IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

CG18745 (Dmel_CG18745)

CG18745 gene product from transcript CG18745-RA

(Aliases: Dmel\CG18745)

FLYBASE: FBgn0042102
Entrez: 59141
UniProtKB: Q9I7L0

Process Predictions
Disease Predictions

CG18745 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
post embryonic appendage morphogenesis	GO:0035120	385	0.788
appendage development	GO:0048736	401	0.739
appendage morphogenesis	GO:0035107	397	0.724
imaginal disc derived appendage development	GO:0048737	399	0.687
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.556
wing disc morphogenesis	GO:0007472	344	0.478
imaginal disc derived wing morphogenesis	GO:0007476	337	0.369
acylglycerol biosynthetic process	GO:0046463	2	0.257
triglyceride biosynthetic process	GO:0019432	2	0.202
imaginal disc derived leg morphogenesis	GO:0007480	80	0.201
leg disc development	GO:0035218	92	0.161
response to other organism	GO:0051707	293	0.128
anion homeostasis	GO:0055081	3	0.125
positive regulation of sequestering of triglyceride	GO:0010890	1	0.125
vesicle mediated transport	GO:0016192	381	0.123	Fly
response to organonitrogen compound	GO:0010243	75	0.114
catabolic process	GO:0009056	409	0.114
homeostatic process	GO:0042592	199	0.113
phospholipid homeostasis	GO:0055091	1	0.109
organophosphate metabolic process	GO:0019637	195	0.107
endocytosis	GO:0006897	310	0.103	Fly
regulation of programmed cell death	GO:0043067	152	0.102
cellular response to chemical stimulus	GO:0070887	199	0.101
regulation of sequestering of triglyceride	GO:0010889	3	0.100
cellular protein modification process	GO:0006464	438	0.097
phagocytosis	GO:0006909	215	0.095	Fly
anatomical structure homeostasis	GO:0060249	97	0.091
neutral lipid biosynthetic process	GO:0046460	2	0.090
cholesterol homeostasis	GO:0042632	3	0.088
cellular catabolic process	GO:0044248	372	0.085
response to external biotic stimulus	GO:0043207	293	0.083
regulation of synapse assembly	GO:0051963	94	0.082
lipid catabolic process	GO:0016042	21	0.082
leg disc morphogenesis	GO:0007478	80	0.081
septate junction assembly	GO:0019991	26	0.080
epithelial structure maintenance	GO:0010669	17	0.079
open tracheal system development	GO:0007424	204	0.076
sterol homeostasis	GO:0055092	4	0.073
regulation of apoptotic process	GO:0042981	130	0.072
regulation of cell death	GO:0010941	173	0.071
morphogenesis of an epithelium	GO:0002009	276	0.071
cellular lipid catabolic process	GO:0044242	16	0.071
response to biotic stimulus	GO:0009607	294	0.069
small molecule metabolic process	GO:0044281	305	0.067
tissue morphogenesis	GO:0048729	297	0.066
synapse organization	GO:0050808	196	0.066
segmentation	GO:0035282	207	0.065
organonitrogen compound metabolic process	GO:1901564	318	0.065
ethanolamine containing compound metabolic process	GO:0042439	4	0.064
protein modification by small protein conjugation or removal	GO:0070647	106	0.063
glycerolipid catabolic process	GO:0046503	3	0.061
tissue homeostasis	GO:0001894	36	0.061
multicellular organismal homeostasis	GO:0048871	41	0.060
death	GO:0016265	284	0.059
negative regulation of programmed cell death	GO:0043069	72	0.057
response to oxygen containing compound	GO:1901700	200	0.057
triglyceride catabolic process	GO:0019433	3	0.054
ubiquitin dependent protein catabolic process	GO:0006511	78	0.054
oxoacid metabolic process	GO:0043436	103	0.053
carboxylic acid metabolic process	GO:0019752	92	0.053
positive regulation of lipid storage	GO:0010884	4	0.051
sulfur compound metabolic process	GO:0006790	59	0.051
neurological system process	GO:0050877	358	0.050
epithelial cell migration	GO:0010631	148	0.050
centrosome cycle	GO:0007098	137	0.048
cell proliferation	GO:0008283	299	0.048
protein catabolic process	GO:0030163	101	0.048
single organism catabolic process	GO:0044712	228	0.047
acylglycerol catabolic process	GO:0046464	3	0.046
