Drosophila melanogaster

94 known processes

Brca2 (Dmel_CG30169)

Breast cancer 2, early onset homolog

(Aliases: brca2,30169,BcDNA:SD25109,dmbrca2,CG13584,CG13583,Dmel\CG30169,CG30169)

Brca2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
double strand break repair via synthesis dependent strand annealingGO:004500360.997
germarium derived oocyte fate determinationGO:0007294260.995
recombinational repairGO:0000725130.995
dna repairGO:0006281540.981
non recombinational repairGO:000072670.980
dna recombinationGO:0006310320.979
mitotic dna damage checkpointGO:0044773740.969
double strand break repair via nonhomologous end joiningGO:000630350.969
chorion containing eggshell formationGO:00073041050.959
negative regulation of cell cycle phase transitionGO:19019881030.958
oocyte differentiationGO:00099941450.946
germarium derived egg chamber formationGO:00072931010.942
double strand break repairGO:0006302260.937
karyosome formationGO:0030717220.933
germarium derived oocyte differentiationGO:0030706290.918
double strand break repair via homologous recombinationGO:0000724130.910
meiosis iGO:0007127590.906
dna double strand break processingGO:000072930.896
g2 dna damage checkpointGO:0031572690.876
nucleotide excision repairGO:000628980.870
dna damage checkpointGO:0000077780.837
mitotic g2 m transition checkpointGO:0044818700.837
cellular response to dna damage stimulusGO:00069742230.804
meiotic cell cycle processGO:19030461320.785
reciprocal meiotic recombinationGO:0007131190.749
mitotic g2 dna damage checkpointGO:0007095690.748
anterior posterior axis specificationGO:00099481090.716
regionalizationGO:00030024160.707
mitotic cell cycle checkpointGO:0007093880.655
telomere maintenance via recombinationGO:000072210.641
regulation of cell cycle phase transitionGO:19019871300.640
dna synthesis involved in dna repairGO:000073150.623
eggshell formationGO:00307031050.606
mitotic dna integrity checkpointGO:0044774750.591
oocyte fate determinationGO:0030716270.582
negative regulation of cell cycleGO:00457861160.573
negative regulation of mitotic cell cycle phase transitionGO:19019911030.563
dorsal ventral axis specificationGO:0009950660.559
polarity specification of dorsal ventral axisGO:000995160.501
meiotic chromosome segregationGO:0045132590.477
specification of axis polarityGO:006500160.463
negative regulation of mitotic cell cycleGO:00459301090.432
regulation of cell cycleGO:00517262910.430
polarity specification of anterior posterior axisGO:000994950.428
mitotic cell cycle phase transitionGO:00447721380.424
mitotic dna replication checkpointGO:003331450.384
axis specificationGO:00097981670.375
dna geometric changeGO:0032392160.350
response to organic cyclic compoundGO:0014070890.338
dorsal ventral pattern formationGO:00099531330.328
intracellular mrna localizationGO:0008298660.328
regulation of dna recombinationGO:000001840.325
oocyte constructionGO:00073081120.318
dna duplex unwindingGO:0032508160.313
organic cyclic compound catabolic processGO:19013611680.310
oocyte developmentGO:00485991240.306
dna conformation changeGO:00711031050.290
eggshell chorion assemblyGO:0007306660.283
negative regulation of cell cycle processGO:00109481090.269
cell cycle phase transitionGO:00447701400.265
rna localizationGO:00064031150.247
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630110.230
organophosphate metabolic processGO:00196371950.220
columnar cuboidal epithelial cell developmentGO:00020662490.215
postreplication repairGO:000630120.214
ovarian follicle cell developmentGO:00307072480.211
columnar cuboidal epithelial cell differentiationGO:00020652560.205
regulation of double strand break repairGO:200077930.199
regulation of mitotic cell cycleGO:00073461900.198
small molecule metabolic processGO:00442813050.194
regulation of mitotic cell cycle phase transitionGO:19019901300.187
dna metabolic processGO:00062592270.175
dorsal appendage formationGO:0046843470.163
translesion synthesisGO:001998520.162
chromosome segregationGO:00070591570.161
cellular catabolic processGO:00442483720.158
nucleobase containing compound catabolic processGO:00346551650.157
response to organic substanceGO:00100332840.157
cell fate determinationGO:0001709910.150
regulation of cell cycle processGO:00105641810.148
response to alkaloidGO:0043279260.145
aromatic compound catabolic processGO:00194391660.142
regulation of dna repairGO:000628250.141
response to nitrogen compoundGO:1901698900.139
epithelial cell developmentGO:00020642740.137
cellular nitrogen compound catabolic processGO:00442701650.134
organic substance catabolic processGO:19015753080.130
negative regulation of nucleobase containing compound metabolic processGO:00459342610.127
response to organonitrogen compoundGO:0010243750.117
chromosome organizationGO:00512763600.116
