IMP: Integrative Multi-species Prediction

Drosophila melanogaster

250 known processes

dlg1 (Dmel_CG1725)

discs large 1

(Aliases: anon-WO03040301.258,Dlg,SAP97,PSD95,d. lg.-1,CPD,misb,DlgA,l(1)G0276,l(1)L11,Drodlg,l(1)d.lg-1,dlg,l(1)10Bf,anon-EST:Posey93,Dlg-A,l(1)lpr-2,CG1725,Dmel\CG1725,Dlg1,DLG,anon-WO03040301.268,dlg-A,anon-WO03040301.260,dlgS97,l(1)G0456,l(1)dlg-1,l(1)G19,l(1)dlg,Discs-large,11,l(1)discs large,l(1)bwn,DLG-A,l(1)dlg1,dlgA,l(1)l.pr.-2,CG1730,l(1)G0342,dlg-1,l(1)d.lg.-1)

Entrez: 32083
FLYBASE: FBgn0001624
UniProtKB: P31007
UniProtKB: M9PHK8
UniProtKB: E8NH13
UniProtKB: E1JJH5
UniProtKB: E1JJH6
UniProtKB: M9NGZ2
UniProtKB: M9PEB3
UniProtKB: C1C536
UniProtKB: M9PJI4

Process Predictions
Disease Predictions

dlg1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
locomotory behavior	GO:0007626	176	0.997
single organism behavior	GO:0044708	391	0.994
ovarian follicle cell migration	GO:0007297	121	0.978
neuron neuron synaptic transmission	GO:0007270	14	0.977
response to endogenous stimulus	GO:0009719	119	0.938
epithelial cell development	GO:0002064	274	0.936
neurological system process	GO:0050877	358	0.912	Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.897
adult locomotory behavior	GO:0008344	76	0.882
cell division	GO:0051301	248	0.877
ovarian follicle cell development	GO:0030707	248	0.860
segmentation	GO:0035282	207	0.851
negative regulation of signal transduction	GO:0009968	206	0.849	Mouse
border follicle cell migration	GO:0007298	113	0.823
establishment of localization in cell	GO:0051649	402	0.781
establishment or maintenance of cell polarity	GO:0007163	167	0.778
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.777
macromolecular complex assembly	GO:0065003	256	0.776	Human Mouse
synaptic transmission	GO:0007268	288	0.775
secretion by cell	GO:0032940	101	0.764
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.741
head development	GO:0060322	135	0.737
cell junction organization	GO:0034330	57	0.715	Human Worm
regulation of synaptic transmission	GO:0050804	69	0.709	Mouse Rat
regulation of cellular component biogenesis	GO:0044087	201	0.699
regulation of cellular localization	GO:0060341	136	0.692	Human
synaptic vesicle endocytosis	GO:0048488	28	0.653	Mouse
neurotransmitter transport	GO:0006836	37	0.609
negative regulation of cellular biosynthetic process	GO:0031327	277	0.570
oocyte construction	GO:0007308	112	0.566
appendage development	GO:0048736	401	0.564
protein catabolic process	GO:0030163	101	0.562
epithelial cell migration	GO:0010631	148	0.546
negative regulation of cell communication	GO:0010648	223	0.529	Mouse
learning or memory	GO:0007611	141	0.517
organelle localization	GO:0051640	148	0.513
transcription from rna polymerase ii promoter	GO:0006366	368	0.507
cell proliferation	GO:0008283	299	0.447	Human Mouse
regulation of anatomical structure morphogenesis	GO:0022603	242	0.444
organ growth	GO:0035265	56	0.444
semaphorin plexin signaling pathway	GO:0071526	4	0.443
embryonic pattern specification	GO:0009880	174	0.441
ameboidal type cell migration	GO:0001667	151	0.421
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.421
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.419	Mouse
defense response	GO:0006952	300	0.415
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.414
adult behavior	GO:0030534	137	0.412
synapse organization	GO:0050808	196	0.409
tissue migration	GO:0090130	155	0.409
regulation of phosphate metabolic process	GO:0019220	210	0.403	Human Mouse
columnar cuboidal epithelial cell development	GO:0002066	249	0.403
epidermis development	GO:0008544	65	0.400
regulation of cell morphogenesis	GO:0022604	163	0.400
neurotransmitter secretion	GO:0007269	35	0.397
stem cell division	GO:0017145	69	0.394
blastoderm segmentation	GO:0007350	159	0.392
positive regulation of secretion	GO:0051047	22	0.376
negative regulation of cellular metabolic process	GO:0031324	382	0.369
developmental growth	GO:0048589	280	0.367
dorsal closure	GO:0007391	79	0.365
axonogenesis	GO:0007409	290	0.363
imaginal disc growth	GO:0007446	37	0.359
