IMP: Integrative Multi-species Prediction

Drosophila melanogaster

119 known processes

SoxN (Dmel_CG18024)

SoxNeuro

(Aliases: Sry-rDM64,soxN,Dmel\CG18024,CG18024,SOX29F,Sox B1,SOXB1,DM64)

FLYBASE: FBgn0029123
Entrez: 44275
UniProtKB: Q9VLH8
UniProtKB: M9PCZ7

Process Predictions
Disease Predictions

SoxN biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
axon development	GO:0061564	297	0.999
axonogenesis	GO:0007409	290	0.999
neuron projection guidance	GO:0097485	241	0.997
axon guidance	GO:0007411	233	0.996
stem cell proliferation	GO:0072089	88	0.993	Mouse
chemotaxis	GO:0006935	249	0.992
motor neuron axon guidance	GO:0008045	58	0.991
epithelial cell differentiation	GO:0030855	322	0.979	Mouse
axon midline choice point recognition	GO:0016199	26	0.970
dendrite guidance	GO:0070983	21	0.968	Fly
cell proliferation	GO:0008283	299	0.966	Human Mouse Fly
neuroblast division	GO:0055057	35	0.959
taxis	GO:0042330	304	0.958
central nervous system development	GO:0007417	201	0.941
neuroblast differentiation	GO:0014016	29	0.940
asymmetric neuroblast division	GO:0055059	33	0.925
growth	GO:0040007	359	0.920	Zebrafish
somatic stem cell division	GO:0048103	37	0.916
neural precursor cell proliferation	GO:0061351	75	0.886	Mouse
regulation of anatomical structure morphogenesis	GO:0022603	242	0.882
establishment or maintenance of cell polarity	GO:0007163	167	0.876
regulation of cell differentiation	GO:0045595	302	0.874	Human Mouse
negative regulation of cell communication	GO:0010648	223	0.843	Human Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.843
cell migration	GO:0016477	238	0.837
axon choice point recognition	GO:0016198	26	0.834
forebrain development	GO:0030900	2	0.823	Human Mouse
regionalization	GO:0003002	416	0.818	Zebrafish Fly
negative regulation of cellular biosynthetic process	GO:0031327	277	0.810	Mouse Fly
cell junction organization	GO:0034330	57	0.800
digestive system development	GO:0055123	149	0.789	Human Zebrafish Fly
localization of cell	GO:0051674	257	0.789
positive regulation of gene expression	GO:0010628	290	0.786
asymmetric cell division	GO:0008356	37	0.773
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.770
regulation of neural precursor cell proliferation	GO:2000177	35	0.768	Mouse
neuroblast fate commitment	GO:0014017	19	0.766
positive regulation of cellular biosynthetic process	GO:0031328	316	0.760
morphogenesis of a polarized epithelium	GO:0001738	93	0.757
sensory organ morphogenesis	GO:0090596	260	0.755	Zebrafish Mouse
regulation of multicellular organismal development	GO:2000026	414	0.750	Mouse
head development	GO:0060322	135	0.743	Human Mouse Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.742
eye development	GO:0001654	323	0.738	Human Zebrafish Mouse
epidermis development	GO:0008544	65	0.726
regulation of localization	GO:0032879	275	0.720
cell motility	GO:0048870	251	0.715
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.708	Mouse Fly
locomotory behavior	GO:0007626	176	0.688
imaginal disc derived wing hair organization	GO:0035317	45	0.682
skin development	GO:0043588	65	0.677
transcription from rna polymerase ii promoter	GO:0006366	368	0.669
adult behavior	GO:0030534	137	0.669
blastoderm segmentation	GO:0007350	159	0.666	Fly
neuronal stem cell division	GO:0036445	35	0.654
respiratory system development	GO:0060541	213	0.650	Mouse
negative regulation of rna metabolic process	GO:0051253	251	0.650	Mouse Fly
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.649
epithelial cell development	GO:0002064	274	0.647	Mouse
single organism behavior	GO:0044708	391	0.647
ameboidal type cell migration	GO:0001667	151	0.642
negative regulation of cellular metabolic process	GO:0031324	382	0.640	Mouse Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.637
circulatory system development	GO:0072359	82	0.630
negative regulation of response to stimulus	GO:0048585	258	0.628	Human Mouse
regulation of protein metabolic process	GO:0051246	256	0.623	Human
