Drosophila melanogaster

207 known processes

lwr (Dmel_CG3018)

lesswright

(Aliases: ubc9,Lwr,dip4,dUBC9,l(2)05487,l(2)05486,UBC9,Ubc 9,Dmubc9,CG3018,Dmel\CG3018,FBgn0010602,l(2)01519,dUbc9,Ubc9,DmUbc9,i56,hbl,semi,Ubc-9,DUbc9,i105,l(2)02858)

lwr biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
embryo development ending in birth or egg hatchingGO:00097921520.989
negative regulation of cellular metabolic processGO:00313243820.988
Human Mouse Worm
negative regulation of cellular biosynthetic processGO:00313272770.987
Human Mouse Worm
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.981
Human Mouse Worm
positive regulation of cellular biosynthetic processGO:00313283160.974
positive regulation of rna metabolic processGO:00512542710.968
negative regulation of transcription dna templatedGO:00458922370.966
Human Mouse Worm
negative regulation of macromolecule biosynthetic processGO:00105582700.961
Human Mouse Worm
chromosome organizationGO:00512763600.953
positive regulation of macromolecule metabolic processGO:00106044050.946
protein modification processGO:00362114380.944
negative regulation of nitrogen compound metabolic processGO:00511722650.938
Human Mouse Worm
positive regulation of nitrogen compound metabolic processGO:00511733540.937
positive regulation of transcription dna templatedGO:00458932660.908
immune system processGO:00023763470.906
chromatin organizationGO:00063252070.874
chromatin modificationGO:00165681470.847
positive regulation of gene expressionGO:00106282900.845
negative regulation of biosynthetic processGO:00098902770.839
Human Mouse Worm
positive regulation of rna biosynthetic processGO:19026802660.829
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.826
negative regulation of gene expressionGO:00106293870.800
Human Mouse Worm
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.775
Human Mouse Worm
cellular protein modification processGO:00064644380.769
response to external biotic stimulusGO:00432072930.742
transcription from rna polymerase ii promoterGO:00063663680.741
Human Mouse Worm
positive regulation of cellular protein metabolic processGO:00322701180.736
defense response to other organismGO:00985422250.731
cellular macromolecular complex assemblyGO:00346221530.728
regulation of gene expression epigeneticGO:00400291280.720
negative regulation of rna biosynthetic processGO:19026792400.683
Human Mouse Worm
axonogenesisGO:00074092900.664
regulation of transcription from rna polymerase ii promoterGO:00063573780.661
Human Mouse Worm
positive regulation of biosynthetic processGO:00098913160.649
multicellular organismal reproductive behaviorGO:00330571100.646
Worm
covalent chromatin modificationGO:00165691060.623
camera type eye developmentGO:004301040.615
apoptotic processGO:00069151590.596
Worm
taxisGO:00423303040.587
negative regulation of signalingGO:00230572190.568
posttranscriptional gene silencing by rnaGO:0035194450.544
negative regulation of nucleic acid templated transcriptionGO:19035072400.542
Human Mouse Worm
histone modificationGO:00165701060.537
regulation of multi organism processGO:00439001310.528
regulation of response to stressGO:00801342000.511
rna interferenceGO:0016246270.510
cell deathGO:00082192790.504
Worm
protein complex assemblyGO:00064612000.501
negative regulation of rna metabolic processGO:00512532510.489
Human Mouse Worm
chemotaxisGO:00069352490.476
positive regulation of nucleobase containing compound metabolic processGO:00459353320.473
regulation of apoptotic processGO:00429811300.471
cellular response to organic substanceGO:00713101320.464
positive regulation of multi organism processGO:0043902400.459
deathGO:00162652840.456
Worm
macromolecular complex assemblyGO:00650032560.455
regionalizationGO:00030024160.451
appendage developmentGO:00487364010.449
immune responseGO:00069552460.431
meiotic nuclear divisionGO:00071261510.427
positive regulation of protein metabolic processGO:00512471280.421
protein acetylationGO:0006473390.407
negative regulation of mitotic cell cycle phase transitionGO:19019911030.404
posttranscriptional regulation of gene expressionGO:00106081450.396
neuron projection guidanceGO:00974852410.382
negative regulation of gene expression epigeneticGO:0045814770.381
embryonic pattern specificationGO:00098801740.380
cellular component assembly involved in morphogenesisGO:00109271510.370
intracellular transportGO:00469072280.368
chromatin assemblyGO:0031497480.357
regulation of cellular component biogenesisGO:00440872010.355