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.357
regulation of organelle organization	GO:0033043	196	0.357	Mouse
negative regulation of response to stimulus	GO:0048585	258	0.350	Mouse
germarium derived egg chamber formation	GO:0007293	101	0.348
regulation of tube architecture open tracheal system	GO:0035152	68	0.347
tissue morphogenesis	GO:0048729	297	0.346
regulation of neuromuscular synaptic transmission	GO:1900073	15	0.340
regulation of synapse structure and activity	GO:0050803	128	0.333
regulation of cell cycle process	GO:0010564	181	0.323
appendage morphogenesis	GO:0035107	397	0.317
morphogenesis of an epithelium	GO:0002009	276	0.311
compound eye photoreceptor cell differentiation	GO:0001751	140	0.311
synaptic growth at neuromuscular junction	GO:0051124	119	0.306
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.300
receptor clustering	GO:0043113	3	0.300	Rat
axon development	GO:0061564	297	0.294
regulation of cell projection organization	GO:0031344	92	0.287
positive regulation of signaling	GO:0023056	243	0.284	Rat
negative regulation of rna biosynthetic process	GO:1902679	240	0.271
cellular amino acid metabolic process	GO:0006520	61	0.266
regulation of intracellular signal transduction	GO:1902531	236	0.265
r3 r4 cell fate commitment	GO:0007464	10	0.264
regulation of localization	GO:0032879	275	0.257	Human Rat
chemotaxis	GO:0006935	249	0.250
regulation of secretion	GO:0051046	44	0.249
regulation of multicellular organismal development	GO:2000026	414	0.236
positive regulation of cell communication	GO:0010647	250	0.233	Rat
embryonic morphogenesis	GO:0048598	206	0.233	Mouse
neuromuscular synaptic transmission	GO:0007274	67	0.227
regulation of phosphorylation	GO:0042325	147	0.225	Mouse
imaginal disc derived appendage development	GO:0048737	399	0.222
skin development	GO:0043588	65	0.220
organelle fission	GO:0048285	340	0.213
synaptic vesicle localization	GO:0097479	53	0.212	Mouse
positive regulation of synapse assembly	GO:0051965	29	0.209
growth	GO:0040007	359	0.204
protein localization	GO:0008104	284	0.204
negative regulation of rna metabolic process	GO:0051253	251	0.201
central nervous system development	GO:0007417	201	0.197
negative regulation of signaling	GO:0023057	219	0.194	Mouse
positive regulation of response to stimulus	GO:0048584	323	0.192
cellular protein modification process	GO:0006464	438	0.189	Mouse
cell maturation	GO:0048469	144	0.189
axis specification	GO:0009798	167	0.187
vesicle mediated transport	GO:0016192	381	0.187	Mouse Rat
nucleobase containing small molecule metabolic process	GO:0055086	174	0.183
cell motility	GO:0048870	251	0.177
negative regulation of biosynthetic process	GO:0009890	277	0.174
compound eye photoreceptor fate commitment	GO:0001752	36	0.174
larval development	GO:0002164	104	0.173	Worm
negative regulation of cellular component organization	GO:0051129	108	0.173	Rat
chemical homeostasis	GO:0048878	92	0.173	Rat
regulation of developmental growth	GO:0048638	174	0.172
post embryonic appendage morphogenesis	GO:0035120	385	0.160
protein modification process	GO:0036211	438	0.159	Mouse
positive regulation of proteolysis	GO:0045862	52	0.158
single organismal cell cell adhesion	GO:0016337	45	0.150	Human
epithelium migration	GO:0090132	148	0.147
establishment of ommatidial planar polarity	GO:0042067	49	0.141
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	24	0.138	Mouse
photoreceptor cell differentiation	GO:0046530	170	0.138
regulation of neurotransmitter levels	GO:0001505	38	0.137
regulation of mitotic cell cycle	GO:0007346	190	0.136	Human
dna metabolic process	GO:0006259	227	0.134
cognition	GO:0050890	141	0.133
open tracheal system development	GO:0007424	204	0.130
negative regulation of gene expression	GO:0010629	387	0.128
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.127
regulation of neuron differentiation	GO:0045664	103	0.126
positive regulation of synaptic transmission	GO:0050806	15	0.123	Rat
single organism cell adhesion	GO:0098602	47	0.122	Human
male courtship behavior	GO:0008049	63	0.120
