IMP: Integrative Multi-species Prediction

Drosophila melanogaster

154 known processes

esc (Dmel_CG14941)

extra sexcombs

(Aliases: Dmel\CG14941,L41867,Esc,sc,CG14941,ESC,dESC)

Entrez: 34595
FLYBASE: FBgn0000588
UniProtKB: Q24338

Process Predictions
Disease Predictions

esc biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
gene silencing	GO:0016458	138	0.996
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.988
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.972
negative regulation of biosynthetic process	GO:0009890	277	0.959
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.956
negative regulation of cellular biosynthetic process	GO:0031327	277	0.950
epithelial cell differentiation	GO:0030855	322	0.940
chromatin silencing	GO:0006342	76	0.937
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.912
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.887
mitotic cell cycle phase transition	GO:0044772	138	0.840
negative regulation of gene expression epigenetic	GO:0045814	77	0.839
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.839
embryonic morphogenesis	GO:0048598	206	0.830
negative regulation of gene expression	GO:0010629	387	0.821
nuclear division	GO:0000280	332	0.819
chromosome organization	GO:0051276	360	0.817
negative regulation of rna biosynthetic process	GO:1902679	240	0.805
negative regulation of transcription dna templated	GO:0045892	237	0.796
dna replication	GO:0006260	48	0.791
regionalization	GO:0003002	416	0.767
negative regulation of rna metabolic process	GO:0051253	251	0.714
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.670
regulation of gene expression epigenetic	GO:0040029	128	0.655
regulation of mitotic cell cycle	GO:0007346	190	0.650
dna metabolic process	GO:0006259	227	0.628
cellular response to dna damage stimulus	GO:0006974	223	0.603
mitotic nuclear division	GO:0007067	213	0.568
regulation of molecular function	GO:0065009	217	0.512
taxis	GO:0042330	304	0.501
organelle fission	GO:0048285	340	0.483
axon development	GO:0061564	297	0.473
regulation of cell cycle	GO:0051726	291	0.450
sensory organ morphogenesis	GO:0090596	260	0.434
embryo development ending in birth or egg hatching	GO:0009792	152	0.433	Worm
regulation of nervous system development	GO:0051960	248	0.427
programmed cell death	GO:0012501	257	0.420	Worm
heterocycle catabolic process	GO:0046700	166	0.412
compound eye development	GO:0048749	307	0.402
negative regulation of cell cycle phase transition	GO:1901988	103	0.393
death	GO:0016265	284	0.385	Worm
epithelial cell development	GO:0002064	274	0.355
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.353
neuron projection guidance	GO:0097485	241	0.341
axonogenesis	GO:0007409	290	0.319
negative regulation of cellular metabolic process	GO:0031324	382	0.319
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.316
segment specification	GO:0007379	33	0.312
columnar cuboidal epithelial cell development	GO:0002066	249	0.306
regulation of cell cycle phase transition	GO:1901987	130	0.297
chorion containing eggshell formation	GO:0007304	105	0.296
cell motility	GO:0048870	251	0.289
aromatic compound catabolic process	GO:0019439	166	0.279
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.274
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.274
protein localization	GO:0008104	284	0.268
mitotic dna integrity checkpoint	GO:0044774	75	0.268
chromatin organization	GO:0006325	207	0.266
negative regulation of cell cycle process	GO:0010948	109	0.248
eggshell formation	GO:0030703	105	0.238
ovarian follicle cell development	GO:0030707	248	0.236
covalent chromatin modification	GO:0016569	106	0.235
cell death	GO:0008219	279	0.234	Worm
endocytosis	GO:0006897	310	0.232
appendage morphogenesis	GO:0035107	397	0.223
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.219
dorsal appendage formation	GO:0046843	47	0.210
macromolecular complex assembly	GO:0065003	256	0.204
sister chromatid segregation	GO:0000819	92	0.202