cell growth	GO:0016049	108	0.617
programmed cell death	GO:0012501	257	0.616	Human Fly
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.602
reproductive system development	GO:0061458	74	0.602	Mouse Worm
positive regulation of developmental process	GO:0051094	143	0.593	Mouse
negative regulation of rna biosynthetic process	GO:1902679	240	0.590	Mouse Fly
morphogenesis of an epithelium	GO:0002009	276	0.584	Zebrafish Mouse
epidermal cell differentiation	GO:0009913	51	0.575
stem cell fate commitment	GO:0048865	25	0.566
endocytosis	GO:0006897	310	0.553
development of primary sexual characteristics	GO:0045137	50	0.549	Mouse Worm
asymmetric protein localization	GO:0008105	33	0.548
response to wounding	GO:0009611	94	0.521	Human Zebrafish
regulation of cell development	GO:0060284	215	0.518	Mouse
ventral cord development	GO:0007419	16	0.507
neuroblast proliferation	GO:0007405	74	0.502	Mouse
tissue morphogenesis	GO:0048729	297	0.499	Zebrafish Mouse
cell death	GO:0008219	279	0.498	Human Fly
neuron recognition	GO:0008038	101	0.496
neuron fate commitment	GO:0048663	50	0.493	Mouse
positive regulation of biosynthetic process	GO:0009891	316	0.481
positive regulation of rna metabolic process	GO:0051254	271	0.471
developmental maturation	GO:0021700	172	0.470	Fly
homeostatic process	GO:0042592	199	0.466
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.458	Mouse Fly
positive regulation of multicellular organismal process	GO:0051240	143	0.456	Mouse
embryonic pattern specification	GO:0009880	174	0.450	Fly
positive regulation of transcription dna templated	GO:0045893	266	0.450
hindbrain development	GO:0030902	2	0.450
cell junction assembly	GO:0034329	42	0.447
detection of stimulus	GO:0051606	156	0.444	Mouse
non sensory hair organization	GO:0035316	47	0.442
spinal cord development	GO:0021510	1	0.442
regulation of cell death	GO:0010941	173	0.440	Human Fly
response to alcohol	GO:0097305	95	0.430
wnt signaling pathway	GO:0016055	98	0.428
positive regulation of rna biosynthetic process	GO:1902680	266	0.426
columnar cuboidal epithelial cell development	GO:0002066	249	0.425
stem cell division	GO:0017145	69	0.410
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.410	Mouse Fly
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.409	Mouse Fly
death	GO:0016265	284	0.408	Human Fly
developmental growth	GO:0048589	280	0.403	Zebrafish
establishment of planar polarity	GO:0001736	87	0.402
regulation of cell proliferation	GO:0042127	163	0.401	Human Mouse Fly
stem cell differentiation	GO:0048863	117	0.394	Human Mouse
neurological system process	GO:0050877	358	0.394	Mouse
dorsal ventral axon guidance	GO:0033563	2	0.390
meiotic nuclear division	GO:0007126	151	0.377
positive regulation of macromolecule metabolic process	GO:0010604	405	0.375
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.361
regulation of nervous system development	GO:0051960	248	0.357	Mouse
segmentation	GO:0035282	207	0.355	Fly
response to organic substance	GO:0010033	284	0.329	Human Mouse
negative regulation of signal transduction	GO:0009968	206	0.321	Human Mouse
negative regulation of cell differentiation	GO:0045596	143	0.316	Human Mouse
regulation of cellular protein metabolic process	GO:0032268	243	0.312
brain development	GO:0007420	120	0.311	Human Mouse Fly
eye morphogenesis	GO:0048592	260	0.310	Zebrafish Mouse
response to external biotic stimulus	GO:0043207	293	0.310
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.305
salivary gland development	GO:0007431	162	0.305
dendrite development	GO:0016358	204	0.305	Fly
establishment of cell polarity	GO:0030010	40	0.302
camera type eye development	GO:0043010	4	0.301	Mouse
regulation of programmed cell death	GO:0043067	152	0.299	Human Fly
wound healing	GO:0042060	75	0.289	Zebrafish
protein localization	GO:0008104	284	0.288
positive regulation of cell development	GO:0010720	61	0.288	Mouse
asymmetric stem cell division	GO:0098722	49	0.278
detection of light stimulus	GO:0009583	58	0.277
