Drosophila melanogaster

125 known processes

Mmp2 (Dmel_CG1794)

Matrix metalloproteinase 2

(Aliases: Dmel\CG1794,mmp2,anon-WO0118547.84,Dm2-MMP,dm-2MMP,CG1794,l(2)02353,MMP2,2-MMP)

Mmp2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
neuron projection guidanceGO:00974852410.571
growthGO:00400073590.556
Fly
taxisGO:00423303040.547
regulation of cell developmentGO:00602842150.383
regulation of cell differentiationGO:00455953020.353
Mouse
axonogenesisGO:00074092900.285
axon developmentGO:00615642970.277
axon guidanceGO:00074112330.237
chemotaxisGO:00069352490.232
regulation of multicellular organismal developmentGO:20000264140.201
regulation of notch signaling pathwayGO:00085931000.196
eye developmentGO:00016543230.193
negative regulation of response to stimulusGO:00485852580.187
phosphorylationGO:00163102940.181
regulation of phosphorylationGO:00423251470.180
negative regulation of cellular metabolic processGO:00313243820.177
transcription from rna polymerase ii promoterGO:00063663680.169
regulation of nervous system developmentGO:00519602480.168
open tracheal system developmentGO:00074242040.163
regulation of cellular protein metabolic processGO:00322682430.159
positive regulation of macromolecule metabolic processGO:00106044050.158
regulation of intracellular signal transductionGO:19025312360.139
regulation of organelle organizationGO:00330431960.139
regulation of protein metabolic processGO:00512462560.135
cellular response to dna damage stimulusGO:00069742230.134
positive regulation of cell developmentGO:0010720610.131
cell proliferationGO:00082832990.130
single organismal cell cell adhesionGO:0016337450.129
regulation of cell morphogenesisGO:00226041630.129
negative regulation of macromolecule biosynthetic processGO:00105582700.126
notch signaling pathwayGO:00072191200.122
negative regulation of gene expressionGO:00106293870.116
regulation of neuron differentiationGO:00456641030.115
negative regulation of rna biosynthetic processGO:19026792400.113
positive regulation of cell migrationGO:003033520.109
epithelial cell differentiationGO:00308553220.109
negative regulation of rna metabolic processGO:00512532510.106
motor neuron axon guidanceGO:0008045580.105
regulation of neurogenesisGO:00507671580.104
localization of cellGO:00516742570.103
response to glucoseGO:000974920.103
positive regulation of protein metabolic processGO:00512471280.102
developmental growthGO:00485892800.101
Fly
immune responseGO:00069552460.099
protein modification processGO:00362114380.095
regulation of phosphorus metabolic processGO:00511742100.095
positive regulation of cellular protein metabolic processGO:00322701180.095
cell deathGO:00082192790.095
Fly
regulation of dendrite morphogenesisGO:0048814280.095
negative regulation of nucleic acid templated transcriptionGO:19035072400.093
central nervous system developmentGO:00074172010.091
dendrite developmentGO:00163582040.090
organic substance transportGO:00717022570.088
response to monosaccharideGO:003428440.084
regulation of response to stressGO:00801342000.081
negative regulation of cell cycleGO:00457861160.081
cell migrationGO:00164772380.080
negative regulation of nucleobase containing compound metabolic processGO:00459342610.080
positive regulation of rna biosynthetic processGO:19026802660.079
programmed cell deathGO:00125012570.078
Fly
regulation of cell cycleGO:00517262910.078
small molecule metabolic processGO:00442813050.077
sensory organ morphogenesisGO:00905962600.075
negative regulation of cell differentiationGO:00455961430.074
Mouse
stem cell proliferationGO:0072089880.073
cellular response to chemical stimulusGO:00708871990.072
negative regulation of developmental processGO:00510932010.070
Mouse
cellular metal ion homeostasisGO:0006875310.069
proteolysisGO:00065081920.068
hindbrain developmentGO:003090220.067
regulation of molecular functionGO:00650092170.066
negative regulation of protein metabolic processGO:0051248850.064
cellular protein modification processGO:00064644380.064
