Drosophila melanogaster

27 known processes

Gcn2 (Dmel_CG1609)

CG1609 gene product from transcript CG1609-RA

(Aliases: EIF2,dGCN2,CG1609,GCN2,Dmel\CG1609,DGCN2)

Gcn2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
defense response to bacteriumGO:00427421780.292
immune system processGO:00023763470.220
protein modification processGO:00362114380.202
regionalizationGO:00030024160.186
positive regulation of macromolecule metabolic processGO:00106044050.180
response to biotic stimulusGO:00096072940.177
negative regulation of gene expressionGO:00106293870.167
Mouse
intracellular signal transductionGO:00355563000.156
response to external biotic stimulusGO:00432072930.155
cuticle developmentGO:0042335860.146
regulation of catabolic processGO:00098941700.145
negative regulation of cellular metabolic processGO:00313243820.142
Mouse
positive regulation of protein metabolic processGO:00512471280.132
transcription from rna polymerase ii promoterGO:00063663680.128
catabolic processGO:00090564090.123
defense responseGO:00069523000.121
response to other organismGO:00517072930.119
chromosome organizationGO:00512763600.112
organonitrogen compound metabolic processGO:19015643180.107
Yeast
cell proliferationGO:00082832990.104
cellular protein modification processGO:00064644380.099
innate immune responseGO:00450871440.099
regulation of cell cycle processGO:00105641810.098
positive regulation of catabolic processGO:00098961050.098
response to abiotic stimulusGO:00096283410.093
response to bacteriumGO:00096171980.091
regulation of chitin based cuticle tanningGO:0007564140.088
negative regulation of signal transductionGO:00099682060.087
negative regulation of response to stimulusGO:00485852580.086
regulation of molecular functionGO:00650092170.085
cell cell signaling involved in cell fate commitmentGO:00451682100.083
positive regulation of biosynthetic processGO:00098913160.082
organic substance catabolic processGO:19015753080.082
cellular catabolic processGO:00442483720.081
dorsal ventral pattern formationGO:00099531330.080
pigmentationGO:0043473750.079
trna aminoacylationGO:004303920.078
purine containing compound catabolic processGO:00725231120.078
vesicle mediated transportGO:00161923810.078
regulation of small gtpase mediated signal transductionGO:0051056930.078
posttranscriptional regulation of gene expressionGO:00106081450.075
Yeast Mouse
proteolysisGO:00065081920.073
imaginal disc derived appendage morphogenesisGO:00351143950.073
phagocytosisGO:00069092150.073
regulation of intracellular signal transductionGO:19025312360.072
regulation of catalytic activityGO:00507901850.072
negative regulation of biosynthetic processGO:00098902770.071
Mouse
regulation of hydrolase activityGO:0051336970.071
positive regulation of nucleobase containing compound metabolic processGO:00459353320.069
molting cycle chitin based cuticleGO:0007591560.068
localization of cellGO:00516742570.066
positive regulation of hydrolase activityGO:0051345780.063
regulation of transcription from rna polymerase ii promoterGO:00063573780.063
lateral inhibitionGO:00463312060.062
response to organic substanceGO:00100332840.062
Mouse
molting cycleGO:0042303560.061
chromatin assembly or disassemblyGO:0006333520.061
positive regulation of molecular functionGO:00440931360.061
regulation of protein metabolic processGO:00512462560.061
Yeast Mouse
mapk cascadeGO:00001651070.060
positive regulation of nitrogen compound metabolic processGO:00511733540.060
regulation of transportGO:00510491810.060
regulation of phosphate metabolic processGO:00192202100.059
negative regulation of developmental processGO:00510932010.058
ribonucleotide catabolic processGO:00092611090.058
regulation of ras protein signal transductionGO:0046578930.058
regulation of cell cycleGO:00517262910.056
positive regulation of phosphate metabolic processGO:00459371390.056
positive regulation of cellular catabolic processGO:0031331950.055
dna damage checkpointGO:0000077780.055
Yeast
regulation of phosphorus metabolic processGO:00511742100.055
response to lipopolysaccharideGO:003249640.055
organelle fissionGO:00482853400.055
phosphorylationGO:00163102940.054
negative regulation of cellular biosynthetic processGO:00313272770.054
Mouse
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.054
Mouse
positive regulation of catalytic activityGO:00430851180.053
