IMP: Integrative Multi-species Prediction

Drosophila melanogaster

5 known processes

Tif-IA (Dmel_CG3278)

CG3278 gene product from transcript CG3278-RA

(Aliases: TifIA,CG3278,dTIF-IA,Dmel\CG3278,TIF-1A,Tif-1A,TIF-IA,CG16938,CG5951)

Entrez: 35454
FLYBASE: FBgn0032988
UniProtKB: Q9V9M6

Process Predictions
Disease Predictions

Tif-IA biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of cell differentiation	GO:0045595	302	0.749
positive regulation of biosynthetic process	GO:0009891	316	0.490	Mouse
protein localization	GO:0008104	284	0.473
cellular macromolecule localization	GO:0070727	220	0.424
single organism cellular localization	GO:1902580	180	0.402
cardiovascular system development	GO:0072358	82	0.372
establishment of localization in cell	GO:0051649	402	0.273
protein transport	GO:0015031	155	0.258
protein complex biogenesis	GO:0070271	201	0.239	Mouse
nuclear transport	GO:0051169	72	0.216
positive regulation of rna biosynthetic process	GO:1902680	266	0.198	Mouse
protein targeting	GO:0006605	64	0.181
positive regulation of macromolecule metabolic process	GO:0010604	405	0.179	Mouse
establishment of protein localization	GO:0045184	163	0.156
intracellular transport	GO:0046907	228	0.152
positive regulation of rna metabolic process	GO:0051254	271	0.140	Mouse
cellular protein localization	GO:0034613	160	0.137
single organism intracellular transport	GO:1902582	207	0.132
positive regulation of cellular protein metabolic process	GO:0032270	118	0.121
organic substance transport	GO:0071702	257	0.118
eye development	GO:0001654	323	0.113
cytoplasmic transport	GO:0016482	130	0.111
cytoplasm organization	GO:0007028	64	0.108	Mouse
muscle cell differentiation	GO:0042692	103	0.106
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.106	Mouse
eye morphogenesis	GO:0048592	260	0.089
cellular protein complex assembly	GO:0043623	71	0.085
compound eye morphogenesis	GO:0001745	249	0.080
nuclear export	GO:0051168	24	0.079
multicellular organism growth	GO:0035264	46	0.073
macromolecular complex assembly	GO:0065003	256	0.073	Mouse
nucleocytoplasmic transport	GO:0006913	72	0.067
larval development	GO:0002164	104	0.066
single organism membrane organization	GO:0044802	93	0.065
protein complex assembly	GO:0006461	200	0.061	Mouse
establishment of protein localization to organelle	GO:0072594	62	0.061
cell death	GO:0008219	279	0.059	Mouse
hemopoiesis	GO:0030097	46	0.058
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.058	Mouse
death	GO:0016265	284	0.055	Mouse
programmed cell death	GO:0012501	257	0.055	Mouse
mitochondrion organization	GO:0007005	65	0.054
positive regulation of cellular biosynthetic process	GO:0031328	316	0.052	Mouse
protein localization to organelle	GO:0033365	82	0.052
developmental growth	GO:0048589	280	0.052
apoptotic process	GO:0006915	159	0.050	Mouse
gland development	GO:0048732	191	0.050
regulation of multicellular organismal development	GO:2000026	414	0.049
translation	GO:0006412	69	0.048
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.047	Mouse
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.046	Mouse
regulation of cell proliferation	GO:0042127	163	0.046
regulation of nervous system development	GO:0051960	248	0.043
regulation of programmed cell death	GO:0043067	152	0.043	Mouse
regulation of apoptotic process	GO:0042981	130	0.042	Mouse
stem cell maintenance	GO:0019827	67	0.042
embryo development ending in birth or egg hatching	GO:0009792	152	0.040	Mouse
positive regulation of protein metabolic process	GO:0051247	128	0.038
hematopoietic or lymphoid organ development	GO:0048534	57	0.037
phagocytosis	GO:0006909	215	0.036
exocrine system development	GO:0035272	162	0.035
regulation of cellular protein metabolic process	GO:0032268	243	0.034
compound eye development	GO:0048749	307	0.034
immune system process	GO:0002376	347	0.033
regulation of localization	GO:0032879	275	0.033
vesicle mediated transport	GO:0016192	381	0.033
gland morphogenesis	GO:0022612	145	0.033
rrna processing	GO:0006364	3	0.032
sensory organ morphogenesis	GO:0090596	260	0.031
positive regulation of gene expression	GO:0010628	290	0.029	Mouse
morphogenesis of an epithelium	GO:0002009	276	0.029
nuclear import	GO:0051170	51	0.029
cellular component disassembly	GO:0022411	46	0.028
negative regulation of signal transduction by p53 class mediator	GO:1901797	1	0.028	Mouse
stem cell division	GO:0017145	69	0.028
membrane organization	GO:0061024	112	0.027
stem cell development	GO:0048864	79	0.027
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.027	Mouse