response to hexoseGO:000974630.064
secondary metabolic processGO:0019748750.063
cell adhesionGO:00071551360.063
Fly
positive regulation of cell motilityGO:200014730.063
dendrite morphogenesisGO:00488131990.063
protein phosphorylationGO:00064681690.062
phenol containing compound metabolic processGO:0018958570.062
catabolic processGO:00090564090.061
Mouse
regulation of protein modification processGO:00313991120.061
organic hydroxy compound metabolic processGO:1901615830.061
positive regulation of cellular amino acid metabolic processGO:004576400.061
regulation of localizationGO:00328792750.060
negative regulation of cellular biosynthetic processGO:00313272770.060
regulation of transcription from rna polymerase ii promoterGO:00063573780.059
respiratory system developmentGO:00605412130.059
regulation of cell cycle processGO:00105641810.058
negative regulation of cell communicationGO:00106482230.057
compound eye photoreceptor cell differentiationGO:00017511400.056
photoreceptor cell differentiationGO:00465301700.054
single organism cell adhesionGO:0098602470.054
pigment metabolic processGO:0042440840.054
regulation of endopeptidase activityGO:0052548360.053
forebrain developmentGO:003090020.053
nuclear divisionGO:00002803320.051
stress activated protein kinase signaling cascadeGO:0031098550.050
intracellular signal transductionGO:00355563000.049
nitrogen compound transportGO:0071705850.049
negative regulation of biosynthetic processGO:00098902770.048
cellular amino acid metabolic processGO:0006520610.047
immune system processGO:00023763470.046
regulation of mapk cascadeGO:0043408920.046
negative regulation of signal transductionGO:00099682060.046
regulation of histone deacetylationGO:003106320.045
melanization defense responseGO:0035006450.045
stem cell divisionGO:0017145690.045
cellular catabolic processGO:00442483720.045
regulation of anatomical structure morphogenesisGO:00226032420.044
regulation of actin cytoskeleton organizationGO:0032956420.044
tracheal outgrowth open tracheal systemGO:0007426180.044
microtubule based transportGO:0010970420.044
regulation of peptide secretionGO:000279160.043
regulation of proteolysisGO:0030162870.043
negative regulation of developmental growthGO:0048640640.043
epithelium migrationGO:00901321480.043
biological adhesionGO:00226101380.042
Fly
compound eye developmentGO:00487493070.042
regulation of cellular response to stressGO:0080135890.041
positive regulation of response to stimulusGO:00485843230.041
positive regulation of cellular amine metabolic processGO:003324000.041
positive regulation of cellular biosynthetic processGO:00313283160.041
regulation of catalytic activityGO:00507901850.041
single organism intracellular transportGO:19025822070.040
response to radiationGO:00093141550.040
wing disc morphogenesisGO:00074723440.040
semaphorin plexin signaling pathwayGO:007152640.039
imaginal disc derived wing morphogenesisGO:00074763370.039
eye morphogenesisGO:00485922600.039
mapk cascadeGO:00001651070.039
negative regulation of cell cycle processGO:00109481090.039
positive regulation of cellular component organizationGO:00511301560.038
organic acid metabolic processGO:00060821030.038
cellular transition metal ion homeostasisGO:004691690.038
response to organic substanceGO:00100332840.037
intracellular protein transportGO:00068861040.037
regulation of dendrite developmentGO:0050773370.037
response to abiotic stimulusGO:00096283410.036
positive regulation of gene expressionGO:00106282900.036
cell motilityGO:00488702510.036
developmental growth involved in morphogenesisGO:0060560650.036
Fly
positive regulation of histone deacetylationGO:003106520.036
positive regulation of phosphorylationGO:0042327870.036
compound eye morphogenesisGO:00017452490.036
negative regulation of transcription dna templatedGO:00458922370.035
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.035
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.035
positive regulation of nitrogen compound metabolic processGO:00511733540.034