positive regulation of nitrogen compound metabolic processGO:00511733540.115
regulation of response to dna damage stimulusGO:2001020230.115
ribonucleotide metabolic processGO:00092591450.115
dna integrity checkpointGO:0031570810.113
neurological system processGO:00508773580.109
macromolecule catabolic processGO:00090571610.107
cell cycle checkpointGO:0000075950.106
positive regulation of biosynthetic processGO:00098913160.105
regulation of cellular catabolic processGO:00313291570.104
gene silencingGO:00164581380.104
heterocycle catabolic processGO:00467001660.104
cellular component assembly involved in morphogenesisGO:00109271510.103
purine ribonucleoside triphosphate catabolic processGO:00092071080.101
mitotic recombinationGO:000631220.100
oocyte dorsal ventral axis specificationGO:0007310340.100
reciprocal dna recombinationGO:0035825190.097
negative regulation of nitrogen compound metabolic processGO:00511722650.095
agingGO:00075681430.094
nucleoside triphosphate catabolic processGO:00091431080.089
cellular macromolecule catabolic processGO:00442651360.087
oocyte axis specificationGO:00073091080.086
purine nucleotide metabolic processGO:00061631460.084
actin polymerization or depolymerizationGO:0008154310.080
catabolic processGO:00090564090.080
cell maturationGO:00484691440.077
cellular macromolecule localizationGO:00707272200.076
single organism biosynthetic processGO:00447112060.076
glycosyl compound metabolic processGO:19016571270.075
regulation of organelle organizationGO:00330431960.075
single organism catabolic processGO:00447122280.072
single organism intracellular transportGO:19025822070.071
response to abiotic stimulusGO:00096283410.069
regulation of phosphate metabolic processGO:00192202100.068
epithelial cell differentiationGO:00308553220.067
positive regulation of nucleobase containing compound metabolic processGO:00459353320.066
regulation of mrna metabolic processGO:1903311720.065
cellular response to organic substanceGO:00713101320.065
pole plasm assemblyGO:0007315610.064
purine containing compound catabolic processGO:00725231120.064
meiotic chromosome separationGO:005130780.063
carbohydrate derivative catabolic processGO:19011361180.062
ribonucleoside catabolic processGO:00424541120.061
nuclear divisionGO:00002803320.060
purine ribonucleoside metabolic processGO:00461281270.059
response to oxygen containing compoundGO:19017002000.058
response to endogenous stimulusGO:00097191190.058
purine nucleoside triphosphate catabolic processGO:00091461080.058
purine ribonucleoside monophosphate metabolic processGO:0009167500.057
regulation of multicellular organismal developmentGO:20000264140.057
organonitrogen compound metabolic processGO:19015643180.056
nucleoside phosphate metabolic processGO:00067531620.056
response to radiationGO:00093141550.055
response to caffeineGO:0031000120.054
anion homeostasisGO:005508130.053
ribonucleoside metabolic processGO:00091191270.052
enzyme linked receptor protein signaling pathwayGO:00071671790.052
positive regulation of gene expressionGO:00106282900.051
purine nucleoside metabolic processGO:00422781270.050
dna biosynthetic processGO:0071897240.050
cellular response to chemical stimulusGO:00708871990.050
organophosphate catabolic processGO:00464341120.050
regulation of transcription from rna polymerase ii promoterGO:00063573780.049
protein complex biogenesisGO:00702712010.049
purine ribonucleoside catabolic processGO:00461301120.049
nucleobase containing small molecule metabolic processGO:00550861740.048
response to ionizing radiationGO:0010212320.047
dna catabolic processGO:0006308160.046
telomere maintenanceGO:0000723210.046
organelle fissionGO:00482853400.045
organonitrogen compound catabolic processGO:19015651280.044
mitotic nuclear divisionGO:00070672130.044
pole plasm rna localizationGO:0007316520.044
g protein coupled receptor signaling pathwayGO:00071861360.044
developmental maturationGO:00217001720.043
regulation of embryonic developmentGO:0045995680.043
negative regulation of transpositionGO:0010529120.043
chromosome separationGO:0051304420.042
nucleotide catabolic processGO:00091661090.041
regulation of anatomical structure sizeGO:00900661630.041
purine ribonucleotide metabolic processGO:00091501450.041
female meiotic divisionGO:0007143700.040
signal transduction in response to dna damageGO:004277030.040
nucleoside phosphate catabolic processGO:19012921100.039
telomere organizationGO:0032200210.039
cellular response to abiotic stimulusGO:0071214580.038
purine ribonucleotide catabolic processGO:00091541090.037
nucleotide metabolic processGO:00091171610.037
negative regulation of transcription dna templatedGO:00458922370.036
regulation of actin filament lengthGO:0030832270.036
response to nutrient levelsGO:00316671140.036