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.276	Mouse Fly
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.270
regulation of organ morphogenesis	GO:2000027	78	0.270
gland development	GO:0048732	191	0.263	Human Mouse
protein modification process	GO:0036211	438	0.261
positive regulation of cell communication	GO:0010647	250	0.259	Human Mouse
response to light stimulus	GO:0009416	124	0.258
hair cell differentiation	GO:0035315	47	0.258
actin filament organization	GO:0007015	126	0.258
compound eye development	GO:0048749	307	0.257
gland morphogenesis	GO:0022612	145	0.257
sensory perception of chemical stimulus	GO:0007606	116	0.257
immune system process	GO:0002376	347	0.253
multicellular organismal reproductive behavior	GO:0033057	110	0.252	Worm
heart morphogenesis	GO:0003007	32	0.252
cellular response to chemical stimulus	GO:0070887	199	0.250
regulation of multi organism process	GO:0043900	131	0.249
retinal ganglion cell axon guidance	GO:0031290	12	0.247
sex differentiation	GO:0007548	81	0.244	Mouse Worm
response to biotic stimulus	GO:0009607	294	0.244
positive regulation of cell proliferation	GO:0008284	47	0.244	Mouse
intracellular signal transduction	GO:0035556	300	0.243	Human
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.242
detection of stimulus involved in sensory perception	GO:0050906	92	0.242	Mouse
epithelial cell migration	GO:0010631	148	0.235
actin filament based movement	GO:0030048	26	0.235
neuroblast development	GO:0014019	13	0.226
establishment of localization in cell	GO:0051649	402	0.226
tube development	GO:0035295	244	0.225	Human Zebrafish Mouse Fly
negative regulation of nervous system development	GO:0051961	92	0.220	Mouse
regulation of cell cycle	GO:0051726	291	0.219	Human
negative regulation of gene expression	GO:0010629	387	0.219	Mouse Fly
adult locomotory behavior	GO:0008344	76	0.204
camera type eye morphogenesis	GO:0048593	2	0.203	Mouse
compound eye morphogenesis	GO:0001745	249	0.203
post embryonic appendage morphogenesis	GO:0035120	385	0.202	Fly
cellular amine metabolic process	GO:0044106	12	0.202
oocyte differentiation	GO:0009994	145	0.201
reproductive structure development	GO:0048608	74	0.191	Mouse Worm
immune response	GO:0006955	246	0.190
regulation of cell morphogenesis	GO:0022604	163	0.189
multi organism behavior	GO:0051705	175	0.188	Worm
axis specification	GO:0009798	167	0.187	Zebrafish Fly
phagocytosis	GO:0006909	215	0.186
imaginal disc derived wing morphogenesis	GO:0007476	337	0.186
regulation of embryonic development	GO:0045995	68	0.184
synaptic transmission	GO:0007268	288	0.181
cell fate specification	GO:0001708	71	0.181	Human Mouse
connective tissue development	GO:0061448	3	0.179
salivary gland morphogenesis	GO:0007435	145	0.173
ectodermal placode morphogenesis	GO:0071697	4	0.173	Zebrafish Mouse
positive regulation of programmed cell death	GO:0043068	62	0.172
neuroblast fate determination	GO:0007400	12	0.169
actin cytoskeleton organization	GO:0030036	206	0.167
heart development	GO:0007507	82	0.166
dendrite morphogenesis	GO:0048813	199	0.165	Fly
response to other organism	GO:0051707	293	0.165
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.162	Mouse Fly
cellular protein modification process	GO:0006464	438	0.161
negative regulation of biosynthetic process	GO:0009890	277	0.160	Mouse Fly
developmental growth involved in morphogenesis	GO:0060560	65	0.160
regulation of molecular function	GO:0065009	217	0.160	Human Zebrafish
biological adhesion	GO:0022610	138	0.159
cardiovascular system development	GO:0072358	82	0.159
embryonic development via the syncytial blastoderm	GO:0001700	148	0.157
regulation of neuron differentiation	GO:0045664	103	0.156	Mouse
dorsal ventral axis specification	GO:0009950	66	0.154	Zebrafish Fly
retina development in camera type eye	GO:0060041	4	0.153	Mouse
regulation of behavior	GO:0050795	75	0.152
cell maturation	GO:0048469	144	0.152	Fly
body morphogenesis	GO:0010171	2	0.152	Worm
