IMP: Integrative Multi-species Prediction

Drosophila melanogaster

176 known processes

Mhc (Dmel_CG17927)

Myosin heavy chain

(Aliases: Dmel\CG17927,mMHC,CG17927,l(2)36Ae,Bsh,Mrp,DmMHC,Sht,l(2)k10423,MRP,Dm II,MHC,Ifm(2)2,DroMII,Stp,Nup,FBgn0002741,sMHC,DROMHC,l(2)M66,mhc,ifm(2)2,Mhc36B,Myo)

FLYBASE: FBgn0086783
Entrez: 35007
UniProtKB: E1JHJ3
UniProtKB: E1JHJ4
UniProtKB: E1JHJ5
UniProtKB: M9NF46
UniProtKB: M9ND95
UniProtKB: M9NEP1
UniProtKB: M9NCU7
UniProtKB: P05661

Process Predictions
Disease Predictions

Mhc biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
sarcomere organization	GO:0045214	26	1.000
muscle structure development	GO:0061061	224	1.000
striated muscle tissue development	GO:0014706	27	0.993	Zebrafish Mouse
muscle organ development	GO:0007517	127	0.991
somatic muscle development	GO:0007525	66	0.987
muscle cell differentiation	GO:0042692	103	0.987
striated muscle cell differentiation	GO:0051146	90	0.977
myofibril assembly	GO:0030239	36	0.976
striated muscle cell development	GO:0055002	50	0.975
cell motility	GO:0048870	251	0.968
localization of cell	GO:0051674	257	0.957
actomyosin structure organization	GO:0031032	56	0.952
actin filament based process	GO:0030029	220	0.948
cell migration	GO:0016477	238	0.933
muscle tissue development	GO:0060537	30	0.933	Zebrafish Mouse
muscle cell development	GO:0055001	50	0.933
heart development	GO:0007507	82	0.933	Mouse
response to abiotic stimulus	GO:0009628	341	0.911	Rat
circulatory system development	GO:0072359	82	0.856	Mouse
muscle system process	GO:0003012	21	0.855
vesicle mediated transport	GO:0016192	381	0.830	Worm
regulation of cell differentiation	GO:0045595	302	0.799	Mouse
regulation of organelle organization	GO:0033043	196	0.739	Mouse
regulation of programmed cell death	GO:0043067	152	0.733
cardiovascular system development	GO:0072358	82	0.732	Mouse
cellular component assembly involved in morphogenesis	GO:0010927	151	0.719
skeletal muscle organ development	GO:0060538	48	0.718	Zebrafish Mouse
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.692
ameboidal type cell migration	GO:0001667	151	0.691
actin cytoskeleton organization	GO:0030036	206	0.674
dendrite development	GO:0016358	204	0.665
epithelium migration	GO:0090132	148	0.658
heart process	GO:0003015	37	0.637	Mouse
transmembrane transport	GO:0055085	139	0.608
muscle tissue morphogenesis	GO:0060415	2	0.573
ion transport	GO:0006811	145	0.560
circulatory system process	GO:0003013	37	0.548	Mouse
regionalization	GO:0003002	416	0.547	Zebrafish
regulation of cell proliferation	GO:0042127	163	0.546
skin development	GO:0043588	65	0.545
heart morphogenesis	GO:0003007	32	0.541
growth	GO:0040007	359	0.532	Mouse
actin filament organization	GO:0007015	126	0.527
epithelial cell development	GO:0002064	274	0.512
muscle contraction	GO:0006936	13	0.506
cell proliferation	GO:0008283	299	0.494
regulation of localization	GO:0032879	275	0.476
negative regulation of cellular metabolic process	GO:0031324	382	0.471
regulation of apoptotic process	GO:0042981	130	0.450
locomotory behavior	GO:0007626	176	0.448	Worm
muscle thin filament assembly	GO:0071689	5	0.408
regulation of cell adhesion	GO:0030155	27	0.402
response to oxygen levels	GO:0070482	59	0.392
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.384
cellular response to chemical stimulus	GO:0070887	199	0.358
divalent inorganic cation homeostasis	GO:0072507	29	0.353
apoptotic process	GO:0006915	159	0.349
striated muscle contraction	GO:0006941	5	0.346	Zebrafish Mouse
protein modification process	GO:0036211	438	0.346
