IMP: Integrative Multi-species Prediction

Drosophila melanogaster

85 known processes

mod(mdg4) (Dmel_CG32491)

modifier of mdg4

(Aliases: E(var)3-93D,E-var(3)1,E-var(3)3,CG7836,CG15802,mod(gypsy),mnm,mnn,CG7859,E(var)129,mdg4,E-(var)3-93D,mod2.2,pf-2,l(3)03852,CG18151,E(var)93D,Doom,MOD(MDG4)56.3,BcDNA:SD03001,mod(mdg-4),CG15500,CG15501,Mod[mdg4],Mod(mdg4)67.2,Mod(mdg4)-67.2,Mod(mdg)4,CG32491,doom,BcDNA:GH07769,Mod(mdg4),CG8076,l(3)j2B7,Dmel\CG32491,bpd,Mod(mdg4)2.2,mod[mdg4],mod(mdg4)67.2,mod,mod(mdg4)-67.2,l(3)L3101,MOD(MDG4))

FLYBASE: FBgn0002781
Entrez: 49228
UniProtKB: Q86B87
UniProtKB: C7LAE7

Process Predictions
Disease Predictions

mod(mdg4) biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
meiotic cell cycle process	GO:1903046	132	1.000
meiotic nuclear division	GO:0007126	151	1.000
nuclear division	GO:0000280	332	0.999
chromosome organization	GO:0051276	360	0.999
positive regulation of transcription dna templated	GO:0045893	266	0.997	Fly
regulation of chromatin silencing	GO:0031935	36	0.995	Fly
organelle fission	GO:0048285	340	0.994
male meiosis	GO:0007140	52	0.990
meiotic cell cycle	GO:0051321	171	0.990
meiotic chromosome segregation	GO:0045132	59	0.988
dendrite morphogenesis	GO:0048813	199	0.964	Fly
chromatin organization	GO:0006325	207	0.962
dendrite development	GO:0016358	204	0.925	Fly
negative regulation of cellular component organization	GO:0051129	108	0.922
regulation of gene silencing	GO:0060968	63	0.897	Fly
chromatin silencing	GO:0006342	76	0.876	Fly
chromosome segregation	GO:0007059	157	0.867
post embryonic appendage morphogenesis	GO:0035120	385	0.842	Fly
histone h4 acetylation	GO:0043967	13	0.833
chromatin modification	GO:0016568	147	0.796
histone acetylation	GO:0016573	38	0.755
negative regulation of gene expression	GO:0010629	387	0.713	Fly
chromatin assembly or disassembly	GO:0006333	52	0.706
histone modification	GO:0016570	106	0.681
covalent chromatin modification	GO:0016569	106	0.631
reproductive structure development	GO:0048608	74	0.592	Fly
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.578	Fly
regulation of gene expression epigenetic	GO:0040029	128	0.561	Fly
neuron projection guidance	GO:0097485	241	0.542	Fly
regulation of rna splicing	GO:0043484	69	0.542
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.476	Fly
negative regulation of nervous system development	GO:0051961	92	0.473
peptidyl lysine acetylation	GO:0018394	39	0.452
cytoskeleton dependent cytokinesis	GO:0061640	81	0.434
male meiosis chromosome segregation	GO:0007060	10	0.412
cell motility	GO:0048870	251	0.406
organelle assembly	GO:0070925	198	0.374
histone h3 acetylation	GO:0043966	11	0.373
rna splicing	GO:0008380	83	0.351
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.346	Fly
growth	GO:0040007	359	0.341	Fly
peptidyl lysine modification	GO:0018205	57	0.325
taxis	GO:0042330	304	0.322	Fly
internal peptidyl lysine acetylation	GO:0018393	38	0.322
spindle organization	GO:0007051	253	0.306	Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.303	Fly
protein acetylation	GO:0006473	39	0.299
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.295	Fly
regulation of multicellular organismal development	GO:2000026	414	0.275	Fly
positive regulation of gene expression	GO:0010628	290	0.272	Fly
photoreceptor cell differentiation	GO:0046530	170	0.257	Fly
negative regulation of organelle organization	GO:0010639	56	0.257
sex differentiation	GO:0007548	81	0.255	Fly
positive regulation of cellular biosynthetic process	GO:0031328	316	0.250	Fly
male gamete generation	GO:0048232	201	0.249	Fly
