory hair organization	GO:0035316	47	0.176
epidermis development	GO:0008544	65	0.173
detection of stimulus involved in sensory perception	GO:0050906	92	0.170
developmental programmed cell death	GO:0010623	138	0.170
morphogenesis of a polarized epithelium	GO:0001738	93	0.170
gland development	GO:0048732	191	0.168
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.161
histolysis	GO:0007559	102	0.149
wing disc morphogenesis	GO:0007472	344	0.147
organonitrogen compound metabolic process	GO:1901564	318	0.145
nurse cell apoptotic process	GO:0045476	17	0.144
feeding behavior	GO:0007631	50	0.141
detection of chemical stimulus	GO:0009593	93	0.141
circadian sleep wake cycle sleep	GO:0050802	23	0.137
response to organic substance	GO:0010033	284	0.136
morphogenesis of an epithelium	GO:0002009	276	0.133
cell death	GO:0008219	279	0.131
tissue death	GO:0016271	102	0.128
defense response to other organism	GO:0098542	225	0.126
cellular component assembly involved in morphogenesis	GO:0010927	151	0.123
gland morphogenesis	GO:0022612	145	0.119
catabolic process	GO:0009056	409	0.118
rhythmic behavior	GO:0007622	76	0.117
chorion containing eggshell formation	GO:0007304	105	0.116
circadian behavior	GO:0048512	76	0.115
wnt signaling pathway	GO:0016055	98	0.113
organic substance catabolic process	GO:1901575	308	0.111
epidermal cell differentiation	GO:0009913	51	0.111
kidney development	GO:0001822	3	0.111
salivary gland morphogenesis	GO:0007435	145	0.106
eggshell formation	GO:0030703	105	0.105
salivary gland cell autophagic cell death	GO:0035071	83	0.105
autophagic cell death	GO:0048102	83	0.103
establishment of tissue polarity	GO:0007164	87	0.102
urogenital system development	GO:0001655	72	0.099
apoptotic process involved in development	GO:1902742	20	0.095
salivary gland histolysis	GO:0035070	88	0.095
imaginal disc derived wing morphogenesis	GO:0007476	337	0.092
sensory perception of chemical stimulus	GO:0007606	116	0.089
renal system development	GO:0072001	72	0.084
hormone catabolic process	GO:0042447	3	0.081
post embryonic appendage morphogenesis	GO:0035120	385	0.081
sleep	GO:0030431	49	0.078
regulation of circadian sleep wake cycle sleep	GO:0045187	21	0.077
regionalization	GO:0003002	416	0.075
programmed cell death	GO:0012501	257	0.075
detection of stimulus	GO:0051606	156	0.073
rhythmic process	GO:0048511	106	0.071
imaginal disc derived appendage development	GO:0048737	399	0.070
sensory perception of smell	GO:0007608	80	0.068
organonitrogen compound catabolic process	GO:1901565	128	0.062
forebrain development	GO:0030900	2	0.060
death	GO:0016265	284	0.058
chemosensory behavior	GO:0007635	106	0.056	Fly
mating	GO:0007618	120	0.053
heart morphogenesis	GO:0003007	32	0.052
defense response to gram negative bacterium	GO:0050829	94	0.052
cellularization	GO:0007349	90	0.051
response to oxygen containing compound	GO:1901700	200	0.048
protein heterooligomerization	GO:0051291	4	0.047
circulatory system development	GO:0072359	82	0.046
response to virus	GO:0009615	28	0.045
protein processing	GO:0016485	68	0.043
negative regulation of gene expression	GO:0010629	387	0.042
brain development	GO:0007420	120	0.042
regulation of response to external stimulus	GO:0032101	115	0.040
defense response to bacterium	GO:0042742	178	0.039
regulation of circadian sleep wake cycle	GO:0042749	25	0.039
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.038
nucleus organization	GO:0006997	45	0.038
regulation of circadian rhythm	GO:0042752	49	0.037
negative regulation of cellular biosynthetic process	GO:0031327	277	0.036
tube morphogenesis	GO:0035239	191	0.036
regulation of heart rate	GO:0002027	11	0.036
defense response	GO:0006952	300	0.036
monocarboxylic acid transport	GO:0015718	3	0.034
acid secretion	GO:0046717	1	0.033
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.033
homeostatic process	GO:0042592	199	0.032
regulation of cell differentiation	GO:0045595	302	0.032
positive regulation of cellular biosynthetic process	GO:0031328	316	0.031
head development	GO:0060322	135	0.031
regulation of cell proliferation	GO:0042127	163	0.031