regulation of cell death	GO:0010941	173	0.337
cardiac muscle tissue development	GO:0048738	9	0.337	Mouse
endocytosis	GO:0006897	310	0.336	Worm
connective tissue development	GO:0061448	3	0.331
regulation of cellular component movement	GO:0051270	42	0.330
response to endogenous stimulus	GO:0009719	119	0.329
regulation of cell development	GO:0060284	215	0.328	Mouse
cellular protein modification process	GO:0006464	438	0.323
head development	GO:0060322	135	0.318
regulation of blood circulation	GO:1903522	21	0.310	Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.299
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.297
camera type eye development	GO:0043010	4	0.276
synaptic transmission	GO:0007268	288	0.271
homeostatic process	GO:0042592	199	0.268
positive regulation of cellular component organization	GO:0051130	156	0.267
regulation of phosphorus metabolic process	GO:0051174	210	0.262	Mouse
cell death	GO:0008219	279	0.261
regulation of system process	GO:0044057	36	0.259	Mouse
embryo development ending in birth or egg hatching	GO:0009792	152	0.259	Zebrafish Mouse Worm
regulation of anatomical structure morphogenesis	GO:0022603	242	0.254	Mouse
hematopoietic or lymphoid organ development	GO:0048534	57	0.254
regulation of cellular component biogenesis	GO:0044087	201	0.246	Mouse
central nervous system development	GO:0007417	201	0.235
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.234
organelle assembly	GO:0070925	198	0.233
single organism intracellular transport	GO:1902582	207	0.229
positive regulation of macromolecule metabolic process	GO:0010604	405	0.226
male mating behavior	GO:0060179	70	0.224
muscle fiber development	GO:0048747	12	0.222	Zebrafish Mouse
positive regulation of gene expression	GO:0010628	290	0.215
negative regulation of signal transduction	GO:0009968	206	0.213
regulation of locomotion	GO:0040012	42	0.204
anatomical structure homeostasis	GO:0060249	97	0.202
establishment of localization in cell	GO:0051649	402	0.185
positive regulation of transcription dna templated	GO:0045893	266	0.182
cellular response to oxygen containing compound	GO:1901701	79	0.182
negative regulation of response to stimulus	GO:0048585	258	0.180
ion transmembrane transport	GO:0034220	122	0.176
immune system process	GO:0002376	347	0.175
columnar cuboidal epithelial cell development	GO:0002066	249	0.174
skeletal muscle adaptation	GO:0043501	1	0.172	Mouse
epithelial cell differentiation	GO:0030855	322	0.164
adult behavior	GO:0030534	137	0.164
regulation of cell motility	GO:2000145	23	0.164
mating	GO:0007618	120	0.161
chromosome organization	GO:0051276	360	0.159
skeletal myofibril assembly	GO:0014866	6	0.159
protein complex assembly	GO:0006461	200	0.158
positive regulation of cellular biosynthetic process	GO:0031328	316	0.156
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.156
positive regulation of cellular component biogenesis	GO:0044089	80	0.155
regulation of epithelial cell proliferation	GO:0050678	4	0.155
single organism behavior	GO:0044708	391	0.154
muscle organ morphogenesis	GO:0048644	7	0.154
larval somatic muscle development	GO:0007526	19	0.152
tissue migration	GO:0090130	155	0.149
stem cell differentiation	GO:0048863	117	0.149
wing disc morphogenesis	GO:0007472	344	0.141
ovarian follicle cell migration	GO:0007297	121	0.139
cellular protein complex assembly	GO:0043623	71	0.138
cardiocyte differentiation	GO:0035051	29	0.136	Mouse
imaginal disc derived appendage development	GO:0048737	399	0.136
heart contraction	GO:0060047	26	0.135	Mouse
positive regulation of cell proliferation	GO:0008284	47	0.133