ribonucleoprotein complex disassembly	GO:0032988	1	0.026
protein modification process	GO:0036211	438	0.026
cellular macromolecular complex assembly	GO:0034622	153	0.026
g2 dna damage checkpoint	GO:0031572	69	0.024
regulation of meiosis	GO:0040020	3	0.024
positive regulation of cell growth	GO:0030307	19	0.024
positive regulation of response to stimulus	GO:0048584	323	0.024
reproductive behavior	GO:0019098	122	0.023
growth	GO:0040007	359	0.023
regulation of immune system process	GO:0002682	176	0.023
chromatin modification	GO:0016568	147	0.023
proteolysis	GO:0006508	192	0.022
ribonucleoprotein complex biogenesis	GO:0022613	31	0.022
regulation of growth	GO:0040008	233	0.021
body morphogenesis	GO:0010171	2	0.021
positive regulation of translation	GO:0045727	12	0.021
salivary gland morphogenesis	GO:0007435	145	0.021
asymmetric stem cell division	GO:0098722	49	0.021
positive regulation of developmental growth	GO:0048639	62	0.021
multicellular organismal aging	GO:0010259	140	0.020
rna processing	GO:0006396	147	0.020
actin filament organization	GO:0007015	126	0.020
cellular macromolecule catabolic process	GO:0044265	136	0.020
intracellular protein transport	GO:0006886	104	0.020
protein ubiquitination	GO:0016567	70	0.019
regulation of organelle organization	GO:0033043	196	0.019
regulation of protein metabolic process	GO:0051246	256	0.019
neural retina development	GO:0003407	4	0.018
regulation of hemocyte proliferation	GO:0035206	37	0.018
circulatory system development	GO:0072359	82	0.017
single organism nuclear import	GO:1902593	51	0.017
regulation of oocyte development	GO:0060281	27	0.017
cellular protein modification process	GO:0006464	438	0.016
rna catabolic process	GO:0006401	37	0.016
gene silencing by mirna	GO:0035195	22	0.016
intermediate filament based process	GO:0045103	1	0.016
response to external biotic stimulus	GO:0043207	293	0.016
salivary gland development	GO:0007431	162	0.015
salivary gland histolysis	GO:0035070	88	0.015
regulation of developmental growth	GO:0048638	174	0.015
negative regulation of gene expression	GO:0010629	387	0.015
cellular amine metabolic process	GO:0044106	12	0.014
negative regulation of developmental process	GO:0051093	201	0.014
mitotic cell cycle phase transition	GO:0044772	138	0.014
protein import	GO:0017038	55	0.014
regulation of phosphorus metabolic process	GO:0051174	210	0.014
regulation of cell cycle process	GO:0010564	181	0.014
regulation of translation	GO:0006417	56	0.013
translational termination	GO:0006415	2	0.013
intermediate filament cytoskeleton organization	GO:0045104	1	0.013
nuclear division	GO:0000280	332	0.013
immune system development	GO:0002520	57	0.013
mrna metabolic process	GO:0016071	124	0.013
negative regulation of phosphatase activity	GO:0010923	3	0.013
regulation of histone methylation	GO:0031060	10	0.012
protein export from nucleus	GO:0006611	10	0.012
cellular catabolic process	GO:0044248	372	0.012
protein modification by small protein conjugation or removal	GO:0070647	106	0.012
photoreceptor cell differentiation	GO:0046530	170	0.012
positive regulation of multicellular organismal process	GO:0051240	143	0.012
homeostatic process	GO:0042592	199	0.011	Mouse
mrna polyadenylation	GO:0006378	11	0.011
establishment of organelle localization	GO:0051656	122	0.011
locomotory behavior	GO:0007626	176	0.011
protein targeting to nucleus	GO:0044744	51	0.011
macromolecule catabolic process	GO:0009057	161	0.011
regulation of protein modification process	GO:0031399	112	0.011
phosphorylation	GO:0016310	294	0.011
negative regulation of growth	GO:0045926	84	0.011
defense response to gram negative bacterium	GO:0050829	94	0.011
organelle localization	GO:0051640	148	0.011
regulation of signal transduction by p53 class mediator	GO:1901796	1	0.010	Mouse
multi organism reproductive behavior	GO:0044705	121	0.010
pole plasm oskar mrna localization	GO:0045451	46	0.010
positive regulation of molecular function	GO:0044093	136	0.010
positive regulation of viral process	GO:0048524	2	0.010

Tif-IA disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
osteogenesis imperfecta	DOID:12347	0.023
disease of anatomical entity	DOID:7	0.023
bone disease	DOID:0080001	0.023
musculoskeletal system disease	DOID:17	0.023
bone development disease	DOID:0080006	0.023
connective tissue disease	DOID:65	0.023
osteochondrodysplasia	DOID:2256	0.023
syndrome	DOID:225	0.013
benign neoplasm	DOID:0060072	0.010
disease of cellular proliferation	DOID:14566	0.010

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