cellular macromolecular complex assembly	GO:0034622	153	0.240
chromatin remodeling	GO:0006338	72	0.239
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.237	Fly
mrna metabolic process	GO:0016071	124	0.229
negative regulation of biosynthetic process	GO:0009890	277	0.228	Fly
mitotic cell cycle phase transition	GO:0044772	138	0.225
positive regulation of rna metabolic process	GO:0051254	271	0.209	Fly
cell proliferation	GO:0008283	299	0.207
positive regulation of macromolecule metabolic process	GO:0010604	405	0.207	Fly
axonogenesis	GO:0007409	290	0.200	Fly
meiosis i	GO:0007127	59	0.198
posttranscriptional gene silencing	GO:0016441	46	0.191
sister chromatid segregation	GO:0000819	92	0.187
regulation of cellular amino acid metabolic process	GO:0006521	0	0.183
negative regulation of cellular biosynthetic process	GO:0031327	277	0.162	Fly
axon development	GO:0061564	297	0.161	Fly
lateral inhibition	GO:0046331	206	0.159
dna packaging	GO:0006323	91	0.158
eye photoreceptor cell differentiation	GO:0001754	145	0.158	Fly
cellular protein modification process	GO:0006464	438	0.146
microtubule polymerization or depolymerization	GO:0031109	39	0.142
negative regulation of cellular metabolic process	GO:0031324	382	0.142	Fly
positive regulation of cellular component organization	GO:0051130	156	0.135
photoreceptor cell development	GO:0042461	96	0.133	Fly
regulation of meiotic cell cycle	GO:0051445	9	0.128
cell maturation	GO:0048469	144	0.127
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.125	Fly
negative regulation of chromatin silencing	GO:0031936	9	0.122
regulation of cell morphogenesis	GO:0022604	163	0.122	Fly
protein catabolic process	GO:0030163	101	0.115
regulation of chromatin modification	GO:1903308	28	0.114
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.114
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.113	Fly
internal protein amino acid acetylation	GO:0006475	38	0.109
positive regulation of biosynthetic process	GO:0009891	316	0.109	Fly
neurological system process	GO:0050877	358	0.107	Fly
eggshell chorion assembly	GO:0007306	66	0.106	Fly
cell fate specification	GO:0001708	71	0.105	Fly
protein acylation	GO:0043543	42	0.104
negative regulation of response to stimulus	GO:0048585	258	0.104
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.103	Fly
programmed cell death	GO:0012501	257	0.100
regulation of mrna splicing via spliceosome	GO:0048024	64	0.099
macromolecule catabolic process	GO:0009057	161	0.096
regulation of cell cycle phase transition	GO:1901987	130	0.095
spermatogenesis	GO:0007283	200	0.092	Fly
gene silencing	GO:0016458	138	0.092	Fly
posttranscriptional regulation of gene expression	GO:0010608	145	0.091
regulation of protein complex disassembly	GO:0043244	29	0.088
regionalization	GO:0003002	416	0.087	Fly
negative regulation of neurogenesis	GO:0050768	53	0.083
regulation of molecular function	GO:0065009	217	0.081	Fly
cellular amine metabolic process	GO:0044106	12	0.080
regulation of meiosis	GO:0040020	3	0.079
chromosome condensation	GO:0030261	41	0.077
regulation of developmental growth	GO:0048638	174	0.077
brain morphogenesis	GO:0048854	16	0.076	Fly
dna recombination	GO:0006310	32	0.076
meiotic cytokinesis	GO:0033206	33	0.072
regulation of neuron projection development	GO:0010975	69	0.072
compound eye photoreceptor cell differentiation	GO:0001751	140	0.072	Fly
regulation of cellular amine metabolic process	GO:0033238	3	0.071
imaginal disc derived appendage development	GO:0048737	399	0.068	Fly
muscle structure development	GO:0061061	224	0.067
regulation of cell cycle process	GO:0010564	181	0.066
