IMP: Integrative Multi-species Prediction

Drosophila melanogaster

111 known processes

Vha55 (Dmel_CG17369)

Vacuolar H[+]-ATPase 55kD B subunit

(Aliases: CG17369,SzA,Dmel\CG17369,1208/13,vha55,l(3)j2E9,l(3)87Ca,VAT-2,l(3)SzA,V-ATPase)

Entrez: 41550
FLYBASE: FBgn0005671
UniProtKB: E1JIJ5
UniProtKB: P31409

Process Predictions
Disease Predictions

Vha55 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
ph reduction	GO:0045851	7	0.579
ion transmembrane transport	GO:0034220	122	0.546
ion transport	GO:0006811	145	0.518
endomembrane system organization	GO:0010256	119	0.491
negative regulation of biosynthetic process	GO:0009890	277	0.449
proton transport	GO:0015992	7	0.421
endosomal transport	GO:0016197	44	0.386
intracellular ph reduction	GO:0051452	7	0.360
establishment of localization in cell	GO:0051649	402	0.330
regulation of catabolic process	GO:0009894	170	0.322
phosphorylation	GO:0016310	294	0.320
retina development in camera type eye	GO:0060041	4	0.297
appendage development	GO:0048736	401	0.295
growth	GO:0040007	359	0.266
regulation of ph	GO:0006885	7	0.244
small molecule metabolic process	GO:0044281	305	0.236
wing disc morphogenesis	GO:0007472	344	0.223
cation transport	GO:0006812	110	0.220
regulation of intracellular signal transduction	GO:1902531	236	0.210
molting cycle	GO:0042303	56	0.197
intracellular transport	GO:0046907	228	0.193
imaginal disc growth	GO:0007446	37	0.186
tube development	GO:0035295	244	0.179
imaginal disc derived wing morphogenesis	GO:0007476	337	0.176
death	GO:0016265	284	0.174	Worm
appendage morphogenesis	GO:0035107	397	0.172
regulation of multicellular organismal development	GO:2000026	414	0.162
negative regulation of transcription dna templated	GO:0045892	237	0.162
regulation of transport	GO:0051049	181	0.158
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.150
camera type eye development	GO:0043010	4	0.149
organic substance transport	GO:0071702	257	0.149
metal ion transport	GO:0030001	74	0.138
inorganic cation transmembrane transport	GO:0098662	61	0.132
catabolic process	GO:0009056	409	0.131
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.121
oxoacid metabolic process	GO:0043436	103	0.118
regulation of localization	GO:0032879	275	0.117
embryo development ending in birth or egg hatching	GO:0009792	152	0.117	Worm
single organism intracellular transport	GO:1902582	207	0.108
tissue morphogenesis	GO:0048729	297	0.108
regulation of cell differentiation	GO:0045595	302	0.103
single organism cellular localization	GO:1902580	180	0.102
mitotic spindle organization	GO:0007052	220	0.102
response to abiotic stimulus	GO:0009628	341	0.101	Worm
post embryonic appendage morphogenesis	GO:0035120	385	0.101
transcription from rna polymerase ii promoter	GO:0006366	368	0.099
purine nucleotide catabolic process	GO:0006195	109	0.099
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.098
secretion	GO:0046903	109	0.093
spindle organization	GO:0007051	253	0.092
purine ribonucleoside metabolic process	GO:0046128	127	0.089
organic substance catabolic process	GO:1901575	308	0.088
regulation of protein metabolic process	GO:0051246	256	0.088
nucleotide catabolic process	GO:0009166	109	0.080
positive regulation of catabolic process	GO:0009896	105	0.079
organ growth	GO:0035265	56	0.075
nuclear import	GO:0051170	51	0.075
purine ribonucleotide metabolic process	GO:0009150	145	0.073
regulation of programmed cell death	GO:0043067	152	0.071	Worm
vesicle mediated transport	GO:0016192	381	0.069
rna localization	GO:0006403	115	0.069
atp metabolic process	GO:0046034	49	0.068
positive regulation of growth	GO:0045927	75	0.068
endocytosis	GO:0006897	310	0.068
endosome organization	GO:0007032	9	0.068
macromolecule catabolic process	GO:0009057	161	0.066
cation homeostasis	GO:0055080	51	0.066
organonitrogen compound metabolic process	GO:1901564	318	0.065
axis specification	GO:0009798	167	0.064
purine ribonucleotide catabolic process	GO:0009154	109	0.064
body morphogenesis	GO:0010171	2	0.063
purine nucleotide metabolic process	GO:0006163	146	0.063
establishment of tissue polarity	GO:0007164	87	0.062
cellular metal ion homeostasis	GO:0006875	31	0.062	Yeast
establishment of protein localization	GO:0045184	163	0.061
response to organic substance	GO:0010033	284	0.060
nucleoside phosphate catabolic process	GO:1901292	110	0.059
imaginal disc derived appendage development	GO:0048737	399	0.057
proteolysis	GO:0006508	192	0.056