cellular amino acid metabolic process	GO:0006520	61	0.045
neutral lipid catabolic process	GO:0046461	3	0.045
homophilic cell adhesion via plasma membrane adhesion molecules	GO:0007156	18	0.044
nucleoside phosphate metabolic process	GO:0006753	162	0.044
cholesterol transport	GO:0030301	2	0.043
response to nutrient levels	GO:0031667	114	0.043
forebrain development	GO:0030900	2	0.043
heart development	GO:0007507	82	0.042
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.042
maintenance of epithelial integrity open tracheal system	GO:0035160	12	0.042
cell adhesion involved in heart morphogenesis	GO:0061343	12	0.042
fatty acid biosynthetic process	GO:0006633	6	0.041
apical junction assembly	GO:0043297	32	0.039
regulation of tube size open tracheal system	GO:0035151	43	0.039
organic substance catabolic process	GO:1901575	308	0.039
cell cell junction organization	GO:0045216	55	0.039
pyridine nucleotide metabolic process	GO:0019362	2	0.038
synapse assembly	GO:0007416	143	0.038
negative regulation of growth	GO:0045926	84	0.037
regulation of synapse organization	GO:0050807	110	0.036
chemical homeostasis	GO:0048878	92	0.036
gland development	GO:0048732	191	0.036
regulation of cholesterol transport	GO:0032374	1	0.036
nucleobase containing small molecule metabolic process	GO:0055086	174	0.035
single organism biosynthetic process	GO:0044711	206	0.034
response to temperature stimulus	GO:0009266	106	0.034
immune system process	GO:0002376	347	0.034
organelle fission	GO:0048285	340	0.034
heparan sulfate proteoglycan biosynthetic process	GO:0015012	10	0.033
regulation of sterol transport	GO:0032371	1	0.033
ion transmembrane transport	GO:0034220	122	0.032
spindle organization	GO:0007051	253	0.032
carbohydrate derivative catabolic process	GO:1901136	118	0.032
regulation of lipid transport	GO:0032368	3	0.032
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.032
cell cycle phase transition	GO:0044770	140	0.032
cellular response to dna damage stimulus	GO:0006974	223	0.031
rhythmic process	GO:0048511	106	0.031
mitotic dna damage checkpoint	GO:0044773	74	0.030
response to endogenous stimulus	GO:0009719	119	0.030
actin filament based process	GO:0030029	220	0.030
response to organic substance	GO:0010033	284	0.030
negative regulation of multicellular organismal process	GO:0051241	142	0.030
embryonic morphogenesis	GO:0048598	206	0.029
glycoprotein biosynthetic process	GO:0009101	41	0.029
transmembrane transport	GO:0055085	139	0.029
cellular macromolecule catabolic process	GO:0044265	136	0.029
organophosphate catabolic process	GO:0046434	112	0.029
body morphogenesis	GO:0010171	2	0.029
imaginal disc derived leg segmentation	GO:0036011	26	0.028
proteasomal protein catabolic process	GO:0010498	59	0.028
pyridine containing compound metabolic process	GO:0072524	3	0.028
macromolecular complex assembly	GO:0065003	256	0.027
protein modification process	GO:0036211	438	0.027
response to copper ion	GO:0046688	4	0.027
regulation of organelle organization	GO:0033043	196	0.027
negative regulation of developmental process	GO:0051093	201	0.026
spermatid differentiation	GO:0048515	114	0.026
regulation of synapse structure and activity	GO:0050803	128	0.026
modification dependent protein catabolic process	GO:0019941	78	0.026
chaeta development	GO:0022416	97	0.026
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.026
nicotinamide nucleotide metabolic process	GO:0046496	2	0.026
ion homeostasis	GO:0050801	55	0.026
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.025
centrosome organization	GO:0051297	163	0.025
response to carbohydrate	GO:0009743	15	0.025
developmental growth	GO:0048589	280	0.025
chromosome organization	GO:0051276	360	0.025
protein localization	GO:0008104	284	0.025
carbohydrate derivative metabolic process	GO:1901135	217	0.025
defense response to bacterium	GO:0042742	178	0.025
proteolysis	GO:0006508	192	0.024