r7 cell differentiation	GO:0045466	43	0.197
catabolic process	GO:0009056	409	0.194
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.193
segmentation	GO:0035282	207	0.188
cell cycle dna replication	GO:0044786	23	0.185
dna integrity checkpoint	GO:0031570	81	0.185
eggshell chorion assembly	GO:0007306	66	0.183
negative regulation of cell cycle	GO:0045786	116	0.181
organic cyclic compound catabolic process	GO:1901361	168	0.165
axon guidance	GO:0007411	233	0.164
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.161
chromosome segregation	GO:0007059	157	0.157
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.157
tissue morphogenesis	GO:0048729	297	0.151
cell cycle phase transition	GO:0044770	140	0.151
cellular protein modification process	GO:0006464	438	0.150
positive regulation of transcription dna templated	GO:0045893	266	0.150
organic substance catabolic process	GO:1901575	308	0.148
mitotic g2 m transition checkpoint	GO:0044818	70	0.148
nucleoside phosphate catabolic process	GO:1901292	110	0.145
dendrite development	GO:0016358	204	0.144
morphogenesis of an epithelium	GO:0002009	276	0.141
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.140
cellular nitrogen compound catabolic process	GO:0044270	165	0.137
purine nucleotide catabolic process	GO:0006195	109	0.136
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.135
cellular component assembly involved in morphogenesis	GO:0010927	151	0.134
cellular catabolic process	GO:0044248	372	0.131
protein modification process	GO:0036211	438	0.126
small molecule metabolic process	GO:0044281	305	0.121
zygotic determination of anterior posterior axis embryo	GO:0007354	27	0.119
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.115
regulation of phosphate metabolic process	GO:0019220	210	0.115
nuclear dna replication	GO:0033260	1	0.114
embryonic pattern specification	GO:0009880	174	0.111
compound eye photoreceptor cell differentiation	GO:0001751	140	0.110
cell cycle checkpoint	GO:0000075	95	0.108
response to biotic stimulus	GO:0009607	294	0.106
positive regulation of cellular biosynthetic process	GO:0031328	316	0.106
protein complex assembly	GO:0006461	200	0.103
nucleoside triphosphate metabolic process	GO:0009141	120	0.102
transcription from rna polymerase ii promoter	GO:0006366	368	0.100
compound eye morphogenesis	GO:0001745	249	0.098
regulation of cell cycle process	GO:0010564	181	0.095
protein complex biogenesis	GO:0070271	201	0.094
positive regulation of biosynthetic process	GO:0009891	316	0.093
g2 dna damage checkpoint	GO:0031572	69	0.092
purine nucleoside metabolic process	GO:0042278	127	0.091
cuticle development	GO:0042335	86	0.090
mushroom body development	GO:0016319	70	0.089
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.087
cell fate determination	GO:0001709	91	0.087
positive regulation of molecular function	GO:0044093	136	0.086
response to oxygen containing compound	GO:1901700	200	0.084
meiotic nuclear division	GO:0007126	151	0.082
blastoderm segmentation	GO:0007350	159	0.079
nucleobase containing compound catabolic process	GO:0034655	165	0.079
purine containing compound catabolic process	GO:0072523	112	0.077
nucleoside triphosphate catabolic process	GO:0009143	108	0.072
response to external biotic stimulus	GO:0043207	293	0.070
nucleobase containing small molecule metabolic process	GO:0055086	174	0.069
regulation of embryonic development	GO:0045995	68	0.069
negative regulation of mitotic cell cycle	GO:0045930	109	0.068
neuroblast fate commitment	GO:0014017	19	0.067
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.067
purine ribonucleoside metabolic process	GO:0046128	127	0.065
positive regulation of rna biosynthetic process	GO:1902680	266	0.065
eye development	GO:0001654	323	0.064
anterior posterior pattern specification	GO:0009952	136	0.064
renal system development	GO:0072001	72	0.064
actin filament based process	GO:0030029	220	0.063
wound healing	GO:0042060	75	0.063
