IMP: Integrative Multi-species Prediction

Drosophila melanogaster

304 known processes

phl (Dmel_CG2845)

pole hole

(Aliases: l(1)2Fe,raf,11-29,raf-1,l(1)raf,DRaf,l(1)ph,RAF,rafl,Phl,D-RAF,DRaf1,Draf,ph,CG2845,C110,Raf/phl,l(1)phl,D-raf1,Draf1,draf,D-raf,l(1)G0475,Raf1,EG:BACH48C10.3,Raf,l(1)polehole,l(1)pole hole,Draf-1,D-Raf,Dmel\CG2845,l(1)polehole/draf,raf1)

Entrez: 31221
FLYBASE: FBgn0003079
UniProtKB: P11346

Process Predictions
Disease Predictions

phl biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of photoreceptor cell differentiation	GO:0046534	12	1.000
axis specification	GO:0009798	167	1.000
regionalization	GO:0003002	416	0.999
positive regulation of rna metabolic process	GO:0051254	271	0.998
growth	GO:0040007	359	0.997
regulation of cell cycle	GO:0051726	291	0.996
positive regulation of rna biosynthetic process	GO:1902680	266	0.996
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.996
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.995
positive regulation of transcription dna templated	GO:0045893	266	0.994
eggshell chorion assembly	GO:0007306	66	0.993
multicellular organism growth	GO:0035264	46	0.993
positive regulation of macromolecule metabolic process	GO:0010604	405	0.992	Human Rat
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.992
positive regulation of biosynthetic process	GO:0009891	316	0.989
positive regulation of nervous system development	GO:0051962	69	0.987
open tracheal system development	GO:0007424	204	0.986	Fly
negative regulation of mitotic cell cycle	GO:0045930	109	0.985
regulation of neuron differentiation	GO:0045664	103	0.983
cell cycle phase transition	GO:0044770	140	0.982
r3 r4 cell differentiation	GO:0048056	12	0.982
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.981
anterior posterior axis specification	GO:0009948	109	0.980
eye morphogenesis	GO:0048592	260	0.980
blastoderm segmentation	GO:0007350	159	0.977
regulation of nervous system development	GO:0051960	248	0.977
photoreceptor cell differentiation	GO:0046530	170	0.976
columnar cuboidal epithelial cell development	GO:0002066	249	0.975
ovarian follicle cell development	GO:0030707	248	0.973
cell proliferation	GO:0008283	299	0.972
regulation of anatomical structure morphogenesis	GO:0022603	242	0.972	Mouse
epithelial cell development	GO:0002064	274	0.972
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.971
developmental growth	GO:0048589	280	0.971
phosphorylation	GO:0016310	294	0.970
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.969
chorion containing eggshell formation	GO:0007304	105	0.968
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.966
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.965
response to organic substance	GO:0010033	284	0.964	Mouse
regulation of multicellular organismal development	GO:2000026	414	0.961
embryonic pattern specification	GO:0009880	174	0.960
compound eye development	GO:0048749	307	0.959
negative regulation of autophagy	GO:0010507	16	0.957
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.957
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.955
regulation of multicellular organism growth	GO:0040014	40	0.945
intracellular signal transduction	GO:0035556	300	0.941
tissue morphogenesis	GO:0048729	297	0.940
eggshell formation	GO:0030703	105	0.936
positive regulation of cellular biosynthetic process	GO:0031328	316	0.934
regulation of cell development	GO:0060284	215	0.924
development of primary sexual characteristics	GO:0045137	50	0.923
positive regulation of multicellular organismal process	GO:0051240	143	0.922
regulation of neurogenesis	GO:0050767	158	0.921
imaginal disc derived appendage development	GO:0048737	399	0.921
eye development	GO:0001654	323	0.919
respiratory system development	GO:0060541	213	0.914	Fly
regulation of map kinase activity	GO:0043405	17	0.913	Rat
regulation of cell cycle phase transition	GO:1901987	130	0.912
digestive system development	GO:0055123	149	0.910