cell division	GO:0051301	248	0.024
regulation of transport	GO:0051049	181	0.024
response to extracellular stimulus	GO:0009991	116	0.024
exocrine system development	GO:0035272	162	0.024
multi multicellular organism process	GO:0044706	123	0.024
cell adhesion	GO:0007155	136	0.024
regulation of localization	GO:0032879	275	0.023
phosphatidic acid metabolic process	GO:0046473	1	0.023
limb development	GO:0060173	1	0.023
cell junction organization	GO:0034330	57	0.023
morphogenesis of embryonic epithelium	GO:0016331	94	0.023
cell junction assembly	GO:0034329	42	0.023
developmental maturation	GO:0021700	172	0.023
organonitrogen compound biosynthetic process	GO:1901566	117	0.022
spermatid development	GO:0007286	98	0.022
phosphatidylethanolamine metabolic process	GO:0046337	1	0.022
macromolecule catabolic process	GO:0009057	161	0.022
wound healing	GO:0042060	75	0.022
negative regulation of synapse assembly	GO:0051964	39	0.022
cellular lipid metabolic process	GO:0044255	83	0.022
dna packaging	GO:0006323	91	0.021
response to peptide hormone	GO:0043434	29	0.021
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.021
regulation of cytoskeleton organization	GO:0051493	89	0.021
modification dependent macromolecule catabolic process	GO:0043632	79	0.021
positive regulation of cell migration	GO:0030335	2	0.021
dna metabolic process	GO:0006259	227	0.021
glycoprotein metabolic process	GO:0009100	41	0.020
heparan sulfate proteoglycan metabolic process	GO:0030201	10	0.020
response to nitrogen compound	GO:1901698	90	0.020
posttranscriptional regulation of gene expression	GO:0010608	145	0.020
proteoglycan biosynthetic process	GO:0030166	10	0.020
mitotic nuclear division	GO:0007067	213	0.020
biological adhesion	GO:0022610	138	0.020
cellular protein catabolic process	GO:0044257	83	0.020
ovarian follicle cell development	GO:0030707	248	0.020
regulation of phosphorus metabolic process	GO:0051174	210	0.020
meiosis i	GO:0007127	59	0.020
developmental growth involved in morphogenesis	GO:0060560	65	0.019
negative regulation of nervous system development	GO:0051961	92	0.019
programmed cell death	GO:0012501	257	0.019
regulation of tube architecture open tracheal system	GO:0035152	68	0.019
mitotic cell cycle phase transition	GO:0044772	138	0.019
positive regulation of gene expression	GO:0010628	290	0.019
appendage segmentation	GO:0035285	26	0.019
response to heat	GO:0009408	63	0.019
male courtship behavior veined wing generated song production	GO:0045433	20	0.019
telomere organization	GO:0032200	21	0.019
negative regulation of cell proliferation	GO:0008285	69	0.018
cardiovascular system development	GO:0072358	82	0.018
negative regulation of cell cycle process	GO:0010948	109	0.018
androgen metabolic process	GO:0008209	1	0.018
mating	GO:0007618	120	0.018
response to abiotic stimulus	GO:0009628	341	0.017
negative regulation of cell death	GO:0060548	81	0.017
learning or memory	GO:0007611	141	0.017
cellular component assembly involved in morphogenesis	GO:0010927	151	0.017
organic acid metabolic process	GO:0006082	103	0.017
cellular modified amino acid metabolic process	GO:0006575	45	0.017
response to wounding	GO:0009611	94	0.017
response to lipopolysaccharide	GO:0032496	4	0.017
response to acid chemical	GO:0001101	25	0.016
actin filament organization	GO:0007015	126	0.016
regulation of cellular component biogenesis	GO:0044087	201	0.016
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.016
cellular nitrogen compound catabolic process	GO:0044270	165	0.016
response to organophosphorus	GO:0046683	2	0.016
negative regulation of mitotic cell cycle	GO:0045930	109	0.016
chemotaxis	GO:0006935	249	0.016
chromosome condensation	GO:0030261	41	0.016
regulation of nervous system development	GO:0051960	248	0.015
cell death	GO:0008219	279	0.015
regulation of cellular catabolic process	GO:0031329	157	0.015
mitotic cell cycle checkpoint	GO:0007093	88	0.015