central nervous system development	GO:0007417	201	0.062
purine ribonucleoside catabolic process	GO:0046130	112	0.061
actin cytoskeleton organization	GO:0030036	206	0.059
posttranscriptional regulation of gene expression	GO:0010608	145	0.058
mitotic sister chromatid segregation	GO:0000070	87	0.058
brain development	GO:0007420	120	0.057
respiratory system development	GO:0060541	213	0.056
nucleotide catabolic process	GO:0009166	109	0.055
positive regulation of phosphorus metabolic process	GO:0010562	139	0.055
dna conformation change	GO:0071103	105	0.054
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.054
positive regulation of catalytic activity	GO:0043085	118	0.053
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.052
nucleus organization	GO:0006997	45	0.052
purine ribonucleotide catabolic process	GO:0009154	109	0.052
regulation of immune system process	GO:0002682	176	0.051
regulation of programmed cell death	GO:0043067	152	0.051
mitotic g2 dna damage checkpoint	GO:0007095	69	0.051
organophosphate catabolic process	GO:0046434	112	0.051
body morphogenesis	GO:0010171	2	0.051
regulation of phosphorus metabolic process	GO:0051174	210	0.050
regulation of catalytic activity	GO:0050790	185	0.050
germarium derived egg chamber formation	GO:0007293	101	0.049
protein localization to nucleus	GO:0034504	55	0.049
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.048
specification of segmental identity trunk	GO:0035292	7	0.048
reproductive system development	GO:0061458	74	0.047
protein import into nucleus	GO:0006606	51	0.047
developmental programmed cell death	GO:0010623	138	0.046
muscle cell differentiation	GO:0042692	103	0.046
protein targeting to nucleus	GO:0044744	51	0.046
positive regulation of rna metabolic process	GO:0051254	271	0.046
homeostatic process	GO:0042592	199	0.046
terminal region determination	GO:0007362	25	0.045
positive regulation of phosphate metabolic process	GO:0045937	139	0.045
post embryonic appendage morphogenesis	GO:0035120	385	0.045
regulation of anatomical structure morphogenesis	GO:0022603	242	0.044
response to organophosphorus	GO:0046683	2	0.044
eye photoreceptor cell differentiation	GO:0001754	145	0.043
mitotic spindle organization	GO:0007052	220	0.042
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.041
dna damage checkpoint	GO:0000077	78	0.039
urogenital system development	GO:0001655	72	0.039
mitotic cell cycle embryonic	GO:0045448	38	0.039
purine containing compound metabolic process	GO:0072521	155	0.039
ribonucleoside catabolic process	GO:0042454	112	0.038
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.038
wing disc morphogenesis	GO:0007472	344	0.038
methylation	GO:0032259	47	0.038
cellular macromolecular complex assembly	GO:0034622	153	0.038
regulation of protein metabolic process	GO:0051246	256	0.038
tube morphogenesis	GO:0035239	191	0.037
regulation of localization	GO:0032879	275	0.036
morphogenesis of embryonic epithelium	GO:0016331	94	0.036
nuclear import	GO:0051170	51	0.036
protein dna complex assembly	GO:0065004	63	0.035
chromatin modification	GO:0016568	147	0.035
posttranscriptional gene silencing by rna	GO:0035194	45	0.035
ribose phosphate metabolic process	GO:0019693	145	0.034
eye morphogenesis	GO:0048592	260	0.034
organonitrogen compound metabolic process	GO:1901564	318	0.034
nucleoside metabolic process	GO:0009116	127	0.033
cellular macromolecule catabolic process	GO:0044265	136	0.033
organonitrogen compound catabolic process	GO:1901565	128	0.033
atp metabolic process	GO:0046034	49	0.033
regulation of organelle organization	GO:0033043	196	0.032
response to organic cyclic compound	GO:0014070	89	0.032
regulation of protein localization	GO:0032880	76	0.031
positive regulation of macromolecule metabolic process	GO:0010604	405	0.031
reproductive structure development	GO:0048608	74	0.030
positive regulation of cell cycle process	GO:0090068	28	0.030
regulation of apoptotic cell clearance	GO:2000425	2	0.029