establishment of tissue polarity	GO:0007164	87	0.149
chaeta development	GO:0022416	97	0.149	Fly
regulation of cellular amine metabolic process	GO:0033238	3	0.149
protein transport	GO:0015031	155	0.147
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.147
exocrine system development	GO:0035272	162	0.147
positive regulation of cell motility	GO:2000147	3	0.147
cell cell junction organization	GO:0045216	55	0.146
cell recognition	GO:0008037	102	0.145
dorsal closure	GO:0007391	79	0.145
regulation of synapse structure and activity	GO:0050803	128	0.144
positive regulation of cell migration	GO:0030335	2	0.142
leg disc development	GO:0035218	92	0.141
positive regulation of nervous system development	GO:0051962	69	0.141	Mouse
response to radiation	GO:0009314	155	0.138
digestive tract development	GO:0048565	149	0.136	Human Zebrafish Fly
spermatogenesis	GO:0007283	200	0.136	Mouse
cardiac cell fate determination	GO:0060913	3	0.136
eye photoreceptor cell differentiation	GO:0001754	145	0.134
positive regulation of cellular component organization	GO:0051130	156	0.133
synapse assembly	GO:0007416	143	0.131
positive regulation of cell differentiation	GO:0045597	64	0.131	Mouse
regulation of growth	GO:0040008	233	0.130
regulation of hormone levels	GO:0010817	40	0.128
small molecule metabolic process	GO:0044281	305	0.128
positive regulation of signaling	GO:0023056	243	0.127	Human Mouse
regulation of cell division	GO:0051302	72	0.126
response to abiotic stimulus	GO:0009628	341	0.126	Mouse
regulation of epithelial cell differentiation	GO:0030856	4	0.125	Mouse
embryonic organ development	GO:0048568	50	0.124	Zebrafish Mouse
photoreceptor cell axon guidance	GO:0072499	23	0.123
response to organic cyclic compound	GO:0014070	89	0.122
organic substance transport	GO:0071702	257	0.121
regulation of synaptic transmission	GO:0050804	69	0.121
immune effector process	GO:0002252	98	0.121
digestive tract morphogenesis	GO:0048546	127	0.120	Human Zebrafish Fly
learning or memory	GO:0007611	141	0.119
phosphatidylinositol mediated signaling	GO:0048015	4	0.119
anterior posterior pattern specification	GO:0009952	136	0.118
proximal distal pattern formation	GO:0009954	15	0.117
enteroendocrine cell differentiation	GO:0035883	1	0.116
oocyte development	GO:0048599	124	0.116
embryonic hemopoiesis	GO:0035162	26	0.116
regulation of dendrite morphogenesis	GO:0048814	28	0.116
mesenchymal cell differentiation	GO:0048762	1	0.115
synaptic target recognition	GO:0008039	45	0.114
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.113
regulation of protein modification process	GO:0031399	112	0.112
wing disc morphogenesis	GO:0007472	344	0.112
g protein coupled receptor signaling pathway	GO:0007186	136	0.110
negative regulation of cell death	GO:0060548	81	0.110	Fly
single organism cell adhesion	GO:0098602	47	0.106
germ cell migration	GO:0008354	43	0.105
amine metabolic process	GO:0009308	12	0.104
retina morphogenesis in camera type eye	GO:0060042	2	0.104	Mouse
negative regulation of signaling	GO:0023057	219	0.104	Human Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.104
oocyte axis specification	GO:0007309	108	0.103
regulation of notch signaling pathway	GO:0008593	100	0.102	Mouse
gliogenesis	GO:0042063	80	0.101
response to ethanol	GO:0045471	59	0.101
nephron epithelium development	GO:0072009	3	0.101
detection of abiotic stimulus	GO:0009582	66	0.100	Mouse
pole plasm oskar mrna localization	GO:0045451	46	0.099
hemocyte differentiation	GO:0042386	38	0.099
regulation of cell fate commitment	GO:0010453	29	0.098
appendage morphogenesis	GO:0035107	397	0.098	Fly
imaginal disc derived appendage development	GO:0048737	399	0.098
regulation of neuroblast proliferation	GO:1902692	34	0.098	Mouse
gonad development	GO:0008406	50	0.097	Mouse Worm
multi organism reproductive behavior	GO:0044705	121	0.097	Worm
apoptotic signaling pathway	GO:0097190	27	0.096
tube morphogenesis	GO:0035239	191	0.095	Human Zebrafish Mouse Fly
positive regulation of cell cycle process	GO:0090068	28	0.093
