Drosophila melanogaster

52 known processes

PEK (Dmel_CG2087)

pancreatic eIF-2alpha kinase

(Aliases: CG2087,PERK,EIF2-like,DPERK,DpERK,Perk,DmPEK,Dmel\CG2087)

PEK biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
developmental programmed cell deathGO:00106231380.303
single organism catabolic processGO:00447122280.293
regulation of cellular catabolic processGO:00313291570.291
heterocycle catabolic processGO:00467001660.239
regulation of mitotic cell cycleGO:00073461900.230
nucleotide metabolic processGO:00091171610.223
compound eye developmentGO:00487493070.212
positive regulation of cell communicationGO:00106472500.193
Mouse
neurological system processGO:00508773580.181
Mouse
positive regulation of nucleobase containing compound metabolic processGO:00459353320.169
Mouse
deathGO:00162652840.168
Mouse Worm
intracellular signal transductionGO:00355563000.165
Mouse
response to biotic stimulusGO:00096072940.137
Human
positive regulation of nitrogen compound metabolic processGO:00511733540.126
Mouse
purine containing compound metabolic processGO:00725211550.121
organophosphate metabolic processGO:00196371950.110
negative regulation of cellular metabolic processGO:00313243820.107
Mouse Rat
purine ribonucleotide metabolic processGO:00091501450.106
nucleobase containing compound catabolic processGO:00346551650.105
negative regulation of multicellular organismal processGO:00512411420.104
Mouse
compound eye morphogenesisGO:00017452490.097
regulation of cell cycleGO:00517262910.088
regulation of response to stressGO:00801342000.086
Mouse
organonitrogen compound metabolic processGO:19015643180.081
positive regulation of signalingGO:00230562430.081
Mouse
positive regulation of rna metabolic processGO:00512542710.076
Mouse
chromosome organizationGO:00512763600.076
organic substance catabolic processGO:19015753080.075
purine ribonucleoside metabolic processGO:00461281270.075
regulation of catabolic processGO:00098941700.072
programmed cell deathGO:00125012570.072
Mouse
positive regulation of nervous system developmentGO:0051962690.072
response to other organismGO:00517072930.072
purine ribonucleoside triphosphate catabolic processGO:00092071080.071
positive regulation of response to stimulusGO:00485843230.071
Mouse
positive regulation of biosynthetic processGO:00098913160.071
Mouse
phagocytosisGO:00069092150.070
sensory organ morphogenesisGO:00905962600.070
defense response to other organismGO:00985422250.070
response to oxygen containing compoundGO:19017002000.068
immune system processGO:00023763470.068
regulation of protein metabolic processGO:00512462560.067
Mouse Rat
nucleobase containing small molecule metabolic processGO:00550861740.065
establishment of localization in cellGO:00516494020.065
response to temperature stimulusGO:00092661060.065
purine nucleoside triphosphate metabolic processGO:00091441190.064
defense responseGO:00069523000.063
regulation of erbb signaling pathwayGO:1901184420.062
regulation of phosphorus metabolic processGO:00511742100.060
glycosyl compound metabolic processGO:19016571270.060
response to external biotic stimulusGO:00432072930.060
cell deathGO:00082192790.059
Mouse Worm
eye developmentGO:00016543230.059
ribonucleoside triphosphate catabolic processGO:00092031080.059
positive regulation of programmed cell deathGO:0043068620.058
Mouse
regulation of immune responseGO:00507761180.057
purine ribonucleoside catabolic processGO:00461301120.055
regulation of cell differentiationGO:00455953020.054
post embryonic appendage morphogenesisGO:00351203850.053
head developmentGO:00603221350.053
chromatin modificationGO:00165681470.052
nucleoside catabolic processGO:00091641120.052
ribonucleotide metabolic processGO:00092591450.052
protein modification processGO:00362114380.051
vesicle mediated transportGO:00161923810.050
cellular catabolic processGO:00442483720.050
regulation of catalytic activityGO:00507901850.050
Mouse
brain developmentGO:00074201200.050
regulation of r7 cell differentiationGO:0045676150.049
purine nucleotide metabolic processGO:00061631460.049
nucleoside metabolic processGO:00091161270.048
phosphorylationGO:00163102940.047
atp metabolic processGO:0046034490.047
immune responseGO:00069552460.047
ribonucleoside catabolic processGO:00424541120.047
ommatidial rotationGO:0016318200.046
organic substance transportGO:00717022570.046
forebrain developmentGO:003090020.046
nucleoside phosphate metabolic processGO:00067531620.045
purine nucleoside catabolic processGO:00061521120.045
camera type eye developmentGO:004301040.045
regulation of nucleotide metabolic processGO:0006140620.045