response to organic substance	GO:0010033	284	0.133
regulation of cell migration	GO:0030334	22	0.133
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.132
epithelial cell migration	GO:0010631	148	0.131
eye development	GO:0001654	323	0.129
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.129
regulation of phosphate metabolic process	GO:0019220	210	0.128	Mouse
cellular response to organic substance	GO:0071310	132	0.128
blood circulation	GO:0008015	26	0.126	Mouse
positive regulation of transport	GO:0051050	92	0.124
regulation of cellular localization	GO:0060341	136	0.122
positive regulation of developmental process	GO:0051094	143	0.120
chemical homeostasis	GO:0048878	92	0.118
negative regulation of biosynthetic process	GO:0009890	277	0.115
positive regulation of cell differentiation	GO:0045597	64	0.112
negative regulation of gene expression	GO:0010629	387	0.109
small molecule metabolic process	GO:0044281	305	0.108
regulation of cellular amino acid metabolic process	GO:0006521	0	0.106
cation homeostasis	GO:0055080	51	0.106
reproductive behavior	GO:0019098	122	0.105	Worm
brain development	GO:0007420	120	0.105
response to nitrogen compound	GO:1901698	90	0.104
cation transmembrane transport	GO:0098655	88	0.103
response to hypoxia	GO:0001666	53	0.103
organelle localization	GO:0051640	148	0.102
tissue morphogenesis	GO:0048729	297	0.100
organic substance catabolic process	GO:1901575	308	0.099
digestive tract morphogenesis	GO:0048546	127	0.098
striated muscle adaptation	GO:0014888	1	0.096	Mouse
phagocytosis	GO:0006909	215	0.096
cytoplasmic transport	GO:0016482	130	0.096
chromatin organization	GO:0006325	207	0.095
post embryonic appendage morphogenesis	GO:0035120	385	0.095
skeletal muscle fiber development	GO:0048741	3	0.092	Zebrafish Mouse
cellular protein localization	GO:0034613	160	0.092
muscle attachment	GO:0016203	36	0.091
cellular macromolecule localization	GO:0070727	220	0.091
epidermis development	GO:0008544	65	0.090
cell type specific apoptotic process	GO:0097285	38	0.087
immune system development	GO:0002520	57	0.083
multi organism behavior	GO:0051705	175	0.083	Worm
response to wounding	GO:0009611	94	0.081
oocyte differentiation	GO:0009994	145	0.081
myotube cell development	GO:0014904	3	0.081	Zebrafish Mouse
protein phosphorylation	GO:0006468	169	0.081
multi multicellular organism process	GO:0044706	123	0.079	Worm
regulation of cellular ketone metabolic process	GO:0010565	3	0.078
appendage morphogenesis	GO:0035107	397	0.078
negative regulation of cellular biosynthetic process	GO:0031327	277	0.076
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.075
positive regulation of catalytic activity	GO:0043085	118	0.075
embryonic morphogenesis	GO:0048598	206	0.075
metal ion homeostasis	GO:0055065	44	0.074
regulation of cellular protein metabolic process	GO:0032268	243	0.074
positive regulation of rna metabolic process	GO:0051254	271	0.074
negative regulation of programmed cell death	GO:0043069	72	0.074
protein localization	GO:0008104	284	0.072
reactive oxygen species metabolic process	GO:0072593	22	0.072
multi organism reproductive behavior	GO:0044705	121	0.072	Worm
death	GO:0016265	284	0.072
regulation of catalytic activity	GO:0050790	185	0.071	Mouse
regulation of catabolic process	GO:0009894	170	0.071	Mouse
digestive tract development	GO:0048565	149	0.071
myotube differentiation	GO:0014902	46	0.070	Zebrafish Mouse
nucleoside triphosphate catabolic process	GO:0009143	108	0.069
kidney development	GO:0001822	3	0.069
response to decreased oxygen levels	GO:0036293	58	0.068