eye developmentGO:00016543230.354
negative regulation of signal transductionGO:00099682060.343
dna conformation changeGO:00711031050.337
regulation of protein metabolic processGO:00512462560.325
methylationGO:0032259470.314
vesicle mediated transportGO:00161923810.307
blastoderm segmentationGO:00073501590.306
dna packagingGO:0006323910.299
response to biotic stimulusGO:00096072940.297
histone acetylationGO:0016573380.296
reproductive structure developmentGO:0048608740.286
Worm
negative regulation of cell communicationGO:00106482230.286
cell maturationGO:00484691440.283
striated muscle cell differentiationGO:0051146900.268
endocytosisGO:00068973100.265
negative regulation of apoptotic processGO:0043066630.264
regulation of response to gamma radiationGO:200122840.256
posttranscriptional gene silencingGO:0016441460.255
dendrite developmentGO:00163582040.253
regulation of immune responseGO:00507761180.249
protein dna complex subunit organizationGO:0071824860.245
regulation of cell deathGO:00109411730.245
gonad developmentGO:0008406500.245
Worm
positive regulation of nucleic acid templated transcriptionGO:19035082660.235
phagocytosisGO:00069092150.233
regulation of defense responseGO:00313471020.225
body morphogenesisGO:001017120.222
dendrite morphogenesisGO:00488131990.222
intracellular receptor signaling pathwayGO:0030522190.216
Rat
gene silencing by rnaGO:0031047570.215
defense responseGO:00069523000.213
axon developmentGO:00615642970.211
pole plasm assemblyGO:0007315610.209
negative regulation of nucleobase containing compound metabolic processGO:00459342610.206
Human Mouse Worm
protein complex biogenesisGO:00702712010.205
striated muscle cell developmentGO:0055002500.196
dna metabolic processGO:00062592270.195
segmentationGO:00352822070.191
purine ribonucleoside triphosphate catabolic processGO:00092071080.191
negative regulation of cell differentiationGO:00455961430.188
regulation of molecular functionGO:00650092170.183
Rat
chromatin silencingGO:0006342760.176
response to bacteriumGO:00096171980.175
muscle cell developmentGO:0055001500.174
immune effector processGO:0002252980.165
dna integrity checkpointGO:0031570810.161
internal peptidyl lysine acetylationGO:0018393380.158
regulation of immune system processGO:00026821760.155
cellular response to chemical stimulusGO:00708871990.143
response to other organismGO:00517072930.142
ovipositionGO:0018991190.133
Worm
nuclear divisionGO:00002803320.131
response to light stimulusGO:00094161240.129
regulation of cellular catabolic processGO:00313291570.128
regulation of cell proliferationGO:00421271630.128
cell cycle phase transitionGO:00447701400.128
negative regulation of response to stimulusGO:00485852580.127
retina development in camera type eyeGO:006004140.122
reproductive behaviorGO:00190981220.121
Worm
peptidyl amino acid modificationGO:00181931050.118
positive regulation of phosphate metabolic processGO:00459371390.116
multi multicellular organism processGO:00447061230.115
Worm
camera type eye morphogenesisGO:004859320.113
regulation of intracellular signal transductionGO:19025312360.111
Mouse
sensory organ morphogenesisGO:00905962600.108
regulation of transportGO:00510491810.107
innate immune responseGO:00450871440.106
dendrite guidanceGO:0070983210.106
muscle structure developmentGO:00610612240.102
Worm
cellular protein complex assemblyGO:0043623710.100
molting cycle processGO:0022404290.100
positive regulation of molecular functionGO:00440931360.099
Rat
small molecule metabolic processGO:00442813050.099
interspecies interaction between organismsGO:0044419160.096
g2 dna damage checkpointGO:0031572690.096
genitalia developmentGO:0048806260.096
Worm
mitotic spindle organizationGO:00070522200.095
Yeast
multi organism behaviorGO:00517051750.093
Worm
cell migrationGO:00164772380.092
protein localizationGO:00081042840.092
regulation of proteolysisGO:0030162870.091
nuclear transcribed mrna catabolic processGO:0000956240.091
regulation of cellular protein metabolic processGO:00322682430.091
dna damage checkpointGO:0000077780.090
organic hydroxy compound metabolic processGO:1901615830.090
mitotic g2 dna damage checkpointGO:0007095690.090
regulation of localizationGO:00328792750.089
Worm
regulation of cell cycleGO:00517262910.088
gland developmentGO:00487321910.087
negative regulation of programmed cell deathGO:0043069720.086
transcription initiation from rna polymerase ii promoterGO:0006367250.085
peptidyl lysine acetylationGO:0018394390.085
organelle fissionGO:00482853400.085