macromolecule catabolic processGO:00090571610.053
regulation of mitotic cell cycleGO:00073461900.052
male gamete generationGO:00482322010.052
organic acid metabolic processGO:00060821030.051
Yeast
ribonucleoside catabolic processGO:00424541120.051
regulation of defense response to virus by hostGO:0050691100.051
negative regulation of kinase activityGO:0033673160.050
negative regulation of nucleobase containing compound metabolic processGO:00459342610.049
negative regulation of macromolecule biosynthetic processGO:00105582700.049
Mouse
appendage morphogenesisGO:00351073970.048
regulation of localizationGO:00328792750.047
negative regulation of multicellular organismal processGO:00512411420.047
imaginal disc derived appendage developmentGO:00487373990.047
cell deathGO:00082192790.047
purine ribonucleotide catabolic processGO:00091541090.047
positive regulation of cell communicationGO:00106472500.047
immune responseGO:00069552460.046
negative regulation of nitrogen compound metabolic processGO:00511722650.046
regulation of mapk cascadeGO:0043408920.046
organic cyclic compound catabolic processGO:19013611680.046
endocytosisGO:00068973100.045
dna integrity checkpointGO:0031570810.045
Yeast
protein importGO:0017038550.045
appendage developmentGO:00487364010.044
response to oxidative stressGO:0006979860.044
protein phosphorylationGO:00064681690.043
positive regulation of immune responseGO:0050778630.043
cell fate determinationGO:0001709910.043
regulation of cell differentiationGO:00455953020.042
camera type eye developmentGO:004301040.042
heterochromatin organizationGO:0070828250.041
connective tissue developmentGO:006144830.041
establishment of localization in cellGO:00516494020.041
ras protein signal transductionGO:0007265880.041
heterocycle catabolic processGO:00467001660.041
positive regulation of cellular protein metabolic processGO:00322701180.040
gene silencing by rnaGO:0031047570.039
deathGO:00162652840.039
chromatin modificationGO:00165681470.039
single organism nuclear importGO:1902593510.038
wing disc morphogenesisGO:00074723440.038
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:007005940.037
negative regulation of rna biosynthetic processGO:19026792400.037
regulation of cellular catabolic processGO:00313291570.037
developmental pigmentationGO:0048066680.037
negative regulation of signalingGO:00230572190.037
regulation of gene expression epigeneticGO:00400291280.036
growthGO:00400073590.036
ion transportGO:00068111450.036
programmed cell deathGO:00125012570.035
covalent chromatin modificationGO:00165691060.035
membrane fusionGO:0061025420.035
positive regulation of gene expressionGO:00106282900.035
gene silencingGO:00164581380.035
positive regulation of cellular biosynthetic processGO:00313283160.035
regulation of cytoplasmic transportGO:1903649470.034
posttranscriptional gene silencing by rnaGO:0035194450.034
defense response to other organismGO:00985422250.034
regulation of nucleocytoplasmic transportGO:0046822350.034
trna aminoacylation for protein translationGO:000641820.034
necrotic cell deathGO:007026510.034
positive regulation of defense responseGO:0031349590.033
single organism biosynthetic processGO:00447112060.033
Yeast
positive regulation of nucleic acid templated transcriptionGO:19035082660.033
positive regulation of response to stimulusGO:00485843230.033
nucleoside triphosphate metabolic processGO:00091411200.032
positive regulation of defense response to virus by hostGO:0002230100.032
small molecule metabolic processGO:00442813050.032
Yeast
positive regulation of signalingGO:00230562430.032
purine nucleoside catabolic processGO:00061521120.032
small gtpase mediated signal transductionGO:0007264880.032
adult chitin containing cuticle pigmentationGO:0048085160.031
positive regulation of jun kinase activityGO:004350740.031
nucleobase containing small molecule metabolic processGO:00550861740.031
regulation of organelle organizationGO:00330431960.030
regulation of cellular protein metabolic processGO:00322682430.030
Yeast Mouse
regulation of nuclear divisionGO:0051783580.030
regulation of developmental pigmentationGO:0048070240.029
cellular response to abiotic stimulusGO:0071214580.029
protein catabolic processGO:00301631010.029
positive regulation of proteolysisGO:0045862520.029
single organism membrane fusionGO:0044801420.029