regulation of phosphate metabolic processGO:00192202100.034
negative regulation of cellular protein metabolic processGO:0032269850.034
negative regulation of nitrogen compound metabolic processGO:00511722650.033
positive regulation of phosphate metabolic processGO:00459371390.033
cellular response to hexose stimulusGO:007133110.033
regulation of cell deathGO:00109411730.033
response to ionizing radiationGO:0010212320.033
cellular homeostasisGO:0019725800.033
cell cell signaling involved in cell fate commitmentGO:00451682100.033
regulation of transferase activityGO:0051338580.032
regulation of cellular localizationGO:00603411360.032
camera type eye developmentGO:004301040.032
tissue migrationGO:00901301550.032
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.031
cell divisionGO:00513012480.031
organelle fissionGO:00482853400.031
post embryonic appendage morphogenesisGO:00351203850.031
chromosome organizationGO:00512763600.031
protein transportGO:00150311550.031
endocytosisGO:00068973100.030
ribose phosphate metabolic processGO:00196931450.030
amine metabolic processGO:0009308120.030
carboxylic acid metabolic processGO:0019752920.030
negative regulation of phosphorus metabolic processGO:0010563450.030
regulation of protein deacetylationGO:009031120.029
muscle organ developmentGO:00075171270.029
regulation of cellular ketone metabolic processGO:001056530.029
positive regulation of signalingGO:00230562430.028
vesicle mediated transportGO:00161923810.028
regulation of stress activated mapk cascadeGO:0032872410.028
cell growthGO:00160491080.028
chromatin organizationGO:00063252070.028
chemical homeostasisGO:0048878920.027
mushroom body developmentGO:0016319700.027
regulation of hormone levelsGO:0010817400.027
regulation of cellular amine metabolic processGO:003323830.027
establishment of protein localizationGO:00451841630.027
brain developmentGO:00074201200.027
negative regulation of cellular component organizationGO:00511291080.027
signal transduction by phosphorylationGO:00230141070.027
ribonucleotide metabolic processGO:00092591450.027
cellular response to lipopolysaccharideGO:007122230.027
eye photoreceptor cell differentiationGO:00017541450.027
positive regulation of intracellular signal transductionGO:19025331160.027
establishment of localization in cellGO:00516494020.027
regulation of apoptotic processGO:00429811300.026
organic substance catabolic processGO:19015753080.026
single organism cellular localizationGO:19025801800.026
basement membrane organizationGO:0071711100.026
phagocytosisGO:00069092150.026
regulation of immune responseGO:00507761180.026
negative regulation of nervous system developmentGO:0051961920.026
transition metal ion homeostasisGO:0055076170.026
exocrine system developmentGO:00352721620.026
Fly
cell fate determinationGO:0001709910.026
peptidyl amino acid modificationGO:00181931050.025
anatomical structure homeostasisGO:0060249970.025
regulation of cellular catabolic processGO:00313291570.025
regulation of cellular component sizeGO:0032535980.025
cell cycle phase transitionGO:00447701400.025
rho protein signal transductionGO:0007266140.025
cellular response to organic substanceGO:00713101320.025
stress activated mapk cascadeGO:0051403520.025
positive regulation of cell communicationGO:00106472500.024
transition metal ion transportGO:0000041160.024
regulation of peptidase activityGO:0052547390.024
regulation of hydrolase activityGO:0051336970.024
positive regulation of cell differentiationGO:0045597640.024
response to endogenous stimulusGO:00097191190.024
apoptotic processGO:00069151590.023
cell cycle arrestGO:000705040.023
positive regulation of molecular functionGO:00440931360.023
enzyme linked receptor protein signaling pathwayGO:00071671790.023
cytoplasmic transportGO:00164821300.023
negative regulation of cell proliferationGO:0008285690.023
connective tissue developmentGO:006144830.023
protein complex biogenesisGO:00702712010.023