heterocycle catabolic processGO:00467001660.084
molting cycle chitin based cuticleGO:0007591560.084
internal protein amino acid acetylationGO:0006475380.083
mitotic dna integrity checkpointGO:0044774750.083
mitotic g2 m transition checkpointGO:0044818700.083
transcription elongation from rna polymerase ii promoterGO:0006368180.082
negative regulation of cellular component organizationGO:00511291080.081
dorsal ventral pattern formationGO:00099531330.077
male gamete generationGO:00482322010.077
development of primary sexual characteristicsGO:0045137500.074
Worm
humoral immune responseGO:00069591170.073
developmental maturationGO:00217001720.071
gene silencingGO:00164581380.070
spermatogenesisGO:00072832000.070
columnar cuboidal epithelial cell differentiationGO:00020652560.068
dna templated transcription elongationGO:0006354180.068
positive regulation of response to stimulusGO:00485843230.067
Mouse Rat
regulation of response to external stimulusGO:00321011150.066
pole plasm mrna localizationGO:0019094490.066
positive regulation of programmed cell deathGO:0043068620.065
protein modification by small protein conjugation or removalGO:00706471060.065
regulation of immune effector processGO:0002697520.065
sex differentiationGO:0007548810.064
Worm
positive regulation of proteolysisGO:0045862520.063
regulation of catalytic activityGO:00507901850.063
muscle cell differentiationGO:00426921030.062
central nervous system developmentGO:00074172010.060
response to heatGO:0009408630.059
regulation of response to biotic stimulusGO:0002831630.059
actin cytoskeleton organizationGO:00300362060.059
peptidyl lysine modificationGO:0018205570.057
pole plasm rna localizationGO:0007316520.057
regulation of innate immune responseGO:0045088710.057
telencephalon developmentGO:002153720.056
pole plasm oskar mrna localizationGO:0045451460.055
positive regulation of ribosome biogenesisGO:009007030.054
cellular macromolecule localizationGO:00707272200.053
nuclear transportGO:0051169720.052
regulation of cellular response to stressGO:0080135890.052
negative regulation of cell cycle phase transitionGO:19019881030.051
nucleocytoplasmic transportGO:0006913720.051
determination of dorsal ventral asymmetryGO:004826230.051
positive regulation of macromolecule biosynthetic processGO:00105572830.051
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.051
Rat
positive regulation of protein modification processGO:0031401580.050
cellular amino acid metabolic processGO:0006520610.050
negative regulation of cell cycle processGO:00109481090.048
negative regulation of purine nucleotide catabolic processGO:003312210.048
heart developmentGO:0007507820.048
positive regulation of cellular component biogenesisGO:0044089800.048
regulation of mitotic cell cycle phase transitionGO:19019901300.048
programmed cell deathGO:00125012570.047
Worm
defense response to bacteriumGO:00427421780.046
negative regulation of cell cycleGO:00457861160.046
regulation of catabolic processGO:00098941700.046
embryonic morphogenesisGO:00485982060.046
regulation of cellular localizationGO:00603411360.045
actin filament based processGO:00300292200.044
embryonic organ developmentGO:0048568500.044
cell proliferationGO:00082832990.043
single organism cellular localizationGO:19025801800.043
regulation of programmed cell deathGO:00430671520.042
larval developmentGO:00021641040.042
mitotic cell cycle checkpointGO:0007093880.041
regulation of gene silencingGO:0060968630.041
protein phosphorylationGO:00064681690.041
lipid localizationGO:0010876540.040
anterior posterior axis specificationGO:00099481090.040
oocyte developmentGO:00485991240.040
eye morphogenesisGO:00485922600.040
regulation of production of molecular mediator of immune responseGO:0002700440.040
organic substance transportGO:00717022570.039
response to radiationGO:00093141550.038
regulation of protein modification processGO:00313991120.038
positive regulation of cell proliferationGO:0008284470.038
organelle inheritanceGO:004830820.037
regulation of intracellular transportGO:0032386640.037
wing disc morphogenesisGO:00074723440.037
embryonic axis specificationGO:00005781070.036
negative regulation of nucleoside metabolic processGO:004597810.036
anterior posterior axis specification embryoGO:00085951030.036
organonitrogen compound metabolic processGO:19015643180.036
reproductive system developmentGO:0061458740.035
Worm
meiotic cell cycleGO:00513211710.035
post embryonic appendage morphogenesisGO:00351203850.035
cellular response to organic cyclic compoundGO:0071407320.035