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.065
negative regulation of developmental process	GO:0051093	201	0.064
regulation of organ morphogenesis	GO:2000027	78	0.063	Fly
embryo development ending in birth or egg hatching	GO:0009792	152	0.063	Fly
modification dependent macromolecule catabolic process	GO:0043632	79	0.059
macromolecular complex assembly	GO:0065003	256	0.059	Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.057	Fly
death	GO:0016265	284	0.057
protein modification process	GO:0036211	438	0.057
negative regulation of gene expression epigenetic	GO:0045814	77	0.056	Fly
positive regulation of signaling	GO:0023056	243	0.055
eye photoreceptor cell development	GO:0042462	81	0.055	Fly
regulation of mrna metabolic process	GO:1903311	72	0.053
regulation of cell cycle	GO:0051726	291	0.053
reproductive system development	GO:0061458	74	0.053	Fly
regulation of neurogenesis	GO:0050767	158	0.053
regulation of chromatin organization	GO:1902275	32	0.052
regulation of embryonic development	GO:0045995	68	0.052	Fly
negative regulation of rna metabolic process	GO:0051253	251	0.050	Fly
negative regulation of meiotic cell cycle	GO:0051447	2	0.050
apoptotic process	GO:0006915	159	0.049
mrna splicing via spliceosome	GO:0000398	73	0.049
negative regulation of rna biosynthetic process	GO:1902679	240	0.049	Fly
peptidyl amino acid modification	GO:0018193	105	0.048
protein complex disassembly	GO:0043241	36	0.048
cellular protein complex assembly	GO:0043623	71	0.048
appendage morphogenesis	GO:0035107	397	0.047	Fly
negative regulation of cell differentiation	GO:0045596	143	0.047
establishment of rna localization	GO:0051236	47	0.047
negative regulation of cell communication	GO:0010648	223	0.046
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.045
regulation of cellular component biogenesis	GO:0044087	201	0.045
chemotaxis	GO:0006935	249	0.045	Fly
dorsal ventral pattern formation	GO:0009953	133	0.045
ubiquitin dependent protein catabolic process	GO:0006511	78	0.043
regulation of cellular ketone metabolic process	GO:0010565	3	0.042
localization of cell	GO:0051674	257	0.042
proteolysis	GO:0006508	192	0.042
cuticle development	GO:0042335	86	0.040	Fly
regulation of anatomical structure size	GO:0090066	163	0.040	Fly
sensory organ morphogenesis	GO:0090596	260	0.040	Fly
cellular protein catabolic process	GO:0044257	83	0.040
developmental programmed cell death	GO:0010623	138	0.039	Fly
dosage compensation	GO:0007549	16	0.039	Fly
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.039
negative regulation of cell development	GO:0010721	62	0.039
regulation of localization	GO:0032879	275	0.038
cell death	GO:0008219	279	0.038
positive regulation of multicellular organismal process	GO:0051240	143	0.037
cell division	GO:0051301	248	0.036
chromatin assembly	GO:0031497	48	0.035	Fly
meiosis ii	GO:0007135	23	0.035
small molecule metabolic process	GO:0044281	305	0.035
positive regulation of cell cycle	GO:0045787	43	0.035
positive regulation of response to stimulus	GO:0048584	323	0.034
female germ line cyst formation	GO:0048135	42	0.034
ameboidal type cell migration	GO:0001667	151	0.033	Fly
posttranscriptional gene silencing by rna	GO:0035194	45	0.033
positive regulation of developmental growth	GO:0048639	62	0.032
positive regulation of cell cycle process	GO:0090068	28	0.032
response to abiotic stimulus	GO:0009628	341	0.032
transcription from rna polymerase ii promoter	GO:0006366	368	0.031	Fly
tube morphogenesis	GO:0035239	191	0.031	Fly
epithelial tube morphogenesis	GO:0060562	88	0.031	Fly
actin cytoskeleton organization	GO:0030036	206	0.031
amine metabolic process	GO:0009308	12	0.031