regulation of cellular localization	GO:0060341	136	0.093
regulation of epithelial cell proliferation	GO:0050678	4	0.092	Human
tissue migration	GO:0090130	155	0.091
synapse organization	GO:0050808	196	0.090
positive regulation of molecular function	GO:0044093	136	0.090	Zebrafish
negative regulation of multicellular organismal process	GO:0051241	142	0.090	Mouse
nephron morphogenesis	GO:0072028	3	0.089
covalent chromatin modification	GO:0016569	106	0.086
negative regulation of transcription dna templated	GO:0045892	237	0.086	Mouse Fly
nephron tubule development	GO:0072080	3	0.086
positive regulation of neurogenesis	GO:0050769	41	0.086	Mouse
epithelial cell morphogenesis involved in gastrulation	GO:0003381	7	0.082
establishment of ommatidial planar polarity	GO:0042067	49	0.082
mesenchymal cell development	GO:0014031	1	0.081
negative regulation of cell proliferation	GO:0008285	69	0.081	Human Fly
olfactory bulb axon guidance	GO:0071678	3	0.080
central nervous system neuron differentiation	GO:0021953	8	0.079	Mouse
immune response regulating signaling pathway	GO:0002764	2	0.079
regulation of immune response	GO:0050776	118	0.079
regulation of cellular amino acid metabolic process	GO:0006521	0	0.079
cellular response to carbon dioxide	GO:0071244	2	0.078
cell fate determination	GO:0001709	91	0.078
embryonic axis specification	GO:0000578	107	0.076
divalent inorganic cation transport	GO:0072511	30	0.076
germ band shortening	GO:0007390	19	0.074
regulation of g protein coupled receptor protein signaling pathway	GO:0008277	23	0.074
cell adhesion	GO:0007155	136	0.074
anatomical structure homeostasis	GO:0060249	97	0.073
glial cell differentiation	GO:0010001	35	0.071
nephron tubule morphogenesis	GO:0072078	3	0.070
kidney epithelium development	GO:0072073	3	0.069
negative regulation of programmed cell death	GO:0043069	72	0.068	Fly
adipose tissue development	GO:0060612	2	0.068
pigment cell differentiation	GO:0050931	3	0.067
meiotic cell cycle	GO:0051321	171	0.066
reproductive behavior	GO:0019098	122	0.066	Worm
epithelial cell morphogenesis	GO:0003382	25	0.065
apical constriction	GO:0003383	18	0.065
regulation of stem cell proliferation	GO:0072091	40	0.065	Mouse
cell division	GO:0051301	248	0.064
vesicle mediated transport	GO:0016192	381	0.063
organic hydroxy compound metabolic process	GO:1901615	83	0.063
pigmentation	GO:0043473	75	0.063
negative regulation of cellular protein metabolic process	GO:0032269	85	0.063
organonitrogen compound metabolic process	GO:1901564	318	0.062
cellular response to radiation	GO:0071478	52	0.062
regulation of cellular component movement	GO:0051270	42	0.061
response to endogenous stimulus	GO:0009719	119	0.061
secretion	GO:0046903	109	0.060
tripartite regional subdivision	GO:0007351	103	0.059
polarized epithelial cell differentiation	GO:0030859	10	0.058
regulation of cellular ketone metabolic process	GO:0010565	3	0.058
deactivation of rhodopsin mediated signaling	GO:0016059	17	0.058
eye photoreceptor cell fate commitment	GO:0042706	37	0.057
multi multicellular organism process	GO:0044706	123	0.056	Worm
negative regulation of neurogenesis	GO:0050768	53	0.056	Mouse
mapk cascade	GO:0000165	107	0.055	Human
regulation of photoreceptor cell axon guidance	GO:2000289	5	0.055
cognition	GO:0050890	141	0.054
stem cell development	GO:0048864	79	0.054	Human Mouse
regulation of neurogenesis	GO:0050767	158	0.054	Mouse
cellular ketone metabolic process	GO:0042180	24	0.053
negative regulation of developmental process	GO:0051093	201	0.053	Human Mouse
convergent extension	GO:0060026	2	0.052
nephron development	GO:0072006	3	0.052
regulation of histone modification	GO:0031056	20	0.052
organic acid metabolic process	GO:0006082	103	0.052
positive regulation of response to stimulus	GO:0048584	323	0.052	Human Mouse
telencephalon development	GO:0021537	2	0.052	Mouse
negative regulation of molecular function	GO:0044092	51	0.052
regulation of cell motility	GO:2000145	23	0.052