regulation of programmed cell deathGO:00430671520.044
Mouse
endocytosisGO:00068973100.044
organic cyclic compound catabolic processGO:19013611680.041
regulation of phosphate metabolic processGO:00192202100.041
body morphogenesisGO:001017120.041
catabolic processGO:00090564090.041
developmental growthGO:00485892800.041
taxisGO:00423303040.040
eye photoreceptor cell differentiationGO:00017541450.040
regulation of ras protein signal transductionGO:0046578930.040
defense response to bacteriumGO:00427421780.039
cellular nitrogen compound catabolic processGO:00442701650.039
carbohydrate derivative catabolic processGO:19011361180.039
nucleoside triphosphate metabolic processGO:00091411200.039
positive regulation of signal transductionGO:00099672230.039
Mouse
positive regulation of cellular amino acid metabolic processGO:004576400.038
regulation of cell cycle g1 s phase transitionGO:1902806230.038
aromatic compound catabolic processGO:00194391660.038
regulation of cell cycle processGO:00105641810.038
branched chain amino acid transportGO:001580330.038
ribonucleotide catabolic processGO:00092611090.038
ribonucleoside triphosphate metabolic processGO:00091991190.037
regulation of apoptotic processGO:00429811300.037
Mouse
synaptic transmissionGO:00072682880.036
response to abiotic stimulusGO:00096283410.036
morphogenesis of a branching epitheliumGO:0061138450.036
regulation of developmental growthGO:00486381740.036
ribose phosphate metabolic processGO:00196931450.035
regulation of molecular functionGO:00650092170.035
Mouse
telencephalon developmentGO:002153720.035
tissue morphogenesisGO:00487292970.035
photoreceptor cell differentiationGO:00465301700.034
transcription from rna polymerase ii promoterGO:00063663680.033
Mouse
purine nucleoside metabolic processGO:00422781270.033
regulation of intracellular signal transductionGO:19025312360.033
Mouse
single organism biosynthetic processGO:00447112060.033
positive regulation of macromolecule metabolic processGO:00106044050.032
Mouse
nucleoside triphosphate catabolic processGO:00091431080.032
response to lipopolysaccharideGO:003249640.032
carbohydrate derivative metabolic processGO:19011352170.032
acid secretionGO:004671710.032
cell proliferationGO:00082832990.031
establishment of organelle localizationGO:00516561220.031
negative regulation of macromolecule biosynthetic processGO:00105582700.031
Mouse Rat
establishment of tissue polarityGO:0007164870.031
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.030
Mouse
cellular macromolecule catabolic processGO:00442651360.030
modification dependent protein catabolic processGO:0019941780.030
establishment of planar polarityGO:0001736870.029
embryonic organ developmentGO:0048568500.029
defense response to gram negative bacteriumGO:0050829940.029
regulation of nucleoside metabolic processGO:0009118500.029
regulation of hydrolase activityGO:0051336970.029
Mouse
positive regulation of nucleic acid templated transcriptionGO:19035082660.029
Mouse
purine nucleoside triphosphate catabolic processGO:00091461080.029
secretionGO:00469031090.029
Mouse
regulation of immune system processGO:00026821760.028
protein transportGO:00150311550.028
regulation of small gtpase mediated signal transductionGO:0051056930.028
purine nucleotide catabolic processGO:00061951090.028
wing disc morphogenesisGO:00074723440.028
posttranscriptional regulation of gene expressionGO:00106081450.028
Mouse Rat
positive regulation of purine nucleotide metabolic processGO:1900544550.027
regulation of anatomical structure sizeGO:00900661630.027
intracellular transportGO:00469072280.027
positive regulation of catabolic processGO:00098961050.027
purine nucleoside monophosphate metabolic processGO:0009126500.027
homeostatic processGO:00425921990.026
regulation of nervous system developmentGO:00519602480.026
Mouse
salivary gland developmentGO:00074311620.025
extrinsic apoptotic signaling pathwayGO:009719110.025
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.025
Mouse
purine containing compound catabolic processGO:00725231120.025
morphogenesis of a polarized epitheliumGO:0001738930.025
regionalizationGO:00030024160.025
oxoacid metabolic processGO:00434361030.024
Mouse
response to extracellular stimulusGO:00099911160.024
regulation of cellular amine metabolic processGO:003323830.023
regulation of neurogenesisGO:00507671580.023
pigment metabolic processGO:0042440840.023
positive regulation of cell differentiationGO:0045597640.023
positive regulation of cellular catabolic processGO:0031331950.022
dna metabolic processGO:00062592270.022