appendage developmentGO:00487364010.023
peptide transportGO:0015833100.023
negative regulation of growthGO:0045926840.022
organic cyclic compound catabolic processGO:19013611680.022
cellular ketone metabolic processGO:0042180240.022
positive regulation of phosphorus metabolic processGO:00105621390.022
columnar cuboidal epithelial cell differentiationGO:00020652560.022
neuroblast proliferationGO:0007405740.022
regulation of epithelial cell proliferationGO:005067840.022
microtubule based movementGO:0007018510.021
regulation of stress activated protein kinase signaling cascadeGO:0070302420.021
defense responseGO:00069523000.021
cranial nerve developmentGO:002154510.021
cell cell junction organizationGO:0045216550.021
positive regulation of signal transductionGO:00099672230.021
intracellular transportGO:00469072280.021
mitotic sister chromatid segregationGO:0000070870.021
positive regulation of cell morphogenesis involved in differentiationGO:0010770120.021
neuroblast divisionGO:0055057350.021
cellular response to monosaccharide stimulusGO:007132620.021
glial cell differentiationGO:0010001350.020
cellular response to carbohydrate stimulusGO:007132240.020
regulation of cell sizeGO:0008361630.020
negative regulation of cell developmentGO:0010721620.020
positive regulation of macromolecule biosynthetic processGO:00105572830.020
establishment or maintenance of apical basal cell polarityGO:0035088340.020
positive regulation of nucleobase containing compound metabolic processGO:00459353320.020
jnk cascadeGO:0007254500.020
positive regulation of nucleic acid templated transcriptionGO:19035082660.020
regulation of transportGO:00510491810.020
cell maturationGO:00484691440.020
positive regulation of catalytic activityGO:00430851180.020
protein processingGO:0016485680.020
regulation of kinase activityGO:0043549530.020
regulation of programmed cell deathGO:00430671520.020
gland morphogenesisGO:00226121450.020
Fly
deathGO:00162652840.019
Fly
dna recombinationGO:0006310320.019
cellular component disassemblyGO:0022411460.019
ion transportGO:00068111450.019
eye photoreceptor cell developmentGO:0042462810.019
regulation of chromosome organizationGO:0033044640.019
epithelial cell developmentGO:00020642740.019
asymmetric stem cell divisionGO:0098722490.019
muscle structure developmentGO:00610612240.019
sister chromatid segregationGO:0000819920.019
response to alcoholGO:0097305950.019
macromolecule catabolic processGO:00090571610.018
protein modification by small protein conjugation or removalGO:00706471060.018
monocarboxylic acid transportGO:001571830.018
cell cell adhesion via plasma membrane adhesion moleculesGO:0098742260.018
negative regulation of neurogenesisGO:0050768530.018
positive regulation of secretionGO:0051047220.018
regulation of synapse organizationGO:00508071100.018
positive regulation of multicellular organismal processGO:00512401430.018
stem cell differentiationGO:00488631170.018
secretionGO:00469031090.018
regulation of protein localizationGO:0032880760.017
positive regulation of transportGO:0051050920.017
regulation of stem cell proliferationGO:0072091400.017
homeostatic processGO:00425921990.017
single organism catabolic processGO:00447122280.017
Mouse
telencephalon developmentGO:002153720.017
nucleobase containing compound catabolic processGO:00346551650.017
photoreceptor cell developmentGO:0042461960.017
regulation of anatomical structure sizeGO:00900661630.017
Fly
compound eye photoreceptor developmentGO:0042051780.017
oxoacid metabolic processGO:00434361030.016
stem cell developmentGO:0048864790.016
cellular chemical homeostasisGO:0055082400.016
regulation of catabolic processGO:00098941700.016
positive regulation of organelle organizationGO:0010638650.016
morphogenesis of an epitheliumGO:00020092760.016
imaginal disc fusionGO:0046528190.016
epithelial cell migration open tracheal systemGO:0007427320.016
protein maturationGO:0051604710.016
regulation of locomotionGO:0040012420.016
nuclear importGO:0051170510.016
