Drosophila melanogaster

90 known processes

Uba1 (Dmel_CG1782)

Ubiquitin activating enzyme 1

(Aliases: Dmel\CG1782,l(2)s3484,CG1782,uba1,Uba 1,l(2)05642,DmUba1,uba-1,l(2)03405,UBA-1,E1,2/31)

Uba1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of neuroblast proliferationGO:0007406270.837
modification dependent macromolecule catabolic processGO:0043632790.825
Mouse
negative regulation of neural precursor cell proliferationGO:2000178270.787
agingGO:00075681430.765
cell proliferationGO:00082832990.731
cellular protein localizationGO:00346131600.719
regulation of cell differentiationGO:00455953020.702
purine containing compound catabolic processGO:00725231120.692
purine ribonucleoside metabolic processGO:00461281270.653
cellular protein modification processGO:00064644380.599
central nervous system developmentGO:00074172010.595
purine ribonucleoside triphosphate catabolic processGO:00092071080.594
cellular macromolecule catabolic processGO:00442651360.578
Mouse
glycosyl compound metabolic processGO:19016571270.568
protein complex assemblyGO:00064612000.542
regulation of molecular functionGO:00650092170.513
protein localizationGO:00081042840.511
purine nucleotide catabolic processGO:00061951090.509
embryo development ending in birth or egg hatchingGO:00097921520.508
Worm
purine ribonucleotide catabolic processGO:00091541090.487
regulation of phosphorus metabolic processGO:00511742100.482
endocytosisGO:00068973100.479
Worm
protein modification processGO:00362114380.476
purine nucleoside triphosphate metabolic processGO:00091441190.470
organic substance transportGO:00717022570.466
nuclear divisionGO:00002803320.455
regulation of multicellular organismal developmentGO:20000264140.444
immune system processGO:00023763470.430
ubiquitin dependent protein catabolic processGO:0006511780.426
cytoplasmic transportGO:00164821300.404
regulation of anatomical structure sizeGO:00900661630.396
response to other organismGO:00517072930.390
regulation of cellular protein metabolic processGO:00322682430.381
determination of adult lifespanGO:00083401370.380
nucleotide catabolic processGO:00091661090.366
nucleoside triphosphate catabolic processGO:00091431080.361
organophosphate metabolic processGO:00196371950.359
regulation of cell developmentGO:00602842150.358
protein targetingGO:0006605640.354
regulation of mitotic cell cycleGO:00073461900.352
organelle fissionGO:00482853400.346
regulation of cellular catabolic processGO:00313291570.344
purine nucleoside metabolic processGO:00422781270.342
macromolecular complex assemblyGO:00650032560.322
protein modification by small protein conjugation or removalGO:00706471060.322
establishment of protein localizationGO:00451841630.319
regulation of immune system processGO:00026821760.315
cellular macromolecular complex assemblyGO:00346221530.313
axonogenesisGO:00074092900.307
Zebrafish
purine ribonucleoside triphosphate metabolic processGO:00092051190.305
regulation of catalytic activityGO:00507901850.303
nucleoside metabolic processGO:00091161270.302
organic substance catabolic processGO:19015753080.288
Mouse
ribonucleoside triphosphate metabolic processGO:00091991190.286
purine ribonucleotide metabolic processGO:00091501450.283
ribonucleoside triphosphate catabolic processGO:00092031080.278
ribonucleotide catabolic processGO:00092611090.273
purine nucleoside catabolic processGO:00061521120.269
developmental growthGO:00485892800.266
regulation of protein modification processGO:00313991120.265
regulation of cell cycleGO:00517262910.263
response to external biotic stimulusGO:00432072930.259
organic cyclic compound catabolic processGO:19013611680.259
glycosyl compound catabolic processGO:19016581120.251
nucleoside phosphate catabolic processGO:19012921100.250
multicellular organismal agingGO:00102591400.244
cellular protein complex assemblyGO:0043623710.243
deathGO:00162652840.240
regulation of organelle organizationGO:00330431960.239
dna damage checkpointGO:0000077780.217
purine ribonucleoside catabolic processGO:00461301120.215
negative regulation of cell proliferationGO:0008285690.212
proteolysisGO:00065081920.210
Mouse
protein complex biogenesisGO:00702712010.210
cellular nitrogen compound catabolic processGO:00442701650.206
ribonucleotide metabolic processGO:00092591450.201
regulation of neurogenesisGO:00507671580.197
eye developmentGO:00016543230.196
heterocycle catabolic processGO:00467001660.195
mitotic dna integrity checkpointGO:0044774750.192
response to organic substanceGO:00100332840.192