appendage development	GO:0048736	401	0.068
regulation of actin filament length	GO:0030832	27	0.067
dendrite morphogenesis	GO:0048813	199	0.066
regulation of protein modification process	GO:0031399	112	0.065
photoreceptor cell differentiation	GO:0046530	170	0.065
positive regulation of phosphate metabolic process	GO:0045937	139	0.064
peptidyl amino acid modification	GO:0018193	105	0.064
catabolic process	GO:0009056	409	0.064
nephron development	GO:0072006	3	0.063
regulation of multicellular organismal development	GO:2000026	414	0.063	Mouse
germarium derived egg chamber formation	GO:0007293	101	0.063
positive regulation of cell adhesion	GO:0045785	10	0.062
tube development	GO:0035295	244	0.062
cellular amine metabolic process	GO:0044106	12	0.061
positive regulation of biosynthetic process	GO:0009891	316	0.061
regulation of protein metabolic process	GO:0051246	256	0.061
positive regulation of molecular function	GO:0044093	136	0.060
negative regulation of cell cycle	GO:0045786	116	0.059
organic substance transport	GO:0071702	257	0.057
positive regulation of phosphorus metabolic process	GO:0010562	139	0.057
regulation of intracellular signal transduction	GO:1902531	236	0.057
regulation of dna templated transcription elongation	GO:0032784	17	0.056
regulation of protein phosphorylation	GO:0001932	64	0.056
neurological system process	GO:0050877	358	0.056
regulation of protein localization	GO:0032880	76	0.055
regulation of cellular amine metabolic process	GO:0033238	3	0.055
multicellular organismal reproductive behavior	GO:0033057	110	0.054	Worm
cell cell junction organization	GO:0045216	55	0.052
regulation of phosphatase activity	GO:0010921	3	0.052
regulation of protein complex assembly	GO:0043254	42	0.052
response to oxygen containing compound	GO:1901700	200	0.051	Rat
regulation of immune system process	GO:0002682	176	0.051
actin filament based movement	GO:0030048	26	0.050	Mouse
cytokinesis	GO:0000910	90	0.050
cell recognition	GO:0008037	102	0.049	Worm
calcium ion homeostasis	GO:0055074	23	0.049
body morphogenesis	GO:0010171	2	0.047	Worm
negative regulation of cell death	GO:0060548	81	0.046
ovulation	GO:0030728	4	0.046
organophosphate metabolic process	GO:0019637	195	0.046
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.045
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.044
skeletal muscle tissue development	GO:0007519	13	0.044	Zebrafish Mouse
positive regulation of multicellular organismal process	GO:0051240	143	0.044
mitochondrion organization	GO:0007005	65	0.043
regulation of cellular catabolic process	GO:0031329	157	0.043	Mouse
flight behavior	GO:0007629	26	0.043
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.042	Mouse
imaginal disc derived wing morphogenesis	GO:0007476	337	0.041
regulation of actin filament based process	GO:0032970	42	0.041	Mouse
cognition	GO:0050890	141	0.041
regulation of intracellular transport	GO:0032386	64	0.040
extracellular structure organization	GO:0043062	46	0.040
amine metabolic process	GO:0009308	12	0.039
cellular cation homeostasis	GO:0030003	38	0.039
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.038
cellular catabolic process	GO:0044248	372	0.038
regulation of heart contraction	GO:0008016	21	0.038	Mouse
regulation of muscle contraction	GO:0006937	5	0.037
chemotaxis	GO:0006935	249	0.037
neuromuscular synaptic transmission	GO:0007274	67	0.037
transcription from rna polymerase ii promoter	GO:0006366	368	0.037	Mouse
organic acid metabolic process	GO:0006082	103	0.036
regulation of membrane potential	GO:0042391	35	0.036
actin mediated cell contraction	GO:0070252	21	0.035