single organism biosynthetic process	GO:0044711	206	0.029
negative regulation of purine nucleotide catabolic process	GO:0033122	1	0.029
cellular response to organic substance	GO:0071310	132	0.029
renal tubule development	GO:0061326	64	0.028
regulation of intracellular signal transduction	GO:1902531	236	0.028
regulation of nucleotide catabolic process	GO:0030811	48	0.028
organophosphate metabolic process	GO:0019637	195	0.028
negative regulation of gtp catabolic process	GO:0033125	1	0.028
nucleoside phosphate metabolic process	GO:0006753	162	0.028
ribonucleotide catabolic process	GO:0009261	109	0.027
regulation of hydrolase activity	GO:0051336	97	0.027
apoptotic process	GO:0006915	159	0.027	Worm
regulation of response to stress	GO:0080134	200	0.027
regulation of multicellular organismal development	GO:2000026	414	0.026	Worm
single organism nuclear import	GO:1902593	51	0.026
chemotaxis	GO:0006935	249	0.026
cell migration	GO:0016477	238	0.026
negative regulation of response to stimulus	GO:0048585	258	0.026
mitotic chromosome condensation	GO:0007076	22	0.026
dna dependent dna replication	GO:0006261	17	0.026
negative regulation of molecular function	GO:0044092	51	0.025
purine nucleotide metabolic process	GO:0006163	146	0.025
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.025
regulation of dna metabolic process	GO:0051052	34	0.025
positive regulation of gene expression	GO:0010628	290	0.025
phosphorylation	GO:0016310	294	0.025
regulation of calcium ion transmembrane transport	GO:1903169	2	0.025
male gamete generation	GO:0048232	201	0.024
dendrite morphogenesis	GO:0048813	199	0.024
response to abiotic stimulus	GO:0009628	341	0.024
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.024
stem cell proliferation	GO:0072089	88	0.024
imaginal disc derived appendage development	GO:0048737	399	0.024
nucleoside monophosphate metabolic process	GO:0009123	52	0.024
tube development	GO:0035295	244	0.023
regulation of cellular catabolic process	GO:0031329	157	0.023
head development	GO:0060322	135	0.023
digestive tract development	GO:0048565	149	0.022
gene silencing by rna	GO:0031047	57	0.022
regulation of cell development	GO:0060284	215	0.022
dorsal ventral pattern formation	GO:0009953	133	0.022
hindbrain development	GO:0030902	2	0.022
regulation of ras protein signal transduction	GO:0046578	93	0.022
sex determination	GO:0007530	18	0.022
positive regulation of nucleotide metabolic process	GO:0045981	55	0.022
sex differentiation	GO:0007548	81	0.022
response to radiation	GO:0009314	155	0.022
regulation of cell shape	GO:0008360	113	0.021
g1 s transition of mitotic cell cycle	GO:0000082	31	0.021
nucleotide metabolic process	GO:0009117	161	0.021
regulation of transport	GO:0051049	181	0.021
glycosyl compound catabolic process	GO:1901658	112	0.021
protein import	GO:0017038	55	0.020
positive regulation of signal transduction	GO:0009967	223	0.020
organelle assembly	GO:0070925	198	0.020
head involution	GO:0008258	35	0.020
stem cell division	GO:0017145	69	0.020
phagocytosis	GO:0006909	215	0.019
guanosine containing compound catabolic process	GO:1901069	74	0.019
glycosyl compound metabolic process	GO:1901657	127	0.019
single organism catabolic process	GO:0044712	228	0.019
organelle inheritance	GO:0048308	2	0.018
localization of cell	GO:0051674	257	0.018
spermatogenesis	GO:0007283	200	0.018
negative regulation of cell communication	GO:0010648	223	0.018
establishment of protein localization to organelle	GO:0072594	62	0.018
single organism cellular localization	GO:1902580	180	0.018
negative regulation of signal transduction	GO:0009968	206	0.018
epithelial cell migration	GO:0010631	148	0.017
kidney development	GO:0001822	3	0.017
gland development	GO:0048732	191	0.016
intracellular signal transduction	GO:0035556	300	0.016
cell division	GO:0051301	248	0.016
protein transport	GO:0015031	155	0.016
carbohydrate derivative catabolic process	GO:1901136	118	0.016