embryonic morphogenesis	GO:0048598	206	0.031
transcription from rna polymerase ii promoter	GO:0006366	368	0.030
positive regulation of multicellular organismal process	GO:0051240	143	0.030
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.030
protein complex biogenesis	GO:0070271	201	0.030
immune system process	GO:0002376	347	0.029
macromolecular complex assembly	GO:0065003	256	0.028
chaeta development	GO:0022416	97	0.028
central nervous system development	GO:0007417	201	0.028
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.027	Fly
interspecies interaction between organisms	GO:0044419	16	0.027
regulation of localization	GO:0032879	275	0.027
positive regulation of rna biosynthetic process	GO:1902680	266	0.027
male courtship behavior	GO:0008049	63	0.027
negative regulation of cellular metabolic process	GO:0031324	382	0.027
positive regulation of signaling	GO:0023056	243	0.026
ion transport	GO:0006811	145	0.026
blastoderm segmentation	GO:0007350	159	0.026
vesicle mediated transport	GO:0016192	381	0.025
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.025
notch signaling pathway	GO:0007219	120	0.025
dendrite morphogenesis	GO:0048813	199	0.025
negative regulation of biosynthetic process	GO:0009890	277	0.024
peripheral nervous system development	GO:0007422	52	0.024
regulation of multi organism process	GO:0043900	131	0.024
antimicrobial peptide production	GO:0002775	46	0.024
regulation of response to stress	GO:0080134	200	0.024
positive regulation of biosynthetic process	GO:0009891	316	0.023
cell type specific apoptotic process	GO:0097285	38	0.023
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.023
cell migration	GO:0016477	238	0.023
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.023
localization of cell	GO:0051674	257	0.023
regulation of cell projection organization	GO:0031344	92	0.023
regulation of multicellular organismal development	GO:2000026	414	0.023
circadian rhythm	GO:0007623	105	0.023
regulation of immune system process	GO:0002682	176	0.022
cell division	GO:0051301	248	0.022
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.022
hormone metabolic process	GO:0042445	33	0.022
immune effector process	GO:0002252	98	0.021
apoptotic process	GO:0006915	159	0.021
compound eye photoreceptor cell differentiation	GO:0001751	140	0.021
organonitrogen compound biosynthetic process	GO:1901566	117	0.021
negative regulation of transcription dna templated	GO:0045892	237	0.021
cell growth	GO:0016049	108	0.021
telencephalon development	GO:0021537	2	0.021
positive regulation of transcription dna templated	GO:0045893	266	0.021
inorganic cation transmembrane transport	GO:0098662	61	0.021
compound eye development	GO:0048749	307	0.020
eye development	GO:0001654	323	0.020
heart development	GO:0007507	82	0.020
establishment of localization in cell	GO:0051649	402	0.020
respiratory system development	GO:0060541	213	0.020
amide biosynthetic process	GO:0043604	42	0.020
positive regulation of rna metabolic process	GO:0051254	271	0.020
heart contraction	GO:0060047	26	0.020
regulation of production of molecular mediator of immune response	GO:0002700	44	0.020
developmental growth	GO:0048589	280	0.019
establishment or maintenance of cell polarity	GO:0007163	167	0.019
positive regulation of response to external stimulus	GO:0032103	44	0.019
circadian sleep wake cycle	GO:0042745	28	0.019
sensory organ morphogenesis	GO:0090596	260	0.019
cation transmembrane transport	GO:0098655	88	0.019
cellular response to starvation	GO:0009267	61	0.019
compound eye morphogenesis	GO:0001745	249	0.019
secretion	GO:0046903	109	0.019
limb development	GO:0060173	1	0.019
nuclear division	GO:0000280	332	0.019
negative regulation of cell proliferation	GO:0008285	69	0.019
chromosome organization	GO:0051276	360	0.019
carboxylic acid transport	GO:0046942	18	0.019
eye morphogenesis	GO:0048592	260	0.019
organic substance transport	GO:0071702	257	0.018
antimicrobial humoral response	GO:0019730	99	0.018
spinal cord development	GO:0021510	1	0.018
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.018