post embryonic appendage morphogenesis	GO:0035120	385	0.910
erbb signaling pathway	GO:0038127	58	0.907
negative regulation of cell cycle process	GO:0010948	109	0.901
negative regulation of cell cycle	GO:0045786	116	0.894
cellular component assembly involved in morphogenesis	GO:0010927	151	0.888
cell projection assembly	GO:0030031	94	0.885
r3 r4 cell fate commitment	GO:0007464	10	0.879
signal transduction by phosphorylation	GO:0023014	107	0.877
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.861
germarium derived egg chamber formation	GO:0007293	101	0.857
cell migration	GO:0016477	238	0.856
regulation of cell differentiation	GO:0045595	302	0.852
mitotic cell cycle phase transition	GO:0044772	138	0.849
negative regulation of programmed cell death	GO:0043069	72	0.841
cell death	GO:0008219	279	0.835
embryonic morphogenesis	GO:0048598	206	0.835
negative regulation of cellular catabolic process	GO:0031330	34	0.834
r7 cell differentiation	GO:0045466	43	0.831
compound eye photoreceptor fate commitment	GO:0001752	36	0.821
eye antennal disc development	GO:0035214	60	0.815
dna metabolic process	GO:0006259	227	0.814
eye photoreceptor cell fate commitment	GO:0042706	37	0.803
cell cycle g1 s phase transition	GO:0044843	31	0.801
cytoplasmic transport	GO:0016482	130	0.792
apoptotic process	GO:0006915	159	0.792
cell fate specification	GO:0001708	71	0.790	Worm
positive regulation of developmental process	GO:0051094	143	0.787
cellular catabolic process	GO:0044248	372	0.779
regulation of photoreceptor cell differentiation	GO:0046532	34	0.777
ras protein signal transduction	GO:0007265	88	0.774
positive regulation of developmental growth	GO:0048639	62	0.773
single organism cellular localization	GO:1902580	180	0.772
positive regulation of gene expression	GO:0010628	290	0.770	Human
dorsal appendage formation	GO:0046843	47	0.763
regulation of phosphate metabolic process	GO:0019220	210	0.750
embryonic axis specification	GO:0000578	107	0.749
regulation of intracellular signal transduction	GO:1902531	236	0.747
anterior posterior pattern specification	GO:0009952	136	0.743
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.742
negative regulation of macroautophagy	GO:0016242	6	0.740
regulation of growth	GO:0040008	233	0.740
erk1 and erk2 cascade	GO:0070371	39	0.739
activation of protein kinase activity	GO:0032147	12	0.736	Rat
regulation of response to external stimulus	GO:0032101	115	0.736
positive regulation of signaling	GO:0023056	243	0.729
positive regulation of cell communication	GO:0010647	250	0.724
appendage morphogenesis	GO:0035107	397	0.724
death	GO:0016265	284	0.723
axon guidance	GO:0007411	233	0.723
epithelium migration	GO:0090132	148	0.712
cellular response to chemical stimulus	GO:0070887	199	0.711	Human Mouse
compound eye morphogenesis	GO:0001745	249	0.710
regulation of cellular catabolic process	GO:0031329	157	0.705
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.702
intermediate filament cytoskeleton organization	GO:0045104	1	0.701	Mouse
positive regulation of mapk cascade	GO:0043410	63	0.692
digestive tract morphogenesis	GO:0048546	127	0.692
dorsal ventral pattern formation	GO:0009953	133	0.680
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.677
organelle fission	GO:0048285	340	0.667
segmentation	GO:0035282	207	0.666
muscle cell differentiation	GO:0042692	103	0.661
regulation of developmental growth	GO:0048638	174	0.658
cellular response to dna damage stimulus	GO:0006974	223	0.651
single organism behavior	GO:0044708	391	0.650	Mouse
cellular macromolecule localization	GO:0070727	220	0.636
regulation of apoptotic process	GO:0042981	130	0.622
programmed cell death	GO:0012501	257	0.612
regulation of mitotic cell cycle	GO:0007346	190	0.612
secretion	GO:0046903	109	0.610	Mouse
negative regulation of cell cycle phase transition	GO:1901988	103	0.604
cellularization	GO:0007349	90	0.601
positive regulation of neurogenesis	GO:0050769	41	0.599