positive regulation of macromolecule biosynthetic processGO:00105572830.035
intracellular signal transductionGO:00355563000.035
response to light stimulusGO:00094161240.035
atp metabolic processGO:0046034490.035
anterior posterior pattern specificationGO:00099521360.035
pole plasm oskar mrna localizationGO:0045451460.033
negative regulation of signal transductionGO:00099682060.033
cellular response to organic cyclic compoundGO:0071407320.033
carbohydrate derivative metabolic processGO:19011352170.032
g2 m transition of mitotic cell cycleGO:0000086190.032
programmed cell deathGO:00125012570.032
purine ribonucleoside triphosphate metabolic processGO:00092051190.031
ribonucleotide catabolic processGO:00092611090.031
negative regulation of gene expressionGO:00106293870.031
purine nucleoside monophosphate catabolic processGO:0009128380.031
multicellular organismal agingGO:00102591400.030
cellular response to light stimulusGO:0071482370.030
negative regulation of nucleic acid templated transcriptionGO:19035072400.030
gene silencing by rnaGO:0031047570.030
lipid metabolic processGO:00066291210.029
regulation of mrna processingGO:0050684710.029
apoptotic processGO:00069151590.029
regulation of actin polymerization or depolymerizationGO:0008064270.029
purine containing compound metabolic processGO:00725211550.029
cellular response to radiationGO:0071478520.028
nucleoside triphosphate metabolic processGO:00091411200.028
ribonucleoside triphosphate metabolic processGO:00091991190.027
single organism cellular localizationGO:19025801800.027
determination of adult lifespanGO:00083401370.027
tripartite regional subdivisionGO:00073511030.027
regulation of transpositionGO:0010528130.026
transcription from rna polymerase ii promoterGO:00063663680.026
regulation of cellular response to stressGO:0080135890.026
dna replicationGO:0006260480.026
positive regulation of nucleic acid templated transcriptionGO:19035082660.026
phosphorylationGO:00163102940.026
epithelial cell migrationGO:00106311480.026
cell agingGO:000756920.025
homeostatic processGO:00425921990.025
ribose phosphate metabolic processGO:00196931450.025
purine nucleoside catabolic processGO:00061521120.025
eggshell chorion gene amplificationGO:000730790.025
response to purine containing compoundGO:0014074120.025
response to temperature stimulusGO:00092661060.024
cell deathGO:00082192790.024
sensory perception of painGO:001923340.024
cell proliferationGO:00082832990.024
pirna metabolic processGO:0034587100.024
meiotic cell cycleGO:00513211710.023
nucleoside catabolic processGO:00091641120.023
negative regulation of cell divisionGO:0051782170.023
cellular response to organonitrogen compoundGO:0071417360.023
segmentationGO:00352822070.023
oocyte anterior posterior axis specificationGO:0007314720.022
regulation of alternative mrna splicing via spliceosomeGO:0000381600.022
positive regulation of rna biosynthetic processGO:19026802660.022
resolution of meiotic recombination intermediatesGO:000071260.022
apoptotic signaling pathwayGO:0097190270.022
deathGO:00162652840.022
positive regulation of cellular catabolic processGO:0031331950.022
positive regulation of macromolecule metabolic processGO:00106044050.021
alternative mrna splicing via spliceosomeGO:0000380600.021
ribonucleoside monophosphate metabolic processGO:0009161510.021
protein phosphorylationGO:00064681690.021
mitotic sister chromatid segregationGO:0000070870.021
synaptic transmissionGO:00072682880.021
blastoderm segmentationGO:00073501590.021
regulation of actin filament polymerizationGO:0030833250.021
cellular response to nitrogen compoundGO:1901699510.021
regulation of phosphorus metabolic processGO:00511742100.021
response to metal ionGO:0010038230.021
cellular response to ionizing radiationGO:0071479150.020
response to alcoholGO:0097305950.020
positive regulation of rna metabolic processGO:00512542710.020
positive regulation of phosphorus metabolic processGO:00105621390.020
purine nucleoside monophosphate metabolic processGO:0009126500.020
immune system processGO:00023763470.020
positive regulation of organelle organizationGO:0010638650.020
dna dependent dna replicationGO:0006261170.020
ribonucleoside triphosphate catabolic processGO:00092031080.020
positive regulation of response to stimulusGO:00485843230.020
compound eye developmentGO:00487493070.020
oxoacid metabolic processGO:00434361030.019
cell migrationGO:00164772380.019
nucleoside metabolic processGO:00091161270.019
cytoplasm organizationGO:0007028640.019
oocyte maturationGO:000155630.019
chorion containing eggshell pattern formationGO:0030381110.019
regulation of gene expression epigeneticGO:00400291280.018
ion homeostasisGO:0050801550.018
dna amplificationGO:0006277110.018
organ growthGO:0035265560.018
negative regulation of rna biosynthetic processGO:19026792400.018