cation transmembrane transport	GO:0098655	88	0.056
cell junction assembly	GO:0034329	42	0.056
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.053
nucleoside metabolic process	GO:0009116	127	0.053
negative regulation of gene expression	GO:0010629	387	0.052
cellular ion homeostasis	GO:0006873	39	0.052
kidney development	GO:0001822	3	0.051
nucleoside triphosphate catabolic process	GO:0009143	108	0.049
neurological system process	GO:0050877	358	0.049
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.048
lipid modification	GO:0030258	24	0.048
purine ribonucleoside catabolic process	GO:0046130	112	0.048
eye development	GO:0001654	323	0.047
response to oxygen containing compound	GO:1901700	200	0.047
epithelial cell differentiation	GO:0030855	322	0.047
response to unfolded protein	GO:0006986	9	0.046
single organism membrane organization	GO:0044802	93	0.046
regulation of protein localization	GO:0032880	76	0.044
cellular response to chemical stimulus	GO:0070887	199	0.044
regulation of hydrolase activity	GO:0051336	97	0.044
inorganic ion transmembrane transport	GO:0098660	73	0.044
single organism catabolic process	GO:0044712	228	0.043
developmental growth	GO:0048589	280	0.043
actin cytoskeleton organization	GO:0030036	206	0.043
developmental maturation	GO:0021700	172	0.043
glycosyl compound catabolic process	GO:1901658	112	0.043
cellular catabolic process	GO:0044248	372	0.043
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.043
nucleobase containing compound catabolic process	GO:0034655	165	0.043
nucleoside triphosphate metabolic process	GO:0009141	120	0.043
secretion by cell	GO:0032940	101	0.043
negative regulation of cell cycle	GO:0045786	116	0.042
regulation of growth	GO:0040008	233	0.042
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.042
negative regulation of developmental process	GO:0051093	201	0.041
protein modification process	GO:0036211	438	0.040
cellular protein modification process	GO:0006464	438	0.040
positive regulation of response to stimulus	GO:0048584	323	0.040
purine nucleoside metabolic process	GO:0042278	127	0.039
glycosyl compound metabolic process	GO:1901657	127	0.039
sensory perception of sound	GO:0007605	56	0.039
gastrulation	GO:0007369	70	0.038
ribonucleotide metabolic process	GO:0009259	145	0.038
cell cell junction organization	GO:0045216	55	0.038
positive regulation of multicellular organismal process	GO:0051240	143	0.038
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.037
nucleoside catabolic process	GO:0009164	112	0.037
negative regulation of cellular metabolic process	GO:0031324	382	0.036
ribonucleoside metabolic process	GO:0009119	127	0.036
multicellular organismal aging	GO:0010259	140	0.036
regulation of cellular protein metabolic process	GO:0032268	243	0.035
negative regulation of epithelial cell proliferation	GO:0050680	4	0.034
carboxylic acid metabolic process	GO:0019752	92	0.034
protein localization	GO:0008104	284	0.033
eye morphogenesis	GO:0048592	260	0.032
transmembrane transport	GO:0055085	139	0.032
morphogenesis of an epithelium	GO:0002009	276	0.032
ribonucleotide catabolic process	GO:0009261	109	0.032
cellular divalent inorganic cation homeostasis	GO:0072503	23	0.032	Yeast
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.032
g2 dna damage checkpoint	GO:0031572	69	0.032
regulation of protein transport	GO:0051223	57	0.031
apical junction assembly	GO:0043297	32	0.031
negative regulation of cellular biosynthetic process	GO:0031327	277	0.031
regulation of molecular function	GO:0065009	217	0.031
protein targeting to nucleus	GO:0044744	51	0.030
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.030
embryonic morphogenesis	GO:0048598	206	0.030
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.030
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.030
regulation of hormone levels	GO:0010817	40	0.029
cell death	GO:0008219	279	0.029	Worm
lipid biosynthetic process	GO:0008610	46	0.029
basement membrane organization	GO:0071711	10	0.029
metal ion homeostasis	GO:0055065	44	0.028	Yeast
ribose phosphate metabolic process	GO:0019693	145	0.028
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.028
cellular macromolecule localization	GO:0070727	220	0.028
regulation of phosphorus metabolic process	GO:0051174	210	0.028
heterocycle catabolic process	GO:0046700	166	0.027
autophagy	GO:0006914	108	0.026
positive regulation of signaling	GO:0023056	243	0.026