establishment of epithelial cell planar polarity	GO:0090163	4	0.120
regulation of transport	GO:0051049	181	0.119	Human Rat
brain development	GO:0007420	120	0.119
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.117
multi organism behavior	GO:0051705	175	0.116
establishment of apical basal cell polarity	GO:0035089	12	0.116
regulation of cell differentiation	GO:0045595	302	0.115
asymmetric protein localization	GO:0008105	33	0.114
regulation of cell proliferation	GO:0042127	163	0.113	Mouse
asymmetric neuroblast division	GO:0055059	33	0.110
regulation of cell division	GO:0051302	72	0.110
eye morphogenesis	GO:0048592	260	0.109
synaptic vesicle recycling	GO:0036465	28	0.108	Mouse
neuroblast proliferation	GO:0007405	74	0.106
immune system process	GO:0002376	347	0.105	Mouse
circadian rhythm	GO:0007623	105	0.104
positive regulation of phosphorus metabolic process	GO:0010562	139	0.104	Mouse
taxis	GO:0042330	304	0.103
regulation of epithelial cell proliferation	GO:0050678	4	0.102	Mouse
catabolic process	GO:0009056	409	0.101
regulation of secretion by cell	GO:1903530	39	0.099
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.099
reproductive behavior	GO:0019098	122	0.099
circulatory system development	GO:0072359	82	0.097
muscle organ development	GO:0007517	127	0.097
morphogenesis of embryonic epithelium	GO:0016331	94	0.096
negative regulation of hormone biosynthetic process	GO:0032353	1	0.095
oocyte differentiation	GO:0009994	145	0.093
establishment of organelle localization	GO:0051656	122	0.092
protein complex biogenesis	GO:0070271	201	0.091	Human Mouse
immune system development	GO:0002520	57	0.091
muscle system process	GO:0003012	21	0.091	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	405	0.090	Mouse
regulation of notch signaling pathway	GO:0008593	100	0.090
cell cell junction organization	GO:0045216	55	0.089	Human Worm
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.089
cellular response to chemical stimulus	GO:0070887	199	0.088
cellular macromolecular complex assembly	GO:0034622	153	0.088	Mouse
purine nucleotide metabolic process	GO:0006163	146	0.088
developmental maturation	GO:0021700	172	0.088
heart process	GO:0003015	37	0.087
single organism cellular localization	GO:1902580	180	0.087
regulation of actin filament based process	GO:0032970	42	0.087	Mouse
eye photoreceptor cell differentiation	GO:0001754	145	0.085
regulation of neuron projection development	GO:0010975	69	0.085
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.084
negative regulation of cell development	GO:0010721	62	0.083
protein transport	GO:0015031	155	0.083
digestive system development	GO:0055123	149	0.083
stem cell proliferation	GO:0072089	88	0.080
carbohydrate derivative metabolic process	GO:1901135	217	0.079
regulation of programmed cell death	GO:0043067	152	0.079
positive regulation of biosynthetic process	GO:0009891	316	0.079
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.077
photoreceptor cell fate commitment	GO:0046552	41	0.077
multicellular organismal reproductive behavior	GO:0033057	110	0.077
negative regulation of cell proliferation	GO:0008285	69	0.077	Mouse
cellular protein catabolic process	GO:0044257	83	0.075
nucleoside phosphate metabolic process	GO:0006753	162	0.075
membrane depolarization	GO:0051899	4	0.072	Rat
notch signaling pathway	GO:0007219	120	0.071
synaptic transmission glutamatergic	GO:0035249	7	0.070
smoothened signaling pathway	GO:0007224	49	0.070
carbohydrate derivative biosynthetic process	GO:1901137	85	0.069
regulation of vesicle mediated transport	GO:0060627	59	0.069	Rat
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.068
intraspecies interaction between organisms	GO:0051703	4	0.068	Mouse
regulation of cell death	GO:0010941	173	0.068
regulation of synaptic transmission glutamatergic	GO:0051966	5	0.067
single organism carbohydrate metabolic process	GO:0044723	72	0.065
endomembrane system organization	GO:0010256	119	0.065	Human
rhythmic process	GO:0048511	106	0.065
negative regulation of epithelial cell proliferation	GO:0050680	4	0.065	Mouse