photoreceptor cell fate commitment	GO:0046552	41	0.592
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.581
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.581
protein catabolic process	GO:0030163	101	0.572	Human
negative regulation of response to nutrient levels	GO:0032108	6	0.571
male gamete generation	GO:0048232	201	0.570
single organism intracellular transport	GO:1902582	207	0.564
regulation of immune system process	GO:0002682	176	0.556
border follicle cell migration	GO:0007298	113	0.555
establishment of ommatidial planar polarity	GO:0042067	49	0.552
meiotic cell cycle	GO:0051321	171	0.552
regulation of macroautophagy	GO:0016241	15	0.546
nucleocytoplasmic transport	GO:0006913	72	0.540
neuron fate commitment	GO:0048663	50	0.537
aging	GO:0007568	143	0.536	Worm
hemocyte differentiation	GO:0042386	38	0.531
negative regulation of multicellular organismal process	GO:0051241	142	0.525
peptidyl tyrosine phosphorylation	GO:0018108	24	0.519
eye antennal disc morphogenesis	GO:0007455	34	0.516
wing disc morphogenesis	GO:0007472	344	0.507
transcription from rna polymerase ii promoter	GO:0006366	368	0.506
zygotic determination of anterior posterior axis embryo	GO:0007354	27	0.501
regulation of cellular protein metabolic process	GO:0032268	243	0.482	Human Rat
negative regulation of developmental process	GO:0051093	201	0.477	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	0	0.476
protein modification process	GO:0036211	438	0.466
negative regulation of cellular metabolic process	GO:0031324	382	0.464
leg disc development	GO:0035218	92	0.458
regulation of cell cycle process	GO:0010564	181	0.458
malpighian tubule development	GO:0072002	64	0.436
torc1 signaling	GO:0038202	12	0.436
regulation of protein phosphorylation	GO:0001932	64	0.431	Human Rat
mesoderm morphogenesis	GO:0048332	22	0.430
positive regulation of catalytic activity	GO:0043085	118	0.421	Rat
macromolecule catabolic process	GO:0009057	161	0.416	Human
positive regulation of cell differentiation	GO:0045597	64	0.413
cellular protein localization	GO:0034613	160	0.411
regulation of protein kinase activity	GO:0045859	51	0.411	Rat
regulation of kinase activity	GO:0043549	53	0.403	Rat
second mitotic wave involved in compound eye morphogenesis	GO:0016330	7	0.391
embryonic organ development	GO:0048568	50	0.388
malpighian tubule morphogenesis	GO:0007443	44	0.379
cellular response to organic substance	GO:0071310	132	0.378	Mouse
cellular response to growth factor stimulus	GO:0071363	30	0.373	Mouse
regulation of phosphorylation	GO:0042325	147	0.373
negative regulation of cell differentiation	GO:0045596	143	0.372	Mouse
cell motility	GO:0048870	251	0.372
larval lymph gland hemocyte differentiation	GO:0035168	11	0.372
protein localization to organelle	GO:0033365	82	0.369
localization of cell	GO:0051674	257	0.367
cellular protein modification process	GO:0006464	438	0.365
epithelial cell differentiation	GO:0030855	322	0.365
positive regulation of wnt signaling pathway	GO:0030177	25	0.360
dendrite regeneration	GO:0031104	2	0.358
positive regulation of molecular function	GO:0044093	136	0.357	Rat
digestive tract development	GO:0048565	149	0.355
reproductive structure development	GO:0048608	74	0.353
positive regulation of protein modification process	GO:0031401	58	0.352	Human Rat
chemotaxis	GO:0006935	249	0.350
mapk cascade	GO:0000165	107	0.348
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	13	0.347
larval lymph gland hemopoiesis	GO:0035167	17	0.344
regulation of mapk cascade	GO:0043408	92	0.338
maintenance of location	GO:0051235	73	0.337
positive regulation of signal transduction	GO:0009967	223	0.334
peptidyl tyrosine modification	GO:0018212	24	0.325
regulation of gtpase activity	GO:0043087	44	0.325
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.322
oocyte differentiation	GO:0009994	145	0.322
nuclear division	GO:0000280	332	0.318
establishment of tissue polarity	GO:0007164	87	0.318