cellular response to dna damage stimulus	GO:0006974	223	0.018
positive regulation of gene expression	GO:0010628	290	0.018
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.018
cell motility	GO:0048870	251	0.018
blood circulation	GO:0008015	26	0.018
chemical homeostasis	GO:0048878	92	0.018
peptide biosynthetic process	GO:0043043	42	0.018
regulation of humoral immune response	GO:0002920	51	0.018
chemotaxis	GO:0006935	249	0.017
sperm individualization	GO:0007291	48	0.017
regulation of immune effector process	GO:0002697	52	0.017
regulation of growth	GO:0040008	233	0.017
response to lipopolysaccharide	GO:0032496	4	0.017
regulation of antimicrobial humoral response	GO:0002759	50	0.017
cellular response to extracellular stimulus	GO:0031668	64	0.017
hindbrain development	GO:0030902	2	0.017
production of molecular mediator of immune response	GO:0002440	46	0.017
metal ion transport	GO:0030001	74	0.016
digestive tract morphogenesis	GO:0048546	127	0.016
cell recognition	GO:0008037	102	0.016
positive regulation of signal transduction	GO:0009967	223	0.016
open tracheal system development	GO:0007424	204	0.016
negative regulation of rna biosynthetic process	GO:1902679	240	0.016
taxis	GO:0042330	304	0.016
dendrite development	GO:0016358	204	0.016
regulation of cell morphogenesis	GO:0022604	163	0.016
protein complex assembly	GO:0006461	200	0.016
lateral inhibition	GO:0046331	206	0.016	Fly
photoreceptor cell development	GO:0042461	96	0.016
endocytosis	GO:0006897	310	0.016
growth	GO:0040007	359	0.016
hindgut morphogenesis	GO:0007442	58	0.016
multi organism reproductive behavior	GO:0044705	121	0.015
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.015
wound healing spreading of epidermal cells	GO:0035313	1	0.015
negative regulation of response to stimulus	GO:0048585	258	0.015
positive regulation of cell migration	GO:0030335	2	0.015
neuron projection guidance	GO:0097485	241	0.015
regulation of antimicrobial peptide production	GO:0002784	44	0.015
positive regulation of macromolecule metabolic process	GO:0010604	405	0.015
eye photoreceptor cell differentiation	GO:0001754	145	0.015
regulation of cellular amide metabolic process	GO:0034248	39	0.015
protein dna complex assembly	GO:0065004	63	0.015
organelle fission	GO:0048285	340	0.015
anterior posterior pattern specification	GO:0009952	136	0.014
water homeostasis	GO:0030104	3	0.014
hindgut development	GO:0061525	58	0.014
neuron recognition	GO:0008038	101	0.014
detection of pheromone	GO:0043695	14	0.014
cellular macromolecular complex assembly	GO:0034622	153	0.014
regulation of nervous system development	GO:0051960	248	0.014
wound healing	GO:0042060	75	0.014
regulation of cellular catabolic process	GO:0031329	157	0.014
ameboidal type cell migration	GO:0001667	151	0.014
antennal development	GO:0007469	25	0.014
protein dna complex subunit organization	GO:0071824	86	0.014
antimicrobial peptide biosynthetic process	GO:0002777	38	0.014
carbohydrate derivative metabolic process	GO:1901135	217	0.014
regulation of cellular component size	GO:0032535	98	0.014
regulation of phosphorus metabolic process	GO:0051174	210	0.014
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.014
microtubule based movement	GO:0007018	51	0.013
response to alcohol	GO:0097305	95	0.013
epiboly	GO:0090504	2	0.013
multi organism behavior	GO:0051705	175	0.013
negative regulation of mitotic cell cycle	GO:0045930	109	0.013
endomembrane system organization	GO:0010256	119	0.013
embryonic axis specification	GO:0000578	107	0.013
cation transport	GO:0006812	110	0.013
negative regulation of growth	GO:0045926	84	0.013
regulation of immune response	GO:0050776	118	0.013
regulation of molecular function	GO:0065009	217	0.013
dna metabolic process	GO:0006259	227	0.013
behavioral response to pain	GO:0048266	3	0.013
heart process	GO:0003015	37	0.013
cellular response to chemical stimulus	GO:0070887	199	0.013
circulatory system process	GO:0003013	37	0.013
epithelium migration	GO:0090132	148	0.013
digestive tract development	GO:0048565	149	0.013
lipid metabolic process	GO:0006629	121	0.013