tripartite regional subdivision	GO:0007351	103	0.065
nucleoside triphosphate metabolic process	GO:0009141	120	0.064
organic substance transport	GO:0071702	257	0.063
epithelial cell differentiation	GO:0030855	322	0.062
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.062
cellular catabolic process	GO:0044248	372	0.061
protein complex assembly	GO:0006461	200	0.061	Human Mouse
asymmetric stem cell division	GO:0098722	49	0.060
ribonucleoside metabolic process	GO:0009119	127	0.060
wing disc morphogenesis	GO:0007472	344	0.060
organic substance catabolic process	GO:1901575	308	0.060
nucleoside phosphate catabolic process	GO:1901292	110	0.059
non sensory hair organization	GO:0035316	47	0.059
regulation of system process	GO:0044057	36	0.059
oocyte axis specification	GO:0007309	108	0.058
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.058
response to alcohol	GO:0097305	95	0.057
mesenchymal cell development	GO:0014031	1	0.057
organophosphate metabolic process	GO:0019637	195	0.057
tube development	GO:0035295	244	0.057	Mouse
metal ion homeostasis	GO:0055065	44	0.056	Rat
negative regulation of nervous system development	GO:0051961	92	0.056
establishment of epithelial cell apical basal polarity	GO:0045198	10	0.055
secretion	GO:0046903	109	0.055
regulation of hydrolase activity	GO:0051336	97	0.055	Human
regulation of immune system process	GO:0002682	176	0.055	Mouse
striated muscle contraction	GO:0006941	5	0.055
oocyte development	GO:0048599	124	0.054
response to organic cyclic compound	GO:0014070	89	0.054
actin filament based process	GO:0030029	220	0.053	Human Mouse
positive regulation of protein metabolic process	GO:0051247	128	0.053	Mouse
neuron fate commitment	GO:0048663	50	0.053
phosphorylation	GO:0016310	294	0.052	Mouse
regulation of catabolic process	GO:0009894	170	0.052
epithelial cell proliferation	GO:0050673	15	0.052	Human Mouse
cell adhesion	GO:0007155	136	0.050	Human Rat
localization of cell	GO:0051674	257	0.050
morphogenesis of follicular epithelium	GO:0016333	36	0.050
negative regulation of growth	GO:0045926	84	0.050
cation homeostasis	GO:0055080	51	0.049	Rat
synaptic vesicle transport	GO:0048489	50	0.049	Mouse
response to abiotic stimulus	GO:0009628	341	0.048
developmental growth involved in morphogenesis	GO:0060560	65	0.048
regulation of cell cycle	GO:0051726	291	0.047	Human
neuron recognition	GO:0008038	101	0.047
cell cell junction assembly	GO:0007043	38	0.047	Human Worm
sister chromatid segregation	GO:0000819	92	0.047
regulation of molecular function	GO:0065009	217	0.046	Human Mouse Rat
positive regulation of signal transduction	GO:0009967	223	0.046
ubiquitin dependent protein catabolic process	GO:0006511	78	0.046
regulation of actin cytoskeleton organization	GO:0032956	42	0.046	Mouse
cation transport	GO:0006812	110	0.046	Human Rat
apical junction assembly	GO:0043297	32	0.045	Human Worm
regulation of organ growth	GO:0046620	42	0.044
blood circulation	GO:0008015	26	0.044
retina development in camera type eye	GO:0060041	4	0.043
metal ion transport	GO:0030001	74	0.042	Human Rat
positive regulation of protein catabolic process	GO:0045732	34	0.042
cell recognition	GO:0008037	102	0.041	Mouse
imaginal disc derived wing morphogenesis	GO:0007476	337	0.041
synapse assembly	GO:0007416	143	0.041
r3 r4 cell differentiation	GO:0048056	12	0.041
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.041
regulation of excitatory postsynaptic membrane potential	GO:0060079	3	0.041	Rat
regulation of phosphorus metabolic process	GO:0051174	210	0.040	Human Mouse
regulation of imaginal disc growth	GO:0045570	26	0.040
organonitrogen compound metabolic process	GO:1901564	318	0.040
intracellular signal transduction	GO:0035556	300	0.040
regulation of blood circulation	GO:1903522	21	0.039
posttranscriptional regulation of gene expression	GO:0010608	145	0.039
regulation of cellular catabolic process	GO:0031329	157	0.038
sensory perception	GO:0007600	196	0.038	Mouse
regulation of protein catabolic process	GO:0042176	55	0.038