response to oxygen containing compound	GO:1901700	200	0.316
oocyte morphogenesis	GO:0048601	3	0.316
organic acid metabolic process	GO:0006082	103	0.311
secretion by cell	GO:0032940	101	0.305	Mouse
neuron projection guidance	GO:0097485	241	0.295
sensory organ morphogenesis	GO:0090596	260	0.293
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.293
response to endogenous stimulus	GO:0009719	119	0.292
small gtpase mediated signal transduction	GO:0007264	88	0.289
gtp catabolic process	GO:0006184	72	0.288
eye photoreceptor cell differentiation	GO:0001754	145	0.288
axon development	GO:0061564	297	0.287
regulation of rac protein signal transduction	GO:0035020	3	0.287
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.286
regulation of dna metabolic process	GO:0051052	34	0.284
regulation of molecular function	GO:0065009	217	0.283	Rat
positive regulation of multicellular organism growth	GO:0040018	21	0.282
protein localization	GO:0008104	284	0.280
regulation of cytoskeleton organization	GO:0051493	89	0.278	Mouse
regulation of cell proliferation	GO:0042127	163	0.269
cognition	GO:0050890	141	0.268	Mouse
organic substance transport	GO:0071702	257	0.268
dna packaging	GO:0006323	91	0.260
positive regulation of cellular protein metabolic process	GO:0032270	118	0.259	Human Rat
establishment of protein localization	GO:0045184	163	0.257
axonogenesis	GO:0007409	290	0.256
meiotic nuclear envelope disassembly	GO:0051078	2	0.256
regulation of cellular component biogenesis	GO:0044087	201	0.253	Human Mouse
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	2	0.252
immune system development	GO:0002520	57	0.249
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.248
prostaglandin biosynthetic process	GO:0001516	1	0.246
protein transport	GO:0015031	155	0.244
actin cytoskeleton organization	GO:0030036	206	0.242	Mouse
photoreceptor cell development	GO:0042461	96	0.242
regulation of organ morphogenesis	GO:2000027	78	0.242
tube development	GO:0035295	244	0.240
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.240
hindgut morphogenesis	GO:0007442	58	0.237
negative regulation of cell death	GO:0060548	81	0.236
regulation of cell projection organization	GO:0031344	92	0.236
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.234	Rat
regulation of anatomical structure size	GO:0090066	163	0.233
regulation of phosphorus metabolic process	GO:0051174	210	0.232
g1 s transition of mitotic cell cycle	GO:0000082	31	0.231
response to radiation	GO:0009314	155	0.230	Mouse
leg disc morphogenesis	GO:0007478	80	0.223
dorsal closure leading edge cell differentiation	GO:0046663	2	0.223
compound eye photoreceptor cell differentiation	GO:0001751	140	0.221
intracellular transport	GO:0046907	228	0.219
regulation of nuclear division	GO:0051783	58	0.217
establishment or maintenance of polarity of larval imaginal disc epithelium	GO:0016336	3	0.216
icosanoid biosynthetic process	GO:0046456	1	0.210
spermatogenesis	GO:0007283	200	0.209
positive regulation of protein metabolic process	GO:0051247	128	0.208	Human Rat
positive regulation of phosphorus metabolic process	GO:0010562	139	0.207
nuclear transport	GO:0051169	72	0.203
regulation of sequence specific dna binding transcription factor activity	GO:0051090	12	0.202
positive regulation of intracellular signal transduction	GO:1902533	116	0.201
connective tissue development	GO:0061448	3	0.201
morphogenesis of a polarized epithelium	GO:0001738	93	0.200
negative regulation of neurotransmitter secretion	GO:0046929	2	0.195	Mouse
negative regulation of response to extracellular stimulus	GO:0032105	6	0.189
regulation of protein modification process	GO:0031399	112	0.188	Human Rat
regulation of erk1 and erk2 cascade	GO:0070372	39	0.187
cellular response to oxygen containing compound	GO:1901701	79	0.185
regulation of protein metabolic process	GO:0051246	256	0.184	Human Rat
response to abiotic stimulus	GO:0009628	341	0.183	Mouse Rat
regulation of erbb signaling pathway	GO:1901184	42	0.181
