IMP: Integrative Multi-species Prediction

Drosophila melanogaster

25 known processes

msl-2 (Dmel_CG3241)

male-specific lethal 2

(Aliases: MSL-2,Dmel\CG3241,Msl2,MSL2,msl,CG3241,Msl-2,kmA,MSL,msl2,Msl 1-3,km(2)A)

Entrez: 33565
FLYBASE: FBgn0005616
UniProtKB: A4V038
UniProtKB: P50534

Process Predictions
Disease Predictions

msl-2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
histone h4 k16 acetylation	GO:0043984	4	0.894	Human
histone h4 acetylation	GO:0043967	13	0.581	Human
negative regulation of gene expression epigenetic	GO:0045814	77	0.450
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.293
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.287
positive regulation of gene expression	GO:0010628	290	0.257
negative regulation of gene expression	GO:0010629	387	0.232
dosage compensation	GO:0007549	16	0.220
positive regulation of cellular biosynthetic process	GO:0031328	316	0.208
chromatin silencing	GO:0006342	76	0.198
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.190
positive regulation of biosynthetic process	GO:0009891	316	0.172
positive regulation of transcription dna templated	GO:0045893	266	0.166
negative regulation of cellular metabolic process	GO:0031324	382	0.161
negative regulation of rna biosynthetic process	GO:1902679	240	0.132
peptidyl lysine acetylation	GO:0018394	39	0.129	Human
peptidyl lysine modification	GO:0018205	57	0.127	Human
negative regulation of chromatin silencing	GO:0031936	9	0.127
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.123
regulation of gene silencing	GO:0060968	63	0.115
negative regulation of biosynthetic process	GO:0009890	277	0.106
regulation of chromatin silencing	GO:0031935	36	0.103
internal peptidyl lysine acetylation	GO:0018393	38	0.102	Human
protein modification process	GO:0036211	438	0.099
internal protein amino acid acetylation	GO:0006475	38	0.099	Human
positive regulation of rna metabolic process	GO:0051254	271	0.099
negative regulation of cellular biosynthetic process	GO:0031327	277	0.087
posttranscriptional regulation of gene expression	GO:0010608	145	0.084
negative regulation of transcription dna templated	GO:0045892	237	0.073
protein acylation	GO:0043543	42	0.069	Human
positive regulation of macromolecule metabolic process	GO:0010604	405	0.068
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.068
positive regulation of rna biosynthetic process	GO:1902680	266	0.067
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.066
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.065
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.063
regulation of gene expression epigenetic	GO:0040029	128	0.062
chromatin modification	GO:0016568	147	0.061	Human
positive regulation of gene expression epigenetic	GO:0045815	16	0.060
positive regulation of response to stimulus	GO:0048584	323	0.060
axon cargo transport	GO:0008088	29	0.053
regionalization	GO:0003002	416	0.052
sensory perception of chemical stimulus	GO:0007606	116	0.050
synaptic transmission	GO:0007268	288	0.048
sex determination	GO:0007530	18	0.045
negative regulation of rna metabolic process	GO:0051253	251	0.045
smoothened signaling pathway	GO:0007224	49	0.044
covalent chromatin modification	GO:0016569	106	0.044	Human
mrna splicing via spliceosome	GO:0000398	73	0.043
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.043
cell death	GO:0008219	279	0.042
histone modification	GO:0016570	106	0.042	Human
protein acetylation	GO:0006473	39	0.041	Human
anterograde axon cargo transport	GO:0008089	6	0.040
cellular protein modification process	GO:0006464	438	0.040
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.038
regulation of immune system process	GO:0002682	176	0.038
chromatin organization	GO:0006325	207	0.037	Human
negative regulation of cell communication	GO:0010648	223	0.034
chromatin assembly or disassembly	GO:0006333	52	0.034
programmed cell death	GO:0012501	257	0.033
cell proliferation	GO:0008283	299	0.033
male mating behavior	GO:0060179	70	0.033
rna splicing	GO:0008380	83	0.033
organelle fission	GO:0048285	340	0.033
body morphogenesis	GO:0010171	2	0.033
regulation of cellular amino acid metabolic process	GO:0006521	0	0.031
chromosome organization	GO:0051276	360	0.031	Human
transmembrane transport	GO:0055085	139	0.031
cellular homeostasis	GO:0019725	80	0.031
histone acetylation	GO:0016573	38	0.029	Human
mating	GO:0007618	120	0.029
chromatin remodeling	GO:0006338	72	0.028
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.028
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.028
zinc ion homeostasis	GO:0055069	6	0.027
appendage morphogenesis	GO:0035107	397	0.027
wing disc morphogenesis	GO:0007472	344	0.026
eye photoreceptor cell development	GO:0042462	81	0.026
regulation of intracellular signal transduction	GO:1902531	236	0.025
cellular response to chemical stimulus	GO:0070887	199	0.025