establishment of protein localization	GO:0045184	163	0.038	Human
regulation of multi organism process	GO:0043900	131	0.037
immune response	GO:0006955	246	0.037	Mouse
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO:1902254	1	0.037
instar larval development	GO:0002168	55	0.037
modification dependent macromolecule catabolic process	GO:0043632	79	0.037
cellular response to organic substance	GO:0071310	132	0.037
establishment of monopolar cell polarity	GO:0061162	15	0.037
regulation of cell growth	GO:0001558	43	0.036
cell migration	GO:0016477	238	0.036
determination of adult lifespan	GO:0008340	137	0.036
regulation of proteasomal protein catabolic process	GO:0061136	39	0.036
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	9	0.036
compound eye morphogenesis	GO:0001745	249	0.036
circulatory system process	GO:0003013	37	0.036
establishment of spindle orientation	GO:0051294	18	0.036
proteasomal protein catabolic process	GO:0010498	59	0.036
regulation of cellular amino acid metabolic process	GO:0006521	0	0.036
regulation of jnk cascade	GO:0046328	40	0.035
positive regulation of molecular function	GO:0044093	136	0.035	Mouse
eye development	GO:0001654	323	0.035	Mouse
regulation of catalytic activity	GO:0050790	185	0.035	Human Mouse
negative regulation of developmental process	GO:0051093	201	0.035
cuticle development	GO:0042335	86	0.034
cell fate commitment involved in pattern specification	GO:0060581	31	0.034
regulation of growth	GO:0040008	233	0.033
regulation of protein metabolic process	GO:0051246	256	0.033	Mouse
nucleoside metabolic process	GO:0009116	127	0.033
response to oxygen containing compound	GO:1901700	200	0.033
regulation of protein phosphorylation	GO:0001932	64	0.032	Mouse
regulation of cellular response to stress	GO:0080135	89	0.032
biological adhesion	GO:0022610	138	0.031	Human Rat
ribonucleotide metabolic process	GO:0009259	145	0.031
regulation of cellular response to growth factor stimulus	GO:0090287	13	0.031
response to decreased oxygen levels	GO:0036293	58	0.030
regulation of cellular component size	GO:0032535	98	0.030	Mouse
small molecule metabolic process	GO:0044281	305	0.029
macromolecule catabolic process	GO:0009057	161	0.029
eye photoreceptor cell fate commitment	GO:0042706	37	0.029
negative regulation of intracellular signal transduction	GO:1902532	57	0.029	Mouse
endocytosis	GO:0006897	310	0.029	Mouse Rat
reproductive structure development	GO:0048608	74	0.028	Mouse
actin cytoskeleton organization	GO:0030036	206	0.028	Human Mouse
regulation of nucleotide metabolic process	GO:0006140	62	0.028
zonula adherens assembly	GO:0045186	6	0.028	Worm
synaptic vesicle exocytosis	GO:0016079	16	0.027
regulation of neurotransmitter secretion	GO:0046928	14	0.027
positive regulation of cell death	GO:0010942	69	0.027
chromosome segregation	GO:0007059	157	0.027
establishment of cell polarity	GO:0030010	40	0.027
stem cell development	GO:0048864	79	0.027
organonitrogen compound catabolic process	GO:1901565	128	0.027
forebrain development	GO:0030900	2	0.027
modification dependent protein catabolic process	GO:0019941	78	0.026
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.026
negative regulation of imaginal disc growth	GO:0045571	8	0.026
positive regulation of cell projection organization	GO:0031346	29	0.025
heart development	GO:0007507	82	0.025
establishment of mitotic spindle orientation	GO:0000132	13	0.025
regulation of membrane potential	GO:0042391	35	0.025	Human Mouse Rat
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.025
regulation of cell development	GO:0060284	215	0.025
periodic partitioning	GO:0007365	29	0.025
mushroom body development	GO:0016319	70	0.025
regulation of rac gtpase activity	GO:0032314	1	0.024
nuclear division	GO:0000280	332	0.024
regionalization	GO:0003002	416	0.024
negative regulation of dendrite morphogenesis	GO:0050774	2	0.024
response to hypoxia	GO:0001666	53	0.024
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.024
regulation of actin polymerization or depolymerization	GO:0008064	27	0.023	Mouse