negative regulation of wnt signaling pathway	GO:0030178	28	0.178
appendage development	GO:0048736	401	0.176
protein phosphorylation	GO:0006468	169	0.176
imaginal disc derived wing morphogenesis	GO:0007476	337	0.173
autophagy	GO:0006914	108	0.173
regulation of protein serine threonine kinase activity	GO:0071900	25	0.171	Rat
regulation of notch signaling pathway	GO:0008593	100	0.169
oocyte fate commitment	GO:0048600	2	0.168
brain development	GO:0007420	120	0.164
regulation of immune response	GO:0050776	118	0.164
negative regulation of cell communication	GO:0010648	223	0.161
positive regulation of cell motility	GO:2000147	3	0.161
negative regulation of immune system process	GO:0002683	50	0.160
positive regulation of golgi to plasma membrane protein transport	GO:0042998	2	0.160
negative regulation of cell development	GO:0010721	62	0.158
regulation of cell fate commitment	GO:0010453	29	0.158
regulation of cell fate specification	GO:0042659	27	0.155
establishment of localization in cell	GO:0051649	402	0.154	Mouse
body morphogenesis	GO:0010171	2	0.153
positive regulation of phosphate metabolic process	GO:0045937	139	0.151
cell cycle checkpoint	GO:0000075	95	0.149
regulation of locomotion	GO:0040012	42	0.149	Mouse
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded	GO:0008070	2	0.148
epithelial cell migration	GO:0010631	148	0.148
sex differentiation	GO:0007548	81	0.148
muscle structure development	GO:0061061	224	0.147
negative regulation of terminal cell fate specification open tracheal system	GO:0035155	2	0.146
endodermal cell differentiation	GO:0035987	3	0.143
regulation of canonical wnt signaling pathway	GO:0060828	15	0.142
gliogenesis	GO:0042063	80	0.139
neurological system process	GO:0050877	358	0.138	Mouse
defense response	GO:0006952	300	0.136
meiotic spindle checkpoint	GO:0044779	1	0.136
sister chromatid segregation	GO:0000819	92	0.133
negative regulation of apoptotic process	GO:0043066	63	0.133
wnt signaling pathway	GO:0016055	98	0.133
regulation of rap protein signal transduction	GO:0032487	4	0.131
immune response	GO:0006955	246	0.129
posttranscriptional regulation of gene expression	GO:0010608	145	0.128
gonad development	GO:0008406	50	0.127
endocytosis	GO:0006897	310	0.127
organophosphate metabolic process	GO:0019637	195	0.122
multicellular organismal reproductive behavior	GO:0033057	110	0.121
positive regulation of transcription involved in g2 m transition of mitotic cell cycle	GO:0090282	1	0.120
taxis	GO:0042330	304	0.119
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.118
regulation of ras protein signal transduction	GO:0046578	93	0.117
glycerolipid metabolic process	GO:0046486	34	0.115
trachea development	GO:0060438	29	0.113
regulation of nucleotide catabolic process	GO:0030811	48	0.113
specification of segmental identity antennal segment	GO:0007383	2	0.111
embryonic hindgut morphogenesis	GO:0048619	48	0.110
regulation of cellular response to stress	GO:0080135	89	0.109
positive regulation of chromatin silencing at telomere	GO:0031940	2	0.109
ribonucleoside catabolic process	GO:0042454	112	0.109
striated muscle cell differentiation	GO:0051146	90	0.109
negative regulation of dna templated transcription initiation	GO:2000143	1	0.108
cellular lipid metabolic process	GO:0044255	83	0.108
negative regulation of response to stimulus	GO:0048585	258	0.107
dna templated transcriptional start site selection	GO:0001173	1	0.107
ovarian follicle cell migration	GO:0007297	121	0.105
tube morphogenesis	GO:0035239	191	0.105
hindbrain development	GO:0030902	2	0.105
hindgut development	GO:0061525	58	0.103
rho protein signal transduction	GO:0007266	14	0.101
regulation of cell migration	GO:0030334	22	0.100	Mouse
regulation of catalytic activity	GO:0050790	185	0.100	Rat
formation of primary germ layer	GO:0001704	24	0.100
regulation of hemocyte differentiation	GO:0045610	22	0.099
organ growth	GO:0035265	56	0.098
stem cell fate commitment	GO:0048865	25	0.096