membrane organization	GO:0061024	112	0.025
regulation of cell cycle process	GO:0010564	181	0.025
tube morphogenesis	GO:0035239	191	0.025
positive regulation of programmed cell death	GO:0043068	62	0.024	Worm
response to wounding	GO:0009611	94	0.024
regulation of cellular catabolic process	GO:0031329	157	0.024
regulation of hemocyte proliferation	GO:0035206	37	0.023
regulation of wnt signaling pathway	GO:0030111	68	0.023
regulation of notch signaling pathway	GO:0008593	100	0.023
organic cyclic compound catabolic process	GO:1901361	168	0.023
muscle organ development	GO:0007517	127	0.023
epidermis development	GO:0008544	65	0.023
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.023
nucleoside phosphate metabolic process	GO:0006753	162	0.022
nucleocytoplasmic transport	GO:0006913	72	0.022
protein import into nucleus	GO:0006606	51	0.021
regulation of catalytic activity	GO:0050790	185	0.021
vacuolar acidification	GO:0007035	4	0.021
golgi organization	GO:0007030	66	0.021
mitochondrion organization	GO:0007005	65	0.021
extracellular matrix organization	GO:0030198	32	0.021
compound eye morphogenesis	GO:0001745	249	0.020
pigmentation	GO:0043473	75	0.020
cell proliferation	GO:0008283	299	0.020
regulation of phosphorylation	GO:0042325	147	0.020
organic acid metabolic process	GO:0006082	103	0.020
peptide metabolic process	GO:0006518	80	0.020
notch signaling pathway	GO:0007219	120	0.020
positive regulation of signal transduction	GO:0009967	223	0.020
regulation of anatomical structure morphogenesis	GO:0022603	242	0.020	Worm
cellular monovalent inorganic cation homeostasis	GO:0030004	7	0.020
organophosphate catabolic process	GO:0046434	112	0.020
aging	GO:0007568	143	0.019
cellular response to decreased oxygen levels	GO:0036294	30	0.019
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.019
cellular nitrogen compound catabolic process	GO:0044270	165	0.019
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.019
mitotic g2 dna damage checkpoint	GO:0007095	69	0.019
positive regulation of cellular amine metabolic process	GO:0033240	0	0.019
regulation of protein modification process	GO:0031399	112	0.019
regulation of nucleoside metabolic process	GO:0009118	50	0.019
protein transport	GO:0015031	155	0.018
anterior posterior pattern specification	GO:0009952	136	0.018
establishment of planar polarity	GO:0001736	87	0.018
modification dependent protein catabolic process	GO:0019941	78	0.018
neuroblast proliferation	GO:0007405	74	0.018
cellular homeostasis	GO:0019725	80	0.018
modification dependent macromolecule catabolic process	GO:0043632	79	0.018
ion homeostasis	GO:0050801	55	0.017
establishment of rna localization	GO:0051236	47	0.017
molting cycle chitin based cuticle	GO:0007591	56	0.017
programmed cell death	GO:0012501	257	0.017	Worm
urogenital system development	GO:0001655	72	0.017
lipid localization	GO:0010876	54	0.017
central nervous system development	GO:0007417	201	0.017
cellular cation homeostasis	GO:0030003	38	0.017
cell junction organization	GO:0034330	57	0.017
hydrogen ion transmembrane transport	GO:1902600	5	0.017
mapk cascade	GO:0000165	107	0.017
positive regulation of phosphate metabolic process	GO:0045937	139	0.017
regulation of phosphatase activity	GO:0010921	3	0.016
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.016
regulation of secretion by cell	GO:1903530	39	0.016
purine containing compound catabolic process	GO:0072523	112	0.016
regulation of phosphate metabolic process	GO:0019220	210	0.016
striated muscle myosin thick filament assembly	GO:0071688	3	0.016
gastrulation with mouth forming first	GO:0001703	36	0.016
olfactory behavior	GO:0042048	97	0.016
smoothened signaling pathway	GO:0007224	49	0.016
regulation of cellular localization	GO:0060341	136	0.016
negative regulation of rna biosynthetic process	GO:1902679	240	0.016
cellular chemical homeostasis	GO:0055082	40	0.016
cellular macromolecule catabolic process	GO:0044265	136	0.015
sterol homeostasis	GO:0055092	4	0.015
regulation of cellular ketone metabolic process	GO:0010565	3	0.015
negative regulation of multicellular organismal process	GO:0051241	142	0.015
larval development	GO:0002164	104	0.015	Worm
monovalent inorganic cation transport	GO:0015672	40	0.015
epithelial tube morphogenesis	GO:0060562	88	0.015
response to topologically incorrect protein	GO:0035966	10	0.015
blastoderm segmentation	GO:0007350	159	0.015