regulation of wnt signaling pathwayGO:0030111680.016
hormone secretionGO:004687970.016
head developmentGO:00603221350.016
negative regulation of epithelial cell proliferationGO:005068040.016
endomembrane system organizationGO:00102561190.016
cell cycle checkpointGO:0000075950.016
membrane organizationGO:00610241120.016
nucleotide metabolic processGO:00091171610.016
negative regulation of molecular functionGO:0044092510.016
protein localizationGO:00081042840.016
chromatin modificationGO:00165681470.016
cell junction organizationGO:0034330570.016
protein targetingGO:0006605640.016
cation homeostasisGO:0055080510.015
regulation of cellular component movementGO:0051270420.015
imaginal disc derived appendage developmentGO:00487373990.015
imaginal disc eversionGO:000756140.015
extracellular structure organizationGO:0043062460.015
negative regulation of catalytic activityGO:0043086420.015
covalent chromatin modificationGO:00165691060.015
nucleocytoplasmic transportGO:0006913720.015
signal releaseGO:0023061490.015
regulation of defense responseGO:00313471020.015
negative regulation of multicellular organismal processGO:00512411420.015
regulation of response to external stimulusGO:00321011150.015
single organism membrane organizationGO:0044802930.015
positive regulation of protein modification processGO:0031401580.015
cellular macromolecule localizationGO:00707272200.015
developmental maturationGO:00217001720.015
neural precursor cell proliferationGO:0061351750.015
innate immune responseGO:00450871440.015
regulation of cell cell adhesionGO:0022407210.014
tube morphogenesisGO:00352391910.014
positive regulation of protein kinase activityGO:0045860250.014
stem cell maintenanceGO:0019827670.014
regulation of cellular component biogenesisGO:00440872010.014
regulation of organ morphogenesisGO:2000027780.014
wnt signaling pathwayGO:0016055980.014
regulation of synaptic growth at neuromuscular junctionGO:0008582890.014
epithelial cell migrationGO:00106311480.014
cellular protein localizationGO:00346131600.014
peptide secretionGO:000279070.014
spermatogenesisGO:00072832000.014
regulation of cellular amino acid metabolic processGO:000652100.014
positive regulation of peptidase activityGO:0010952290.014
regulation of cytoskeleton organizationGO:0051493890.014
organonitrogen compound metabolic processGO:19015643180.014
leg disc morphogenesisGO:0007478800.014
positive regulation of transcription dna templatedGO:00458932660.014
regulation of growthGO:00400082330.014
gland developmentGO:00487321910.013
Fly
single organism behaviorGO:00447083910.013
response to decreased oxygen levelsGO:0036293580.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.013
positive regulation of rna metabolic processGO:00512542710.013
negative regulation of immune responseGO:0050777390.013
positive regulation of neurogenesisGO:0050769410.013
negative regulation of fibroblast growth factor receptor signaling pathwayGO:004003720.013
response to woundingGO:0009611940.013
regulation of chromatin organizationGO:1902275320.013
establishment or maintenance of cell polarityGO:00071631670.013
mesenchymal cell differentiationGO:004876210.013
response to lipopolysaccharideGO:003249640.013
defense response to gram negative bacteriumGO:0050829940.013
positive regulation of nervous system developmentGO:0051962690.013
synapse organizationGO:00508081960.013
mitotic spindle organizationGO:00070522200.013
neuromuscular junction developmentGO:00075281490.013
extracellular matrix disassemblyGO:002261740.013
intrinsic apoptotic signaling pathwayGO:0097193160.013
immune response regulating signaling pathwayGO:000276420.013
mitotic cell cycle phase transitionGO:00447721380.013
single organism biosynthetic processGO:00447112060.013
negative regulation of cell cell adhesionGO:002240880.013
sarcomere organizationGO:0045214260.013
regulation of mitotic cell cycle phase transitionGO:19019901300.012
blastoderm segmentationGO:00073501590.012
regulation of cell divisionGO:0051302720.012