regulation of compound eye photoreceptor development	GO:0045314	12	0.095
regulation of ran gtpase activity	GO:0032316	1	0.093
cuticle development	GO:0042335	86	0.093
negative regulation of mitotic anaphase promoting complex activity	GO:0060564	2	0.093
positive regulation of map kinase activity	GO:0043406	11	0.093	Rat
regulation of centriole replication	GO:0046599	2	0.091
regulation of transferase activity	GO:0051338	58	0.090	Rat
tripartite regional subdivision	GO:0007351	103	0.090
regulation of nucleotide metabolic process	GO:0006140	62	0.090
positive regulation of r7 cell differentiation	GO:0045678	7	0.089
positive regulation of ribosome biogenesis	GO:0090070	3	0.089
actomyosin structure organization	GO:0031032	56	0.088	Mouse
multi organism reproductive behavior	GO:0044705	121	0.087
cellular response to extracellular stimulus	GO:0031668	64	0.086
negative regulation of mrna 3 end processing	GO:0031441	3	0.086
regulation of trichome morphogenesis	GO:2000039	3	0.085
regulation of autophagy	GO:0010506	62	0.085
intracellular protein transport	GO:0006886	104	0.084
response to wounding	GO:0009611	94	0.084
male meiosis	GO:0007140	52	0.083
endodermal cell fate commitment	GO:0001711	3	0.083
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.083
dormancy process	GO:0022611	2	0.083
histone h4 acetylation involved in response to dna damage stimulus	GO:2000776	1	0.082
renal system development	GO:0072001	72	0.081
anterior head segmentation	GO:0035288	3	0.080
cellular response to nutrient levels	GO:0031669	62	0.080
notch signaling pathway	GO:0007219	120	0.080
positive regulation of protein kinase activity	GO:0045860	25	0.079	Rat
positive regulation of ras protein signal transduction	GO:0046579	43	0.079
protein complex assembly	GO:0006461	200	0.079	Human Mouse
regulation of hematopoietic stem cell differentiation	GO:1902036	1	0.078
anterior posterior axis specification follicular epithelium	GO:0030714	2	0.078
response to bacterium	GO:0009617	198	0.077
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0017055	1	0.077
dna replication	GO:0006260	48	0.077
intermediate filament based process	GO:0045103	1	0.077	Mouse
regulation of cell morphogenesis	GO:0022604	163	0.077	Mouse
catabolic process	GO:0009056	409	0.077
positive regulation of catabolic process	GO:0009896	105	0.076
meiotic chromosome movement towards spindle pole	GO:0016344	1	0.075
developmental programmed cell death	GO:0010623	138	0.075
chromatin modification	GO:0016568	147	0.075
regulation of wnt signaling pathway	GO:0030111	68	0.073
response to nutrient levels	GO:0031667	114	0.073
negative regulation of catabolic process	GO:0009895	36	0.071
negative regulation of intracellular signal transduction	GO:1902532	57	0.071
negative regulation of transcription initiation from rna polymerase ii promoter	GO:0060633	1	0.071
single organism cell adhesion	GO:0098602	47	0.071	Mouse
unsaturated fatty acid biosynthetic process	GO:0006636	1	0.071
cell aging	GO:0007569	2	0.069
dna integrity checkpoint	GO:0031570	81	0.068
ribonucleoprotein complex disassembly	GO:0032988	1	0.068
terminal region determination	GO:0007362	25	0.067
release of cytoplasmic sequestered nf kappab	GO:0008588	1	0.067
morphogenesis of an epithelium	GO:0002009	276	0.067
positive regulation of protein import into nucleus translocation	GO:0033160	2	0.067
response to uv b	GO:0010224	1	0.067
compound eye retinal cell programmed cell death	GO:0046667	23	0.066
forebrain development	GO:0030900	2	0.066
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.066
mesoderm development	GO:0007498	78	0.065
imaginal disc derived leg morphogenesis	GO:0007480	80	0.065
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.065
negative regulation of catalytic activity	GO:0043086	42	0.064
response to red light	GO:0010114	2	0.063
reproductive system development	GO:0061458	74	0.063
urogenital system development	GO:0001655	72	0.063