protein transportGO:00150311550.189
nucleoside catabolic processGO:00091641120.184
intracellular protein transportGO:00068861040.182
regulation of neural precursor cell proliferationGO:2000177350.181
catabolic processGO:00090564090.179
regulation of cell cycle phase transitionGO:19019871300.175
immune responseGO:00069552460.174
regulation of cell proliferationGO:00421271630.170
organophosphate catabolic processGO:00464341120.167
eye morphogenesisGO:00485922600.165
defense response to other organismGO:00985422250.164
regulation of protein metabolic processGO:00512462560.162
establishment of localization in cellGO:00516494020.161
rna interferenceGO:0016246270.161
apoptotic processGO:00069151590.157
Worm
dna integrity checkpointGO:0031570810.150
small molecule metabolic processGO:00442813050.149
cell divisionGO:00513012480.147
protein modification by small protein conjugationGO:0032446790.147
positive regulation of protein metabolic processGO:00512471280.145
sex differentiationGO:0007548810.144
Worm
mitotic dna damage checkpointGO:0044773740.144
mitotic cell cycle phase transitionGO:00447721380.143
regulation of phosphate metabolic processGO:00192202100.142
enzyme linked receptor protein signaling pathwayGO:00071671790.141
mitotic nuclear divisionGO:00070672130.141
salivary gland morphogenesisGO:00074351450.140
segmentationGO:00352822070.140
purine nucleotide metabolic processGO:00061631460.139
aromatic compound catabolic processGO:00194391660.134
modification dependent protein catabolic processGO:0019941780.132
Mouse
negative regulation of mitotic cell cycle phase transitionGO:19019911030.129
axon developmentGO:00615642970.128
Zebrafish
protein ubiquitinationGO:0016567700.127
negative regulation of cellular metabolic processGO:00313243820.127
regulation of localizationGO:00328792750.126
cell migrationGO:00164772380.126
ribose phosphate metabolic processGO:00196931450.125
tissue deathGO:00162711020.125
protein phosphorylationGO:00064681690.122
atp metabolic processGO:0046034490.119
regulation of cellular component sizeGO:0032535980.118
posttranscriptional regulation of gene expressionGO:00106081450.117
regulation of cellular amine metabolic processGO:003323830.117
circulatory system developmentGO:0072359820.116
purine containing compound metabolic processGO:00725211550.114
defense response to virusGO:0051607230.113
regulation of anatomical structure morphogenesisGO:00226032420.112
purine nucleoside triphosphate catabolic processGO:00091461080.111
ribonucleoside metabolic processGO:00091191270.110
gtp catabolic processGO:0006184720.109
posttranscriptional gene silencing by rnaGO:0035194450.108
negative regulation of developmental processGO:00510932010.105
growthGO:00400073590.103
proteolysis involved in cellular protein catabolic processGO:0051603830.103
Mouse
macromolecular complex disassemblyGO:0032984370.103
cell deathGO:00082192790.102
regulation of neuroblast proliferationGO:1902692340.101
multicellular organismal reproductive behaviorGO:00330571100.099
regulation of cytoskeleton organizationGO:0051493890.098
regulation of catabolic processGO:00098941700.097
regulation of small gtpase mediated signal transductionGO:0051056930.097
regulation of cell deathGO:00109411730.096
negative regulation of stem cell proliferationGO:2000647300.093
mitotic g2 m transition checkpointGO:0044818700.093
posttranscriptional gene silencingGO:0016441460.092
carbohydrate derivative catabolic processGO:19011361180.092
regulation of cell cycle processGO:00105641810.090
regulation of purine nucleotide metabolic processGO:1900542620.090
programmed cell deathGO:00125012570.090
cellular macromolecule localizationGO:00707272200.086
response to biotic stimulusGO:00096072940.086
sensory organ morphogenesisGO:00905962600.083
positive regulation of cellular protein metabolic processGO:00322701180.083
response to abiotic stimulusGO:00096283410.082
gene silencing by rnaGO:0031047570.082
nucleobase containing small molecule metabolic processGO:00550861740.081
reproductive system developmentGO:0061458740.080
dna repairGO:0006281540.080
regulation of mitotic cell cycle phase transitionGO:19019901300.080
single organism catabolic processGO:00447122280.079
defense response to gram negative bacteriumGO:0050829940.077
ribonucleoside catabolic processGO:00424541120.075
response to ionizing radiationGO:0010212320.075
vesicle mediated transportGO:00161923810.075
Worm
negative regulation of mitotic cell cycleGO:00459301090.074
regulation of nervous system developmentGO:00519602480.073