negative regulation of cell communication	GO:0010648	223	0.035
morphogenesis of a branching structure	GO:0001763	45	0.034
macromolecular complex assembly	GO:0065003	256	0.034
regulation of anatomical structure size	GO:0090066	163	0.033
mating behavior	GO:0007617	106	0.033
circadian rhythm	GO:0007623	105	0.033
adult locomotory behavior	GO:0008344	76	0.033
axonal fasciculation	GO:0007413	12	0.032	Worm
cellular amino acid metabolic process	GO:0006520	61	0.032
purine containing compound catabolic process	GO:0072523	112	0.032
response to organonitrogen compound	GO:0010243	75	0.032
positive regulation of cell development	GO:0010720	61	0.031
negative regulation of molecular function	GO:0044092	51	0.031
regulation of molecular function	GO:0065009	217	0.031	Mouse
protein complex biogenesis	GO:0070271	201	0.030
response to organic cyclic compound	GO:0014070	89	0.030
reproductive system development	GO:0061458	74	0.028
cation transport	GO:0006812	110	0.028
regulation of response to stress	GO:0080134	200	0.028
programmed cell death	GO:0012501	257	0.028
positive regulation of rna biosynthetic process	GO:1902680	266	0.027
regulation of protein transport	GO:0051223	57	0.027
renal system development	GO:0072001	72	0.026
urogenital system development	GO:0001655	72	0.026
negative regulation of apoptotic process	GO:0043066	63	0.025
positive regulation of cell motility	GO:2000147	3	0.025
mitotic cytokinesis	GO:0000281	50	0.025
mapk cascade	GO:0000165	107	0.025
cellular chemical homeostasis	GO:0055082	40	0.025
sensory perception of mechanical stimulus	GO:0050954	72	0.024
anterior posterior pattern specification	GO:0009952	136	0.024	Zebrafish
organonitrogen compound metabolic process	GO:1901564	318	0.024
heterocycle catabolic process	GO:0046700	166	0.024
cell division	GO:0051301	248	0.024
oocyte development	GO:0048599	124	0.024
cuticle development	GO:0042335	86	0.024
hemopoiesis	GO:0030097	46	0.024
carboxylic acid metabolic process	GO:0019752	92	0.024
cellular macromolecular complex assembly	GO:0034622	153	0.024
ion homeostasis	GO:0050801	55	0.024
cellular ion homeostasis	GO:0006873	39	0.024
glycosyl compound metabolic process	GO:1901657	127	0.023
hematopoietic progenitor cell differentiation	GO:0002244	1	0.023
feeding behavior	GO:0007631	50	0.023	Worm
eye antennal disc morphogenesis	GO:0007455	34	0.023
wound healing	GO:0042060	75	0.022
negative regulation of transcription dna templated	GO:0045892	237	0.022
compound eye development	GO:0048749	307	0.022
negative regulation of developmental process	GO:0051093	201	0.022
regulation of nucleotide metabolic process	GO:0006140	62	0.022	Mouse
response to oxidative stress	GO:0006979	86	0.021	Rat
actin filament bundle organization	GO:0061572	28	0.021
reproductive structure development	GO:0048608	74	0.021
renal tubule development	GO:0061326	64	0.021
cellular response to endogenous stimulus	GO:0071495	80	0.021
organic cyclic compound catabolic process	GO:1901361	168	0.021
embryonic pattern specification	GO:0009880	174	0.020	Zebrafish
oxoacid metabolic process	GO:0043436	103	0.020
embryonic organ development	GO:0048568	50	0.020
negative regulation of rna biosynthetic process	GO:1902679	240	0.020
regulation of ion transport	GO:0043269	39	0.020
negative regulation of phosphorus metabolic process	GO:0010563	45	0.020
regulation of cell cycle process	GO:0010564	181	0.020
positive regulation of cellular protein metabolic process	GO:0032270	118	0.020
regulation of establishment of protein localization	GO:0070201	61	0.020
multicellular organism growth	GO:0035264	46	0.020