regulation of developmental growthGO:00486381740.029
regulation of i kappab kinase nf kappab signalingGO:004312220.028
central nervous system developmentGO:00074172010.028
mucosal immune responseGO:0002385100.028
spindle assemblyGO:0051225800.028
positive regulation of intracellular signal transductionGO:19025331160.028
antimicrobial humoral responseGO:0019730990.028
regulation of growthGO:00400082330.028
cellular amino acid metabolic processGO:0006520610.027
Yeast
glycosyl compound catabolic processGO:19016581120.027
cellular response to chemical stimulusGO:00708871990.027
Mouse
regulation of establishment of protein localizationGO:0070201610.027
immune response regulating signaling pathwayGO:000276420.027
spermatogenesisGO:00072832000.027
dna repairGO:0006281540.027
nuclear divisionGO:00002803320.026
epithelial cell differentiationGO:00308553220.026
defense response to gram negative bacteriumGO:0050829940.026
regulation of proteolysisGO:0030162870.026
positive regulation of peptidase activityGO:0010952290.026
glycosyl compound metabolic processGO:19016571270.026
regulation of defense responseGO:00313471020.026
organelle assemblyGO:00709251980.026
carbohydrate metabolic processGO:0005975820.025
mitotic dna integrity checkpointGO:0044774750.025
imaginal disc derived wing morphogenesisGO:00074763370.025
cellular response to organic substanceGO:00713101320.025
Mouse
positive regulation of transcription dna templatedGO:00458932660.025
regulation of protein transportGO:0051223570.025
regulation of multicellular organismal developmentGO:20000264140.025
regulation of map kinase activityGO:0043405170.025
cellular nitrogen compound catabolic processGO:00442701650.025
regulation of intracellular transportGO:0032386640.024
positive regulation of mapk cascadeGO:0043410630.024
mitotic nuclear divisionGO:00070672130.024
humoral immune responseGO:00069591170.024
intracellular transportGO:00469072280.024
negative regulation of transcription dna templatedGO:00458922370.024
single organism catabolic processGO:00447122280.024
protein transportGO:00150311550.023
positive regulation of rna metabolic processGO:00512542710.023
ribonucleoside triphosphate metabolic processGO:00091991190.023
purine ribonucleoside catabolic processGO:00461301120.023
purine ribonucleoside monophosphate catabolic processGO:0009169380.023
anatomical structure homeostasisGO:0060249970.023
chromatin organizationGO:00063252070.023
dna metabolic processGO:00062592270.023
protein localization to nucleusGO:0034504550.023
regulation of innate immune responseGO:0045088710.023
macromolecular complex assemblyGO:00650032560.023
carbohydrate derivative catabolic processGO:19011361180.023
imaginal disc pattern formationGO:0007447910.023
negative regulation of cell cycle phase transitionGO:19019881030.023
protein complex biogenesisGO:00702712010.023
positive regulation of apoptotic signaling pathwayGO:200123540.023
regulation of adult chitin containing cuticle pigmentationGO:0048082130.023
carbohydrate derivative metabolic processGO:19011352170.023
positive regulation of phosphorus metabolic processGO:00105621390.022
nucleoside catabolic processGO:00091641120.022
membrane organizationGO:00610241120.022
positive regulation of transportGO:0051050920.022
regulation of jun kinase activityGO:004350680.022
establishment of protein localizationGO:00451841630.022
jak stat cascadeGO:0007259490.022
regulation of mitosisGO:0007088560.021
response to starvationGO:0042594970.021
Mouse
organophosphate metabolic processGO:00196371950.021
posttranscriptional gene silencingGO:0016441460.021
heart developmentGO:0007507820.021
negative regulation of cell communicationGO:00106482230.021
regulation of multi organism processGO:00439001310.021
negative regulation of rna metabolic processGO:00512532510.021
nucleotide catabolic processGO:00091661090.021
protein targeting to nucleusGO:0044744510.021
positive regulation of signal transductionGO:00099672230.021
regulation of intracellular protein transportGO:0033157460.021
regulation of response to stressGO:00801342000.021
regulation of cell cycle phase transitionGO:19019871300.020
post embryonic appendage morphogenesisGO:00351203850.020
response to light stimulusGO:00094161240.020
regulation of dna metabolic processGO:0051052340.020
mrna metabolic processGO:00160711240.020