cellular macromolecule localizationGO:00707272200.022
negative regulation of developmental growthGO:0048640640.022
regulation of mitotic sister chromatid separationGO:0010965280.022
regulation of growthGO:00400082330.022
Worm
small gtpase mediated signal transductionGO:0007264880.022
eye morphogenesisGO:00485922600.021
stem cell differentiationGO:00488631170.021
endomembrane system organizationGO:00102561190.021
Mouse
memoryGO:0007613940.021
positive regulation of macromolecule biosynthetic processGO:00105572830.021
Mouse
innate immune responseGO:00450871440.021
apoptotic processGO:00069151590.021
Mouse
establishment or maintenance of cell polarityGO:00071631670.021
nucleotide catabolic processGO:00091661090.021
regulation of cell deathGO:00109411730.021
Mouse Worm
regulation of purine nucleotide metabolic processGO:1900542620.021
nucleoside monophosphate metabolic processGO:0009123520.020
agingGO:00075681430.020
Worm
ribonucleoside metabolic processGO:00091191270.020
response to heatGO:0009408630.020
cell cycle checkpointGO:0000075950.020
regulation of transcription from rna polymerase ii promoterGO:00063573780.019
Mouse
epithelial cell developmentGO:00020642740.019
organonitrogen compound biosynthetic processGO:19015661170.019
purine ribonucleotide catabolic processGO:00091541090.019
macromolecule catabolic processGO:00090571610.019
negative regulation of cell proliferationGO:0008285690.019
positive regulation of phosphorus metabolic processGO:00105621390.019
regulation of organ morphogenesisGO:2000027780.019
nitrogen compound transportGO:0071705850.019
growthGO:00400073590.019
Worm
single organism intracellular transportGO:19025822070.018
gtp catabolic processGO:0006184720.018
mitotic cell cycle phase transitionGO:00447721380.018
negative regulation of cell developmentGO:0010721620.018
regulation of innate immune responseGO:0045088710.018
ribonucleoside monophosphate metabolic processGO:0009161510.018
proteasomal protein catabolic processGO:0010498590.018
purine ribonucleoside triphosphate metabolic processGO:00092051190.018
regulation of cell developmentGO:00602842150.018
positive regulation of rna biosynthetic processGO:19026802660.018
Mouse
regulation of organelle organizationGO:00330431960.018
positive regulation of cellular biosynthetic processGO:00313283160.017
Mouse
negative regulation of cell differentiationGO:00455961430.017
organonitrogen compound catabolic processGO:19015651280.017
positive regulation of cell deathGO:0010942690.017
Mouse
negative regulation of apoptotic processGO:0043066630.017
Mouse
regulation of immune effector processGO:0002697520.017
imaginal disc pattern formationGO:0007447910.017
guanosine containing compound catabolic processGO:1901069740.017
mitotic nuclear divisionGO:00070672130.017
lipid localizationGO:0010876540.017
skin developmentGO:0043588650.017
columnar cuboidal epithelial cell differentiationGO:00020652560.016
chemosensory behaviorGO:00076351060.016
tube morphogenesisGO:00352391910.016
secretion by cellGO:00329401010.016
small molecule metabolic processGO:00442813050.016
Mouse
compound eye photoreceptor cell differentiationGO:00017511400.016
r3 r4 cell differentiationGO:0048056120.016
regulation of intracellular transportGO:0032386640.016
dorsal ventral axis specification ovarian follicular epitheliumGO:0008069130.016
organophosphate catabolic processGO:00464341120.016
vesicle organizationGO:0016050440.016
notch signaling pathwayGO:00072191200.016
positive regulation of multicellular organismal processGO:00512401430.016
regulation of cellular localizationGO:00603411360.016
regulation of organ growthGO:0046620420.016
actin filament organizationGO:00070151260.015
proteolysisGO:00065081920.015
Mouse
gland developmentGO:00487321910.015
Mouse
positive regulation of developmental processGO:00510941430.015
spindle organizationGO:00070512530.015
response to nutrient levelsGO:00316671140.015
salivary gland morphogenesisGO:00074351450.015
negative regulation of programmed cell deathGO:0043069720.015
Mouse
appendage morphogenesisGO:00351073970.015
positive regulation of transcription dna templatedGO:00458932660.015
Mouse
regulation of gene expression epigeneticGO:00400291280.014
branching morphogenesis of an epithelial tubeGO:0048754450.014
autophagic cell deathGO:0048102830.014
regulation of gtp catabolic processGO:0033124440.014
purine ribonucleoside monophosphate metabolic processGO:0009167500.014
carboxylic acid metabolic processGO:0019752920.014
Mouse
response to bacteriumGO:00096171980.014
positive regulation of phosphate metabolic processGO:00459371390.014