embryonic hindgut morphogenesis	GO:0048619	48	0.013
regulation of epithelial cell differentiation	GO:0030856	4	0.013
single organism catabolic process	GO:0044712	228	0.013
meiotic nuclear division	GO:0007126	151	0.012
regulation of epidermal cell differentiation	GO:0045604	3	0.012
malpighian tubule development	GO:0072002	64	0.012
photoreceptor cell differentiation	GO:0046530	170	0.012
regulation of cell cycle	GO:0051726	291	0.012
limb morphogenesis	GO:0035108	1	0.012
actin cytoskeleton organization	GO:0030036	206	0.012
regulation of organelle organization	GO:0033043	196	0.012
regulation of cell size	GO:0008361	63	0.012
photoreceptor cell fate commitment	GO:0046552	41	0.012
regulation of axon extension involved in axon guidance	GO:0048841	4	0.012
eye antennal disc development	GO:0035214	60	0.012
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.012
axis specification	GO:0009798	167	0.012
phagocytosis	GO:0006909	215	0.012
positive regulation of cell motility	GO:2000147	3	0.012
autophagy	GO:0006914	108	0.012
intracellular transport	GO:0046907	228	0.012
cellular response to organic substance	GO:0071310	132	0.012
single organism biosynthetic process	GO:0044711	206	0.012
regulation of response to nutrient levels	GO:0032107	18	0.012
cytoplasmic transport	GO:0016482	130	0.011
locomotory behavior	GO:0007626	176	0.011
cellular protein modification process	GO:0006464	438	0.011
gastrulation involving germ band extension	GO:0010004	36	0.011
dorsal ventral axis specification	GO:0009950	66	0.011
cellular response to nutrient levels	GO:0031669	62	0.011
sensory perception of pain	GO:0019233	4	0.011
compound eye photoreceptor development	GO:0042051	78	0.011
response to ecdysone	GO:0035075	34	0.011
response to symbiotic bacterium	GO:0009609	2	0.011
segmentation	GO:0035282	207	0.011
cell fate determination	GO:0001709	91	0.011
immune response	GO:0006955	246	0.011
axon development	GO:0061564	297	0.011
protein localization	GO:0008104	284	0.011
regulation of response to biotic stimulus	GO:0002831	63	0.011
positive regulation of cell communication	GO:0010647	250	0.011
mitotic nuclear division	GO:0007067	213	0.011
organ formation	GO:0048645	39	0.011
axon guidance	GO:0007411	233	0.011
hair cell differentiation	GO:0035315	47	0.011
biological adhesion	GO:0022610	138	0.011
regulation of gene expression epigenetic	GO:0040029	128	0.011
meiotic cell cycle	GO:0051321	171	0.011
cholesterol homeostasis	GO:0042632	3	0.011
organelle assembly	GO:0070925	198	0.011
positive regulation of programmed cell death	GO:0043068	62	0.011
male mating behavior	GO:0060179	70	0.011
embryonic development via the syncytial blastoderm	GO:0001700	148	0.011
cell proliferation	GO:0008283	299	0.011
phosphorylation	GO:0016310	294	0.011
organic cyclic compound catabolic process	GO:1901361	168	0.010
compound eye photoreceptor fate commitment	GO:0001752	36	0.010
tube development	GO:0035295	244	0.010
courtship behavior	GO:0007619	68	0.010
regulation of anatomical structure size	GO:0090066	163	0.010
male courtship behavior veined wing vibration	GO:0016545	21	0.010
convergent extension	GO:0060026	2	0.010
response to organophosphorus	GO:0046683	2	0.010
rna processing	GO:0006396	147	0.010
golgi organization	GO:0007030	66	0.010
neuron fate commitment	GO:0048663	50	0.010
positive regulation of cell death	GO:0010942	69	0.010
regulation of cellular component biogenesis	GO:0044087	201	0.010
cellular nitrogen compound catabolic process	GO:0044270	165	0.010
regulation of programmed cell death	GO:0043067	152	0.010

Or22a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.201
nervous system disease	DOID:863	0.065
urinary system disease	DOID:18	0.032
kidney disease	DOID:557	0.032
renal tubular transport disease	DOID:447	0.032
bone disease	DOID:0080001	0.019
musculoskeletal system disease	DOID:17	0.019
connective tissue disease	DOID:65	0.019
central nervous system disease	DOID:331	0.018
hypophosphatasia	DOID:14213	0.012
disease of metabolism	DOID:0014667	0.011
neurodegenerative disease	DOID:1289	0.010

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