blastoderm segmentation	GO:0007350	159	0.019
sensory perception of sound	GO:0007605	56	0.019
regulation of phosphorylation	GO:0042325	147	0.019
developmental maturation	GO:0021700	172	0.019
mesoderm development	GO:0007498	78	0.019
nucleoside catabolic process	GO:0009164	112	0.019
organonitrogen compound catabolic process	GO:1901565	128	0.018
covalent chromatin modification	GO:0016569	106	0.018
striated muscle myosin thick filament assembly	GO:0071688	3	0.018
regulation of protein polymerization	GO:0032271	28	0.018
chromatin modification	GO:0016568	147	0.018
negative regulation of actin filament depolymerization	GO:0030835	2	0.018
negative regulation of cell migration	GO:0030336	5	0.018
eye morphogenesis	GO:0048592	260	0.018
imaginal disc derived wing hair organization	GO:0035317	45	0.018
cell projection assembly	GO:0030031	94	0.018
morphogenesis of an epithelium	GO:0002009	276	0.017
segmentation	GO:0035282	207	0.017	Zebrafish
positive regulation of actin filament polymerization	GO:0030838	11	0.017
sex differentiation	GO:0007548	81	0.017
negative regulation of rna metabolic process	GO:0051253	251	0.017
regulation of cell substrate adhesion	GO:0010810	2	0.017
regulation of cell cycle	GO:0051726	291	0.017
signal transduction by phosphorylation	GO:0023014	107	0.017
glycosyl compound catabolic process	GO:1901658	112	0.017
negative regulation of cell differentiation	GO:0045596	143	0.017
nucleotide metabolic process	GO:0009117	161	0.017
positive regulation of protein complex assembly	GO:0031334	22	0.017
cellular homeostasis	GO:0019725	80	0.016
regulation of tube size	GO:0035150	46	0.016
negative regulation of signaling	GO:0023057	219	0.016
actin filament bundle assembly	GO:0051017	26	0.016
purine nucleoside metabolic process	GO:0042278	127	0.016
regulation of protein complex disassembly	GO:0043244	29	0.016
regulation of cytoskeleton organization	GO:0051493	89	0.016	Mouse
compound eye morphogenesis	GO:0001745	249	0.016
organophosphate catabolic process	GO:0046434	112	0.016
phosphorylation	GO:0016310	294	0.016
carbohydrate derivative catabolic process	GO:1901136	118	0.016
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.016
histone modification	GO:0016570	106	0.015
cellular response to hormone stimulus	GO:0032870	44	0.015
cellular lipid metabolic process	GO:0044255	83	0.015
response to hormone	GO:0009725	45	0.015
developmental growth	GO:0048589	280	0.015	Mouse
regulation of actin filament depolymerization	GO:0030834	3	0.015
nucleotide catabolic process	GO:0009166	109	0.015
purine ribonucleotide metabolic process	GO:0009150	145	0.015
response to radiation	GO:0009314	155	0.015
cardiac muscle cell differentiation	GO:0055007	4	0.014	Mouse
negative regulation of intracellular signal transduction	GO:1902532	57	0.014
negative regulation of phosphatase activity	GO:0010923	3	0.014
positive regulation of catabolic process	GO:0009896	105	0.014
intracellular signal transduction	GO:0035556	300	0.014	Worm
establishment of organelle localization	GO:0051656	122	0.014
rho protein signal transduction	GO:0007266	14	0.014
epithelial cell migration open tracheal system	GO:0007427	32	0.014
regulation of apoptotic signaling pathway	GO:2001233	10	0.014
positive regulation of organelle organization	GO:0010638	65	0.014
regulation of synapse assembly	GO:0051963	94	0.014
nuclear transport	GO:0051169	72	0.014
multicellular organismal signaling	GO:0035637	12	0.014
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.014
cellular metal ion homeostasis	GO:0006875	31	0.014
negative regulation of mapk cascade	GO:0043409	23	0.014