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.025
cellular catabolic process	GO:0044248	372	0.025
growth	GO:0040007	359	0.025
positive regulation of cell communication	GO:0010647	250	0.025
immune system process	GO:0002376	347	0.024
neurological system process	GO:0050877	358	0.024
peptidyl amino acid modification	GO:0018193	105	0.023	Human
regulation of response to external stimulus	GO:0032101	115	0.023
establishment of synaptic vesicle localization	GO:0097480	50	0.023
negative regulation of response to stimulus	GO:0048585	258	0.023
eye photoreceptor cell differentiation	GO:0001754	145	0.022
rna processing	GO:0006396	147	0.022
organic acid metabolic process	GO:0006082	103	0.022
imaginal disc derived wing morphogenesis	GO:0007476	337	0.021
small molecule metabolic process	GO:0044281	305	0.021
male courtship behavior veined wing generated song production	GO:0045433	20	0.021
positive regulation of peptidase activity	GO:0010952	29	0.021
regulation of cell cycle process	GO:0010564	181	0.021
macromolecular complex assembly	GO:0065003	256	0.020
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.020
alternative mrna splicing via spliceosome	GO:0000380	60	0.020
defense response	GO:0006952	300	0.020
response to pain	GO:0048265	3	0.020
homeostatic process	GO:0042592	199	0.020
oxoacid metabolic process	GO:0043436	103	0.019
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.019
gene silencing	GO:0016458	138	0.019
positive regulation of signal transduction	GO:0009967	223	0.019
positive regulation of signaling	GO:0023056	243	0.019
synaptic vesicle localization	GO:0097479	53	0.019
death	GO:0016265	284	0.019
regulation of response to stress	GO:0080134	200	0.019
compound eye development	GO:0048749	307	0.018
photoreceptor cell differentiation	GO:0046530	170	0.018
organic substance catabolic process	GO:1901575	308	0.018
mrna metabolic process	GO:0016071	124	0.018
developmental growth	GO:0048589	280	0.018
mitotic cell cycle checkpoint	GO:0007093	88	0.017
regulation of cellular ketone metabolic process	GO:0010565	3	0.017
catabolic process	GO:0009056	409	0.017
female meiotic division	GO:0007143	70	0.017
spindle organization	GO:0007051	253	0.017
translation	GO:0006412	69	0.017
vesicle mediated transport	GO:0016192	381	0.016
response to organic substance	GO:0010033	284	0.016
stem cell differentiation	GO:0048863	117	0.016
carbohydrate derivative metabolic process	GO:1901135	217	0.016
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.016
chromosome segregation	GO:0007059	157	0.016
carboxylic acid metabolic process	GO:0019752	92	0.016
limb development	GO:0060173	1	0.016
regulation of rna splicing	GO:0043484	69	0.015
negative regulation of smoothened signaling pathway	GO:0045879	16	0.015
axonogenesis	GO:0007409	290	0.015
negative regulation of neuron apoptotic process	GO:0043524	14	0.015
establishment of vesicle localization	GO:0051650	51	0.015
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.015
cation transmembrane transport	GO:0098655	88	0.015
compound eye photoreceptor cell differentiation	GO:0001751	140	0.015
appendage development	GO:0048736	401	0.015
male courtship behavior veined wing extension	GO:0048065	22	0.015
negative regulation of cellular response to oxidative stress	GO:1900408	1	0.015
regulation of cellular amine metabolic process	GO:0033238	3	0.015
response to abiotic stimulus	GO:0009628	341	0.015
reproductive system development	GO:0061458	74	0.015
vesicle localization	GO:0051648	55	0.015
rna splicing via transesterification reactions	GO:0000375	73	0.015
limb morphogenesis	GO:0035108	1	0.015
regulation of cellular response to stress	GO:0080135	89	0.015
ion transmembrane transport	GO:0034220	122	0.015
response to other organism	GO:0051707	293	0.015
imaginal disc derived appendage development	GO:0048737	399	0.015
female meiosis chromosome segregation	GO:0016321	33	0.015
endocytosis	GO:0006897	310	0.015
organic cyclic compound catabolic process	GO:1901361	168	0.015
male courtship behavior	GO:0008049	63	0.014
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.014
sensory perception	GO:0007600	196	0.014
somatic muscle development	GO:0007525	66	0.014
aromatic compound catabolic process	GO:0019439	166	0.014
chemical homeostasis	GO:0048878	92	0.014
protein complex biogenesis	GO:0070271	201	0.014
response to lipopolysaccharide	GO:0032496	4	0.014
post embryonic appendage morphogenesis	GO:0035120	385	0.014
cellular ketone metabolic process	GO:0042180	24	0.014
meiotic cell cycle	GO:0051321	171	0.014
learning	GO:0007612	75	0.014
defense response to other organism	GO:0098542	225	0.014
regulation of notch signaling pathway	GO:0008593	100	0.014
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.013
regulation of molecular function	GO:0065009	217	0.013
ommochrome biosynthetic process	GO:0006727	19	0.013