protein targetingGO:0006605640.020
regulation of protein modification processGO:00313991120.020
eye developmentGO:00016543230.020
aromatic compound catabolic processGO:00194391660.020
skin developmentGO:0043588650.020
positive regulation of protein transportGO:0051222370.020
ribonucleotide metabolic processGO:00092591450.019
cellular response to dsrnaGO:0071359150.019
protein modification by small protein conjugationGO:0032446790.019
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.019
homeostatic processGO:00425921990.019
negative regulation of nucleic acid templated transcriptionGO:19035072400.019
nucleoside phosphate catabolic processGO:19012921100.019
regulation of cell developmentGO:00602842150.019
agingGO:00075681430.019
Yeast
single organism carbohydrate metabolic processGO:0044723720.019
sensory organ morphogenesisGO:00905962600.018
ribonucleoside triphosphate catabolic processGO:00092031080.018
response to organic cyclic compoundGO:0014070890.018
purine ribonucleoside triphosphate metabolic processGO:00092051190.018
atp catabolic processGO:0006200380.018
nucleoside metabolic processGO:00091161270.018
organonitrogen compound catabolic processGO:19015651280.017
response to organophosphorusGO:004668320.017
purine ribonucleotide metabolic processGO:00091501450.017
telencephalon developmentGO:002153720.017
regulation of immune system processGO:00026821760.017
protein import into nucleusGO:0006606510.017
nucleoside triphosphate catabolic processGO:00091431080.017
nucleotide metabolic processGO:00091171610.017
positive regulation of nucleoside metabolic processGO:0045979470.017
negative regulation of nervous system developmentGO:0051961920.017
regulation of cellular localizationGO:00603411360.017
response to radiationGO:00093141550.017
cation transmembrane transportGO:0098655880.017
chitin based cuticle sclerotizationGO:0007593190.017
cell divisionGO:00513012480.017
detection of stimulusGO:00516061560.017
positive regulation of cell deathGO:0010942690.017
purine nucleoside triphosphate metabolic processGO:00091441190.016
negative regulation of cellular protein metabolic processGO:0032269850.016
Mouse
cellular response to unfolded proteinGO:003462090.016
Mouse
cellular macromolecule catabolic processGO:00442651360.016
cellular hyperosmotic salinity responseGO:007147510.016
response to copper ionGO:004668840.016
regulation of cuticle pigmentationGO:0048079160.016
germ line stem cell maintenanceGO:0030718500.016
regulation of protein catabolic processGO:0042176550.016
ensheathment of neuronsGO:0007272100.016
cation homeostasisGO:0055080510.016
negative regulation of growthGO:0045926840.016
dorsal ventral pattern formation imaginal discGO:0007450510.016
response to temperature stimulusGO:00092661060.016
positive regulation of cellular component biogenesisGO:0044089800.016
purine nucleotide catabolic processGO:00061951090.016
regulation of purine nucleotide catabolic processGO:0033121480.016
purine ribonucleoside triphosphate catabolic processGO:00092071080.016
organophosphate catabolic processGO:00464341120.015
regulation of response to external stimulusGO:00321011150.015
cellular response to biotic stimulusGO:007121640.015
negative regulation of epidermal growth factor receptor signaling pathwayGO:0042059290.015
cell migrationGO:00164772380.015
negative regulation of developmental growthGO:0048640640.015
regulation of programmed cell deathGO:00430671520.015
skeletal muscle fiber developmentGO:004874130.015
antennal developmentGO:0007469250.015
autophagyGO:00069141080.015
response to alcoholGO:0097305950.015
regulation of membrane potentialGO:0042391350.015
regulation of protein import into nucleusGO:0042306280.015
ribonucleoside metabolic processGO:00091191270.015
organ or tissue specific immune responseGO:0002251100.015
hair cell differentiationGO:0035315470.014
response to endoplasmic reticulum stressGO:0034976280.014
Mouse
organic substance transportGO:00717022570.014
defense response to gram positive bacteriumGO:0050830410.014
limb developmentGO:006017310.014
positive regulation of multicellular organismal processGO:00512401430.014
antimicrobial peptide productionGO:0002775460.014
immune response activating signal transductionGO:000275720.014
oxoacid metabolic processGO:00434361030.014
Yeast
spindle organizationGO:00070512530.014
forebrain developmentGO:003090020.014