epidermal cell differentiationGO:0009913510.012
regulation of protein catabolic processGO:0042176550.012
cellular component assembly involved in morphogenesisGO:00109271510.012
secretion by cellGO:00329401010.012
imaginal disc derived appendage morphogenesisGO:00351143950.012
histone modificationGO:00165701060.012
signal transduction in response to dna damageGO:004277030.012
regulation of cell growthGO:0001558430.012
imaginal disc derived leg morphogenesisGO:0007480800.012
cellular response to molecule of bacterial originGO:007121930.012
appendage morphogenesisGO:00351073970.012
myotube cell developmentGO:001490430.012
response to anestheticGO:007234790.012
regulation of axon extension involved in axon guidanceGO:004884140.012
positive regulation of cell deathGO:0010942690.012
regulation of intracellular protein transportGO:0033157460.012
organelle assemblyGO:00709251980.012
positive regulation of protein deacetylationGO:009031220.012
multicellular organismal agingGO:00102591400.012
columnar cuboidal epithelial cell developmentGO:00020662490.012
nucleus organizationGO:0006997450.012
negative regulation of proteolysisGO:0045861310.012
melanin metabolic processGO:0006582470.012
positive regulation of mapk cascadeGO:0043410630.012
neural retina developmentGO:000340740.012
negative regulation of phosphate metabolic processGO:0045936450.012
centrosome organizationGO:00512971630.012
nephron developmentGO:007200630.011
jak stat cascadeGO:0007259490.011
transmembrane transportGO:00550851390.011
nucleoside phosphate metabolic processGO:00067531620.011
germ line stem cell maintenanceGO:0030718500.011
instar larval developmentGO:0002168550.011
Fly
positive regulation of protein phosphorylationGO:0001934340.011
purine ribonucleotide metabolic processGO:00091501450.011
regulation of protein kinase activityGO:0045859510.011
regulation of cell motilityGO:2000145230.011
cellular response to biotic stimulusGO:007121640.011
positive regulation of biosynthetic processGO:00098913160.011
cellular response to oxygen containing compoundGO:1901701790.011
macromolecular complex assemblyGO:00650032560.011
nucleoside catabolic processGO:00091641120.011
aromatic compound catabolic processGO:00194391660.011
negative regulation of intracellular signal transductionGO:1902532570.011
regulation of camp metabolic processGO:0030814120.011
negative regulation of protein maturationGO:1903318310.011
mitotic cell cycle checkpointGO:0007093880.011
salivary gland morphogenesisGO:00074351450.011
Fly
ovarian follicle cell developmentGO:00307072480.011
nerve developmentGO:002167560.011
axis specificationGO:00097981670.011
response to extracellular stimulusGO:00099911160.011
neuronal stem cell divisionGO:0036445350.011
negative regulation of mitotic cell cycle phase transitionGO:19019911030.011
regulation of intracellular transportGO:0032386640.011
regulation of cell projection organizationGO:0031344920.010
hematopoietic or lymphoid organ developmentGO:0048534570.010
agingGO:00075681430.010
positive regulation of endopeptidase activityGO:0010950260.010
response to external biotic stimulusGO:00432072930.010
regulation of microtubule based processGO:0032886490.010
regulation of production of molecular mediator of immune responseGO:0002700440.010
negative regulation of cellular catabolic processGO:0031330340.010
negative regulation of notch signaling pathwayGO:0045746410.010
peptidyl threonine phosphorylationGO:001810720.010
positive regulation of dendrite developmentGO:190000690.010
regulation of protein phosphorylationGO:0001932640.010
regulation of protein stabilityGO:0031647430.010
peptide hormone secretionGO:003007250.010
bmp signaling pathwayGO:0030509270.010

Mmp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.062
nervous system diseaseDOID:86300.022
cancerDOID:16200.015
disease of cellular proliferationDOID:1456600.015
organ system cancerDOID:005068600.015
sensory system diseaseDOID:005015500.013
eye diseaseDOID:561400.013
eye and adnexa diseaseDOID:149200.013