inorganic ion transmembrane transport	GO:0098660	73	0.013
dna integrity checkpoint	GO:0031570	81	0.013
heterochromatin assembly	GO:0031507	13	0.013
regulation of phosphate metabolic process	GO:0019220	210	0.013
single organism membrane organization	GO:0044802	93	0.013
phosphorylation	GO:0016310	294	0.013
posttranscriptional gene silencing	GO:0016441	46	0.013
microtubule based transport	GO:0010970	42	0.013
l glutamate import	GO:0051938	1	0.013
positive regulation of endopeptidase activity	GO:0010950	26	0.013
dna metabolic process	GO:0006259	227	0.013
cell growth	GO:0016049	108	0.013
immune system development	GO:0002520	57	0.013
cell fate determination	GO:0001709	91	0.013
dna packaging	GO:0006323	91	0.013
indole containing compound biosynthetic process	GO:0042435	4	0.013
regulation of mrna metabolic process	GO:1903311	72	0.013
regulation of localization	GO:0032879	275	0.012
histone exchange	GO:0043486	21	0.012
ion homeostasis	GO:0050801	55	0.012
heterocycle catabolic process	GO:0046700	166	0.012
amine metabolic process	GO:0009308	12	0.012
detection of chemical stimulus	GO:0009593	93	0.012
regulation of response to oxidative stress	GO:1902882	4	0.012
dendrite morphogenesis	GO:0048813	199	0.012
axon development	GO:0061564	297	0.012
meiotic cell cycle process	GO:1903046	132	0.012
g protein coupled receptor signaling pathway	GO:0007186	136	0.012
determination of adult lifespan	GO:0008340	137	0.012
regulation of mrna splicing via spliceosome	GO:0048024	64	0.012
open tracheal system development	GO:0007424	204	0.012
response to monosaccharide	GO:0034284	4	0.012
cytoskeleton dependent intracellular transport	GO:0030705	44	0.012
organonitrogen compound metabolic process	GO:1901564	318	0.012
cell junction organization	GO:0034330	57	0.012
multi organism reproductive behavior	GO:0044705	121	0.012
meiotic chromosome segregation	GO:0045132	59	0.012
single fertilization	GO:0007338	24	0.011
regulation of endocytosis	GO:0030100	37	0.011
developmental growth involved in morphogenesis	GO:0060560	65	0.011
cellular component assembly involved in morphogenesis	GO:0010927	151	0.011
golgi vesicle transport	GO:0048193	27	0.011
respiratory system development	GO:0060541	213	0.011
behavioral response to ethanol	GO:0048149	49	0.011
regulation of protein metabolic process	GO:0051246	256	0.011
cellular nitrogen compound catabolic process	GO:0044270	165	0.011
transcription from rna polymerase ii promoter	GO:0006366	368	0.011
connective tissue development	GO:0061448	3	0.011
protein prenylation	GO:0018342	3	0.011
morphogenesis of embryonic epithelium	GO:0016331	94	0.011
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.011
lipid metabolic process	GO:0006629	121	0.011
single organism catabolic process	GO:0044712	228	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011
nucleotide excision repair	GO:0006289	8	0.011
imaginal disc derived wing vein specification	GO:0007474	48	0.011
nucleoside triphosphate catabolic process	GO:0009143	108	0.011
response to bacterium	GO:0009617	198	0.011
mrna processing	GO:0006397	104	0.011
stem cell division	GO:0017145	69	0.011
response to starvation	GO:0042594	97	0.011
meiosis i	GO:0007127	59	0.011
establishment of localization in cell	GO:0051649	402	0.011
regulation of cell cycle	GO:0051726	291	0.011
regulation of smoothened signaling pathway	GO:0008589	28	0.011
regulation of mrna processing	GO:0050684	71	0.011
gland morphogenesis	GO:0022612	145	0.011
bmp signaling pathway	GO:0030509	27	0.011
apoptotic process involved in morphogenesis	GO:0060561	3	0.010
defense response to bacterium	GO:0042742	178	0.010
cell cycle checkpoint	GO:0000075	95	0.010
posttranscriptional gene silencing by rna	GO:0035194	45	0.010
ovarian follicle cell stalk formation	GO:0030713	17	0.010
dna damage checkpoint	GO:0000077	78	0.010
photoreceptor cell development	GO:0042461	96	0.010
stress activated protein kinase signaling cascade	GO:0031098	55	0.010
establishment of organelle localization	GO:0051656	122	0.010
negative regulation of neuron death	GO:1901215	18	0.010
signal transduction by phosphorylation	GO:0023014	107	0.010
imaginal disc growth	GO:0007446	37	0.010
midgut development	GO:0007494	23	0.010
cell projection assembly	GO:0030031	94	0.010
cell fate specification	GO:0001708	71	0.010
regulation of cell substrate adhesion	GO:0010810	2	0.010
cell division	GO:0051301	248	0.010

msl-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.036
disease of metabolism	DOID:0014667	0.018
organ system cancer	DOID:0050686	0.017
cancer	DOID:162	0.017
disease of cellular proliferation	DOID:14566	0.017
cardiovascular system disease	DOID:1287	0.013
acquired metabolic disease	DOID:0060158	0.012
nervous system disease	DOID:863	0.011
musculoskeletal system disease	DOID:17	0.010

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