ribonucleoprotein complex subunit organizationGO:0071826280.035
axis specificationGO:00097981670.034
nitrogen compound transportGO:0071705850.034
multi organism reproductive behaviorGO:00447051210.034
Worm
axon guidanceGO:00074112330.034
macromolecule methylationGO:0043414450.034
oocyte anterior posterior axis specificationGO:0007314720.034
appendage morphogenesisGO:00351073970.033
molting cycleGO:0042303560.033
positive regulation of growthGO:0045927750.033
regulation of symbiosis encompassing mutualism through parasitismGO:0043903150.033
positive regulation of intracellular signal transductionGO:19025331160.032
Mouse
photoreceptor cell differentiationGO:00465301700.032
regulation of i kappab kinase nf kappab signalingGO:004312220.032
Mouse
defense response to virusGO:0051607230.031
histone h2a acetylationGO:004396810.031
establishment of localization in cellGO:00516494020.031
chromatin assembly or disassemblyGO:0006333520.031
mrna metabolic processGO:00160711240.031
organelle assemblyGO:00709251980.031
single organism nuclear importGO:1902593510.030
regulation of meiosisGO:004002030.030
negative regulation of cell proliferationGO:0008285690.029
ribonucleoprotein complex biogenesisGO:0022613310.029
positive regulation of catabolic processGO:00098961050.029
maternal determination of anterior posterior axis embryoGO:0008358740.028
retina morphogenesis in camera type eyeGO:006004220.028
organic cyclic compound catabolic processGO:19013611680.027
cellular macromolecule catabolic processGO:00442651360.027
Rat
myofibril assemblyGO:0030239360.027
protein alkylationGO:0008213430.027
receptor mediated endocytosisGO:0006898210.026
protein acylationGO:0043543420.026
negative regulation of cell deathGO:0060548810.026
compound eye developmentGO:00487493070.025
protein transportGO:00150311550.025
stem cell differentiationGO:00488631170.025
cellular protein localizationGO:00346131600.025
regulation of dna templated transcription elongationGO:0032784170.025
dna templated transcription initiationGO:0006352250.024
intracellular signal transductionGO:00355563000.024
Mouse
intracellular mrna localizationGO:0008298660.024
neural retina developmentGO:000340740.023
negative regulation of immune system processGO:0002683500.023
oocyte morphogenesisGO:004860130.023
negative regulation of organelle organizationGO:0010639560.023
dendrite regenerationGO:003110420.023
compound eye photoreceptor cell differentiationGO:00017511400.023
positive regulation of signal transductionGO:00099672230.023
Mouse Rat
response to lipidGO:0033993380.023
cellular response to lipidGO:0071396200.023
cellular catabolic processGO:00442483720.023
Rat
mitotic sister chromatid segregationGO:0000070870.022
tube developmentGO:00352952440.022
Worm
regulation of striated muscle contractionGO:000694220.022
positive regulation of phosphorus metabolic processGO:00105621390.022
zygotic specification of dorsal ventral axisGO:000735230.022
histone h4 acetylationGO:0043967130.022
negative regulation of protein metabolic processGO:0051248850.021
localization of cellGO:00516742570.021
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encodedGO:000807110.021
organic substance catabolic processGO:19015753080.021
Rat
regulation of planar cell polarity pathway involved in axis elongationGO:200004020.020
cytoplasmic transportGO:00164821300.020
regulation of phosphorylationGO:00423251470.020
membrane organizationGO:00610241120.019
chromosome condensationGO:0030261410.019
cellular response to dna damage stimulusGO:00069742230.019
response to organic cyclic compoundGO:0014070890.019
defense response to gram negative bacteriumGO:0050829940.019
positive regulation of cell maturationGO:190343120.019
cellular component disassemblyGO:0022411460.018
exocrine system developmentGO:00352721620.018
regulation of hydrolase activityGO:0051336970.018
negative regulation of gtp catabolic processGO:003312510.018
regulation of ras protein signal transductionGO:0046578930.018
growthGO:00400073590.018
intracellular mrna localization involved in pattern specification processGO:0060810560.018
regulation of heterochromatin assemblyGO:003144580.018
phospholipid transportGO:001591420.018
regulation of mitotic cell cycleGO:00073461900.018
nucleoside phosphate catabolic processGO:19012921100.017
regulation of ruffle assemblyGO:190002710.017
response to organic substanceGO:00100332840.017
glycosyl compound metabolic processGO:19016571270.017
cell motilityGO:00488702510.017
chromatin remodelingGO:0006338720.017