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycle	GO:0051436	2	0.063
defense response to bacterium	GO:0042742	178	0.062
dna templated transcription elongation	GO:0006354	18	0.062
purine containing compound catabolic process	GO:0072523	112	0.061
lateral inhibition	GO:0046331	206	0.061
magnesium ion homeostasis	GO:0010960	1	0.061
positive regulation of stem cell differentiation	GO:2000738	3	0.061
positive regulation of neuron differentiation	GO:0045666	26	0.060
eye photoreceptor cell development	GO:0042462	81	0.060
central nervous system development	GO:0007417	201	0.060
positive regulation of cell maturation	GO:1903431	2	0.060
cell morphogenesis involved in malpighian tubule morphogenesis	GO:0061336	1	0.060
epithelial tube morphogenesis	GO:0060562	88	0.059
gastrulation	GO:0007369	70	0.059
organ formation	GO:0048645	39	0.059
cellular response to starvation	GO:0009267	61	0.058
ganglion mother cell fate determination	GO:0007402	2	0.058
centripetally migrating follicle cell migration	GO:0060269	1	0.057
dorsal vessel heart proper cell fate commitment	GO:0035053	2	0.056
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.056
regulation of neuron projection development	GO:0010975	69	0.055
trichome morphogenesis	GO:0010090	3	0.055
establishment or maintenance of cell polarity	GO:0007163	167	0.055
positive regulation of protein phosphorylation	GO:0001934	34	0.055	Human Rat
stress activated mapk cascade	GO:0051403	52	0.054
heart field specification	GO:0003128	0	0.054
protein targeting	GO:0006605	64	0.054
regulation of viral entry into host cell	GO:0046596	2	0.054
juvenile hormone mediated signaling pathway	GO:0035626	3	0.053
chorion containing eggshell pattern formation	GO:0030381	11	0.053
nuclear membrane organization	GO:0071763	2	0.053
stress activated protein kinase signaling cascade	GO:0031098	55	0.053

phl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of cellular proliferation	DOID:14566	0.840	Human
cancer	DOID:162	0.693	Human
organ system cancer	DOID:0050686	0.456	Human
large intestine cancer	DOID:5672	0.118
gastrointestinal system cancer	DOID:3119	0.118
intestinal cancer	DOID:10155	0.118
colorectal cancer	DOID:9256	0.118
head and neck cancer	DOID:11934	0.109
hepatobiliary disease	DOID:3118	0.103
disease of anatomical entity	DOID:7	0.103	Human
gastrointestinal system disease	DOID:77	0.103
liver disease	DOID:409	0.103
alagille syndrome	DOID:9245	0.103
organ system benign neoplasm	DOID:0060085	0.097
pilomatrixoma	DOID:5374	0.097
hair follicle neoplasm	DOID:5375	0.097
benign neoplasm	DOID:0060072	0.097
skin benign neoplasm	DOID:3165	0.097
integumentary system benign neoplasm	DOID:0060121	0.097
tuberous sclerosis	DOID:13515	0.089
artery disease	DOID:0050828	0.089
vascular disease	DOID:178	0.089
cardiovascular system disease	DOID:1287	0.089	Human
aortic disease	DOID:520	0.089
myopathy	DOID:423	0.083	Human
muscular disease	DOID:0080000	0.083	Human
heart disease	DOID:114	0.083	Human
cardiomyopathy	DOID:0050700	0.083	Human
intrinsic cardiomyopathy	DOID:0060036	0.083	Human
arrhythmogenic right ventricular cardiomyopathy	DOID:0050431	0.083
musculoskeletal system disease	DOID:17	0.083	Human
muscle tissue disease	DOID:66	0.083	Human
hajdu cheney syndrome	DOID:2736	0.078
leopard syndrome	DOID:14291	0.078	Human
colon cancer	DOID:219	0.071
disease of metabolism	DOID:0014667	0.067
hemochromatosis	DOID:2352	0.067
inherited metabolic disorder	DOID:655	0.067
metal metabolism disorder	DOID:896	0.067
female reproductive system disease	DOID:229	0.066
ovarian disease	DOID:1100	0.066
reproductive system disease	DOID:15	0.066
premature ovarian failure	DOID:5426	0.066
costello syndrome	DOID:0050469	0.062
myeloma	DOID:0070004	0.053
hemorrhagic thrombocythemia	DOID:2224	0.053
chronic myeloproliferative disease	DOID:2226	0.053
immune system cancer	DOID:0060083	0.053
hematologic cancer	DOID:2531	0.053
bone marrow cancer	DOID:4960	0.053

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