regulation of synapse assembly	GO:0051963	94	0.023
eye antennal disc morphogenesis	GO:0007455	34	0.023
amine metabolic process	GO:0009308	12	0.023
neuroblast division	GO:0055057	35	0.023
positive regulation of catabolic process	GO:0009896	105	0.023
cuticle pattern formation	GO:0035017	27	0.023
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.022
anterior posterior axis specification	GO:0009948	109	0.022
adherens junction organization	GO:0034332	27	0.022	Worm
heart morphogenesis	GO:0003007	32	0.022
memory	GO:0007613	94	0.022
purine nucleoside metabolic process	GO:0042278	127	0.022
positive regulation of rna biosynthetic process	GO:1902680	266	0.022
nucleotide metabolic process	GO:0009117	161	0.022
regulation of kinase activity	GO:0043549	53	0.022	Mouse
regulation of neurogenesis	GO:0050767	158	0.021
establishment of synaptic vesicle localization	GO:0097480	50	0.021	Mouse
polarized epithelial cell differentiation	GO:0030859	10	0.021
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.021
asymmetric cell division	GO:0008356	37	0.021
hindgut morphogenesis	GO:0007442	58	0.021
negative regulation of dendrite development	GO:2000171	2	0.021
malpighian tubule development	GO:0072002	64	0.020
camera type eye development	GO:0043010	4	0.020	Mouse
axon guidance	GO:0007411	233	0.020
specification of organ identity	GO:0010092	3	0.020
regulation of cellular protein catabolic process	GO:1903362	44	0.020
intracellular protein transport	GO:0006886	104	0.020
oocyte anterior posterior axis specification	GO:0007314	72	0.020
response to radiation	GO:0009314	155	0.020
social behavior	GO:0035176	4	0.020	Mouse
regulation of anatomical structure size	GO:0090066	163	0.020	Mouse
regulation of response to stress	GO:0080134	200	0.020
negative regulation of cellular protein metabolic process	GO:0032269	85	0.019
lateral inhibition	GO:0046331	206	0.019
detection of stimulus	GO:0051606	156	0.019
regulation of protein localization	GO:0032880	76	0.019	Human Rat
positive regulation of cellular component organization	GO:0051130	156	0.019
endoderm formation	GO:0001706	3	0.019
regulation of circadian rhythm	GO:0042752	49	0.019
striated muscle tissue development	GO:0014706	27	0.019
mitotic nuclear division	GO:0007067	213	0.019
positive regulation of cell proliferation	GO:0008284	47	0.018	Mouse
cell fate specification	GO:0001708	71	0.018
protein modification by small protein conjugation	GO:0032446	79	0.018
negative regulation of nucleotide metabolic process	GO:0045980	4	0.018
circadian behavior	GO:0048512	76	0.018
negative regulation of phosphate metabolic process	GO:0045936	45	0.018	Human
central nervous system neuron differentiation	GO:0021953	8	0.018
programmed cell death	GO:0012501	257	0.018
mesenchymal cell differentiation	GO:0048762	1	0.018
regulation of protein modification process	GO:0031399	112	0.017	Mouse
purine containing compound metabolic process	GO:0072521	155	0.017
positive regulation of hydrolase activity	GO:0051345	78	0.017
cellular amine metabolic process	GO:0044106	12	0.017
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.017
meiotic nuclear envelope disassembly	GO:0051078	2	0.017
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.017
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.017
cellular macromolecule localization	GO:0070727	220	0.017	Human Rat
negative regulation of protein phosphorylation	GO:0001933	17	0.017
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.017
epithelial tube morphogenesis	GO:0060562	88	0.017	Mouse
nucleoside catabolic process	GO:0009164	112	0.017
ribose phosphate metabolic process	GO:0019693	145	0.017
positive regulation of cell development	GO:0010720	61	0.017
regulation of cytoskeleton organization	GO:0051493	89	0.017	Mouse
regulation of cellular amine metabolic process	GO:0033238	3	0.016
axonal fasciculation	GO:0007413	12	0.016
eye antennal disc development	GO:0035214	60	0.016
single organism biosynthetic process	GO:0044711	206	0.016
positive regulation of intracellular signal transduction	GO:1902533	116	0.016
regulation of dendrite morphogenesis	GO:0048814	28	0.016