cell cycle phase transition	GO:0044770	140	0.029
imaginal disc derived wing morphogenesis	GO:0007476	337	0.029	Fly
oocyte differentiation	GO:0009994	145	0.029
regulation of compound eye cone cell fate specification	GO:0042682	4	0.028	Fly
anterior posterior axis specification	GO:0009948	109	0.027	Fly
regulation of cell proliferation	GO:0042127	163	0.027
cellular component disassembly	GO:0022411	46	0.027
dna conformation change	GO:0071103	105	0.027
gonad development	GO:0008406	50	0.026	Fly
body morphogenesis	GO:0010171	2	0.025
compound eye development	GO:0048749	307	0.025	Fly
appendage development	GO:0048736	401	0.025	Fly
reproductive behavior	GO:0019098	122	0.025
genitalia development	GO:0048806	26	0.025
positive regulation of cellular amine metabolic process	GO:0033240	0	0.025
regulation of cell fate commitment	GO:0010453	29	0.024	Fly
eye morphogenesis	GO:0048592	260	0.024	Fly
negative regulation of microtubule polymerization or depolymerization	GO:0031111	21	0.024
proteasomal protein catabolic process	GO:0010498	59	0.024
negative regulation of transcription factor import into nucleus	GO:0042992	4	0.023
regulation of protein complex assembly	GO:0043254	42	0.023
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.023
mitotic chromosome condensation	GO:0007076	22	0.023
axon guidance	GO:0007411	233	0.023	Fly
establishment of tissue polarity	GO:0007164	87	0.022	Fly
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.022
ribonucleoprotein complex assembly	GO:0022618	23	0.022
dendrite regeneration	GO:0031104	2	0.022
mrna processing	GO:0006397	104	0.022
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.022
positive regulation of molecular function	GO:0044093	136	0.022	Fly
oocyte morphogenesis	GO:0048601	3	0.022
negative regulation of developmental growth	GO:0048640	64	0.022
negative regulation of multicellular organismal process	GO:0051241	142	0.022
regulation of chromosome organization	GO:0033044	64	0.021
mitotic dna damage checkpoint	GO:0044773	74	0.021
regulation of neuron differentiation	GO:0045664	103	0.021
compound eye photoreceptor development	GO:0042051	78	0.020	Fly
ovulation cycle	GO:0042698	1	0.020
notch signaling pathway	GO:0007219	120	0.020
cellular macromolecule catabolic process	GO:0044265	136	0.020
positive regulation of developmental process	GO:0051094	143	0.020
r1 r6 cell differentiation	GO:0048052	4	0.020	Fly
tracheal outgrowth open tracheal system	GO:0007426	18	0.019	Fly
regulation of cellular protein metabolic process	GO:0032268	243	0.019
modification dependent protein catabolic process	GO:0019941	78	0.019
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.018
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.018
heterochromatin organization	GO:0070828	25	0.018
histone methylation	GO:0016571	40	0.018
morphogenesis of an epithelium	GO:0002009	276	0.018	Fly
protein dna complex subunit organization	GO:0071824	86	0.018
cellular catabolic process	GO:0044248	372	0.018
dorsal closure leading edge cell differentiation	GO:0046663	2	0.018
protein localization	GO:0008104	284	0.018	Fly
organonitrogen compound metabolic process	GO:1901564	318	0.018
gene silencing by rna	GO:0031047	57	0.017
gland morphogenesis	GO:0022612	145	0.017	Fly
endocytosis	GO:0006897	310	0.017
regulation of programmed cell death	GO:0043067	152	0.017
regulation of histone modification	GO:0031056	20	0.017
catabolic process	GO:0009056	409	0.017
ovarian follicle cell development	GO:0030707	248	0.017	Fly
regulation of protein acetylation	GO:1901983	7	0.016
larval development	GO:0002164	104	0.016