intracellular signal transductionGO:00355563000.073
positive regulation of protein modification processGO:0031401580.072
positive regulation of molecular functionGO:00440931360.072
embryonic pattern specificationGO:00098801740.072
multi organism reproductive behaviorGO:00447051210.071
neuron maturationGO:0042551310.071
cell maturationGO:00484691440.071
gonad developmentGO:0008406500.070
mitotic spindle organizationGO:00070522200.070
positive regulation of phosphorus metabolic processGO:00105621390.069
single organism cellular localizationGO:19025801800.069
regulation of stem cell proliferationGO:0072091400.069
guanosine containing compound catabolic processGO:1901069740.068
exocrine system developmentGO:00352721620.067
regulation of programmed cell deathGO:00430671520.067
double strand break repairGO:0006302260.065
dna metabolic processGO:00062592270.065
nucleoside triphosphate metabolic processGO:00091411200.065
positive regulation of endopeptidase activityGO:0010950260.064
protein targeting to nucleusGO:0044744510.064
regulation of response to biotic stimulusGO:0002831630.064
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.063
regulation of intracellular signal transductionGO:19025312360.063
multi organism behaviorGO:00517051750.063
positive regulation of phosphate metabolic processGO:00459371390.061
spindle organizationGO:00070512530.061
cell motilityGO:00488702510.060
regulation of establishment of protein localizationGO:0070201610.060
ribonucleoside monophosphate metabolic processGO:0009161510.060
stem cell differentiationGO:00488631170.060
nucleoside phosphate metabolic processGO:00067531620.059
reproductive structure developmentGO:0048608740.058
salivary gland developmentGO:00074311620.058
regulation of growthGO:00400082330.058
regulation of gene expression epigeneticGO:00400291280.058
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.057
eye photoreceptor cell differentiationGO:00017541450.056
cellular component disassemblyGO:0022411460.055
establishment of protein localization to organelleGO:0072594620.054
protein catabolic processGO:00301631010.054
Mouse
dendrite developmentGO:00163582040.054
response to oxygen containing compoundGO:19017002000.053
multi multicellular organism processGO:00447061230.052
organonitrogen compound catabolic processGO:19015651280.052
cell cycle phase transitionGO:00447701400.051
cell cycle checkpointGO:0000075950.050
g2 dna damage checkpointGO:0031572690.049
regulation of apoptotic processGO:00429811300.049
single organism nuclear importGO:1902593510.048
body morphogenesisGO:001017120.047
negative regulation of cell cycleGO:00457861160.046
negative regulation of cell cycle phase transitionGO:19019881030.046
development of primary sexual characteristicsGO:0045137500.046
single organism membrane organizationGO:0044802930.045
protein import into nucleusGO:0006606510.045
nucleotide metabolic processGO:00091171610.044
carbohydrate derivative metabolic processGO:19011352170.044
cellular amino acid metabolic processGO:0006520610.044
cellular response to chemical stimulusGO:00708871990.044
taxisGO:00423303040.044
cellular response to dna damage stimulusGO:00069742230.042
Human
regulation of purine nucleotide catabolic processGO:0033121480.041
negative regulation of multicellular organismal processGO:00512411420.040
cellular protein catabolic processGO:0044257830.040
Mouse
defense responseGO:00069523000.040
negative regulation of cellular protein metabolic processGO:0032269850.040
developmental programmed cell deathGO:00106231380.040
spindle assemblyGO:0051225800.039
regulation of cell sizeGO:0008361630.039
positive regulation of protein catabolic processGO:0045732340.039
phagocytosisGO:00069092150.038
positive regulation of response to stimulusGO:00485843230.038
purine nucleoside monophosphate metabolic processGO:0009126500.038
blastoderm segmentationGO:00073501590.038
epidermis developmentGO:0008544650.038
single organism intracellular transportGO:19025822070.038
negative regulation of biosynthetic processGO:00098902770.037
cellular response to dsrnaGO:0071359150.037
scf dependent proteasomal ubiquitin dependent protein catabolic processGO:003114610.037
positive regulation of cellular component organizationGO:00511301560.036
protein importGO:0017038550.035
organelle assemblyGO:00709251980.034
chemotaxisGO:00069352490.034
guanosine containing compound metabolic processGO:1901068740.033
axon guidanceGO:00074112330.033
regulation of meiosisGO:004002030.033