respiratory system development	GO:0060541	213	0.016
response to organic substance	GO:0010033	284	0.016
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.016
epidermal cell differentiation	GO:0009913	51	0.016
anterior posterior axis specification follicular epithelium	GO:0030714	2	0.016
exocytosis	GO:0006887	28	0.016
neuron projection guidance	GO:0097485	241	0.016
establishment of vesicle localization	GO:0051650	51	0.015	Mouse
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	6	0.015
kidney development	GO:0001822	3	0.015	Mouse
jnk cascade	GO:0007254	50	0.015
flight behavior	GO:0007629	26	0.015
regulation of behavior	GO:0050795	75	0.015	Mouse
carbohydrate metabolic process	GO:0005975	82	0.015
regulation of phosphatase activity	GO:0010921	3	0.015	Human
peptidyl threonine phosphorylation	GO:0018107	2	0.015
somatic stem cell division	GO:0048103	37	0.015
cellular carbohydrate metabolic process	GO:0044262	22	0.015
divalent inorganic cation transport	GO:0072511	30	0.014
reproductive system development	GO:0061458	74	0.014	Mouse
actin mediated cell contraction	GO:0070252	21	0.014
regulation of purine nucleotide metabolic process	GO:1900542	62	0.014
hematopoietic or lymphoid organ development	GO:0048534	57	0.014
detection of external stimulus	GO:0009581	66	0.014
nucleoside phosphate biosynthetic process	GO:1901293	34	0.014
purine ribonucleotide metabolic process	GO:0009150	145	0.014
negative regulation of organelle organization	GO:0010639	56	0.013
regulation of ion transport	GO:0043269	39	0.013	Human Rat
courtship behavior	GO:0007619	68	0.013
embryonic development via the syncytial blastoderm	GO:0001700	148	0.013
cellular protein complex assembly	GO:0043623	71	0.013	Mouse
nucleoside triphosphate catabolic process	GO:0009143	108	0.013
maintenance of apical basal cell polarity	GO:0035090	8	0.013
nucleotide catabolic process	GO:0009166	109	0.013
regulation of smoothened signaling pathway	GO:0008589	28	0.013
ion transport	GO:0006811	145	0.013	Human Rat
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.013
body morphogenesis	GO:0010171	2	0.013
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.013
positive regulation of chromatin silencing at telomere	GO:0031940	2	0.013
hair cell differentiation	GO:0035315	47	0.013
multi multicellular organism process	GO:0044706	123	0.013
negative regulation of mitotic anaphase promoting complex activity	GO:0060564	2	0.013
telencephalon development	GO:0021537	2	0.013
mapk cascade	GO:0000165	107	0.013
digestive tract morphogenesis	GO:0048546	127	0.013
protein ubiquitination	GO:0016567	70	0.012
positive regulation of organelle organization	GO:0010638	65	0.012	Mouse
wnt signaling pathway	GO:0016055	98	0.012
positive regulation of multicellular organismal process	GO:0051240	143	0.012
establishment of nucleus localization	GO:0040023	26	0.012
regulation of cell shape	GO:0008360	113	0.012
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.012
purine ribonucleotide catabolic process	GO:0009154	109	0.012
carboxylic acid metabolic process	GO:0019752	92	0.012
positive regulation of phosphorylation	GO:0042327	87	0.012	Mouse
innate immune response	GO:0045087	144	0.012
signal release	GO:0023061	49	0.012
regulation of cell cycle phase transition	GO:1901987	130	0.012
single organism catabolic process	GO:0044712	228	0.012
oocyte morphogenesis	GO:0048601	3	0.012
regulation of necrotic cell death	GO:0010939	1	0.012
positive regulation of catalytic activity	GO:0043085	118	0.012	Mouse
tendon development	GO:0035989	1	0.012
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.012
nucleobase containing compound catabolic process	GO:0034655	165	0.012

dlg1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.074
nervous system disease	DOID:863	0.074
musculoskeletal system disease	DOID:17	0.015
bone disease	DOID:0080001	0.015
connective tissue disease	DOID:65	0.015
bone development disease	DOID:0080006	0.015
brachydactyly	DOID:0050581	0.015
dysostosis	DOID:1934	0.015

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