rna splicing via transesterification reactions	GO:0000375	73	0.016
neuron fate commitment	GO:0048663	50	0.015	Fly
positive regulation of histone acetylation	GO:0035066	3	0.015
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	2	0.015
brain development	GO:0007420	120	0.015	Fly
regulation of protein metabolic process	GO:0051246	256	0.015
cytokinesis	GO:0000910	90	0.015
negative regulation of cell division	GO:0051782	17	0.015
stem cell maintenance	GO:0019827	67	0.015
salivary gland histolysis	GO:0035070	88	0.015
dna methylation or demethylation	GO:0044728	4	0.015
gliogenesis	GO:0042063	80	0.014
negative regulation of neuron differentiation	GO:0045665	16	0.014
wing disc morphogenesis	GO:0007472	344	0.014	Fly
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.014
negative regulation of signaling	GO:0023057	219	0.014
organic acid metabolic process	GO:0006082	103	0.014
negative regulation of nucleoside metabolic process	GO:0045978	1	0.014
dorsal vessel heart proper cell fate commitment	GO:0035053	2	0.014
eye development	GO:0001654	323	0.014	Fly
histone h4 k12 acetylation	GO:0043983	2	0.013
negative regulation of terminal cell fate specification open tracheal system	GO:0035155	2	0.013
positive regulation of organelle organization	GO:0010638	65	0.013
regulation of cytoskeleton organization	GO:0051493	89	0.013
multi organism behavior	GO:0051705	175	0.013	Fly
rna interference	GO:0016246	27	0.013
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.012
regulation of mrna processing	GO:0050684	71	0.012
oxoacid metabolic process	GO:0043436	103	0.012
regulation of cell differentiation	GO:0045595	302	0.012	Fly
regulation of cellular protein catabolic process	GO:1903362	44	0.012
formation of a compartment boundary	GO:0060288	4	0.012
regulation of cell development	GO:0060284	215	0.012
nucleobase containing compound transport	GO:0015931	56	0.011
oocyte fate commitment	GO:0048600	2	0.011
single organism biosynthetic process	GO:0044711	206	0.011
eggshell formation	GO:0030703	105	0.011	Fly
ribonucleoprotein complex disassembly	GO:0032988	1	0.011
alternative mrna splicing via spliceosome	GO:0000380	60	0.011
establishment or maintenance of polarity of larval imaginal disc epithelium	GO:0016336	3	0.011
multi organism reproductive behavior	GO:0044705	121	0.011
anterior posterior axis specification follicular epithelium	GO:0030714	2	0.011
negative regulation of nucleotide metabolic process	GO:0045980	4	0.011
cellular ketone metabolic process	GO:0042180	24	0.011
development of primary sexual characteristics	GO:0045137	50	0.011	Fly
meiotic nuclear envelope disassembly	GO:0051078	2	0.011
cellular component assembly involved in morphogenesis	GO:0010927	151	0.011	Fly
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.010
border follicle cell delamination	GO:0030709	3	0.010
stem cell differentiation	GO:0048863	117	0.010
phospholipid transport	GO:0015914	2	0.010
oocyte maturation	GO:0001556	3	0.010
meiotic spindle checkpoint	GO:0044779	1	0.010
regulation of apoptotic process	GO:0042981	130	0.010
positive regulation of growth	GO:0045927	75	0.010
cell cycle arrest	GO:0007050	4	0.010

mod(mdg4) disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
aortic aneurysm	DOID:3627	0.018
disease of anatomical entity	DOID:7	0.018
artery disease	DOID:0050828	0.018
aortic disease	DOID:520	0.018
vascular disease	DOID:178	0.018
cardiovascular system disease	DOID:1287	0.018
cancer	DOID:162	0.013
disease of cellular proliferation	DOID:14566	0.013
head and neck cancer	DOID:11934	0.013
organ system cancer	DOID:0050686	0.013

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