response to other organism	GO:0051707	293	0.016
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.015
response to alcohol	GO:0097305	95	0.015
immune response	GO:0006955	246	0.015
neuroblast proliferation	GO:0007405	74	0.015
muscle structure development	GO:0061061	224	0.015
nucleoside catabolic process	GO:0009164	112	0.015
posttranscriptional gene silencing	GO:0016441	46	0.015
anterior posterior axis specification	GO:0009948	109	0.015
defense response to gram negative bacterium	GO:0050829	94	0.014
larval development	GO:0002164	104	0.014	Worm
protein localization to organelle	GO:0033365	82	0.014
regulation of chromosome organization	GO:0033044	64	0.014
macromolecule catabolic process	GO:0009057	161	0.014
response to organic substance	GO:0010033	284	0.014
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.014
regulation of dna replication	GO:0006275	13	0.014
mitotic cell cycle checkpoint	GO:0007093	88	0.014
germarium derived female germ line cyst encapsulation	GO:0030708	8	0.013
regulation of striated muscle contraction	GO:0006942	2	0.013
cellular response to oxygen containing compound	GO:1901701	79	0.013
positive regulation of chromatin modification	GO:1903310	17	0.013
tissue migration	GO:0090130	155	0.013
multi organism behavior	GO:0051705	175	0.013
oxoacid metabolic process	GO:0043436	103	0.013
purine nucleoside catabolic process	GO:0006152	112	0.013
regulation of embryonic cell shape	GO:0016476	30	0.013
neural precursor cell proliferation	GO:0061351	75	0.013
regulation of protein localization to nucleus	GO:1900180	29	0.013
ribonucleotide metabolic process	GO:0009259	145	0.013
nitric oxide metabolic process	GO:0046209	1	0.013
dna recombination	GO:0006310	32	0.012
leg disc development	GO:0035218	92	0.012
cellular amino acid metabolic process	GO:0006520	61	0.012
positive regulation of response to stimulus	GO:0048584	323	0.012
molting cycle	GO:0042303	56	0.012
open tracheal system development	GO:0007424	204	0.012
atp catabolic process	GO:0006200	38	0.012
negative regulation of cytoskeleton organization	GO:0051494	30	0.012
ribonucleoside metabolic process	GO:0009119	127	0.012
protein targeting	GO:0006605	64	0.012
rna processing	GO:0006396	147	0.012
regulation of organ morphogenesis	GO:2000027	78	0.012
positive regulation of signaling	GO:0023056	243	0.012
positive regulation of nucleotide catabolic process	GO:0030813	46	0.012
smad protein import into nucleus	GO:0007184	11	0.012
rna interference	GO:0016246	27	0.011
regulation of mitosis	GO:0007088	56	0.011
nucleoside monophosphate catabolic process	GO:0009125	39	0.011
digestive tract morphogenesis	GO:0048546	127	0.011
histone modification	GO:0016570	106	0.011
positive regulation of cellular catabolic process	GO:0031331	95	0.011
regulation of phosphorylation	GO:0042325	147	0.011
establishment of localization in cell	GO:0051649	402	0.011
guanosine containing compound metabolic process	GO:1901068	74	0.011
regulation of cellular protein metabolic process	GO:0032268	243	0.011
negative regulation of gtpase activity	GO:0034260	1	0.011
establishment of protein localization	GO:0045184	163	0.011
gonad development	GO:0008406	50	0.011
cell fate specification	GO:0001708	71	0.011
regulation of phosphatase activity	GO:0010921	3	0.011
small gtpase mediated signal transduction	GO:0007264	88	0.011
regulation of apoptotic process	GO:0042981	130	0.010
neurological system process	GO:0050877	358	0.010
regulation of catabolic process	GO:0009894	170	0.010
negative regulation of cell death	GO:0060548	81	0.010
positive regulation of developmental process	GO:0051094	143	0.010
defense response to other organism	GO:0098542	225	0.010
regulation of cell death	GO:0010941	173	0.010
embryonic organ development	GO:0048568	50	0.010
negative regulation of chromatin silencing	GO:0031936	9	0.010
response to wounding	GO:0009611	94	0.010

esc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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