guanosine containing compound catabolic processGO:1901069740.017
establishment of protein localizationGO:00451841630.017
mitochondrion organizationGO:0007005650.016
synapse organizationGO:00508081960.016
response to oxygen containing compoundGO:19017002000.016
actomyosin structure organizationGO:0031032560.016
intracellular mrna localization involved in anterior posterior axis specificationGO:0060811530.016
amine metabolic processGO:0009308120.016
positive regulation of immune responseGO:0050778630.016
regulation of phosphate metabolic processGO:00192202100.016
positive regulation of catalytic activityGO:00430851180.016
modification dependent macromolecule catabolic processGO:0043632790.015
Rat
pigment metabolic processGO:0042440840.015
purine nucleoside triphosphate catabolic processGO:00091461080.015
production of small rna involved in gene silencing by rnaGO:0070918150.015
regulation of hemocyte proliferationGO:0035206370.015
oocyte microtubule cytoskeleton polarizationGO:0008103220.015
meiotic nuclear envelope disassemblyGO:005107820.015
imaginal disc derived appendage developmentGO:00487373990.015
histone methylationGO:0016571400.014
regulation of cellular amine metabolic processGO:003323830.014
symbiosis encompassing mutualism through parasitismGO:0044403160.014
regulation of cell proliferation involved in compound eye morphogenesisGO:200049520.014
positive regulation of phosphorylationGO:0042327870.014
protein importGO:0017038550.014
oocyte fate commitmentGO:004860020.014
positive regulation of defense responseGO:0031349590.014
regulation of sequence specific dna binding transcription factor activityGO:0051090120.014
Rat
lateral inhibitionGO:00463312060.014
positive regulation of cell communicationGO:00106472500.013
Mouse Rat
regulation of nucleotide metabolic processGO:0006140620.013
imaginal disc derived wing expansionGO:004852670.013
antimicrobial humoral responseGO:0019730990.013
positive regulation of cellular catabolic processGO:0031331950.013
purine ribonucleotide catabolic processGO:00091541090.013
negative regulation of developmental growthGO:0048640640.013
regulation of cell cycle processGO:00105641810.012
border follicle cell delaminationGO:003070930.012
anatomical structure homeostasisGO:0060249970.012
i kappab kinase nf kappab signalingGO:000724960.012
Mouse
negative regulation of nucleotide catabolic processGO:003081210.012
oocyte constructionGO:00073081120.012
response to extracellular stimulusGO:00099911160.012
meiotic spindle checkpointGO:004477910.012
dorsal vessel heart proper cell fate commitmentGO:003505320.012
regenerationGO:0031099160.012
phosphorylationGO:00163102940.012
tissue deathGO:00162711020.012
cellular amide metabolic processGO:0043603800.011
negative regulation of terminal cell fate specification open tracheal systemGO:003515520.011
regulation of system processGO:0044057360.011
nitric oxide metabolic processGO:004620910.011
specification of segmental identity antennal segmentGO:000738320.011
oocyte differentiationGO:00099941450.011
carboxylic acid metabolic processGO:0019752920.011
tripartite regional subdivisionGO:00073511030.011
oocyte axis specificationGO:00073091080.011
ribonucleotide catabolic processGO:00092611090.011
regulation of ral gtpase activityGO:003231510.011
regulation of cdc42 protein signal transductionGO:003248930.011
post embryonic hemopoiesisGO:0035166170.011
regulation of cell cycle phase transitionGO:19019871300.011
dna integrationGO:001507410.011
regulation of growthGO:00400082330.011
regulation of protein stabilityGO:0031647430.011
tricarboxylic acid metabolic processGO:007235010.011
regulation of humoral immune responseGO:0002920510.011
nucleoside triphosphate metabolic processGO:00091411200.011
negative regulation of multicellular organismal processGO:00512411420.011
regulation of endocrine processGO:004406020.011
imaginal disc derived appendage morphogenesisGO:00351143950.010
respiratory system developmentGO:00605412130.010
histone lysine methylationGO:0034968320.010
mitotic dna damage checkpointGO:0044773740.010
regulation of dna metabolic processGO:0051052340.010
negative regulation of dna templated transcription initiationGO:200014310.010

lwr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
spinocerebellar degenerationDOID:247800.018
disease of anatomical entityDOID:700.018
central nervous system diseaseDOID:33100.018
spinocerebellar ataxiaDOID:144100.018
neurodegenerative diseaseDOID:128900.018
nervous system diseaseDOID:86300.018
syndromeDOID:22500.011