axonogenesis	GO:0007409	290	0.015
antimicrobial humoral response	GO:0019730	99	0.015
telencephalon development	GO:0021537	2	0.015
negative regulation of stress activated protein kinase signaling cascade	GO:0070303	20	0.015
indole containing compound biosynthetic process	GO:0042435	4	0.015
regulation of purine nucleotide metabolic process	GO:1900542	62	0.015
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.015
nad metabolic process	GO:0019674	1	0.015
regulation of protein metabolic process	GO:0051246	256	0.015
growth	GO:0040007	359	0.015
cellular ketone metabolic process	GO:0042180	24	0.015
secondary metabolic process	GO:0019748	75	0.015
asymmetric cell division	GO:0008356	37	0.015
response to bacterium	GO:0009617	198	0.015
positive regulation of transcription dna templated	GO:0045893	266	0.015
positive regulation of macromolecule metabolic process	GO:0010604	405	0.015
cell maturation	GO:0048469	144	0.015
cellular response to endogenous stimulus	GO:0071495	80	0.014
carboxylic acid biosynthetic process	GO:0046394	15	0.014
heart morphogenesis	GO:0003007	32	0.014
cellular homeostasis	GO:0019725	80	0.014
male courtship behavior veined wing extension	GO:0048065	22	0.014
multi organism behavior	GO:0051705	175	0.014
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.014
positive regulation of cell motility	GO:2000147	3	0.014
reproductive behavior	GO:0019098	122	0.014
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.014
regionalization	GO:0003002	416	0.014
regulation of cell cycle	GO:0051726	291	0.014
negative regulation of apoptotic process	GO:0043066	63	0.014
positive regulation of rna biosynthetic process	GO:1902680	266	0.014
digestive system development	GO:0055123	149	0.014
vesicle organization	GO:0016050	44	0.014
locomotory behavior	GO:0007626	176	0.014
defense response to other organism	GO:0098542	225	0.014
tissue migration	GO:0090130	155	0.013
mitotic g2 dna damage checkpoint	GO:0007095	69	0.013
regulation of mitotic cell cycle	GO:0007346	190	0.013
salivary gland morphogenesis	GO:0007435	145	0.013
protein complex biogenesis	GO:0070271	201	0.013
response to peptide	GO:1901652	29	0.013
cuticle development	GO:0042335	86	0.013
negative regulation of cellular component organization	GO:0051129	108	0.013
synaptic growth at neuromuscular junction	GO:0051124	119	0.013
eye antennal disc development	GO:0035214	60	0.013
epithelium migration	GO:0090132	148	0.013
regulation of molecular function	GO:0065009	217	0.013
camera type eye development	GO:0043010	4	0.013
axon development	GO:0061564	297	0.013
cation transport	GO:0006812	110	0.013
positive regulation of cell death	GO:0010942	69	0.013
rho protein signal transduction	GO:0007266	14	0.013
spinal cord development	GO:0021510	1	0.013
regulation of cell cycle process	GO:0010564	181	0.012
lipid storage	GO:0019915	38	0.012
mitotic g2 m transition checkpoint	GO:0044818	70	0.012
male courtship behavior veined wing vibration	GO:0016545	21	0.012
egg activation	GO:0007343	9	0.012
potassium ion transport	GO:0006813	20	0.012
lipid metabolic process	GO:0006629	121	0.012
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.012
convergent extension	GO:0060026	2	0.012
gland morphogenesis	GO:0022612	145	0.012
ribose phosphate metabolic process	GO:0019693	145	0.012
columnar cuboidal epithelial cell development	GO:0002066	249	0.012
acylglycerol homeostasis	GO:0055090	19	0.012
germ cell migration	GO:0008354	43	0.012
peptidyl amino acid modification	GO:0018193	105	0.012
regulation of cellular amino acid metabolic process	GO:0006521	0	0.012
circulatory system development	GO:0072359	82	0.012
regulation of lipid storage	GO:0010883	22	0.012
phosphatidylcholine metabolic process	GO:0046470	3	0.012
positive regulation of programmed cell death	GO:0043068	62	0.012
membrane organization	GO:0061024	112	0.012
regulation of cell proliferation	GO:0042127	163	0.012