negative regulation of cytoskeleton organizationGO:0051494300.032
regulation of protein phosphorylationGO:0001932640.032
response to nitrogen compoundGO:1901698900.032
localization of cellGO:00516742570.031
purine nucleoside monophosphate catabolic processGO:0009128380.031
positive regulation of transportGO:0051050920.030
mitotic g2 dna damage checkpointGO:0007095690.030
negative regulation of neurogenesisGO:0050768530.030
stem cell proliferationGO:0072089880.030
chromosome segregationGO:00070591570.030
positive regulation of cellular amine metabolic processGO:003324000.030
nucleobase containing compound catabolic processGO:00346551650.030
ribonucleoside monophosphate catabolic processGO:0009158390.030
camera type eye morphogenesisGO:004859320.029
negative regulation of macromolecule biosynthetic processGO:00105582700.029
neurological system processGO:00508773580.029
Worm
regulation of dna bindingGO:0051101100.029
gene silencingGO:00164581380.029
regulation of nucleotide metabolic processGO:0006140620.029
regulation of developmental growthGO:00486381740.029
gliogenesisGO:0042063800.028
protein complex disassemblyGO:0043241360.028
membrane organizationGO:00610241120.028
chromosome organizationGO:00512763600.028
cardiovascular system developmentGO:0072358820.028
cell recognitionGO:00080371020.027
telencephalon developmentGO:002153720.027
regionalizationGO:00030024160.026
proteasome assemblyGO:004324820.026
positive regulation of cellular component biogenesisGO:0044089800.026
larval developmentGO:00021641040.025
Worm
regulation of response to external stimulusGO:00321011150.025
neural precursor cell proliferationGO:0061351750.025
positive regulation of developmental growthGO:0048639620.025
mesenchymal cell developmentGO:001403110.024
nuclear transportGO:0051169720.024
response to sterolGO:0036314340.024
response to radiationGO:00093141550.024
purine ribonucleoside monophosphate metabolic processGO:0009167500.024
cellular catabolic processGO:00442483720.023
positive regulation of catabolic processGO:00098961050.023
neuron remodelingGO:0016322290.023
positive regulation of cellular catabolic processGO:0031331950.022
negative regulation of cell cycle processGO:00109481090.022
lamellipodium organizationGO:0097581210.022
negative regulation of response to stimulusGO:00485852580.022
regulation of protein dephosphorylationGO:003530450.021
negative regulation of cell communicationGO:00106482230.021
nuclear importGO:0051170510.021
anterior posterior pattern specificationGO:00099521360.021
atp catabolic processGO:0006200380.021
amine metabolic processGO:0009308120.020
regulation of cell morphogenesisGO:00226041630.020
negative regulation of phosphate metabolic processGO:0045936450.020
cellular amine metabolic processGO:0044106120.020
purine ribonucleoside monophosphate catabolic processGO:0009169380.020
response to virusGO:0009615280.019
negative regulation of protein metabolic processGO:0051248850.019
regulation of microtubule cytoskeleton organizationGO:0070507410.019
response to woundingGO:0009611940.019
gland morphogenesisGO:00226121450.019
organonitrogen compound metabolic processGO:19015643180.019
regulation of actin filament lengthGO:0030832270.019
female germ line cyst formationGO:0048135420.019
macromolecule catabolic processGO:00090571610.019
Mouse
regulation of cellular component biogenesisGO:00440872010.018
receptor mediated endocytosisGO:0006898210.018
Worm
immune system developmentGO:0002520570.018
translationGO:0006412690.018
sister chromatid segregationGO:0000819920.017
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.017
regulation of intracellular protein transportGO:0033157460.017
gtp metabolic processGO:0046039720.017
regulation of protein stabilityGO:0031647430.017
columnar cuboidal epithelial cell differentiationGO:00020652560.017
positive regulation of cell differentiationGO:0045597640.017
actin filament polymerizationGO:0030041270.017
histone ubiquitinationGO:001657440.017
regulation of translationGO:0006417560.017
peptidyl amino acid modificationGO:00181931050.017
regulation of nucleoside metabolic processGO:0009118500.017
regulation of protein complex assemblyGO:0043254420.016
negative regulation of transcription dna templatedGO:00458922370.016
homeostatic processGO:00425921990.016
photoreceptor cell developmentGO:0042461960.016
response to bacteriumGO:00096171980.016
disaccharide metabolic processGO:000598440.016
positive regulation of apoptotic processGO:0043065470.016
mesenchymal cell differentiationGO:004876210.016