cardioblast cell fate determination	GO:0007510	3	0.052
oocyte construction	GO:0007308	112	0.052
developmental programmed cell death	GO:0010623	138	0.050
germarium derived egg chamber formation	GO:0007293	101	0.050
cellular response to hexose stimulus	GO:0071331	1	0.050
skeletal muscle organ development	GO:0060538	48	0.050
regulation of cell cycle process	GO:0010564	181	0.050
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.050
calcium ion transport	GO:0006816	24	0.049
phenol containing compound metabolic process	GO:0018958	57	0.049
regulation of intracellular signal transduction	GO:1902531	236	0.048	Human
regulation of hemocyte differentiation	GO:0045610	22	0.048
kidney development	GO:0001822	3	0.048
larval development	GO:0002164	104	0.047	Worm Fly
organonitrogen compound biosynthetic process	GO:1901566	117	0.047
regulation of body fluid levels	GO:0050878	14	0.047
histone modification	GO:0016570	106	0.047
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.046
negative regulation of neuron differentiation	GO:0045665	16	0.046	Mouse
regulation of neuron projection development	GO:0010975	69	0.045
photoreceptor cell fate commitment	GO:0046552	41	0.045
embryo development ending in birth or egg hatching	GO:0009792	152	0.045	Worm
segment polarity determination	GO:0007367	25	0.045
cellular catabolic process	GO:0044248	372	0.044
response to oxygen containing compound	GO:1901700	200	0.044	Mouse
regulation of chromatin organization	GO:1902275	32	0.044
regulation of phosphate metabolic process	GO:0019220	210	0.043	Human
carbohydrate homeostasis	GO:0033500	12	0.043
negative regulation of cell development	GO:0010721	62	0.043	Mouse
regulation of neuron death	GO:1901214	26	0.042
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.042
chromatin organization	GO:0006325	207	0.041
regulation of transport	GO:0051049	181	0.041
regulation of actin cytoskeleton organization	GO:0032956	42	0.040
muscle organ development	GO:0007517	127	0.040
glial cell migration	GO:0008347	31	0.039
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.039
regulation of response to external stimulus	GO:0032101	115	0.039
chromosome organization	GO:0051276	360	0.039
positive regulation of cell adhesion	GO:0045785	10	0.039
sensory perception of taste	GO:0050909	25	0.038
urogenital system development	GO:0001655	72	0.038
renal system development	GO:0072001	72	0.038
positive regulation of transport	GO:0051050	92	0.038
regulation of cell cell adhesion	GO:0022407	21	0.037
establishment of organelle localization	GO:0051656	122	0.037
regulation of humoral immune response	GO:0002920	51	0.037
inositol lipid mediated signaling	GO:0048017	4	0.037
genitalia development	GO:0048806	26	0.037	Mouse Worm
cellular response to growth factor stimulus	GO:0071363	30	0.037
cellular amino acid metabolic process	GO:0006520	61	0.037
positive regulation of locomotion	GO:0040017	8	0.037
neural retina development	GO:0003407	4	0.036
regulation of cellular response to stress	GO:0080135	89	0.036
regulation of oocyte development	GO:0060281	27	0.035
regulation of axonogenesis	GO:0050770	32	0.035
notch signaling pathway	GO:0007219	120	0.035	Mouse
regulation of locomotion	GO:0040012	42	0.035
spindle organization	GO:0007051	253	0.035
response to bacterium	GO:0009617	198	0.035
male sex differentiation	GO:0046661	25	0.035	Mouse
regulation of immune effector process	GO:0002697	52	0.034
response to nitrogen compound	GO:1901698	90	0.034
nuclear transport	GO:0051169	72	0.034
meiosis i	GO:0007127	59	0.034
carboxylic acid metabolic process	GO:0019752	92	0.034
regulation of embryonic pattern specification	GO:1902875	27	0.033
positive regulation of cell cycle	GO:0045787	43	0.033
positive regulation of growth	GO:0045927	75	0.033
cellular response to organic substance	GO:0071310	132	0.033
regulation of cell substrate adhesion	GO:0010810	2	0.033
oxoacid metabolic process	GO:0043436	103	0.033
regulation of endocytosis	GO:0030100	37	0.032