mrna processingGO:00063971040.018
meiotic nuclear divisionGO:00071261510.018
positive regulation of phosphate metabolic processGO:00459371390.018
regulation of double strand break repair via homologous recombinationGO:001056920.018
purine ribonucleoside monophosphate catabolic processGO:0009169380.017
connective tissue developmentGO:006144830.017
organic acid metabolic processGO:00060821030.017
nucleoside monophosphate metabolic processGO:0009123520.017
response to oxygen levelsGO:0070482590.017
response to decreased oxygen levelsGO:0036293580.016
purine nucleotide catabolic processGO:00061951090.016
negative regulation of dna recombinationGO:004591020.016
dna methylation or demethylationGO:004472840.016
anatomical structure homeostasisGO:0060249970.016
embryonic pattern specificationGO:00098801740.016
cellular macromolecular complex assemblyGO:00346221530.016
negative regulation of response to stimulusGO:00485852580.016
negative regulation of g1 s transition of mitotic cell cycleGO:2000134130.016
cellular lipid metabolic processGO:0044255830.015
regulation of catabolic processGO:00098941700.015
regulation of response to stressGO:00801342000.015
cell cycle g2 m phase transitionGO:0044839220.015
positive regulation of mapk cascadeGO:0043410630.015
negative regulation of cellular biosynthetic processGO:00313272770.015
regulation of intracellular signal transductionGO:19025312360.015
glycerolipid metabolic processGO:0046486340.015
intracellular mrna localization involved in pattern specification processGO:0060810560.015
regulation of rna splicingGO:0043484690.015
embryonic axis specificationGO:00005781070.015
protein modification processGO:00362114380.015
cellular response to gamma radiationGO:0071480100.015
epithelium migrationGO:00901321480.014
oocyte nucleus localization involved in oocyte dorsal ventral axis specificationGO:0051663120.014
response to ethanolGO:0045471590.014
regulation of cellular amine metabolic processGO:003323830.014
cellular protein modification processGO:00064644380.014
regulation of dna metabolic processGO:0051052340.014
tor signalingGO:0031929320.014
negative regulation of macromolecule biosynthetic processGO:00105582700.013
response to other organismGO:00517072930.013
regulation of embryonic pattern specificationGO:1902875270.013
negative regulation of cellular metabolic processGO:00313243820.013
negative regulation of cell communicationGO:00106482230.013
actin filament organizationGO:00070151260.013
chaeta developmentGO:0022416970.013
cellular homeostasisGO:0019725800.013
cellular cation homeostasisGO:0030003380.013
regulation of transposition rna mediatedGO:001052530.013
intrinsic apoptotic signaling pathwayGO:0097193160.013
ribonucleoside monophosphate catabolic processGO:0009158390.013
response to hypoxiaGO:0001666530.012
ras protein signal transductionGO:0007265880.012
transmembrane transportGO:00550851390.012
negative regulation of cell cycle g2 m phase transitionGO:190275080.012
vesicle mediated transportGO:00161923810.012
spermatogenesisGO:00072832000.012
cellular response to oxygen containing compoundGO:1901701790.012
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.012
toxin metabolic processGO:000940420.012
modification dependent protein catabolic processGO:0019941780.012
defense response to other organismGO:00985422250.012
response to extracellular stimulusGO:00099911160.012
anterior posterior axis specification embryoGO:00085951030.012
inositol lipid mediated signalingGO:004801740.011
regulation of developmental growthGO:00486381740.011
cellular protein complex assemblyGO:0043623710.011
regulation of hydrolase activityGO:0051336970.011
regulation of small gtpase mediated signal transductionGO:0051056930.011
positive regulation of intracellular signal transductionGO:19025331160.011
single organism behaviorGO:00447083910.011
positive regulation of signalingGO:00230562430.011
regulation of catalytic activityGO:00507901850.011
positive regulation of cellular component organizationGO:00511301560.011
protein complex assemblyGO:00064612000.011
transposition rna mediatedGO:003219730.010
cellular amine metabolic processGO:0044106120.010
localization of cellGO:00516742570.010
dna packagingGO:0006323910.010
ameboidal type cell migrationGO:00016671510.010
neuron remodelingGO:0016322290.010
male gamete generationGO:00482322010.010

Brca2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
organ system cancerDOID:005068600.092
disease of cellular proliferationDOID:1456600.092
cancerDOID:16200.092
thoracic cancerDOID:509300.092
hypertensionDOID:1076300.034
cardiovascular system diseaseDOID:128700.034
vascular diseaseDOID:17800.034
disease of anatomical entityDOID:700.034
artery diseaseDOID:005082800.034
breast cancerDOID:161200.021