regulation of protein catabolic processGO:0042176550.015
compound eye photoreceptor cell differentiationGO:00017511400.015
response to dsrnaGO:0043331150.015
response to gamma radiationGO:0010332170.015
compound eye morphogenesisGO:00017452490.015
gland developmentGO:00487321910.015
cellular response to oxygen containing compoundGO:1901701790.015
protein polymerizationGO:0051258420.015
cellular protein complex disassemblyGO:0043624350.015
negative regulation of molecular functionGO:0044092510.014
oocyte microtubule cytoskeleton organizationGO:0016325350.014
positive regulation of nitrogen compound metabolic processGO:00511733540.014
negative regulation of cellular component organizationGO:00511291080.014
eye antennal disc developmentGO:0035214600.014
positive regulation of developmental processGO:00510941430.014
regulation of mitosisGO:0007088560.014
epithelial cell differentiationGO:00308553220.014
ncrna metabolic processGO:0034660430.013
salivary gland histolysisGO:0035070880.013
actin polymerization or depolymerizationGO:0008154310.013
positive regulation of cellular amino acid metabolic processGO:004576400.013
innate immune responseGO:00450871440.013
nucleoside monophosphate catabolic processGO:0009125390.013
germarium derived female germ line cyst formationGO:0030727420.013
rna catabolic processGO:0006401370.013
positive regulation of multicellular organismal processGO:00512401430.013
negative regulation of catalytic activityGO:0043086420.013
cellular ketone metabolic processGO:0042180240.013
regulation of actin cytoskeleton organizationGO:0032956420.013
regulation of transportGO:00510491810.013
positive regulation of cell deathGO:0010942690.013
regulation of protein localizationGO:0032880760.012
regulation of response to gamma radiationGO:200122840.012
histolysisGO:00075591020.012
regulation of cellular ketone metabolic processGO:001056530.012
positive regulation of purine nucleotide metabolic processGO:1900544550.012
glial cell differentiationGO:0010001350.012
establishment of protein localization to membraneGO:0090150110.012
regulation of insulin receptor signaling pathwayGO:0046626170.012
negative regulation of cell developmentGO:0010721620.012
regulation of defense responseGO:00313471020.012
regulation of cell morphogenesis involved in differentiationGO:0010769610.012
primary mirna processingGO:003105350.012
negative regulation of phosphorus metabolic processGO:0010563450.012
retina morphogenesis in camera type eyeGO:006004220.012
regulation of gtpase activityGO:0043087440.012
smad protein import into nucleusGO:0007184110.012
wound healingGO:0042060750.012
embryonic heart tube developmentGO:0035050220.012
ribonucleoprotein complex subunit organizationGO:0071826280.012
nucleoside monophosphate metabolic processGO:0009123520.012
cell growthGO:00160491080.012
response to lipidGO:0033993380.012
response to endogenous stimulusGO:00097191190.012
regulation of hemocyte proliferationGO:0035206370.011
regulation of cell growthGO:0001558430.011
response to peptide hormoneGO:0043434290.011
lamellipodium assemblyGO:0030032210.011
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.011
apoptotic signaling pathwayGO:0097190270.011
mitotic sister chromatid segregationGO:0000070870.011
positive regulation of immune responseGO:0050778630.011
regulation of bindingGO:0051098160.011
jak stat cascadeGO:0007259490.011
appendage morphogenesisGO:00351073970.011
regulation of ras gtpase activityGO:0032318380.011
positive regulation of programmed cell deathGO:0043068620.011
dendrite morphogenesisGO:00488131990.011
response to alcoholGO:0097305950.011
positive regulation of catalytic activityGO:00430851180.010
negative regulation of cell differentiationGO:00455961430.010
nitrogen compound transportGO:0071705850.010
regulation of cellular response to insulin stimulusGO:1900076170.010
retina development in camera type eyeGO:006004140.010
humoral immune responseGO:00069591170.010
execution phase of apoptosisGO:009719470.010
hematopoietic or lymphoid organ developmentGO:0048534570.010
muscle structure developmentGO:00610612240.010
regulation of phosphorylationGO:00423251470.010
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436190.010
stem cell maintenanceGO:0019827670.010

Uba1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
benign neoplasmDOID:006007200.025
disease of cellular proliferationDOID:1456600.025
cancerDOID:16200.023
organ system cancerDOID:005068600.023
disease of anatomical entityDOID:700.019
nervous system diseaseDOID:86300.011