regulation of actin polymerization or depolymerization	GO:0008064	27	0.013
lipid storage	GO:0019915	38	0.013
muscle adaptation	GO:0043500	1	0.013	Mouse
renal tubule morphogenesis	GO:0061333	44	0.013
larval development	GO:0002164	104	0.013	Worm
substrate dependent cell migration	GO:0006929	3	0.013
cellular response to decreased oxygen levels	GO:0036294	30	0.013
intracellular transport	GO:0046907	228	0.013
cellular response to abiotic stimulus	GO:0071214	58	0.013
single organism catabolic process	GO:0044712	228	0.013
gonad development	GO:0008406	50	0.013
cellular response to nitrogen compound	GO:1901699	51	0.013
regulation of ion transmembrane transport	GO:0034765	27	0.013
positive regulation of hydrolase activity	GO:0051345	78	0.013
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.013
cellular response to oxygen levels	GO:0071453	30	0.013
biological adhesion	GO:0022610	138	0.012
negative regulation of epithelial cell proliferation	GO:0050680	4	0.012
cellular response to growth factor stimulus	GO:0071363	30	0.012
cytoskeleton dependent cytokinesis	GO:0061640	81	0.012
eye photoreceptor cell differentiation	GO:0001754	145	0.012
cell adhesion	GO:0007155	136	0.012
negative regulation of cytoskeleton organization	GO:0051494	30	0.012
neuron projection guidance	GO:0097485	241	0.012
cell cycle phase transition	GO:0044770	140	0.012
courtship behavior	GO:0007619	68	0.012
single organism biosynthetic process	GO:0044711	206	0.012
positive regulation of programmed cell death	GO:0043068	62	0.012
macromolecule catabolic process	GO:0009057	161	0.012
positive regulation of protein modification process	GO:0031401	58	0.012
regulation of actin cytoskeleton organization	GO:0032956	42	0.012	Mouse
actin filament polymerization	GO:0030041	27	0.012
purine ribonucleoside metabolic process	GO:0046128	127	0.011
aging	GO:0007568	143	0.011
rhythmic process	GO:0048511	106	0.011
negative regulation of catalytic activity	GO:0043086	42	0.011
nuclear import	GO:0051170	51	0.011
response to growth factor	GO:0070848	31	0.011
extrinsic apoptotic signaling pathway	GO:0097191	1	0.011
cell junction organization	GO:0034330	57	0.011
male courtship behavior veined wing extension	GO:0048065	22	0.011
cellular divalent inorganic cation homeostasis	GO:0072503	23	0.011
regulation of transcription elongation from rna polymerase ii promoter	GO:0034243	15	0.011
cell junction assembly	GO:0034329	42	0.011
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO:1902254	1	0.011
cellular response to organonitrogen compound	GO:0071417	36	0.011
response to purine containing compound	GO:0014074	12	0.010
cell substrate adhesion	GO:0031589	10	0.010
response to temperature stimulus	GO:0009266	106	0.010	Rat
cardiac muscle cell development	GO:0055013	3	0.010	Mouse
regulation of spindle checkpoint	GO:0090231	2	0.010
cell fate specification	GO:0001708	71	0.010
response to hexose	GO:0009746	3	0.010
regulation of dna templated transcription in response to stress	GO:0043620	4	0.010
protein transport	GO:0015031	155	0.010

Mhc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
myopathy	DOID:423	0.690
heart disease	DOID:114	0.690
cardiomyopathy	DOID:0050700	0.690
cardiovascular system disease	DOID:1287	0.690
disease of anatomical entity	DOID:7	0.690
musculoskeletal system disease	DOID:17	0.690
muscle tissue disease	DOID:66	0.690
muscular disease	DOID:0080000	0.690
intrinsic cardiomyopathy	DOID:0060036	0.643
dilated cardiomyopathy	DOID:12930	0.643
nervous system disease	DOID:863	0.023

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