rna processingGO:00063961470.014
cellular response to dna damage stimulusGO:00069742230.014
Yeast
stem cell maintenanceGO:0019827670.014
ribonucleoside monophosphate catabolic processGO:0009158390.014
regulation of sequestering of calcium ionGO:005128230.014
regulation of cellular component biogenesisGO:00440872010.013
neuronal action potentialGO:0019228100.013
regulation of nucleotide metabolic processGO:0006140620.013
axon ensheathmentGO:0008366100.013
positive regulation of phosphorylationGO:0042327870.013
negative regulation of cell cycle processGO:00109481090.013
carboxylic acid metabolic processGO:0019752920.013
Yeast
hindbrain developmentGO:003090220.013
epithelial cell developmentGO:00020642740.013
amino acid activationGO:004303830.013
response to nitrogen compoundGO:1901698900.013
response to decreased oxygen levelsGO:0036293580.013
wnt signaling pathwayGO:0016055980.013
body morphogenesisGO:001017120.012
regulation of nucleoside metabolic processGO:0009118500.012
regulation of cellular amine metabolic processGO:003323830.012
glycoprotein metabolic processGO:0009100410.012
regulation of immune responseGO:00507761180.012
protein localizationGO:00081042840.012
regulation of apoptotic processGO:00429811300.012
cytoplasmic translationGO:000218100.012
nuclear transportGO:0051169720.012
regulation of response to oxidative stressGO:190288240.012
purine containing compound metabolic processGO:00725211550.012
positive regulation of ras gtpase activityGO:0032320360.012
gastrulation with mouth forming firstGO:0001703360.012
regulation of mrna metabolic processGO:1903311720.012
dna conformation changeGO:00711031050.012
regulation of protein phosphorylationGO:0001932640.012
cellular macromolecular complex assemblyGO:00346221530.012
taxisGO:00423303040.012
regulation of phosphorylationGO:00423251470.012
nucleoside monophosphate catabolic processGO:0009125390.012
inositol lipid mediated signalingGO:004801740.012
endosomal transportGO:0016197440.012
response to hexoseGO:000974630.012
single organism intracellular transportGO:19025822070.012
purine nucleoside metabolic processGO:00422781270.011
regulation of protein localizationGO:0032880760.011
immune effector processGO:0002252980.011
apoptotic processGO:00069151590.011
purine nucleotide metabolic processGO:00061631460.011
purine nucleoside monophosphate catabolic processGO:0009128380.011
nucleocytoplasmic transportGO:0006913720.011
response to topologically incorrect proteinGO:0035966100.011
Mouse
cation transportGO:00068121100.011
regulation of epithelial cell differentiationGO:003085640.011
positive regulation of exocytosisGO:004592140.011
i kappab phosphorylationGO:000725230.011
production of small rna involved in gene silencing by rnaGO:0070918150.011
regulation of cellular component sizeGO:0032535980.011
positive regulation of reactive oxygen species metabolic processGO:200037900.011
ribonucleoside monophosphate metabolic processGO:0009161510.011
positive regulation of macromolecule biosynthetic processGO:00105572830.011
regulation of gtpase activityGO:0043087440.011
single organism membrane organizationGO:0044802930.010
cellular homeostasisGO:0019725800.010
regulation of gtp catabolic processGO:0033124440.010
response to organonitrogen compoundGO:0010243750.010
regulation of rab gtpase activityGO:003231370.010
ribose phosphate metabolic processGO:00196931450.010
positive regulation of peptidyl tyrosine phosphorylationGO:005073140.010
extrinsic apoptotic signaling pathwayGO:009719110.010
regulation of mitotic cell cycle phase transitionGO:19019901300.010
negative regulation of homeostatic processGO:003284520.010
cellular response to lipopolysaccharideGO:007122230.010
detection of stimulus involved in sensory perceptionGO:0050906920.010
positive regulation of ion transmembrane transporter activityGO:003241440.010
guanosine containing compound catabolic processGO:1901069740.010
eye antennal disc developmentGO:0035214600.010
xenobiotic transportGO:004290810.010

Gcn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.053
disease of metabolismDOID:001466700.019
nervous system diseaseDOID:86300.018
disease of cellular proliferationDOID:1456600.017
cancerDOID:16200.017
organ system cancerDOID:005068600.017
inherited metabolic disorderDOID:65500.015
central nervous system diseaseDOID:33100.013