regulation of phosphorylationGO:00423251470.014
dna integrity checkpointGO:0031570810.014
negative regulation of developmental processGO:00510932010.014
Mouse
respiratory system developmentGO:00605412130.014
gland morphogenesisGO:00226121450.014
negative regulation of nucleobase containing compound metabolic processGO:00459342610.014
positive regulation of gene expressionGO:00106282900.014
Mouse
regulation of notch signaling pathwayGO:00085931000.014
positive regulation of cellular component biogenesisGO:0044089800.014
regulation of multicellular organismal developmentGO:20000264140.014
Mouse
negative regulation of response to stimulusGO:00485852580.014
modification dependent macromolecule catabolic processGO:0043632790.014
epithelial cell differentiationGO:00308553220.014
ras protein signal transductionGO:0007265880.014
eggshell formationGO:00307031050.013
mitotic dna damage checkpointGO:0044773740.013
male gamete generationGO:00482322010.013
negative regulation of phosphate metabolic processGO:0045936450.013
cell cycle g1 s phase transitionGO:0044843310.013
atp catabolic processGO:0006200380.013
negative regulation of transcription dna templatedGO:00458922370.013
cellular amino acid metabolic processGO:0006520610.013
positive regulation of apoptotic processGO:0043065470.013
Mouse
connective tissue developmentGO:006144830.013
Mouse
negative regulation of signal transductionGO:00099682060.013
lateral inhibitionGO:00463312060.013
mesenchymal cell developmentGO:001403110.013
establishment of protein localizationGO:00451841630.013
positive regulation of nucleotide catabolic processGO:0030813460.013
cellular protein modification processGO:00064644380.013
positive regulation of organelle organizationGO:0010638650.013
cell type specific apoptotic processGO:0097285380.013
positive regulation of molecular functionGO:00440931360.013
Mouse
protein phosphorylationGO:00064681690.012
nucleoside phosphate catabolic processGO:19012921100.012
positive regulation of protein metabolic processGO:00512471280.012
Mouse
regulation of proteolysisGO:0030162870.012
Mouse
negative regulation of immune system processGO:0002683500.012
epidermal growth factor receptor signaling pathwayGO:0007173580.012
negative regulation of cell cycle phase transitionGO:19019881030.012
dorsal ventral axis specificationGO:0009950660.012
regulation of secretionGO:0051046440.012
erbb signaling pathwayGO:0038127580.012
developmental pigmentationGO:0048066680.012
organelle localizationGO:00516401480.012
imaginal disc derived appendage developmentGO:00487373990.012
positive regulation of exocytosisGO:004592140.012
regulation of photoreceptor cell differentiationGO:0046532340.012
regulation of cellular component sizeGO:0032535980.012
carbohydrate derivative biosynthetic processGO:1901137850.012
signal transduction by phosphorylationGO:00230141070.011
imaginal disc growthGO:0007446370.011
regulation of purine nucleotide catabolic processGO:0033121480.011
negative regulation of nervous system developmentGO:0051961920.011
Mouse
regulation of g1 s transition of mitotic cell cycleGO:2000045230.011
nuclear divisionGO:00002803320.011
exocytosisGO:0006887280.011
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.011
imaginal disc derived appendage morphogenesisGO:00351143950.011
negative regulation of cellular protein metabolic processGO:0032269850.011
Mouse Rat
cell cycle phase transitionGO:00447701400.011
intracellular protein transportGO:00068861040.011
response to metal ionGO:0010038230.011
positive regulation of phosphorylationGO:0042327870.011
dorsal ventral pattern formationGO:00099531330.011
salivary gland cell autophagic cell deathGO:0035071830.011
morphogenesis of an epitheliumGO:00020092760.011
establishment of protein localization to organelleGO:0072594620.011
glycosyl compound catabolic processGO:19016581120.011
anion transportGO:0006820410.011
cellular response to biotic stimulusGO:007121640.011
Human
positive regulation of purine nucleotide catabolic processGO:0033123460.011
negative regulation of nucleic acid templated transcriptionGO:19035072400.011
regulation of hippo signalingGO:0035330140.010
cell cell signaling involved in cell fate commitmentGO:00451682100.010
protein localizationGO:00081042840.010
tissue deathGO:00162711020.010
positive regulation of cellular protein metabolic processGO:00322701180.010
Mouse
embryonic morphogenesisGO:00485982060.010

PEK disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.047
disease of anatomical entityDOID:700.041
cancerDOID:16200.035
organ system cancerDOID:005068600.035