actin cytoskeleton organization	GO:0030036	206	0.012
vitamin metabolic process	GO:0006766	2	0.012
inorganic ion transmembrane transport	GO:0098660	73	0.012
protein modification by small protein conjugation	GO:0032446	79	0.012
regulation of stress activated mapk cascade	GO:0032872	41	0.011
regulation of cell morphogenesis	GO:0022604	163	0.011
ribonucleoside metabolic process	GO:0009119	127	0.011
cation transmembrane transport	GO:0098655	88	0.011
salivary gland development	GO:0007431	162	0.011
positive regulation of cellular biosynthetic process	GO:0031328	316	0.011
axon guidance	GO:0007411	233	0.011
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.011
maintenance of location	GO:0051235	73	0.011
protein phosphorylation	GO:0006468	169	0.011
cellular amine metabolic process	GO:0044106	12	0.011
cell fate specification	GO:0001708	71	0.011
courtship behavior	GO:0007619	68	0.011
cell projection assembly	GO:0030031	94	0.011
extrinsic apoptotic signaling pathway	GO:0097191	1	0.011
actin filament bundle organization	GO:0061572	28	0.011
rhabdomere development	GO:0042052	38	0.011
regulation of cellular component size	GO:0032535	98	0.011
oocyte development	GO:0048599	124	0.011
defense response to gram negative bacterium	GO:0050829	94	0.011
decapentaplegic signaling pathway	GO:0008101	19	0.011
regulation of reproductive process	GO:2000241	54	0.011
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.011
dna conformation change	GO:0071103	105	0.011
regulation of developmental growth	GO:0048638	174	0.011
peptidyl proline modification	GO:0018208	3	0.011
eggshell formation	GO:0030703	105	0.011
mitotic sister chromatid segregation	GO:0000070	87	0.011
nephron tubule development	GO:0072080	3	0.011
response to monosaccharide	GO:0034284	4	0.011
chromosome separation	GO:0051304	42	0.011
regulation of phosphorylation	GO:0042325	147	0.011
chromosome segregation	GO:0007059	157	0.011
steroid catabolic process	GO:0006706	1	0.011
autophagic cell death	GO:0048102	83	0.011
small molecule biosynthetic process	GO:0044283	37	0.011
mitotic dna integrity checkpoint	GO:0044774	75	0.011
cellular response to hormone stimulus	GO:0032870	44	0.010
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	26	0.010
cellular response to organic substance	GO:0071310	132	0.010
cell aging	GO:0007569	2	0.010
jnk cascade	GO:0007254	50	0.010
nucleotide metabolic process	GO:0009117	161	0.010
negative regulation of cell cycle phase transition	GO:1901988	103	0.010
limb morphogenesis	GO:0035108	1	0.010
response to hexose	GO:0009746	3	0.010
monocarboxylic acid transport	GO:0015718	3	0.010
larval behavior	GO:0030537	42	0.010
positive regulation of transport	GO:0051050	92	0.010
regulation of imaginal disc derived wing size	GO:0044719	20	0.010
tube morphogenesis	GO:0035239	191	0.010

CG18745 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
inherited metabolic disorder	DOID:655	0.105
familial combined hyperlipidemia	DOID:13809	0.105
disease of metabolism	DOID:0014667	0.105
lipid metabolism disorder	DOID:3146	0.105
familial hyperlipidemia	DOID:1168	0.105
integumentary system disease	DOID:16	0.064
disease of anatomical entity	DOID:7	0.064
hair disease	DOID:421	0.064
carbohydrate metabolism disease	DOID:0050013	0.060
glucose metabolism disease	DOID:4194	0.060
acquired metabolic disease	DOID:0060158	0.060
type 2 diabetes mellitus	DOID:9352	0.060
diabetes mellitus	DOID:9351	0.060
familial lipoprotein lipase deficiency	DOID:14118	0.039
familial hypertriglyceridemia	DOID:0050527	0.030
cardiovascular system disease	DOID:1287	0.025
vascular disease	DOID:178	0.025
nervous system disease	DOID:863	0.021
urinary system disease	DOID:18	0.016
sensory system disease	DOID:0050155	0.015
kidney disease	DOID:557	0.013
hypertension	DOID:10763	0.011
artery disease	DOID:0050828	0.011

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