adult walking behavior	GO:0007628	9	0.032
regulation of response to stress	GO:0080134	200	0.032
limb morphogenesis	GO:0035108	1	0.032
single organismal cell cell adhesion	GO:0016337	45	0.032
response to hexose	GO:0009746	3	0.032
phosphorylation	GO:0016310	294	0.031	Human
response to glucose	GO:0009749	2	0.031
neuron migration	GO:0001764	5	0.031
negative regulation of protein metabolic process	GO:0051248	85	0.031
response to lipid	GO:0033993	38	0.031	Mouse
negative regulation of cellular component organization	GO:0051129	108	0.031
compound eye photoreceptor cell differentiation	GO:0001751	140	0.031
regulation of dendrite development	GO:0050773	37	0.030
molting cycle	GO:0042303	56	0.030
regulation of cytoskeleton organization	GO:0051493	89	0.030
cellular amide metabolic process	GO:0043603	80	0.030
regulation of wnt signaling pathway	GO:0030111	68	0.030
regulation of embryonic cell shape	GO:0016476	30	0.030
cellular response to hormone stimulus	GO:0032870	44	0.030
negative regulation of catalytic activity	GO:0043086	42	0.030
regulation of cell maturation	GO:1903429	27	0.029
negative regulation of apoptotic process	GO:0043066	63	0.029	Fly
cytoplasmic transport	GO:0016482	130	0.029
regulation of reproductive process	GO:2000241	54	0.029
catabolic process	GO:0009056	409	0.029
positive regulation of synaptic transmission	GO:0050806	15	0.029
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.029
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.029
carbohydrate metabolic process	GO:0005975	82	0.029
intracellular transport	GO:0046907	228	0.029
oocyte anterior posterior axis specification	GO:0007314	72	0.028
establishment of glial blood brain barrier	GO:0060857	14	0.028
developmental pigmentation	GO:0048066	68	0.028
establishment of mitotic spindle localization	GO:0040001	17	0.028
anterior posterior axis specification embryo	GO:0008595	103	0.028
morphogenesis of a branching epithelium	GO:0061138	45	0.028	Mouse
regulation of cellular amide metabolic process	GO:0034248	39	0.027
positive regulation of axonogenesis	GO:0050772	2	0.027
secretion by cell	GO:0032940	101	0.027
cellular response to carbohydrate stimulus	GO:0071322	4	0.027
positive regulation of signal transduction	GO:0009967	223	0.027	Human Mouse
meiotic cell cycle process	GO:1903046	132	0.027
extrinsic apoptotic signaling pathway	GO:0097191	1	0.027
negative regulation of wnt signaling pathway	GO:0030178	28	0.027	Human Mouse
positive regulation of immune system process	GO:0002684	68	0.027
phototransduction visible light	GO:0007603	27	0.026
ion transport	GO:0006811	145	0.026
cardiac cell fate commitment	GO:0060911	17	0.026
phototransduction	GO:0007602	52	0.026
response to organonitrogen compound	GO:0010243	75	0.026
cardioblast cell fate commitment	GO:0042684	14	0.026
epithelium migration	GO:0090132	148	0.026
appendage development	GO:0048736	401	0.026	Fly
regulation of asymmetric cell division	GO:0009786	3	0.026
regulation of response to biotic stimulus	GO:0002831	63	0.025
proteolysis	GO:0006508	192	0.025	Human
regulation of proteolysis	GO:0030162	87	0.025	Human
apical junction assembly	GO:0043297	32	0.025
positive regulation of protein metabolic process	GO:0051247	128	0.025
ovarian follicle cell migration	GO:0007297	121	0.025
cellular homeostasis	GO:0019725	80	0.025
catecholamine biosynthetic process	GO:0042423	3	0.025
negative regulation of axon extension	GO:0030517	3	0.025
neuron projection extension	GO:1990138	32	0.024
single organism carbohydrate metabolic process	GO:0044723	72	0.024
heart process	GO:0003015	37	0.024

SoxN disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of cellular proliferation	DOID:14566	0.268
organ system cancer	DOID:0050686	0.268
cancer	DOID:162	0.268
disease of anatomical entity	DOID:7	0.122	Human
nervous system disease	DOID:863	0.092	Human
sensory system disease	DOID:0050155	0.026	Human
eye and adnexa disease	DOID:1492	0.026	Human

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