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.015
digestive system development	GO:0055123	149	0.014
positive regulation of catalytic activity	GO:0043085	118	0.014
negative regulation of cell proliferation	GO:0008285	69	0.014
cholesterol homeostasis	GO:0042632	3	0.014
carbohydrate derivative catabolic process	GO:1901136	118	0.014
apoptotic process	GO:0006915	159	0.014	Worm
regulation of establishment of protein localization	GO:0070201	61	0.014
purine containing compound metabolic process	GO:0072521	155	0.014
organonitrogen compound catabolic process	GO:1901565	128	0.014
protein catabolic process	GO:0030163	101	0.014
regulation of cell proliferation	GO:0042127	163	0.014
cytoplasmic transport	GO:0016482	130	0.014
lateral inhibition	GO:0046331	206	0.013
chemical homeostasis	GO:0048878	92	0.013
regulation of cellular amine metabolic process	GO:0033238	3	0.013
determination of left right symmetry	GO:0007368	9	0.013
organophosphate metabolic process	GO:0019637	195	0.013
positive regulation of gtp catabolic process	GO:0033126	43	0.013
maintenance of location	GO:0051235	73	0.013
positive regulation of developmental process	GO:0051094	143	0.013
embryonic hindgut morphogenesis	GO:0048619	48	0.013
negative regulation of growth	GO:0045926	84	0.013
segmentation	GO:0035282	207	0.013
regulation of apoptotic process	GO:0042981	130	0.013
regulation of steroid metabolic process	GO:0019218	2	0.012
glial cell development	GO:0021782	27	0.012
purine nucleoside catabolic process	GO:0006152	112	0.012
developmental pigmentation	GO:0048066	68	0.012
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.012
energy derivation by oxidation of organic compounds	GO:0015980	32	0.012
single organism biosynthetic process	GO:0044711	206	0.012
organelle assembly	GO:0070925	198	0.012
protein complex biogenesis	GO:0070271	201	0.012	Yeast
negative regulation of cell cycle process	GO:0010948	109	0.012
pigment granule organization	GO:0048753	12	0.012
homeostatic process	GO:0042592	199	0.012
morphogenesis of a branching structure	GO:0001763	45	0.012
protein maturation	GO:0051604	71	0.012
cognition	GO:0050890	141	0.012
embryonic axis specification	GO:0000578	107	0.012
acyl coa metabolic process	GO:0006637	3	0.012
myosin filament organization	GO:0031033	5	0.012
cellular protein localization	GO:0034613	160	0.012
protein ubiquitination	GO:0016567	70	0.012
negative regulation of nervous system development	GO:0051961	92	0.012
xenobiotic transport	GO:0042908	1	0.011
monocarboxylic acid metabolic process	GO:0032787	29	0.011
cellular response to organic substance	GO:0071310	132	0.011
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.011
gliogenesis	GO:0042063	80	0.011
nucleoside monophosphate metabolic process	GO:0009123	52	0.011
regulation of secretion	GO:0051046	44	0.011
mitotic nuclear division	GO:0007067	213	0.011
response to oxygen levels	GO:0070482	59	0.011	Worm
actin filament based process	GO:0030029	220	0.011
sulfur compound metabolic process	GO:0006790	59	0.011
positive regulation of cell communication	GO:0010647	250	0.011
stem cell differentiation	GO:0048863	117	0.011
response to organic cyclic compound	GO:0014070	89	0.011
long term memory	GO:0007616	62	0.011
anterior posterior axis specification	GO:0009948	109	0.011
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.010
aromatic compound catabolic process	GO:0019439	166	0.010
response to hypoxia	GO:0001666	53	0.010	Worm
developmental growth involved in morphogenesis	GO:0060560	65	0.010
regulation of cell death	GO:0010941	173	0.010	Worm
cellular ketone metabolic process	GO:0042180	24	0.010
regulation of protein import into nucleus	GO:0042306	28	0.010
muscle attachment	GO:0016203	36	0.010
cellular response to ethanol	GO:0071361	4	0.010
substrate adhesion dependent cell spreading	GO:0034446	2	0.010
positive regulation of gtpase activity	GO:0043547	43	0.010
positive regulation of cell motility	GO:2000147	3	0.010
positive regulation of cellular catabolic process	GO:0031331	95	0.010
hindbrain development	GO:0030902	2	0.010

Vha55 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.145
disease of cellular proliferation	DOID:14566	0.048
cancer	DOID:162	0.041
organ system cancer	DOID:0050686	0.041
nervous system disease	DOID:863	0.037
urinary system disease	DOID:18	0.022
renal tubular transport disease	DOID:447	0.022
kidney disease	DOID:557	0.022

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